DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1aa

DIOPT Version :10

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_001429978.1 Gene:cacna1aa / 562059 ZFINID:ZDB-GENE-040724-26 Length:2483 Species:Danio rerio


Alignment Length:2468 Identity:508/2468 - (20%)
Similarity:881/2468 - (35%) Gaps:691/2468 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 SHHPHPHPHGHPHSYP--------HLRHSQPASASQ-FSFNPSPGSSPGNGL----GLGARQDAA 194
            |..||.|.|...||.|        .:.:|:.::..| .:.:|.....||:.|    |:     :.
Zfish    35 SDDPHNHLHSSVHSGPFRKAELSEKILYSEGSAVVQCVALSPHGKKVPGSSLCWINGI-----SV 94

  Fly   195 SALNSPTTIVNSGSGSGGGSSVAFGMQPQQQQQSLAGGGGGGSSATAAPSSGGGHNNGAGLGPVV 259
            .:|:.........||..|        .||.|:....|....|..   .||..||     |.|...
Zfish    95 WSLHVLPVFEWVSSGCSG--------FPQVQRHVQIGMARFGDE---VPSRYGG-----GPGHAQ 143

  Fly   260 GGGGGGLNLLGGLGG----MGGMGGGAAAAGMGI---------CGGISSTV-----------GSA 300
            ||.|.|.:..||..|    |........|..|.:         |..::.::           .:.
Zfish   144 GGPGRGGSRQGGPPGAQQRMYKQSMAQRARTMALYNPIPVRQNCFTVNRSLFIFSEDNFVRKYAK 208

  Fly   301 AITGVPPIG-LGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRL 364
            .||..||.. :.:||.|.|.|:|..:|.|..|:                                
Zfish   209 KITEWPPFEYMILATIIANCIVLALEQHLPDGD-------------------------------- 241

  Fly   365 CALVSLTSVSLNTPKTFERYPSLQ--FITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHW 427
                       .||.: ||....:  ||.         :|..|...|:...|....:..||::.|
Zfish   242 -----------KTPMS-ERLEDTEPYFIG---------IFCFESGIKILALGFAFHKGSYLRNGW 285

  Fly   428 CQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM---IRFLRVFLKFSMPKSRINQ 489
            ...|..:|....:|.:...|::       ..|..:|..|||.:   |..|:|.|| |:.|:.|  
Zfish   286 NVMDFVVVLTGILSTVGSDFDL-------RTLRAVRVLRPLKLVSGIPSLQVVLK-SIMKAMI-- 340

  Fly   490 IFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTINSLAIPDTF 553
                   .:..:.|...|.:.::.::|::|: |:....|....|:              .|.:.|
Zfish   341 -------PLLQIGLLLFFAILMFAIIGLEFYMGKFHTTCFDKITD--------------EIREEF 384

  Fly   554 CSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSL-P 617
            ...:......|..|.||.|.....:|  |...|::|..::.||:|..:.|||..::|.:.|:. .
Zfish   385 PCGEEVPARICPNGTVCKKYWLGPNY--GITQFDNILFAVLTVFQCITMEGWTDLLYYSNDAAGS 447

  Fly   618 AWRAAFYFSTMIFFLAWLVKNVFIAVITETFN------EIRVQFQQMWGAR-------GHIQKTA 669
            ||. ..||..:|...::.:.|:.:.|::..|.      |.|.:|.::...:       |:::...
Zfish   448 AWN-WMYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRSEFLKLKRQQQIERELNGYLEWIC 511

  Fly   670 ASQ--ILSGNDT----------GWRLVTIDDNKHGGLAPETCHAILRSPYFRMLVMS-------- 714
            .::  ||:..|.          ..|..||..:|...|..|.....:.||:.|..:.|        
Zfish   512 KAEEVILADEDNDPDDRMPFDGSRRRPTIKKSKTDLLDAEDGDGDIGSPFARGSLKSSKLEGSSF 576

  Fly   715 -----------------------VILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLE 756
                                   |:...|:.|..:...|..:| :...:..|:.|.:|..:...|
Zfish   577 HKKERRLRFFIRRIVKTQAFYWTVLCLVGLNTLCVAVVHYDQP-ETLSDFLYFAEFIFLGIFMSE 640

  Fly   757 TLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKAS---P 814
            ...|:|.||.|.|:..|.:.|:.::..|:...:: .|..|.   |::..:.||::|:.|.:   .
Zfish   641 MCIKMYGLGTRPYFHSSFNCFDCIVICGSIFEVLWAMIQPGTSFGISVLRALRLLRIFKVTKYWA 705

