DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1e

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_017212914.2 Gene:cacna1e / 564274 -ID:- Length:2444 Species:Danio rerio


Alignment Length:2511 Identity:508/2511 - (20%)
Similarity:863/2511 - (34%) Gaps:788/2511 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 LGLGARQDAASALN--SPTTIVNSGSGSGGGS--SVAFGMQPQQQQQSLAGGG----GGGSSATA 241
            |.||....:|..|:  :...:.:.|.|..|||  |..|.:|||..:..|...|    |..|.:..
Zfish     2 LELGTCSVSAQTLSDRNALAVPSFGQGICGGSPPSRCFLLQPQDPESWLKHRGTLEDGSRSCSLL 66

  Fly   242 APSSGGG---------------HNNGAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGM---- 287
            .|.|...               |....||.|      ..|:|       ||...||||.|:    
Zfish    67 EPQSLADSLLSHASSFDMLYVPHGRPMGLAP------SSLDL-------GGSCEGAAALGLDPDM 118

  Fly   288 --------------------------------------------------GICGGISSTVGSAAI 302
                                                              |:.|........:..
Zfish   119 PVSPNIIKRRRGGLIEQRDIIKAHQAHKIQSTPQARRKEWEMARFGDDVPGLLGAGDGGSERSRN 183

  Fly   303 TGVPPIGLGIATGIG-----NKIMLGRKQSLKGGEPF----------LADYGPEESLNESAD--I 350
            ...|.:..|   |:.     .|....|..:|....|.          |..:|.:..:.:.|.  |
Zfish   184 RDAPAVSTG---GVSPAFKQTKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKII 245

  Fly   351 EW--VNKLWVRRLMRLCALVSL---------TSVSLNTPKTFERYPSLQFITFASDTAVTLLFTA 404
            ||  ...:.:..::..|.:::|         |.::....|| |.|    ||.         :|..
Zfish   246 EWPPFEYMILATIIANCIVLALEQHLPGEDKTPMAKRLEKT-EPY----FIG---------MFCF 296

  Fly   405 EMIAKMHIRGVLHGEVPYLKDHWCQFDASMVS---------FLWISIILQIFEVLEI-------- 452
            |...|:...|.:..:..||::.|...|..:||         .:.||:.|:....:.:        
Zfish   297 EAGIKIIALGFVFHKGSYLRNGWNVMDFIVVSSGILATAGAHMNISLDLRTLRAVRVLRPLKLVS 361

  Fly   453 -VPKFSYL--SIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGL 514
             :|....:  |||:|..||:.|..|                            |||...|  :.:
Zfish   362 GIPSLQIVLKSIMKAMVPLLQIGLL----------------------------LFFAILM--FAI 396

  Fly   515 LGVQFF-GELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPD----SGYQCSPGMVCMKMD 574
            :|::|: |:|...|.....:.:....|   .|........|   ||    |||...|.       
Zfish   397 IGLEFYSGKLHKQCEPVGKDSERADSP---ENEFPCGSKLC---PDHYNCSGYWTGPN------- 448

  Fly   575 FLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNV 639
                  .|...|::|..|:.||:|..:.|||..|:|...|:|.:.....||..:|...::.|.|:
Zfish   449 ------DGITQFDNILFSLLTVFQCITMEGWTTILYYTNDALGSTWNWLYFIPLIIIGSFFVLNL 507

  Fly   640 FIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDTGWR--------LVTIDDNKHGG--- 693
            .:.|::..|.:.|.:.:.    |....|....|.:.....|:|        ::..::||:.|   
Zfish   508 VLGVLSGEFAKERERVEN----RRAFMKLRRQQQIERELNGYRAWIDRAEEVMLAEENKNSGPSA 568

  Fly   694 -------------------LAPETCHAIL----------------RSP--YF----RMLVMSV-- 715
                               .|||..:|.:                |.|  ||    |:|.:||  
Zfish   569 LDVLKRATTIKRRGVDDARRAPEEQYADISSLGMPLNRASIRSAKRGPTSYFRRKERLLRISVRR 633

  Fly   716 ----------ILANGIV---TATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWR 767
                      :|  |:|   |..:...|..:|: ......||.|.:|..|...|...|:|.||.|
Zfish   634 MVKTQTFYWTVL--GLVALNTLCVAIVHHKQPQ-WLSSLLYYAEFLFLGLFLTEMFLKMYGLGPR 695

  Fly   768 GYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTY-FQVLRVVRLIKASPM------LEGFVYKIFG 825
            .|:..|.:.|:..:..|:...:...|:..|.:: ..|||.:||::...:      |...|..:..
Zfish   696 LYFHSSFNCFDCGVIVGSIFEVFWGFFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMN 760

