DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1aa

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_021330047.1 Gene:cacna1aa / 562059 ZFINID:ZDB-GENE-040724-26 Length:2371 Species:Danio rerio


Alignment Length:2363 Identity:481/2363 - (20%)
Similarity:847/2363 - (35%) Gaps:667/2363 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   243 PSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGG----MGGMGGGAAAAGMGI---------CGGIS 294
            ||..||     |.|...||.|.|.:..||..|    |........|..|.:         |..::
Zfish     9 PSRYGG-----GPGHAQGGPGRGGSRQGGPPGAQQRMYKQSMAQRARTMALYNPIPVRQNCFTVN 68

  Fly   295 STV-----------GSAAITGVPPIG-LGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNES 347
            .::           .:..||..||.. :.:||.|.|.|:|..:|.|..|:               
Zfish    69 RSLFIFSEDNFVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDGD--------------- 118

  Fly   348 ADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQ--FITFASDTAVTLLFTAEMIAKM 410
                                        .||.: ||....:  ||.         :|..|...|:
Zfish   119 ----------------------------KTPMS-ERLEDTEPYFIG---------IFCFESGIKI 145

  Fly   411 HIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM---IR 472
            ...|....:..||::.|...|..:|....:|.:...|::       ..|..:|..|||.:   |.
Zfish   146 LALGFAFHKGSYLRNGWNVMDFVVVLTGILSTVGSDFDL-------RTLRAVRVLRPLKLVSGIP 203

  Fly   473 FLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTEYDL 536
            .|:|.|| |:.|:.|         .:..:.|...|.:.::.::|::|: |:....|....|:   
Zfish   204 SLQVVLK-SIMKAMI---------PLLQIGLLLFFAILMFAIIGLEFYMGKFHTTCFDKITD--- 255

  Fly   537 YKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAAS 601
                       .|.:.|...:......|..|.||.|.....:|  |...|::|..::.||:|..:
Zfish   256 -----------EIREEFPCGEEVPARICPNGTVCKKYWLGPNY--GITQFDNILFAVLTVFQCIT 307

  Fly   602 QEGWVFIMYRAIDSL-PAWRAAFYFSTMIFFLAWLVKNVFIAVITETFN------EIRVQFQQMW 659
            .|||..::|.:.|:. .||. ..||..:|...::.:.|:.:.|::..|.      |.|.:|.::.
Zfish   308 MEGWTDLLYYSNDAAGSAWN-WMYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRSEFLKLK 371

  Fly   660 GAR-------GHIQKTAASQ--ILSGNDT----------GWRLVTIDDNKHGGLAPETCHAILRS 705
            ..:       |:::....::  ||:..|.          ..|..||..:|...|..|.....:.|
Zfish   372 RQQQIERELNGYLEWICKAEEVILADEDNDPDDRMPFDGSRRRPTIKKSKTDLLDAEDGDGDIGS 436

  Fly   706 PYFRMLVMS-------------------------------VILANGIVTATMTFKHDGRPRDVFY 739
            |:.|..:.|                               |:...|:.|..:...|..:| :...
Zfish   437 PFARGSLKSSKLEGSSFHKKERRLRFFIRRIVKTQAFYWTVLCLVGLNTLCVAVVHYDQP-ETLS 500

  Fly   740 ERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV-PMFYPS---GLTY 800
            :..|:.|.:|..:...|...|:|.||.|.|:..|.:.|:.::..|:...:: .|..|.   |::.
Zfish   501 DFLYFAEFIFLGIFMSEMCIKMYGLGTRPYFHSSFNCFDCIVICGSIFEVLWAMIQPGTSFGISV 565

  Fly   801 FQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF---- 858
            .:.||::|:.|.:   ..|...|..:....|.:.||:......:::.:.:.||||....:|    
Zfish   566 LRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEAGT 630

  Fly   859 --TKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLV-AVYFILYHLFVTLIVLSLFVA 920
              |.|::||.|.|::|||||.|.|..||.:.:.........:| :|:||:..||....:|::|:|
Zfish   631 PPTNFDTFPAAIMTVFQILTGEDWNMVMYDGIESQGGVKKGMVFSVFFIVLTLFGNYTLLNVFLA 695

  Fly   921 VILDNL----ELDEDIKKLKQL---KFREQSA-EIKETLPF---------------RLRIFEKFP 962
            :.:|||    ||.:|.::.:|.   |...|:| |:.|..|.               ||...|.|.
Zfish   696 IAVDNLANAQELTKDEQEEEQAANKKMALQTAKEVAEVSPLSAANLSIAAVTVNSERLDATEHFL 760

