DRSC/TRiP Functional Genomics Resources

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Protein Alignment na and cacna1fb

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_021333942.1 Gene:cacna1fb / 559964 ZFINID:ZDB-GENE-031104-1 Length:2068 Species:Danio rerio


Alignment Length:2025 Identity:440/2025 - (21%)
Similarity:756/2025 - (37%) Gaps:628/2025 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   400 LLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFE-VLEIVPKFSYLSIMR 463
            ::||.|...|:...|::.....|:::.|...|       ::.:|:.:|. |||.|...|..:...
Zfish   159 IIFTIETFLKILAYGLVMHPSSYIRNGWNLLD-------FVIVIVGLFSVVLETVTHKSGETTSH 216

  Fly   464 AP-RP-LIMIRFLRVF-------LKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGV 517
            .| :| .:.::.||.|       |...:|..:|  |.|.| :...:.:::|..||.:.:|.::|:
Zfish   217 TPGKPGGLDVKALRAFRVLRPLRLVSGVPSLQIVLNSIMK-AMVPLLHISLLVLFVIIIYAIIGL 280

  Fly   518 Q-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDP------DSGYQC-SPGMVCM-KM 573
            : |.|.:...|....|                  |.:...||      ..|.|| ..|..|. |.
Zfish   281 ELFIGRMHRTCFFIGT------------------DNYADDDPLPCAFAGHGRQCYVNGSECRGKW 327

  Fly   574 DFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDS----LPAWRAAFYFSTMIFFLAW 634
            :..:.   |...|::...::.||:|..:.|||..::|...|:    || |   .||.:::.|.::
Zfish   328 EGPNG---GITNFDNFFFAMLTVFQCITMEGWTDVLYWMNDAIGFELP-W---VYFVSLVIFGSF 385

  Fly   635 LVKNVFIAVITETFNEIRVQFQQMWGARGHIQK------------------TAASQILSGNDTGW 681
            .|.|:.:.|::..|::.|.:.:    |||..||                  |.|..|...::.|.
Zfish   386 FVLNLVLGVLSGEFSKEREKAK----ARGDFQKLREKQQMEEDLCGYMDWITQAEDIDEFDEDGN 446

  Fly   682 RLVTIDD----------------NKHGGL-APET------------------------------- 698
            |.||:.|                ..|..| |.||                               
Zfish   447 RRVTLRDLADKKRGKFGWFSHSNETHASLPASETASENTENIDEEHTDCCAACCARIMKIPCCRA 511

  Fly   699 -----------CHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRP------RDVFYERYYYIE 746
                       |...::|..|..||:.::..|   ||....:|..:|      :|:       ..
Zfish   512 LRRWNRCIRRNCRTAVKSVTFYWLVLILVFLN---TALSASEHYNQPEWLTDVQDI-------AN 566

  Fly   747 LVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAG----TTLHIVPMFYPSGLTYFQVLRVV 807
            .|...|..:|.|.|:|.||.:.|:....::|:..:..|    |.|..:.:..|.|::..:.:|::
Zfish   567 KVLLSLFTVEMLLKMYSLGLQVYFVAFFNRFDCFVVCGGILETVLVEMEIMPPLGISVLRCVRLL 631

  Fly   808 RLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF----TK---FE 862
            |:.|.:   ..|...|..:....|.:.||::.....|||.:.:.||||....:|    ||   |:
Zfish   632 RIFKVTRHWTALSNLVASLLNSMKSIASLLLLLFLFLIIFALLGMQLFGGKFNFDETQTKRSTFD 696

  Fly   863 SFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTP--LVAVYFILYHLFVTLIVLSLFVAVILDN 925
            |||:|.::.|||||.|.|..||.:.::.....:.|  :|.:||::..:....|:|::|:|:.:||
Zfish   697 SFPQALLTCFQILTGEDWNVVMYDGIMAYGGPVFPGMIVCLYFVILFICGNYILLNVFLAIAVDN 761

  Fly   926 LE-LDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKH 989
            |. .|.|.||.::.|                                                  
Zfish   762 LAGGDGDNKKNEEKK-------------------------------------------------- 776

  Fly   990 FVIELETEDSLVEN--CKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDS 1052
               |.|.|.:..||  .|..|.|.:|     .:::|..                           
Zfish   777 ---EGEAEPAEEENGEVKVDMDEEYE-----EEEEPEE--------------------------- 806

  Fly  1053 NNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEH 1117
                   ||.                                          ..|.|:|      
Zfish   807 -------GDD------------------------------------------EEGKIQL------ 816

  Fly  1118 LMENGDIA--AAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRE 1180
                 ::|  |.|:.            |:|......|                     .|.:.:.
Zfish   817 -----NVADFAPPKE------------KILPIPEGSA---------------------FFCLSKT 843

  Fly  1181 SRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETP 1245
            :..|..|..::|.                      |.|..|      :::| ..||.||:..|.|
Zfish   844 NPIRVGCHTLIHH----------------------HIFTNL------ILVF-IILSSISLAAEDP 879

  Fly  1246 ----NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFL 1306
                ::|   :..|..|:|.|....::|:.||:...|.|....::.::....||  :.|||.|.:
Zfish   880 IRAHSFR---NNVLGYADYAFTSIFTVEILLKMTVHGAFLHEGSFCRNWFNLLD--LLVVSVSLV 939

  Fly  1307 CWMPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEILLVSTLLILLMFIF 1368
            .:. |:....|..::|.:||.:||||....   :.|:.:.|:...|....|::|:|   ||.|:|
Zfish   940 SFF-LHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT---LLQFMF 1000

