DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1bb

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_021324711.1 Gene:cacna1bb / 562796 ZFINID:ZDB-GENE-090514-4 Length:2345 Species:Danio rerio


Alignment Length:2296 Identity:483/2296 - (21%)
Similarity:831/2296 - (36%) Gaps:632/2296 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   273 GGMGGMGGGAAAAGMGICGGISSTVGSAAITGVPPIGLGIATGIGNKIMLGRKQSLKGGEPFLAD 337
            ||..|.|.|.|.||                   .|.|       |.::.   |||:......:|.
Zfish    16 GGPAGAGRGGARAG-------------------GPSG-------GQRMY---KQSMAQRARTMAL 51

  Fly   338 YGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLF 402
            |.|:::......:.           |...:.|..:|.....|....:|..:::...:..|..::.
Zfish    52 YNPKQTKQNCFTVN-----------RSLFIFSEDNVIRKYAKRITEWPPFEYLILTTIIANCIVL 105

  Fly   403 TAEM----IAKMHIRGVLHGEVPYLKDHWCQFDASMV-----------SFL---W--ISIILQIF 447
            ..|.    :.|..:...|....||....:| |:|.:.           |:|   |  :..::.:.
Zfish   106 ALEQHLPALDKTPMSERLDDTEPYFIGIFC-FEAGIKIIALGFVFHKDSYLRNGWNIMDFVVVVT 169

  Fly   448 EVLEIVPKFSYLSIMRAPRPLIMIRF------LRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFL 506
            .:|..|.....|..:||.|.|..::.      |:|.|| |:.|:.:         .:..:.|...
Zfish   170 GILTTVGSQFDLRTLRAVRVLRPLKLVSGIPSLQVVLK-SIMKAMV---------PLLQIGLLLF 224

  Fly   507 FFMSLYGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVC 570
            |.:.::.::||:|: |:....|...:|.......|             |..:|.| ..|..|..|
Zfish   225 FAIVMFAIIGVEFYMGKFHFTCFKVDTGEKAVDYP-------------CGAEPPS-RSCPVGTNC 275

  Fly   571 MKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWL 635
              .::......|...|::|..:|.||:|..:.|||..::|...|:........||..:|...::.
Zfish   276 --TEYWKGPNFGITNFDNILFAILTVFQCITMEGWTDVLYHTNDAAGNTWNWLYFIPLIIIGSFF 338

  Fly   636 VKNVFIAVIT-------------ETFNEIRVQFQQMWGARGHIQKTA-ASQIL-----------S 675
            :.|:.:.|::             :.|.::|.|.|......|:::... |.::|           |
Zfish   339 MLNLVLGVLSGEFAKERERVEKRQEFLKLRRQQQIERELTGYLEWICKAEEVLLAEEDQNAEEKS 403

  Fly   676 GNDTGW--------------------RLVTIDD-NKH----GGLAP---ETCHAILR------SP 706
            ..|..|                    .|::.:: ::|    ..:||   ....|.|:      |.
Zfish   404 PLDGAWYRRKQNNPVLKRTKSRKGRNDLISAEEGDEHFTDISSVAPPGSPFARASLKSSKNDSSS 468

  Fly   707 YFR--------------------MLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTC 751
            |||                    .:|:.::   |:.|..:...|..:| :...:..|..|.||..
Zfish   469 YFRRKEKRIRFFIRRMVKAQSFYWIVLCLV---GLNTMCVAIVHYDQP-EWLTKALYLAEFVFLG 529

  Fly   752 LLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKA 812
            |...|...|:|.||.|.|:..|.:.|:..:..|:...:: ....|.   |::..:.||::|:.|.
Zfish   530 LFLTEMTLKMYGLGPRNYFHSSFNCFDFGVIVGSIFEVIWAAIQPGASFGISVLRALRLLRIFKV 594

  Fly   813 SP---MLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF------TKFESFPEAF 868
            :.   .|...|..:....|.:.||:......:::.:.:.||||....:|      |.|:|||.|.
Zfish   595 TKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEDETPTTNFDSFPAAI 659

  Fly   869 MSMFQILTQEAWVEVM-----DETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNL-- 926
            |::|||||.|.|..||     .:..:|...    ..:||||:..||....:|::|:|:.:|||  
Zfish   660 MTVFQILTGEDWNAVMYHGIESQGGVRGGM----FSSVYFIVLTLFGNYTLLNVFLAIAVDNLAN 720