  Fly   815 MLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF------TKFESFPEAFMSMFQ 873
            .|...|..:....|.:.||:......:::.:.:.||||....:|      |.|::||.|.|::||
Zfish   706 SLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEAGTPPTNFDTFPAAIMTVFQ 770

  Fly   874 ILTQEAWVEVMDETMIRTSKTLTPLV-AVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQ 937
            |||.|.|..||.:.:.........:| :|:||:..||....:|::|:|:.:|||...:::.|.:|
Zfish   771 ILTGEDWNMVMYDGIESQGGVKKGMVFSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQ 835

  Fly   938 LKFREQSAEIKETLPFRLRIFEKFP-DSPQMTIL-------HRIPNDFMLPKVRESFMKHFVIEL 994
            .:  ||:|..|..|.....:.|..| .:..::|.       |:..| ..:...|....:|| ::.
Zfish   836 EE--EQAANKKMALQTAKEVAEVSPLSAANLSIAASCQPHNHKGQN-VTVNSERLDATEHF-LDC 896

  Fly   995 ETEDSLVENCKRPMSECWESNV-VFRKQKPVR----IMN--------KTAKVRAAGSSL-----R 1041
            :.:....:.||    ..||... ..|:|..|.    :.|        |.:..|.....:     |
Zfish   897 KEQQKNHKGCK----SVWEQRTSELRRQTLVNSREALYNELDPEDRWKVSYSRHIRPDMKTHLDR 957

  Fly  1042 KLAITHIINDSNN-------------QRLMLGDSAMLPVVGTKGGGGLKS-----QGTIT----- 1083
            .|.:....|.:||             ...:|..........|.||||.:|     :|..|     
Zfish   958 PLVVDPQENRNNNTNKTRPGDGQPQHSHQLLHKQPNFNEAETGGGGGSESWPALERGDSTGSRRS 1022

  Fly  1084 -----HSKPWRVDQKKF-------------------------------------------GSRSI 1100
                 |.:..|...::.                                           |.|..
Zfish  1023 LLGSEHYEEGRESHRRHQHSQHCSQARQHRKAAEGGGEPGGRRHRSKAKERGPECEHSDGGERKH 1087

  Fly  1101 RRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGR--------------------------ARPHD 1139
            ||....|..:.::...|.......|:.|..::.|                          .:|||
Zfish  1088 RRHRHEGEGRKERGVRHRNRRDGHASGPTLSTTRPIQKTLSRQDSQYSEDLDNAMNNKLATQPHD 1152

  Fly  1140 -------------------------------------------------LDI--------KLLQA 1147
                                                             :||        .:||.
Zfish  1153 SLLNLANTAHSAGLAHTGTESSLILTNPSSTIANVTSIGHLGMKPEYTAVDIPPMFPSSNAILQV 1217

  Fly  1148 KRQ-------QAEMRRNQREEDLREN------HPFFDTPLFLVPRESRFRKICQKIVHARYDARL 1199
            .:.       :.|..:...::|.:::      .|:  |.:|::...:.||::|..||..|     
Zfish  1218 NKNANTEPLPKKEDTKGDDDDDEKDDGGPKPMPPY--TSMFILTTTNPFRRLCHYIVTLR----- 1275

  Fly  1200 KDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHP---TLQIAEYG 1261
                                    |.:..::....:|.|::..|.|.:  .:.|   .|:..:|.
Zfish  1276 ------------------------YFEMCILLVIAMSSIALAAEDPVW--PESPRNNVLRYFDYV 1314

  Fly  1262 FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTN------SAAQ 1320
            |....:.|:.:|::..||.....:|.:|:...|| || |||.:.:.:.   ...|      |..:
Zfish  1315 FTGVFTFEMLIKMVDLGLVLHQGSYFRDLWNILD-FI-VVSGALVAFA---FTGNSKGKDISTIK 1374

  Fly  1321 LLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCND 1385
            .|.:||.:|||:....:|.::.|...:....|.:|.:..:.:|.|||||...|||:.||...|.|
Zfish  1375 SLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGRFFYCTD 1439

  Fly  1386 PTISRREDCVG---VFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEV 1447
            .:.....||.|   |:.|...|...|               |.| ....|::||:..|:||||.|
Zfish  1440 ESKEFERDCRGEYLVYERDNEVRSQK---------------REW-KKYDFHYDNVLWALLTLFTV 1488

  Fly  1448 LSFKGWLDVR----DVLIKAVGP----------VHAVYIHIYIFLGCMIGLTLFVGVVIANYSEN 1498
            .:.:||..|.    |...:..||          .:.||..::.|    ..:.:||.::|..:.|.
Zfish  1489 STGEGWPQVLKHSVDATYENQGPSPGYRMEMSIFYVVYFVVFPF----FFVNIFVALIIITFQEQ 1549

