DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and scn8a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_031751845.1 Gene:scn8a / 549640 XenbaseID:XB-GENE-1011299 Length:1987 Species:Xenopus tropicalis


Alignment Length:2234 Identity:436/2234 - (19%)
Similarity:755/2234 - (33%) Gaps:788/2234 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 GEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERY---PSLQ---- 388
            |.||:  ||...|...:..||.::..:         |.:.|.:.||..||..|:   |:|.    
 Frog    64 GVPFI--YGDCPSRLIAEPIEDLDPFY---------LHTKTFIVLNRGKTIFRFSAAPALYILSP 117

  Fly   389 ------------------------------FITFAS--------DTAVTLLFTAEMIAKMHIRGV 415
                                          |:||::        :...|.::|.|.:.|:..||.
 Frog   118 FNPLRKFAIKILIHSLFSMIIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESLVKIIARGF 182

  Fly   416 LHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKF 480
            ......:|:|.|...|.|::             ::..|.:|..|..:.|.|...::|.|:.....
 Frog   183 CIDGFTFLRDPWNWLDFSVI-------------MMAYVTEFVDLGNVSALRTFRVLRALKTISVI 234

  Fly   481 SMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCV---------------- 528
            ...|:.:..:. :|.:::.:|.:..:|.:|::.|:|:| |.|.|:..||                
 Frog   235 PGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRRKCVAWPVDMDQMYLANGSK 298

  Fly   529 --------MNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNG 585
                    ||:|.:       ..::. ||....|....|:| ||..|..|||.....:|  |:..
 Frog   299 GFDFDEYIMNDTNF-------FKVHG-AIDPLLCGNGSDAG-QCPEGYTCMKAGRNPNY--GYTS 352

  Fly   586 FEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVIT 645
            |:..:.:...:::..:|:.|..:....:      ||:     .:|..:||..::.:.|:.:||:.
 Frog   353 FDTFSWAFLALFRLMTQDFWENLYQLTL------RASGKTYMIFFVLVIFVGSFYLVNLILAVVA 411

  Fly   646 ETF---------------NEIRVQFQQM------------------------------------- 658
            ..:               ||.:...:||                                     
 Frog   412 MAYEEQNQATLEEAERKENEFKAMLEQMKRMQEEAQAAANATSAGTVTEDAVEDEDGEARMSHTS 476

  Fly   659 ----------------------------------------------------W------------ 659
                                                                |            
 Frog   477 SEFSKPSSKSAKERRNRRKKRKQKELSEGEEKGDSEKVYKSESEDGVKRRGFWYPDNRLGRRFSI 541

  Fly   660 ---------------------------------------------------GAR----------- 662
                                                               |.|           
 Frog   542 MNQSLLSIPGSPYLSRHNSKSSIFSFRGRFRDPVSENEFADDEHSTVEESEGRRDSLFIPVRGHD 606

  Fly   663 -------GHIQKTAASQIL-------------------------SGNDTGWRLV--------TID 687
                   |:.|.:.:|:||                         ..|..|.||:        ..|
 Frog   607 RRNSYNSGYSQGSRSSRILQNLRRNPKRNSTVDCNGVVSLIGGPGSNIPGGRLLPEVKIDKAATD 671

  Fly   688 DNKHGGLAPETCHAILRSPYFRMLV-MSVILAN----------GIVTATMTFKHDGRPRDV---- 737
            |      :|.|...:.|.|...:.| |..:.|:          .:||.|:..:.:...|..    
 Frog   672 D------SPTTEVEVKRKPSGSLRVSMDQLTASFGRKRANSILSVVTQTLVEELEESQRKCPPCW 730

  Fly   738 --FYERYY----------------------YIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFE 778
              |.:.|.                      :::|..|..:.|.|||..     ..:|..:.| ||
 Frog   731 YKFADTYLIWTCCPLWIRIKTIVNMIVMDPFVDLTITICIVLNTLFMA-----MEHYPMTPH-FE 789

  Fly   779 LLLAAGTT-----------LHIVPM----FYPSG--------------------------LTYFQ 802
            .:|..|..           |.::.|    ::..|                          |..|:
 Frog   790 NVLVVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELGLQDVEGLSVLRSFR 854

  Fly   803 VLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF------CFLCDFT- 859
            :|||.:|.|:.|.| ..:.||.|.. ..||:|.:....::.|.:.:.||||      | :|... 
 Frog   855 LLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDC-VCKINP 917

  Fly   860 -------KFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSL 917
                   ....|..:|:.:|::|..| |:|.|.:.|....:.:..:|   |::..:...|:||:|
 Frog   918 ECVLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCIIV---FMMVMVIGNLVVLNL 978

  Fly   918 FVAVIL-----DNLELDEDIKKLKQLKFREQSAEIKETLPF-RLRIFEKFPDSPQMTILHRIPND 976
            |:|::|     |||...:|..::..|:.  ....||:.:.: :|:                 .:|
 Frog   979 FLALLLSSFSADNLAATDDDGEMNNLQI--SVIRIKKGIAWIKLK-----------------AHD 1024

  Fly   977 FMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNV----------VFRKQKPVRIMNKTA 1031
            ||        .|||  :.:..|.:     :|:.|.:|..:          :.|.....:..|.|.
 Frog  1025 FM--------QKHF--KKKDADEV-----KPLDEMYEKKMNCLANNTGADIHRDMDYPKNGNGTT 1074

  Fly  1032 KVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFG 1096
            .  ..|||:.|..|     |.::...:...:..:.|....|....::..|           :.|.
 Frog  1075 S--GIGSSVEKYMI-----DEDHMSFIHNPNLTVKVPIAVGESDFENLNT-----------EDFS 1121

