Protein Alignment na and Nalcn

DIOPT Version :9

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_036014574.1
• Gene: Nalcn / 338370
• MGIID: 2444306
• Length: 1787
• Species: Mus musculus
• Alignment Length: 1977
• Identity: 1001/1977 - (50%)
• Similarity: 1264/1977 - (63%)
• Gaps: 236/1977 - (11%)

  Fly   297 VGSAAITGVPPIGLGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRL 361
            :|...:..:||        ..|..||.||||.:.....:.|:||:|||:::|||.|:||.||..|
Mouse     1 MGPTVVLYLPP--------KANFSMLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSL 57

  Fly   362 MRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDH 426
            :|:||::|:.||.:|||.|||.||.||::||..||.:..|:||||||||||||::.|:..|:||.
Mouse    58 LRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDR 122

  Fly   427 WCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIF 491
            ||.||..||..||:|::||:||:.:||.:.|...::|.||||||||..|::.:|.:|::||..|.
Mouse   123 WCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNIL 187

  Fly   492 KRSSQQIYNVTLFFLFFMSLYGLLGVQFFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSM 556
            |||.:||::|::|.|||:.|||:||||.||....|||:|:|     |...:|.||||||||.||.
Mouse   188 KRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT-----KPGNVTWNSLAIPDTHCSP 247

  Fly   557 DPDSGYQCSPGMVCMKMD--FLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAW 619
            :.:.||||.||..||.::  .||...:|::||.:|.|||||||:|:|||||||:|||||||.|.|
Mouse   248 ELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEASSQEGWVFLMYRAIDSFPRW 312

  Fly   620 RAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDT-GWRL 683
            |:.|||.|:||||||||||||||||.|||.|||||||||||.|.....||.:|:...:.. ||:|
Mouse   313 RSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGTRSSTTSTATTQMFHEDAAGGWQL 377

  Fly   684 VTIDDNKHGGLAPETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELV 748
            |.:|.||..|.||.....::||..|.|.::|::..:.||.|:..:|.:...|.  |:.:|..|:.
Mouse   378 VAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQ--YDEFYLAEVA 440

  Fly   749 FTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTYFQVLRVVRLIKAS 813
            ||.|.|||.|.||:|||:.||...|:|||||||..|||||:.|..|.|..|||||||||||||.|
Mouse   441 FTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRLIKIS 505

  Fly   814 PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDFTKFESFPEAFMSMFQILTQE 878
            |.||.|||||||||||||||::||..|||:.|:||:|:|||:.:..:|.:||.||||||||||||
Mouse   506 PALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQE 570

  Fly   879 AWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQ 943
            .||:|||:|:........||||:||||||||.|||:|||||||||||||||||:|||||||..|.
Mouse   571 GWVDVMDQTLNAVGHMWAPLVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEA 635

  Fly   944 SAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFV------------IELET 996
            :|:.||.||.|||||||||:.|||..:.::|:||.:||:||||||.|:            |...|
Mouse   636 NADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRESFMKQFIDRQQQDTCCLFRILPST 700

  Fly   997 EDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGD 1061
            ..|..:|.|:|.:|  ::..:.:|     :......:||.....::.|:|.|:.....||::.|.
Mouse   701 SSSSCDNPKKPTAE--DNKYIDQK-----LRKSVFSIRARNLLEKETAVTKILRACTRQRMLSGS 758

  Fly  1062 SAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGS----IKLKQTYEHLMENG 1122
            ....|   .|....|..|..|               |..|||:|.||    |...::.|.|.::
Mouse   759 FEGQP---AKERSILSVQHHI---------------RQERRSLRHGSNSQRISRGKSLETLTQD- 804

  Fly  1123 DIAAAPRANSGR---ARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFR 1184
                  .:|:.|   |:..|.:||::|.|::||||:|..:||:||||||:||.|||:|.||.|||
Mouse   805 ------HSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFR 863

  Fly  1185 KICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRV 1249
            ..|:.:|.||::|...||:||..:..:|..|::.||||||||||||..|..||||||||:|..||
Mouse   864 NFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMITVTICSCISMMFESPFRRV 928

  Fly  1250 MDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIP 1314
            |..||||||||.||||||:||.|||:||||||||.|.|:|....:|:|||:||..||||||.|:|
Mouse   929 MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVP 993

  Fly  1315 TNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGR 1379
            ..|.|||||:|||:||||||.|||.|||||.||..|||||.|||.||:.||.:|||:||||:.|:
Mouse   994 AESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGK 1058