  Fly   963 DSPQMTILHR-----------------------------IPNDFMLPKVRESFMKHFVIELETED 998
            |..:....|:                             .|.|    :.:.|:.:|...:::|  
Zfish   761 DCKEQQKNHKGCKSVWEQRTSELRRQTLVNSREALYNELDPED----RWKVSYSRHIRPDMKT-- 819

  Fly   999 SLVENCKRPMSECWESNVVFRKQKPVRIMNKT----------------------AKVRAAGSSLR 1041
                :..||:       ||..::......|||                      |:....|.|..
Zfish   820 ----HLDRPL-------VVDPQENRNNNTNKTRPGDGQPQHSHQLLHKQPNFNEAETGGGGGSES 873

  Fly  1042 KLAITHIINDS-NNQRLMLG--------------------DSAMLPVVGTKGG---GGLKSQGTI 1082
            ..|:..  .|| .::|.:||                    ..|.......:||   ||.:.:...
Zfish   874 WPALER--GDSTGSRRSLLGSEHYEEGRESHRRHQHSQHCSQARQHRKAAEGGGEPGGRRHRSKA 936

  Fly  1083 THSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGR------------- 1134
            ....| ..:....|.|..||....|..:.::...|.......|:.|..::.|             
Zfish   937 KERGP-ECEHSDGGERKHRRHRHEGEGRKERGVRHRNRRDGHASGPTLSTTRPIQKTLSRQDSQY 1000

  Fly  1135 -------------ARPHD----------------------------------------------- 1139
                         .:|||                                               
Zfish  1001 SEDLDNAMNNKLATQPHDSLLNLANTAHSAGLAHTGTESSLILTNPSSTIANVTSIGHLGMKPEY 1065

  Fly  1140 --LDI--------KLLQAKRQ-------QAEMRRNQREEDLREN------HPFFDTPLFLVPRES 1181
              :||        .:||..:.       :.|..:...::|.:::      .|:  |.:|::...:
Zfish  1066 TAVDIPPMFPSSNAILQVNKNANTEPLPKKEDTKGDDDDDEKDDGGPKPMPPY--TSMFILTTTN 1128

  Fly  1182 RFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPN 1246
            .||::|..||..|                             |.:..::....:|.|::..|.|.
Zfish  1129 PFRRLCHYIVTLR-----------------------------YFEMCILLVIAMSSIALAAEDPV 1164

  Fly  1247 YRVMDHP---TLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCW 1308
            :  .:.|   .|:..:|.|....:.|:.:|::..||.....:|.:|:...|| || |||.:.:.:
Zfish  1165 W--PESPRNNVLRYFDYVFTGVFTFEMLIKMVDLGLVLHQGSYFRDLWNILD-FI-VVSGALVAF 1225

  Fly  1309 MPLNIPTNSA-------AQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMF 1366
            ........|:       .:.|.:||.:|||:....:|.::.|...:....|.:|.:..:.:|.||
Zfish  1226 AFTGGSGGSSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMF 1290

  Fly  1367 IFASYGVQLYGGRLARCNDPTISRREDCVG---VFMRRVFVTKMKLTPGPDESYPAMLVPRVWAN 1428
            |||...|||:.||...|.|.:.....||.|   |:.|...|...|               |.| .
Zfish  1291 IFAVVAVQLFKGRFFYCTDESKEFERDCRGEYLVYERDNEVRSQK---------------REW-K 1339

  Fly  1429 PRRFNFDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGP----------VHAVYIHIYIFLG 1479
            ...|::||:..|:||||.|.:.:||..|.    |...:..||          .:.||..::.|  
Zfish  1340 KYDFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATYENQGPSPGYRMEMSIFYVVYFVVFPF-- 1402

  Fly  1480 CMIGLTLFVGVVIANYSENKGTAL----LTVDQRRWCDLKKRLKIAQPL--HLPPRPDGRKIRAF 1538
              ..:.:||.::|..:.|.....:    |..::|...|....   |:||  |:|     :..:.|
Zfish  1403 --FFVNIFVALIIITFQEQGDKMMEDYSLEKNERACIDFAIN---AKPLTRHMP-----QNKQTF 1457

  Fly  1539 TYDITQHII---FKRVIAVVVLINSMLLSITWIKGEV-HTERLVIVSAVLTFVFVVEVVMKNIAF 1599
            .|.:.:.::   |:..|..::.:|:::|.:.:....: :.:.|..::.|.|.:|.:|.::|.|||
Zfish  1458 QYRMWEFVVSPPFEYTIMALIALNTIVLMMKYDGASLTYEDVLKYLNIVFTSLFSMECILKIIAF 1522