  Fly   927 --ELDEDIKKLKQLKFR----EQSAEIKETLP-----FRLRIFEK----------------FPDS 964
              ||.:|.::.::...:    :::.|:||..|     ..:..|.|                .|..
Zfish   721 AQELTKDEEQQEEAAKKSLALQKAMEVKEVSPMSAANISIAAFVKQNRDAISRRSSVCSVHSPKE 785

  Fly   965 PQ-----MTILHRIPNDFMLPKVRESFMKHFVIELETEDSL------------------------ 1000
            .|     ::|..:..|......:|.| .:....|||.|:.|                        
Zfish   786 QQRSLQKLSIWEQRTNQLRRHNLRSS-SEALYNELEPEERLRVSSALHLRPDMKTHHDRPLVVEH 849

  Fly  1001 ---VENCKR----PMSECWESNVVFRKQKPVRIMN------------------------------ 1028
               |:|.:.    ..||...::...||....|..|                              
Zfish   850 RDSVDNLRSDKDGDTSEGQPASNHQRKYHKCRGENGDTGEGRLHRHHSQNRENQGGLERSNSQDG 914

  Fly  1029 -KTAKVRAAGSSLRKLAI---THIINDSNNQRLMLGDSAMLPVVGT-------------KGGGG- 1075
             :....|::||....:.|   .|..:.|...|.:.|:..  .|:|.             :||.| 
Zfish   915 GQRNHHRSSGSPEEGIGIEEREHRHHHSRRPREVNGNGN--GVIGNGGRGERIRGHREGEGGNGE 977

  Fly  1076 -------LKSQGTI-----------THSKPWRVD------------QKKFGSRSIRRSVRSGSIK 1110
                   :|:|.|:           ..|:|...|            :|.....:::.|.|.|...
Zfish   978 RRRHRPRVKAQSTLDGDECRENGGKRRSRPTETDSLTTSPLQSPSEEKPEDKDNLKNSTRVGPSG 1042

  Fly  1111 LKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLF 1175
            :..........|:....|..|.      |.|..||           |:.::||.|.:.  :.|..
Zfish  1043 VNIPVTITAPPGETTVIPMNNI------DGDSLLL-----------NEEKKDLDELNQ--NAPKH 1088

  Fly  1176 LVPRESRF--------RKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFA 1232
            ::|..|.|        |::|..:|:.|                             |.:..::..
Zfish  1089 ILPYSSMFVFGPTNPVRRLCHYVVNLR-----------------------------YFEMCILTV 1124

  Fly  1233 TTLSCISMMFETPNYRVMDH----PTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAA 1293
            .|:|.|::..|.|   |..|    ..|:..:|.|....:.|:.:|::..||...|.:|.:|:...
Zfish  1125 ITMSSIALAAEDP---VQAHAPRNDVLKYLDYVFTGVFTFEMVIKMIDLGLLLHPGSYFRDLWNI 1186

  Fly  1294 LDVFIYVVS---TSFLCWMPLNIPTN----------SAAQLLMILRCVRPLRIFTLVPHMRKVVY 1345
            || || |||   .:|.|...:....:          :..:.|.:||.:|||:....:|.::.|..
Zfish  1187 LD-FI-VVSGALVAFACSSFMGSQQSVTRGTKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFD 1249

  Fly  1346 ELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLT 1410
            .:....|.:|.:..:.||.|||||...|||:.|:...|.|.:.:..:||.|.|          |.
Zfish  1250 CVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFFHCTDESKALEKDCRGQF----------LE 1304

  Fly  1411 PGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGP----- 1466
            .|.|.  .||..||.| ....|::||:..|.||||.|.:.:||..|.    |...:..||     
Zfish  1305 YGSDG--VAMTQPREW-KKYDFHYDNVLWAFLTLFTVSTGEGWPLVLKHSVDATYEDQGPSPGYR 1366

  Fly  1467 -----VHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKRLKI------ 1520
                 .:.||..::.|    ..:.:||.::|..:.|....|:..      |.|:|..:.      
Zfish  1367 METSIFYVVYFIVFPF----FFVNIFVALIIITFQEQGDKAMSE------CSLEKNERACIDFAI 1421

  Fly  1521 -AQPL--HLPPRPDGRKIRAFTYDITQHII---FKRVIAVVVLINSMLLSITWIKG-EVHTERLV 1578
             |:||  ::|     :...::.|.:.:.::   |:..|..::.||:::|.:.:... :.:.:.|.
Zfish  1422 NAKPLTRYMP-----QDKNSYQYKMWKFVVSTPFEYSILTMIAINTVVLMMKFHGAPKPYEDMLK 1481

