DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1da

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_021335251.1 Gene:cacna1da / 403310 ZFINID:ZDB-GENE-030616-135 Length:2093 Species:Danio rerio


Alignment Length:2162 Identity:449/2162 - (20%)
Similarity:781/2162 - (36%) Gaps:691/2162 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   300 AAITGVPPIGLGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRL--- 361
            ||....||   ..|..:.:.:.:|.....|     .|.|...:....||:......|:...|   
Zfish    10 AATPAAPP---AAAVPVPSVVPVGSLAQKK-----RAQYAKSKKQGSSANTRPQRALFCLNLNNP 66

  Fly   362 -MRLCALVSLTSVSLNTPKTFERYPSLQ----------FITFASDT-------------AVTLLF 402
             .|.|       :||...|.|:.:..:.          ::.|..|.             |..::|
Zfish    67 IRRAC-------ISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLIIF 124

  Fly   403 TAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIF--------EVLEIVPKFSY- 458
            |.|...|:...|::..:..|:::.|...|..:|.....|::|::.        ||.|.:....: 
Zfish   125 TIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSAHGHG 189

  Fly   459 ----------LSIMRAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSL 511
                      |...|..|||.::.        .:|..::  |.|.| :...:.::.|..||.:.:
Zfish   190 GKPGGFDVKALRAFRVLRPLRLVS--------GVPSLQVVLNSIIK-AMVPLLHIALLVLFVIII 245

  Fly   512 YGLLGVQ-FFGELKNHCVMNNTEYDLYKRPI-LTIN----SLAIPDTFCSMDPDSGYQCSPGMVC 570
            |.::|:: |.|::...|....|:. |...|. ..:|    :..|..|.|.    .|:|...|   
Zfish   246 YAIIGLELFIGKMHASCYFQGTDI-LEDEPAPCAVNGHGRTCPINGTLCK----EGWQGPNG--- 302

  Fly   571 MKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWL 635
                       |...|::...::.||:|..:.|||..::|...|::.......||.:::.|.::.
Zfish   303 -----------GITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPWVYFVSLVIFGSFF 356

  Fly   636 VKNVFIAVITETFNEIRVQFQQMWGARGHIQK------------------TAASQILSGNDT--- 679
            |.|:.:.|::..|::.|.:.:    |||..||                  |.|..|...|:.   
Zfish   357 VLNLVLGVLSGEFSKEREKAK----ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEEE 417

  Fly   680 --------------------GWRLVTID---------------DNKHG----------------- 692
                                ||...:.|               :|:.|                 
Zfish   418 ESKRNRVTLASLMEKKKKGFGWFSQSSDTHASMPASETESMNTENEKGEDEKATCCGPTCQKISK 482

  Fly   693 -----------GLAPETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRP------RDVFYE 740
                       .|....|...::|..|..||:.::..|   |.|::.:|..:|      :||..:
Zfish   483 SKFSRRWRRWNRLCRRNCRLAVKSVPFYWLVIILVFLN---TLTISSEHYNQPMWLTQVQDVANK 544

  Fly   741 RYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAG----TTLHIVPMFYPSGLTYF 801
               .:..:|||    |.|.|:|.||.:.|:....::|:..:..|    |.|....:..|.|::.|
Zfish   545 ---VLLAMFTC----EMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISVF 602

  Fly   802 QVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF----T 859
            :.:|::|:.|.:   ..|...|..:....|.:.||::.....:||.|.:.||:|....:|    |
Zfish   603 RCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFNFDETQT 667

  Fly   860 K---FESFPEAFMSMFQILTQEAWVEVMDETMIR----TSKTLTPLVAVYFILYHLFVTLIVLSL 917
            |   |::||:|.:::|||||.|.|..||.:.::.    :|..:  :|.:|||:..:....|:|::
Zfish   668 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGM--IVCIYFIILFICGNYILLNV 730

  Fly   918 FVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKV 982
            |:|:.:|||                ..||                                    
Zfish   731 FLAIAVDNL----------------ADAE------------------------------------ 743

  Fly   983 RESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITH 1047
                      .|.|:|:                                                
Zfish   744 ----------SLNTDDT------------------------------------------------ 750

  Fly  1048 IINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLK 1112
                                                 .||..:|:       |....::|....|
Zfish   751 -------------------------------------KKPDEIDE-------IEDEAKAGEEDEK 771

  Fly  1113 QTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLV 1177
            ...|...|..|:.|.||.                   :.:|:.:.::...:.|...|     |:.
Zfish   772 DNAEEDEEEPDVPAGPRP-------------------KISELVKKEKITPIPEGSAF-----FIF 812

  Fly  1178 PRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMF 1242
            ...:..|..|.|:::.                      |.|..|:  |.::|     ||..|:..
Zfish   813 SNTNPVRVACHKLINH----------------------HIFTNLI--LVFIM-----LSSASLAA 848

  Fly  1243 ETP--NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSF 1305
            |.|  |:... :..|...:|.|....::|:.||:...|.|....|:.::....||:.:..||   
Zfish   849 EDPIRNFSAR-NIILGYFDYAFTAIFTVEIVLKMTTYGAFLHKGAFCRNYFNLLDLLVVGVS--- 909

  Fly  1306 LCWMPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEILLVSTLLILLMFI 1367
            |....:.....|..::|.:||.:||||....   :.|:.:.|:...|....|::|:|   ||.|:
Zfish   910 LVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT---LLQFM 971