  Fly  1600 TPRGYWQSRRNRYDLLVTVAGVIWIILQTIL--RNDLSYFFGFMVVILRFFTITGKHTTLKMLML 1662
            ....|::...|.:| .|||.|.|..||.|.|  .|.::..|..:....|...:..:..|:::|:.
Zfish  1523 GALNYFKDAWNIFD-CVTVLGSITDILVTELGMNNFINLSFLRLFRAARLIKLLRQGETIRILLW 1586

  Fly  1663 TVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGE----GIGRRANFGSPVTGVAMLFRIVT 1723
            |...|.....::...:.:|.|.||:.|..|||.:|..|    .|.:..||.:....:.:|||..|
Zfish  1587 TFVQSFKALPYVCLLIAMLFFIYAIIGMQLFGNIKIEENSDSAITQHNNFRTFFQALMLLFRSAT 1651

  Fly  1724 GEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLF 1788
            ||.|:.||..|:.:.| |.:.::..:.:||:..|.| ||.:|..:.::::|||.||:||:||.  
Zfish  1652 GEAWHDIMLSCLGKKP-CDILSDNPKPECGSEFAYL-YFVSFIFLCSFLMLNLFVAVIMDNFE-- 1712

  Fly  1789 YSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQK---DRLL 1846
            |...:.::|....:..:...|...|....|.|..:.:..:||::...|    :| |.:   .|||
Zfish  1713 YLTRDSSILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKC-PHRVACKRLL 1776

  Fly  1847 FKYMCYELD-KLHNGEDVTFHDVINMLSYRSVDIRKA---------------LQLEEL-----LA 1890
                  .:| .:.:...|.|:..:..|...::||:.|               |:.|.:     |:
Zfish  1777 ------RMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGEGGVDKHQMDAELRKEMMAIWPNLS 1835

  Fly  1891 REEFEYLV--EEEVAKMTI-RTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKA 1952
            ::..:.||  .:....:|: :.:....:.:...|:.:|:..:|   ....|..|:|...::    
Zfish  1836 QKNLDLLVTPHKSATDLTVGKIYAAMMIMEYYRQSKAKRTQAL---HDEQNRTPLMFQRLE---- 1893

  Fly  1953 PLGAVDKSAISTISGAVAGACPPT-SDAFSPTFSSTENEEKDGSSSAVV--QLPHSETSIAGTGS 2014
                                 ||: |....|..:...:.:...::...|  ::|.|::.:.....
Zfish  1894 ---------------------PPSPSQDVGPGLTGLPDTQMHPANHLPVDERIPESQSWVTARAQ 1937

  Fly  2015 SATGAATATGTSSGLGVGPPTVQSTARHVMTV-----GKRGYALNRS----DSTGSSAGRKFLAP 2070
            ..:..|   |..|..|..|.......|...||     |:.||:....    :..|.:|....|..
Zfish  1938 EISQKA---GNWSPEGQHPDDTTDNRRQSQTVEMREMGRDGYSDTEQYLPMEGHGRAASMPRLPA 1999

  Fly  2071 TSSDPQQRSTLSDKERLH-ITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSE 2134
            .:..|:::.....:.... ||.....|.|.::|.|           |..|.:.:...:       
Zfish  2000 DNQQPRRKGRHRGENLTQPITDNSPMKRSASSLGH-----------GRAGRSMRGEDY------- 2046

  Fly  2135 IGQFHYPTINAAAAAAALHGYGHGHGHGHGGH--------------------------------- 2166
                      |........|:.|||.|....|                                 
Zfish  2047 ----------AMERVIPEEGHRHGHRHRDRSHRASERSLSRYTDADTGLGTDLSTTTQSGDLPSK 2101

  Fly  2167 ----GGHGGHGEHQMHHHHGGAL 2185
                |.......|..||||.|:|
Zfish  2102 ERDRGRAKDRKHHHHHHHHHGSL 2124

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 66/293 (23%)
Ion_trans 734..927 CDD:278921 58/210 (28%)
Ion_trans 1240..1497 CDD:278921 73/283 (26%)
Ion_trans 1571..1793 CDD:278921 70/228 (31%)
cacna1aaXP_021330047.1 Ion_trans 90..362 CDD:306908 75/358 (21%)
Ion_trans 471..709 CDD:306908 64/238 (27%)
Ion_trans 1141..1377 CDD:306908 69/284 (24%)
Ion_trans 1467..1719 CDD:306908 74/256 (29%)
GPHH 1720..1790 CDD:318993 15/76 (20%)
Ca_chan_IQ 1792..1870 CDD:312334 10/77 (13%)
SOBP <2151..2361 CDD:317654
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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