  Fly  1579 IVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVV 1643
            .::.:.|.:|.:|.|:|.|||.|..|.:...|.:| .|||.|.|..||.|.::.|......|:.:
Zfish  1482 WLNIIFTALFTLECVLKVIAFGPLNYLKEAWNIFD-FVTVLGSITDILVTEIKTDKRINLSFLRL 1545

  Fly  1644 I--LRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYG---EGIG 1703
            .  .|...:..:..|:::|:.|...|.....::...:.:|.|.||:.|..:||.:...   ..|.
Zfish  1546 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALNNEDSAIN 1610

  Fly  1704 RRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVI 1768
            ...||.:....:.:|||..|||.|::||..|:.: .||.:.:.|...:||:..| ..||.:|..:
Zfish  1611 IHNNFRTFFQALMLLFRSATGEAWHEIMLACLSE-RYCDIESGYSGKECGSDFA-YFYFVSFIFL 1673

  Fly  1769 ITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLK 1833
            .::::|||.||:||:||.  |...:.::|....:..|...|...|....|.:....:..:||.:.
Zfish  1674 CSFLMLNLFVAVIMDNFE--YLTRDASILGPHHLDEFIRVWAEYDPAACGRMSYLDMYEMLRHMS 1736

  Fly  1834 GRL----ECDPQKDRLLFKYMCYELDKLHN--GEDVTFHDVINMLSYRSVDIRKALQLE---ELL 1889
            ..|    :|.|   |:.:|    .|.:::.  .||.|.|....:::.    ||.||:::   .:|
Zfish  1737 PPLGLGKKCPP---RIAYK----RLVRMNMPIAEDNTVHFTSTLMAL----IRTALEIKLASGVL 1790

  Fly  1890 AREEFEYLVEEEVAK-------------------------------MTIRTWLEGCLKKIRAQNA 1923
            |:...:..:.:|:.|                               |....:.:...|:::.|.|
Zfish  1791 AQRICDAELRKEINKIWPSLSSKTVDLLVTPHKHNELTVGKVYAALMIFDYYKQNRAKRLQQQQA 1855

  Fly  1924 SKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTE 1988
            :....|.: |:......|:...:.||...|.|........|          |.|||...:|..|.
Zfish  1856 APGTQSKV-GVLFRPMLPLTHLHDQEPLVPKGPPPSHLDIT----------PQSDATPTSFHLTN 1909

  Fly  1989 NEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMT-------V 2046
            .:.....|||:.:.|....|...| ..........|.|..:   |.|.:|.....||       |
Zfish  1910 GDAVQSQSSAMKKSPSGGPSQEVT-QETNRRPIQRGQSEDV---PNTYRSQELVEMTDMENDSDV 1970

  Fly  2047 GKRGYALNRSDSTGSSAGR---------------KFLAPTSS-DPQQRSTLSDKERLHITSQQRK 2095
            |  ||.:.......:|..|               .:|||.:. .|.:|||.|             
Zfish  1971 G--GYHVLEGHGRAASMPRLNAGFQRSHLRHTAGAYLAPIADVSPMRRSTSS------------- 2020

  Fly  2096 KNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGHG 2160
                           |..|||.           .::|........|.::.:...|........|.
Zfish  2021 ---------------LTPQRGA-----------REVNLSEYDLERPRMSPSQTFAQDRERERVHH 2059

  Fly  2161 HGHGGHGGHGGHGEHQMHHHH 2181
            |.|              ||||
Zfish  2060 HHH--------------HHHH 2066

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 62/320 (19%)
Ion_trans 734..927 CDD:278921 61/214 (29%)
Ion_trans 1240..1497 CDD:278921 79/287 (28%)
Ion_trans 1571..1793 CDD:278921 67/226 (30%)
cacna1bbXP_021324711.1 Ion_trans 87..359 CDD:306908 58/298 (19%)
Ion_trans 487..726 CDD:306908 67/246 (27%)
Ion_trans 1115..1404 CDD:306908 85/339 (25%)
Ion_trans 1447..1698 CDD:306908 72/255 (28%)
GPHH 1699..1769 CDD:318993 16/76 (21%)
Ca_chan_IQ 1771..1845 CDD:312334 9/77 (12%)
Transformer <2074..>2135 CDD:253769
THRAP3_BCLAF1 2109..>2285 CDD:317794
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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