  Fly  1369 ASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFN 1433
            |..||||:.|:..||.|...:..|.|.|.|:         :....|.|:| |:..|:|.| ..||
Zfish  1001 ACIGVQLFKGKFYRCTDEAKNTPEQCKGTFV---------VYKDGDVSHP-MVRERIWLN-SDFN 1054

  Fly  1434 FDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV-------GPVH------AVYIHIYIFLGCMIGLT 1485
            |||:...|:.||.|.:|:||   ..:|.||:       ||::      :::..:||.:.....:.
Zfish  1055 FDNVLMGMMALFTVSTFEGW---PALLYKAIDANGENHGPIYNYRVEISIFFIVYIIIIAFFMMN 1116

  Fly  1486 LFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQP--LHLPPRPDGRKIRAFTY 1540
            :|||.||..:.| :|.|     :.:.|:|.|.        || |||  |::|..|...|.    :
Zfish  1117 IFVGFVIITFRE-QGEA-----EFKNCELDKNQRQCVEYALK-AQPLKLYIPKNPVQYKF----W 1170

  Fly  1541 DITQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGY 1604
            .|.....|:.|:.|::|:|::.|::. :.:.:..::.:.|::.|.|.:|.||:::|.:|...|.|
Zfish  1171 SIINSTGFEYVMFVLILLNTVTLAVQHYDQSKFFSQVMDILNMVFTGLFTVEMIIKLMALRLRHY 1235

  Fly  1605 WQSRRNRYDLLVTVAGVIWIIL------QTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLT 1663
            :....|.:|.|:.|..|:.|::      :...|..:::|..|.|  :|...:..|...::.|:.|
Zfish  1236 FVDAWNSFDALIVVGSVVDIVVTEFSSSEDSSRVSITFFRLFRV--MRLVKLLSKGEGIRTLLWT 1298

  Fly  1664 VGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGED 1726
            ...|:....::...:.::.|.||:.|...||.:...:  .|.|..||.:....|.:|||..|||.
Zfish  1299 FVKSLQALPYVALLIAMIFFIYAVIGMQTFGKIAMQDHTQINRNNNFQTFPQAVLLLFRCATGEA 1363

  Fly  1727 WNKIMHDCMVQPP--YCTLGNNY---WETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFS 1786
            |.:||   :...|  .|...:::   .|..||: ..:::||.:|:::..::::||.||:||:||.
Zfish  1364 WQEIM---LASLPGKRCDAESDFEPGEEFSCGS-NIAIVYFISFFMLCAFLIINLFVAVIMDNFD 1424

  Fly  1787 LFYSNEEDALLSYADIRNFQNTWNIVDIHQRG-------VIPVRRVKFIL---RLLKGRLECDPQ 1841
              |...:.::|....:..|:..|:..|...:|       |..:||::..|   :|...|:.|   
Zfish  1425 --YLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVAC--- 1484

  Fly  1842 KDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQL-------EELLAREEFEYLV- 1898
             .||:...|     .|:....|||:..:..|      :|.||::       :|   .||...:: 
Zfish  1485 -KRLVAMNM-----PLNADGTVTFNATLFAL------VRTALKIKTDGNPDQE---NEELRIIIK 1534

  Fly  1899 -------------------EEEV------AKMTIRTWLEGCLKKIRAQNASKQQNS-------LI 1931
                               ||||      |...|:.:.....|:.......::.|.       ..
Zfish  1535 KIWKRTKPKVLDEVIPPPAEEEVTVGKFYATFLIQDYFRKFRKRKEKVGLEEEGNGNPTALQLCQ 1599

  Fly  1932 AGLRATNE-QPVMR----PNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEE 1991
            ||||...| .|.||    .:::|::..|                               ..|.||
Zfish  1600 AGLRTLQELGPEMRLAMNEDLEEEEEGL-------------------------------DEEQEE 1633

  Fly  1992 KDGSSSAVVQLPHSE-------TSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKR 2049
            .|..........|:|       :|:|.|...|.......|..:|                .:|:|
Zfish  1634 DDAHYKNENGYAHTEPLSRSRRSSLATTPIGAPVPVPGDGILNG----------------GLGRR 1682

  Fly  2050 GYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQLA-- 2112
            .......:..|:.....|....|    .||::..:.:..:..|..|:.|....|......:.:  
Zfish  1683 SSLAKTPNGNGALENENFRRRDS----MRSSIHYQHKNGVIDQLPKRPSYYKYPRRDSRDRFSSP 1743

  Fly  2113 -KQRGGGGEATKSSSFFAQ-LNSEIGQFHYPTINAAAAAAALHGY--------GH-----GHGHG 2162
             .:|..|||......|:.: .:||           :..:...|||        ||     ||...
Zfish  1744 LSRREEGGEYPGEQRFYGKDEDSE-----------SVISRERHGYPEDSTIFQGHRDMYDGHSMR 1797

  Fly  2163 HGGHGGHGGH 2172
            |..:|.|.|:
Zfish  1798 HPVYGNHYGN 1807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 65/278 (23%)
Ion_trans 734..927 CDD:278921 59/214 (28%)
Ion_trans 1240..1497 CDD:278921 81/276 (29%)
Ion_trans 1571..1793 CDD:278921 62/234 (26%)
cacna1fbXP_021333942.1 Ion_trans 114..407 CDD:306908 65/280 (23%)
Ion_trans 532..763 CDD:306908 66/240 (28%)
Ion_trans 856..1093 CDD:306908 82/288 (28%)
Ion_trans 1178..1431 CDD:306908 68/260 (26%)
GPHH 1432..1502 CDD:318993 17/78 (22%)
Ca_chan_IQ 1504..1575 CDD:312334 13/79 (16%)
CAC1F_C 1601..2067 CDD:318975 50/269 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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