  Fly  1097 SRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREE 1161
            |.|.....:.   ||..|..  .|...|...|.|.                     |:...|.||
 Frog  1122 SASDEEGSKD---KLDDTSS--SEGSTIDIKPEAE---------------------EVPVEQPEE 1160

  Fly  1162 DLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLD 1226
            .|..::.|.:..:      :|| |.||..|         :...||    .:.:|.....|:...:
 Frog  1161 YLDPDNCFTEGCV------ARF-KCCQVSV---------EEGLGK----SWWTLRKTCFLIVEHN 1205

  Fly  1227 W---VMIFATTLSCISMMFETPNYRVMDHPTLQ-IAEYG---FVIFMSLELALKILADGL--FFT 1282
            |   .:||...||..::.||  :..:....|:: |.||.   |.....||:.||.||.|.  |||
 Frog  1206 WFETFIIFMILLSSGALAFE--DVYIEQRKTIRTILEYADKVFTYIFILEMLLKWLAYGFVKFFT 1268

  Fly  1283 PKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYEL 1347
                  :....||..|..||...|....|......|.:.|..||.:||||..:....||.||..|
 Frog  1269 ------NAWCWLDFLIVDVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNAL 1327

  Fly  1348 CRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPT---------ISRREDCVGVFMRRVF 1403
            ......|:.|..:.::...||:..||.|:.|:...|.:.|         :.....|..:....  
 Frog  1328 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYYCYNETAEGMFEIEDVENETQCFDLIGNN-- 1390

  Fly  1404 VTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVH 1468
            .|:::                 |.|. :.||||:|...|.|.:|.:||||:|:....:.: ..||
 Frog  1391 YTEVR-----------------WKNV-KINFDNVGAGYLALLQVATFKGWMDIMYAAVDS-RKVH 1436

  Fly  1469 A-------VYIHIY----IFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKR 1517
            .       :|::||    |..|....|.||:||:|.|:::.|     ....:|.:|:::.:..|:
 Frog  1437 QQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1501

  Fly  1518 LKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVI-VS 1581
            |...:|....||| ..|.:...:||.....|..||.:::.:|.:.:.:.......:|:.::. ::
 Frog  1502 LGSKKPQKPIPRP-LNKFQGAIFDIITQQAFDIVIMILICLNMVTMMVETDDQSDYTDNVLYWIN 1565

  Fly  1582 AVLTFVFVVEVVMKNIAFTPRGY-----WQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG-- 1639
            .|....|..|.|:|..|.  |.|     |    |.:|.:|.:..::.:.|..::   ..||..  
 Frog  1566 VVFIVFFTTECVLKLCAL--RHYYFTIGW----NIFDFVVVILSIVGMFLADLI---TKYFVSPT 1621

  Fly  1640 -FMVVIL----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYG 1699
             |.|:.|    |...:......::.|:..:.:|:...|.|...:||::|.:::.|...|..||..
 Frog  1622 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKKE 1686

  Fly  1700 EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTL-----GNNYWETDCGNFTASL 1759
            .||....||.:....:..||:|.|...|:.::...:.:||.|..     |:.. :.||||.:..:
 Frog  1687 AGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCDAHKENPGSQV-KGDCGNPSVGI 1750

  Fly  1760 IYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDA-LLSYADIRNFQNTWNIVDIHQRGVIPVR 1823
            .:|.::.:|...||:|:.:|||:||||:  :.||.| .||..|...|...|.             
 Frog  1751 FFFVSYIIISFLIVVNMYIAIILENFSV--ATEESADPLSEDDFETFYEIWE------------- 1800

  Fly  1824 RVKFILRLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEEL 1888
              ||           ||...:.:      :..||.:..|...|         .:.|.|...:|  
 Frog  1801 --KF-----------DPDATQFI------QFSKLPDFADALEH---------PLRIPKPNTIE-- 1835

  Fly  1889 LAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAP 1953
            |...:...:..:.:..:.|   |....|::               |..:.|..::|..::|... 
 Frog  1836 LIAMDLPMVSGDRIHCLDI---LFAFTKRV---------------LGESGELDILRQQMEERFV- 1881

  Fly  1954 LGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATG 2018
                              |..|:..::.|..::...:::| .|:.|:|                 
 Frog  1882 ------------------ASNPSKVSYEPITTTLRRKQED-VSAVVIQ----------------- 1910

  Fly  2019 AATATGTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDST------GSSAGRKFLAP-TSSDPQ 2076
                              |:..||::   |||: ::|..||      |::..:|...| |:|.|.
 Frog  1911 ------------------QAYRRHLV---KRGF-ISRKRSTGKMENGGTNMDKKEGTPSTASLPS 1953

  Fly  2077 QRS-TLSDK---ERLHITSQQRKK 2096
            ..| |..||   ||:....::|.|
 Frog  1954 YDSVTKPDKAKQERIEDAIRERAK 1977

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 70/370 (19%)
Ion_trans 734..927 CDD:278921 60/281 (21%)
Ion_trans 1240..1497 CDD:278921 78/282 (28%)
Ion_trans 1571..1793 CDD:278921 60/239 (25%)
scn8aXP_031751845.1 Ion_trans 131..421 CDD:395416 61/320 (19%)
Na_trans_cytopl 503..709 CDD:403218 21/211 (10%)
Ion_trans 759..972 CDD:395416 48/224 (21%)
Na_trans_assoc 998..1199 CDD:399489 51/298 (17%)
Ion_trans 1204..1480 CDD:395416 84/304 (28%)
Na_channel_gate 1472..1524 CDD:240441 11/52 (21%)
Ion_trans 1529..1783 CDD:395416 65/265 (25%)
GPHH 1795..1842 CDD:407139 14/89 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.950

Return to query results.
Submit another query.