DRSC/TRiP Functional Genomics Resources

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Protein Alignment na and scn1laa

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_956426.2 Gene:scn1laa / 393101 ZFINID:ZDB-GENE-040426-751 Length:1955 Species:Danio rerio


Alignment Length:2023 Identity:411/2023 - (20%)
Similarity:688/2023 - (34%) Gaps:674/2023 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   399 TLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMR 463
            |.::|.|.:.|:..||...|...:|:|.|          .|:..|:   .|:..|.:|..|..:.
Zfish   163 TGIYTLEALVKITARGFCVGRFTFLRDPW----------NWLDFIV---IVMAYVTEFVDLGSVS 214

  Fly   464 APRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHC 527
            |.|...::|.|:........|:.:..:. :|.:::.:|.:..||.:|::.|:|:| |.|.||..|
Zfish   215 ALRAFRVLRALKTISVVPGLKTIVGALI-QSVKKLSDVMILTLFCLSVFALVGLQLFMGILKQKC 278

  Fly   528 V-------------MNNTEYDLYKRPILTINSLAIPD----TFCSMDPDSGYQCSPGMVCMKMDF 575
            |             .|.|..|....|   .|...:|.    ..|....|:| ||..|..|:|...
Zfish   279 VYSTSFTENKEACYKNKTCRDYINNP---SNQYFLPGKKDALICGNSSDAG-QCPEGYTCLKAGK 339

  Fly   576 LSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----FYFSTMIFFLAWL 635
            ...|  |:..|:....:..::::..:|:.|..:..:.:      |||     .:|..:||..::.
Zfish   340 NPDY--GYTSFDSFGWAFLSLFRLMTQDFWENLYQQTL------RAAGKTYMIFFVLVIFLGSFY 396

  Fly   636 VKNVFIAVIT------------------ETFN-------------EIRVQFQQMWGARGHIQKTA 669
            :.|:.:||:.                  |.||             |...:..:..|..|  :||.
Zfish   397 LVNLILAVVAMAYDEQNQATIDEALKKEEEFNAMLEQITRQEQEAEAAAEQSKCEGLSG--EKTD 459

  Fly   670 AS--------------------------------QILSGND------------------------ 678
            :|                                .|..|||                        
Zfish   460 SSSDASKLSSKSAKERRNRKKKRQHQGESEKEEDSIKEGNDRKPNFTFAVDGKIRRSRDRSYTSP 524

  Fly   679 ---------------------------------------------TGWR-----LVT-------- 685
                                                         ||.|     |.|        
Zfish   525 RQSPLSFQGSLLTPRRDSKASVFSFRGRIHSDNNYADDEQSMFEETGSRRDSLFLPTRPERLFSN 589

  Fly   686 --------------------IDDNK------HGGLAP--------------------ETC----- 699
                                :||:.      .|..||                    :||     
Zfish   590 VSKSSLTPHLLLPSNGKARYVDDSNGMVMVTSGASAPNSPVIALNTPEVSRKRAMFDDTCADSDD 654

  Fly   700 ----------------------------------------------------------------- 699
                                                                             
Zfish   655 ERRSRCNSQNFSKAYRQSMRERALSVASGSNNPAECSEIFKQRCEEWWFEFAENYLIWDCSPTWL 719

  Fly   700 ------HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETL 758
                  |.|:..|:..:.:...|:.|.:..|...:..||    .:........:||..:...|.:
Zfish   720 RIKEVVHMIVMDPFADLFITICIVINTVFMAMECYPMDG----PYSSMLSTANVVFIGIFTAEMI 780

  Fly   759 FKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTY---FQVLRVVRLIKASPMLEGFV 820
            ||:..|....|:....:.|:.::...:.:.:......||:.:   |::|||.:|.|:.|.| ..:
Zfish   781 FKVIALDPYSYFLEGWNIFDSIIVTLSLMELCLANVLSGIGFLRPFRLLRVFKLAKSWPTL-NML 844

  Fly   821 YKIFGPGKKLGSLIIFTMCLLI---ISSSISMQLF------CFLCDFTK--------FESFPEAF 868
            .||.  |..||:|...|:.|.|   |.:.:.||||      | :|..:.        ...|..:|
Zfish   845 IKII--GNSLGALSNLTLVLAIIVFIFAVVGMQLFGKSYGEC-VCKISSDCMLPRWHMNDFFHSF 906

  Fly   869 MSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVIL-----DNL-- 926
            :.:|::|..| |:|.|.:.|....:   ||....|::..:...|:||:||:|::|     |||  
Zfish   907 LIVFRVLCGE-WIETMWDCMEVAGQ---PLCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAV 967

  Fly   927 --ELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKH 989
              |.||:..::...:.|:....||..|                                :||.:.
Zfish   968 SGEEDENNLQIAVRRIRKGFTFIKTCL--------------------------------QSFFRS 1000

  Fly   990 FVIELETEDS----LVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIIN 1050
            ..:..:.:.|    ::.|||.                                  ||        
Zfish  1001 GCLRKKKQKSADGNMIVNCKE----------------------------------RK-------- 1023

  Fly  1051 DSNNQRLMLGDSAMLPVVGTKGGGGLK-------SQGTITHSKPWRVDQKKF------GSRSIRR 1102
            ||.|.       ..:.:|.:.||..|.       |..::|.|.|...::..|      ...|:..
Zfish  1024 DSTNH-------TTIELVKSTGGTDLDSDTENFISNPSLTVSVPIAAEESDFECLNTEDFSSLSS 1081

  Fly  1103 SVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENH 1167
            .:.....||........|...:...|....|.   ..|::.|               ||:.    
Zfish  1082 DLEEDKEKLSDVASSFSEGSTVDLRPLGKDGE---DALELVL---------------EEEA---- 1124