  Fly   826 PGKKLGSLIIFTMCLLIISSSISMQLF--CFLCDF---TKFESFPEAFMSMFQILTQEAWVEVMD 885
            ..|.:.||:......:::.:.:.||||  .|:.|.   |.|::||.|.|::|||||.|.|.||| 
Zfish   761 SMKSIISLLFLLFLFIVVFALLGMQLFGGRFIFDEYTPTNFDTFPAAIMTVFQILTGEDWNEVM- 824

  Fly   886 ETMIRTSKTLTPLV--AVYFILYHLFVTLIVLSLFVAVILDNL----ELDED------------- 931
            ...||:...:...:  :||||:..||....:|::|:|:.:|||    ||.:|             
Zfish   825 YNGIRSQGGVKSGMWSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEEEEAFNQKHA 889

  Fly   932 IKKLKQL----------------KFR-------------EQSAEIKETLPFR------------- 954
            ::|.|::                .:|             |.:..:.:..||.             
Zfish   890 LQKAKEVGPMSSFMSSERRRRPYLYRKRAIHRSRAAYSFEDAESLADARPFNASNSFMSRRERRR 954

  Fly   955 ---LRIFE-----------------------KFPDSPQMTILHRIP---------------NDFM 978
               :.::|                       :..|.|....|||.|               :..:
Zfish   955 RLTMSVWEQRTSQLRRHRQMSSREILFSSPSEEQDGPPGCPLHRKPGLSPSGSKRRATETTSTTI 1019

  Fly   979 LPK------------VRESFM------KHFVIELETEDSLVENC--------KRPMSECWESNVV 1017
            :|:            |.|..:      ....|.:......|:.|        ..|::|..||...
Zfish  1020 MPEGTLEPPMPMDMPVDEQALPISIPEPPLAIPIPEPPMPVDACLPEPPVTLNLPLTEPSESKTS 1084

  Fly  1018 ----------------FRKQKPVRIMNKTAKVR--AAGSSL--------RKLAITHIINDSNNQR 1056
                            .|:|:.||      |.|  |.|..|        |:.....:..|...:.
Zfish  1085 PEGALDINNHCPRLNGNRRQRAVR------KHRPPAMGDMLTPDMGPRPRRPRHRELHTDPRGKE 1143

  Fly  1057 LMLGDSAMLPVVGTKG-------GGGLKSQGTI--------------------THSKP------- 1087
            .:.||       |..|       .|..||.|.|                    |.|||       
Zfish  1144 TLQGD-------GVDGKEQKPGSEGDEKSDGEISPDGRGLEQRQNKPDNTESSTESKPANSPRKI 1201

  Fly  1088 ---------------------------WRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIA 1125
                                       ...|....||.:..:|..:.||.::.|           
Zfish  1202 PPLDSEPATLQLTDNTLQQSSQGTTCAGETDNNNHGSLNQDKSSLNTSIVIEVT----------- 1255

  Fly  1126 AAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTP-------LFLVPRESRF 1183
                    ..:| .:::..:....:..|..:.::||:..      |.|       :|:....:..
Zfish  1256 --------DTQP-SMELTSITGNSKDVEASKPEKEEETP------DAPKGPPPVSMFIFKPNNPV 1305

  Fly  1184 RKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETP-NY 1247
            |:.|..:|:.|                             |.:..::.....|.|::..|.| |.
Zfish  1306 RRACHYVVNLR-----------------------------YFEMSILLVIAASSIALAAEDPVNT 1341

  Fly  1248 RVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLN 1312
            ....:..|:..:|.|....:.|:.:|::..||.....:|.:|....|| ||.||.......:...
Zfish  1342 NSDRNKVLRYFDYVFTGVFTFEMIIKMIDQGLVLHYGSYFRDPWNILD-FIVVVGALVAFALTNV 1405

  Fly  1313 IPTNSAAQL-----LMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYG 1372
            :.:|:...:     |.:||.:|||:....:|.::.|...:....|.:..:..:..|.|||||...
Zfish  1406 MGSNTGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIA 1470

  Fly  1373 VQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNI 1437
            |||:.|:...|.|.:.....:|.|.::              |.........|.|.. |.|::||:
Zfish  1471 VQLFKGKFYYCTDSSKDTENECKGYYI--------------DYDKDKKKEKREWKR-RDFHYDNV 1520

  Fly  1438 GDAMLTLFEVLSFKGWLDVR----DVLIKAVGPVH------AVYIHIYIFLGCMIGLTLFVGVVI 1492
            ..|:||||.|.:.:||..|.    ||..:..||..      :::..||..:.....:.:||.::|
Zfish  1521 VWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSQGNRMEMSIFYVIYFVVFPFFFVNIFVALII 1585

  Fly  1493 ANYSENKGTALLTVDQRRWCDLKKRLKI-------AQPL--HLPPRPDGRKIRAFTYDITQHII- 1547
            ..:.| :|..::     ..|.|:|..:.       |:||  ::|     :..:...|.:.|.:: 
Zfish  1586 ITFQE-QGDKMM-----EECSLEKNERACIDFAISAKPLTRYMP-----QNRQTLQYRLWQFVVS 1639