  Fly  1380 LARCNDPTISRREDCVGVFMRRVFVTK---MKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAM 1441
            ||:||||.|.|||||.|:|...|.|:|   :||.||  |..|...|||||||||.|||||:|:||
Mouse  1059 LAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPG--EKKPGFWVPRVWANPRNFNFDNVGNAM 1121

  Fly  1442 LTLFEVLSFKGWLDVRDVLIKAVGPVHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTV 1506
            |.||||||.|||::||||:|..|||:|.:|||:::||||||||||||||||||::||||||||||
Mouse  1122 LALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTV 1186

  Fly  1507 DQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGE 1571
            |||||.|||.|||||||||||||||....||..||||||..|||.||::||..|:|||:.|...:
Mouse  1187 DQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVDD 1251

  Fly  1572 VHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSY 1636
            ..|..|..:|.|.||:||:||.||.||.:|.|:|||||||||||||..||:|::|...|.|..:|
Mouse  1252 PVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTY 1316

  Fly  1637 FFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEG 1701
            ..|..|::.|||:|.|||.|||||:|||.||:.||||||.|||||:..||.||.:|||||||||.
Mouse  1317 MMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN 1381

  Fly  1702 IGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGN-NYWETDCGNFTASLIYFCTF 1765
            |.|.|||.|....:.:||||||||||||||||||||||:||... .||.|||||:..:|:|||:|
Mouse  1382 INRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSF 1446

  Fly  1766 YVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILR 1830
            ||||.||:||||||||:||||||||.|||.||||.|:|:||..||:||..:.||||..||||:||
Mouse  1447 YVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLR 1511

  Fly  1831 LLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFE 1895
            ||:||||.|..||:||||:||||:::||||.|||||||::|||||||||||:||||||||||:.|
Mouse  1512 LLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLE 1576

  Fly  1896 YLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKS 1960
            |.:||||||.|||.||:.|||:|||:  .:|..|:|..||.:.||
Mouse  1577 YTIEEEVAKQTIRMWLKKCLKRIRAK--QQQSCSIIHSLRESQEQ-------------------- 1619

  Fly  1961 AISTISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGT 2025
                                                                            .
Mouse  1620 ----------------------------------------------------------------E 1620

  Fly  2026 SSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRS-TLSDKERLHI 2089
            .|.|.:.||::::|.             ...||..:|........|||..|..| ||||
Mouse  1621 RSRLFLNPPSIETTQ-------------PSEDSNANSQDHSMQPETSSQQQLLSPTLSD------ 1666

  Fly  2090 TSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHG 2154
                                     |||   :.:.::...:...:|||:..|:...|...|.::.
Mouse  1667 -------------------------RGG---SRQDAADTGKPQRKIGQWRLPSAAIAEKTAPVNK 1703

  Fly  2155 YGHGHGHGHGGHGGHGGHGEHQMHHHHGGALGSPS------AMMSQMIGGSG-------KLLPFN 2206
            .           .|:....|.:......|.| :|.      :.::...||..       |:.|..
Mouse  1704 M-----------SGYSQDPEREEEEVSKGFL-APKPISHSVSSVNLRFGGRTTMKTVVCKMNPMP 1756

  Fly  2207 NQANAVYEVHDWWQEQ--VLCPQTSDD 2231
            :.|:...||..||..|  |...::.||
Mouse  1757 DTASCGSEVKKWWTRQLTVESDESGDD 1783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	164/282 (58%)
		Ion_trans	734..927	CDD:278921	125/192 (65%)
		Ion_trans	1240..1497	CDD:278921	177/259 (68%)
		Ion_trans	1571..1793	CDD:278921	143/222 (64%)
Nalcn	XP_036014574.1	Ion_trans	52..347	CDD:395416	172/299 (58%)
		Ion_trans	399..619	CDD:395416	133/221 (60%)
		Ion_trans	903..1177	CDD:395416	189/275 (69%)
		Ion_trans	1225..1474	CDD:395416	156/248 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834729
Domainoid	1	1.000	390	1.000	Domainoid score	I782
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21832
Inparanoid	1	1.050	1816	1.000	Inparanoid score	I63
Isobase	1	0.950	-	0	Normalized mean entropy	S4294
OMA	1	1.010	-	-		QHG48327
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0004135
OrthoInspector	1	1.000	-	-		oto92910
orthoMCL	1	0.900	-	-		OOG6_104443
Panther	1	1.100	-	-	LDO	PTHR46141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	1	1.000	-	-		X3959
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890