  Fly  1368 FASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRF 1432
            ||..||||:.|:..||||...|..|:|.|.::         :....|.:.| ::..|.|.| ..|
Zfish   972 FACIGVQLFKGKFYRCNDEAKSSPEECKGTYI---------MYKEGDVNQP-IIQKRHWHN-SDF 1025

  Fly  1433 NFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV-------GPVH------AVYIHIYIFLGCMIGL 1484
            ||||:..||:.||.|.:|:||   ..:|.||:       ||::      :::..|||.:.....:
Zfish  1026 NFDNVLMAMMALFTVSTFEGW---PALLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAFFMM 1087

  Fly  1485 TLFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQPL--HLPPRPDGRKIRAFT 1539
            .:|||.||..:.| :|.     .:.:.|:|.|.        || |:||  ::|..|...|   |.
Zfish  1088 NIFVGFVIVTFQE-QGE-----KEYKNCELDKNQRQCVEYALK-ARPLRRYIPKNPYQYK---FW 1142

  Fly  1540 YDITQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRG 1603
            | :.....|:.::.|::|:|::.|::. :.:.|:....:.|::.|.|.||.||:|:|.|||.||.
Zfish  1143 Y-VVNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKPRH 1206

  Fly  1604 YWQSRRNRYDLLVTVAGVIWIILQTI-----------------LRNDLSYFFGFMVVILRFFTIT 1651
            |:....|.:|.|:.|..|:.|.:..:                 .|..:::|..|.|  :|...:.
Zfish  1207 YFTDAWNTFDALIVVGSVVDIAITEVNPTEAPQVDESGNTEDSARISITFFRLFRV--MRLVKLL 1269

  Fly  1652 GKHTTLKMLMLTVGVSVCKSF----FIIFGMFLLVFFYALAGTILFGTVKYGE--GIGRRANFGS 1710
            .:...::.|:.|    ..|||    ::...:.:|.|.||:.|..:||.:...:  .|.|..||.:
Zfish  1270 SRGEGIRTLLWT----FIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQT 1330

  Fly  1711 PVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNY---WETDCGNFTASLIYFCTFYVIITYI 1772
            ....|.:|||..|||.|.:||..|| ....|...::|   .|..||: :.::|||.|||::..::
Zfish  1331 FPQAVLLLFRCATGEAWQEIMLACM-PGKLCDPESDYNPGEEMTCGS-SFAIIYFITFYMLCAFL 1393

  Fly  1773 VLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRG-------VIPVRRVKFIL- 1829
            ::||.||:||:||.  |...:.::|....:..|:..|:..|...:|       |..:||::..| 
Zfish  1394 IINLFVAVIMDNFD--YLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLG 1456

  Fly  1830 --RLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLARE 1892
              :|...|:.|    .||:...|     .|::...|.|:..:..|...::.|:....||:  |.|
Zfish  1457 FGKLCPHRVAC----KRLVAMNM-----PLNSDGTVMFNATLFALVRTALKIKTEGNLEQ--ANE 1510

  Fly  1893 EFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAV 1957
            |                 |...:|||..:.:.|..:.::             |...:|:..:|  
Zfish  1511 E-----------------LRAVIKKIWKRTSMKLLDQVV-------------PPAGDDEVTVG-- 1543

  Fly  1958 DKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATA 2022
                                 .|..||...:...|...        ..|..:.|...:....|.|
Zfish  1544 ---------------------KFYATFLIQDYFRKFKK--------RKEEGLVGVHPAQNNTAIA 1579

  Fly  2023 TGTSSGLGVGPPTVQSTARHVMTVG---KRGYALNRSDS----------------TGSSAGRKFL 2068
                         :|:..|.:..:|   :|..:.:..|.                .|...| ..:
Zfish  1580 -------------LQAGLRTLHDIGPEIRRAISCDLQDDELVDFIPEEDEEIYRRNGGLFG-NHI 1630

  Fly  2069 APTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNS 2133
            ...:.||::.|.       |.|:..::...:...||                       :..:..
Zfish  1631 NHINGDPRRSSG-------HQTNATQRPLQVQPPPH-----------------------YVHMEQ 1665

  Fly  2134 EIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGGHGGHGEHQMHHHHGGALG-SPSAMMSQMIG 2197
            .:|:     :..|.|.|..:.:.|.|.|.|              ||||..:.. ||.:....:..
Zfish  1666 PVGR-----LGRANAMAQQNHHRHHHHHHH--------------HHHHNNSYNKSPKSTNINLNN 1711

  Fly  2198 GSGKLLPFNNQANAVYE 2214
            .:...|| |...|..||
Zfish  1712 ANVSSLP-NGGHNRYYE 1727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 66/330 (20%)
Ion_trans 734..927 CDD:278921 61/216 (28%)
Ion_trans 1240..1497 CDD:278921 80/274 (29%)
Ion_trans 1571..1793 CDD:278921 75/247 (30%)
cacna1daXP_021335251.1 Ion_trans 77..377 CDD:306908 64/327 (20%)
Ion_trans 509..744 CDD:306908 71/308 (23%)
Ion_trans 828..1105 CDD:306908 90/332 (27%)
Ion_trans 1150..1414 CDD:306908 80/273 (29%)
GPHH 1415..1485 CDD:318993 17/78 (22%)
Ca_chan_IQ 1487..1558 CDD:312334 18/125 (14%)
CAC1F_C 1583..2092 CDD:318975 33/196 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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