  Fly  1548 --FKRVIAVVVLINSMLLSITW----IKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQ 1606
              |:..:..::.:|:::|.:..    ::|  :.:.|..::.:.|.:|.||.|:|.:||....|::
Zfish  1640 PSFEYTVLTMIALNTIVLMMKHHDPRLEG--YDDVLKYLNTIFTVIFSVECVLKILAFGIMNYFR 1702

  Fly  1607 SRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVI--LRFFTITGKHTTLKMLMLTVGVSVC 1669
            ...|.:| .:||.|.|..||....:...::..||:.:.  .|...:..:..|:::|:.|...|..
Zfish  1703 DTWNIFD-FITVLGSITEILVDKFQTGKTFNMGFLKLFRAARLIKLLRQGYTIRILLWTFVQSFK 1766

  Fly  1670 KSFFIIFGMFLLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMH 1732
            ...::...:.:|.|.||:.|..:||.:|..|  .|....||.:....:.:|||..|||.|.:||.
Zfish  1767 ALPYVCLLIAMLFFIYAIIGMQVFGNIKINEKTQINEHNNFRTFFGALMLLFRSATGESWQEIML 1831

  Fly  1733 DCMVQPPYCTLGNNYWET------DCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSN 1791
            .|:.:.. |.:..:...|      |||...| ..||.:|....::::|||.||:||:||.  |..
Zfish  1832 SCLGEKE-CEIDTSVNSTTKTIKNDCGTDFA-YFYFVSFIFFSSFLMLNLFVAVIMDNFE--YLT 1892

  Fly  1792 EEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQKDRLLFKYMCY 1852
            .:.::|....:..|...|...|....|.:..:.:..::|.:...|    .|.       ::..|.
Zfish  1893 RDSSILGPHHLDEFVRIWGEYDRAACGKLHYKEMYKVVRTISPPLGFGKNCP-------YRVACK 1950

  Fly  1853 ELDKLHN--GEDVTFHDVINMLSYRSVDIRKALQLE-------------EL----------LARE 1892
            .|..::.  .||::.|....:::.    ||.||.::             ||          |:::
Zfish  1951 RLVLMNMPVDEDMSVHFTSTLMAL----IRTALDIKIARGGEDRGQMDVELQKEISVIWPHLSQK 2011

  Fly  1893 EFEYLVE-EEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDK-APL- 1954
            ..:.||. .:.:.|||        .||.|.       .:|......|:...:|..::|.| ||: 
Zfish  2012 SLDLLVPIHKASDMTI--------GKIYAA-------MMIMDYYKQNKAKKLRQQLEEQKHAPMF 2061

  Fly  1955 GAVDKSAIS---------------------TISGAVAGACPPTSDAFSPTFSSTENEEKD----- 1993
            ..:|.|::.                     |..|.||.:.....|.|....:....||::     
Zfish  2062 QRMDASSLPQDILCSAKALPFLTHSAGSALTRGGFVALSPISPQDLFMQPMTQDSMEEREEYQHP 2126

  Fly  1994 -GSSSAVVQLPHSE-------TSIAGTGSSATGAATATGTSS--GLGVGPPTV---QSTARHVMT 2045
             ...|.|.:  |.|       ||:........|...:...||  .|.|.|...   :...|...|
Zfish  2127 YHLQSMVPE--HKEFSSVMCPTSMQADPLQVPGRGVSIRASSMPRLAVEPQASLENKLMKRSFST 2189

  Fly  2046 VG--------KRGYALNR--SDSTGSSAGRKFLAPTSS--DPQQRSTLSDKERLHITS------- 2091
            :|        :..::|.|  .|.......|.|....|:  :|..:.....|||.|:.|       
Zfish  2190 IGDQCVNGDWQEEFSLERVSPDRLERPRQRSFRGVRSNLREPVDKERGRSKERRHLLSPDVSRCN 2254

  Fly  2092 ------QQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSS 2126
                  .|.:::|.:  |..|:.....:|....|....|:|
Zfish  2255 SEERSQSQERRHSPS--PSEGRKHTALRQGNNTGSPIASTS 2293

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 68/305 (22%)
Ion_trans 734..927 CDD:278921 64/210 (30%)
Ion_trans 1240..1497 CDD:278921 67/272 (25%)
Ion_trans 1571..1793 CDD:278921 66/231 (29%)
cacna1eXP_017212914.2 Ion_trans 247..524 CDD:306908 72/339 (21%)
Ion_trans 640..875 CDD:306908 71/238 (30%)
Atrophin-1 887..>1210 CDD:331285 47/335 (14%)
Ion_trans 1316..1549 CDD:306908 64/277 (23%)
Ion_trans 1639..1896 CDD:306908 70/263 (27%)
GPHH 1897..1967 CDD:318993 12/76 (16%)
Ca_chan_IQ 1969..2043 CDD:312334 16/92 (17%)
Transformer 2203..2368 CDD:253769 20/93 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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