  Fly  1499 KGTAL----LTVDQRRWCDLKKRLKIAQPL--HLPPRPDGRKIRAFTYDITQHII---FKRVIAV 1554
            ....:    |..::|...|....   |:||  |:|     :..:.|.|.:.:.::   |:..|..
Zfish  1550 GDKMMEDYSLEKNERACIDFAIN---AKPLTRHMP-----QNKQTFQYRMWEFVVSPPFEYTIMA 1606

  Fly  1555 VVLINSMLLSITWIKGEV-HTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTV 1618
            ::.:|:::|.:.:....: :.:.|..::.|.|.:|.:|.::|.|||....|::...|.:| .|||
Zfish  1607 LIALNTIVLMMKYDGASLTYEDVLKYLNIVFTSLFSMECILKIIAFGALNYFKDAWNIFD-CVTV 1670

  Fly  1619 AGVIWIILQTILRN---DLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFL 1680
            .|.|..||.|.|.|   :||:...|...  |...:..:..|:::|:.|...|.....::...:.:
Zfish  1671 LGSITDILVTELGNNFINLSFLRLFRAA--RLIKLLRQGETIRILLWTFVQSFKALPYVCLLIAM 1733

  Fly  1681 LVFFYALAGTILFGTVKYGE----GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYC 1741
            |.|.||:.|..|||.:|..|    .|.:..||.:....:.:|||..|||.|:.||..|:.:.| |
Zfish  1734 LFFIYAIIGMQLFGNIKIEENSDSAITQHNNFRTFFQALMLLFRSATGEAWHDIMLSCLGKKP-C 1797

  Fly  1742 TLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQ 1806
            .:.::..:.:||:..|.| ||.:|..:.::::|||.||:||:||.  |...:.::|....:..:.
Zfish  1798 DILSDNLKPECGSEFAYL-YFVSFIFLCSFLMLNLFVAVIMDNFE--YLTRDSSILGPHHLDEYV 1859

  Fly  1807 NTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQK---DRLLFKYMCYELD-KLHNGEDV 1863
            ..|...|....|.|..:.:..:||::...|    :| |.:   .|||      .:| .:.:...|
Zfish  1860 RIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKC-PHRVACKRLL------RMDLPVADDNTV 1917

  Fly  1864 TFHDVINMLSYRSVDIRKA------------LQLEEL-----LAREEFEYLV--EEEVAKMTI-R 1908
            .|:..:..|...::||:.|            |:.|.:     |:::..:.||  .:....:|: :
Zfish  1918 HFNSTLMALIRTALDIKIAKGGVDKHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSATDLTVGK 1982

  Fly  1909 TWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGAC 1973
            .:....:.:...|:.:|:..:|   ....|..|:|...::                         
Zfish  1983 IYAAMMIMEYYRQSKAKRTQAL---HDEQNRTPLMFQRLE------------------------- 2019

  Fly  1974 PPT-SDAFSPTFSSTENEEKDGSSSAVV--QLPHSETSIAGTGSSATGAATATGTSSGLGVGPPT 2035
            ||: |....|..:...:.:...::...|  ::|.|::.:.......:..|   |..|..|..|..
Zfish  2020 PPSPSQDVGPGLTGLPDTQMHPANHLPVDERIPESQSWVTARAQEISQKA---GNWSPEGQHPDD 2081

  Fly  2036 VQSTARHVMTV-----GKRGYALNRSDSTGSSAGRKFLAP-TSSDPQQRSTLSDKERLHITSQQR 2094
            .....|...||     |:.||:...........||....| ..:|.||          .||....
Zfish  2082 TTDNRRQSQTVEMREMGRDGYSDTEQYLPMEGHGRAASMPRLPADNQQ----------PITDNSP 2136

  Fly  2095 KKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGH 2159
            .|.|.::|.|           |..|.:.:...:                 |........|:.|||
Zfish  2137 MKRSASSLGH-----------GRAGRSMRGEDY-----------------AMERVIPEEGHRHGH 2173

  Fly  2160 GHGHGGH-------------------------------------GGHGGHGEHQMHHHHGGAL 2185
            .|....|                                     |.......|..||||.|:|
Zfish  2174 RHRDRSHRASERSLSRYTDADTGLGTDLSTTTQSGDLPSKERDRGRAKDRKHHHHHHHHHGSL 2236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 361..654 CDD:459842 66/305 (22%)
Ion_trans 705..927 CDD:459842 65/266 (24%)
Ion_trans 1224..1497 CDD:459842 77/298 (26%)
Ion_trans 1545..1793 CDD:459842 76/258 (29%)
cacna1aaNP_001429978.1 None

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