  Fly  1168 PFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYK------SLHNFLGLVTYLD 1226
              :..|.|......||| .||               ..:|:.:..|      :.:|.:. .::.:
Zfish  1125 --YPEPCFTAGCVRRFR-CCQ---------------VDEEKGIWKKWWLLRQTCYNIVE-HSWFE 1170

  Fly  1227 WVMIFATTLSCISMMFET--PNYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKD 1289
            ..::|...||..::.||.  .:.|......|:.|:..|.....||:.||.:|.|.    ..|..:
Zfish  1171 TFIVFMILLSSGALAFEDIYLDTRKSVKTILEFADKVFTYIFILEMLLKWVAYGF----AKYFTN 1231

  Fly  1290 VAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEI 1354
            :...||..|..||...|....||....||.:.|..||..||||..:....||.||..|......|
Zfish  1232 LWCWLDFVIVDVSLISLVANALNYSELSAIKSLRTLRAFRPLRALSRFDGMRVVVNALLGAIPSI 1296

  Fly  1355 LLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRR---------EDC----VGVFMRRVFVTK 1406
            :.|..:.::...||:..||..:.|:.:.|.:.|..:|         .||    .||..|.|.:  
Zfish  1297 MNVLLVCLIFWLIFSIVGVNFFAGKFSECINITTEQRLPVSEVYNKTDCERMGKGVRWRNVII-- 1359

  Fly  1407 MKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVHA-- 1469
                                      ||||:|:..|.|.:|.:||||:.:....:.:..|...  
Zfish  1360 --------------------------NFDNVGNGYLALLQVATFKGWMPIMYAAVDSRNPEEQPE 1398

  Fly  1470 --------VYIHIYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIA 1521
                    :|..|:|.||....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|...
Zfish  1399 YEVNLYMYLYFVIFIILGAFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSK 1463

  Fly  1522 QPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVH-TERLVIVSAVLT 1585
            :|....|||. .||:...:|:.....|...|.|::.:|.:.:.:......:. |..|..::.:..
Zfish  1464 KPQKPIPRPK-NKIQGLIFDLVTKQAFDIFIMVLIWLNMVTMMLETEDQSIEMTRALYWINVIFI 1527

  Fly  1586 FVFVVEVVMKNIAFTPRGY-----WQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMV 1642
            .:|..|.|:|.||.  |.|     |    |.:|.:|.:..::.:.|..:::   .||..   |.|
Zfish  1528 VLFTTECVLKMIAL--RHYFFTVGW----NVFDFIVVILSIVGMSLTEVIK---KYFVSPTLFRV 1583

  Fly  1643 VIL----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIG 1703
            :.|    |...:......::.|:..:.:|:...|.|...:||::|.||:.|...|..||...||.
Zfish  1584 IRLARIGRVLRLIRSAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKTAGID 1648

  Fly  1704 RRANFGSPVTGVAMLFRIVTGEDWNKIMHDCM-VQPPYCTLGNNYWET----DCGNFTASLIYFC 1763
            ...||.:....:..||:|.|...|:.::...: .:||.|....|:..:    ||||.:..:.:|.
Zfish  1649 DMFNFETFPNSMLCLFQITTSGGWDGLLAPMLNSKPPDCDPTKNFTGSSVVGDCGNPSIGIFFFV 1713

  Fly  1764 TFYVIITYIVLNLLVAIIMENFSLFYSNEEDA-LLSYADIRNFQNTWNIVD-----IHQRGVI-- 1820
            ::.:|...||:|:.:|:|:||||:  :.||.| .||..|...|...|...|     ..:.|.:  
Zfish  1714 SYIIICFLIVVNMYIAVILENFSV--ATEESAEPLSEDDFDRFYEVWEKFDPKATQFMEYGKLSD 1776

  Fly  1821 -------PVRRVK--------FILRLLKG-RLEC-DPQKDRLLFKYMCY------ELDKLHNG-E 1861
                   |:|..|        ..|.::.| |:.| |     :||.:...      |:|.||.. |
Zfish  1777 FADSLDPPLRIPKPNRFQLMSMDLPMVTGDRIHCLD-----ILFAFTKRVLGEGGEMDMLHGQME 1836

  Fly  1862 DVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIR-AQNASK 1925
            |.......:..||..:......:.|::.|.     :::....|..:|    ..:||:| .:..:|
Zfish  1837 DRFMQSNPSKSSYEPITTTLRRKHEDMSAA-----VIQRAFRKHLVR----DSMKKVRNFKKKNK 1892

  Fly  1926 QQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSS-TEN 1989
            .||..:             |:.|       ::||...:..|.|.|....|      |::|| |||
Zfish  1893 HQNGKV-------------PSNQ-------SMDKDMCNEDSDATAATSSP------PSYSSITEN 1931

  Fly  1990 E----EKD 1993
            .    |||
Zfish  1932 AKNKYEKD 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 67/308 (22%)
Ion_trans 734..927 CDD:278921 56/221 (25%)
Ion_trans 1240..1497 CDD:278921 76/281 (27%)
Ion_trans 1571..1793 CDD:278921 62/239 (26%)
scn1laaNP_956426.2 Ion_trans 150..416 CDD:278921 63/278 (23%)
Na_trans_cytopl 483..594 CDD:288761 9/110 (8%)
Ion_trans 749..945 CDD:278921 49/207 (24%)
Na_trans_assoc 972..1161 CDD:284034 45/309 (15%)
Ion_trans 1184..1438 CDD:278921 77/285 (27%)
Na_channel_gate 1430..1482 CDD:240441 12/52 (23%)
Ion_trans 1504..1742 CDD:278921 63/248 (25%)
GPHH 1752..1801 CDD:293510 7/48 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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