Protein Alignment na and para

DIOPT Version :9

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Alignment Length: 2205
• Identity: 417/2205 - (18%)
• Similarity: 766/2205 - (34%)
• Gaps: 713/2205 - (32%)

  Fly   364 LCALVSLTSVSLN-----TPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYL 423
            |.:|..:|::.:|     .|.|    |:::    :::...|.::|.|...|:..||.:.....||
  Fly   154 LFSLFIITTILVNCILMIMPTT----PTVE----STEVIFTGIYTFESAVKVMARGFILCPFTYL 210

  Fly   424 KDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRIN 488
            :|.|...|..:::..::::.:.             |..:.|.|...::|.|:........|:.:.
  Fly   211 RDAWNWLDFVVIALAYVTMGID-------------LGNLAALRTFRVLRALKTVAIVPGLKTIVG 262

  Fly   489 QIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCV-----------MNNTEYDLYKRPI 541
            .:.: |.:.:.:|.:..:|.:|::.|:|:| :.|.|...|:           :.:..:|.:.|
  Fly   263 AVIE-SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNR-- 324

  Fly   542 LTINS---------LAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVY 597
               ||         ::.|  .|.....:| ||....||:: .|..:...|:..|:....:..:.:
  Fly   325 ---NSSNWYSEDEGISFP--LCGNISGAG-QCDDDYVCLQ-GFGPNPNYGYTSFDSFGWAFLSAF 382

  Fly   598 QAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGA- 661
            :..:|:.|..:....:.:...|...| |..:||..::.:.|:.:|::..:::|::.:.::...|
  Fly   383 RLMTQDFWEDLYQLVLRAAGPWHMLF-FIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAE 446

  Fly   662 --------------------RGHIQKTAAS-------------------------QILSGNDTGW 681
                                |.:.|..||:                         ::..|.:.|
  Fly   447 EEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKG- 510

  Fly   682 RLVTIDDNKHGGL-------------------APETCH--------------------------- 700
                .|||....:                   ||.|.|
  Fly   511 ----NDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSR 571

  Fly   701 -----------------------------------------------------AILRSPYF---- 708
                                                                 ||:...|:
  Fly   572 SSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLG 636

  Fly   709 -----------------------RMLVM-------------------SVILANGIVTATMT---- 727
                                   .|.||                   ||...||..|...|
  Fly   637 SRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKL 701

  Fly   728 -----------------FKHDGRP-------------RDVF------------YER--------Y 742
                             .||...|             :||.            :.|        |
  Fly   702 DHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVY 766

  Fly   743 Y---------------------------------------------------YIELVFTCLLDLE 756
            |                                                   ::||..|..:.:.
  Fly   767 YFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVN 831

  Fly   757 TLF---------------------------------KIYCLGWRGYYKHSIHKFELLLAAGTTLH 788
            |:|                                 |:..:..:.|::...:.|:.::.|.:.|.
  Fly   832 TMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLE 896

  Fly   789 IVPMFYPSGLTY---FQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSL--IIFTMCLLI-ISSSI 847
            : .:....||:.   |::|||.:|.|:.|.|...:..:   |:.:|:|  :.|.:|::| |.:.:
  Fly   897 L-GLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIM---GRTMGALGNLTFVLCIIIFIFAVM 957

  Fly   848 SMQLFCFLCDFTK------------FESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVA 900
            .||||.......|            |..|..:||.:|::|..| |:|.|.:.|.....:..|
  Fly   958 GMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYVGDVSCIP--- 1018

  Fly   901 VYFILYHLFVTLIVLSLFVAVILDNL--------ELDEDIKKLKQLKFREQSAEIKETLPFRLRI 957
             :|:...:...|:||:||:|::|.|.        ..|.|..|                      |
  Fly  1019 -FFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNK----------------------I 1060

  Fly   958 FEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWE------SNV 1016
            .|.|         :||..           .|.:|             ||.:::|::      :|.
  Fly  1061 AEAF---------NRIGR-----------FKSWV-------------KRNIADCFKLIRNKLTNQ 1092

  Fly  1017 VFRKQKPVRIMNKTAKVRAAGSSL-RKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQG 1080
            :..:....| .|:.:.:.:.|..: |.::..|     .:..|.||...:|       ..||..:|
  Fly  1093 ISDQPSGER-TNQISWIWSEGKGVCRCISAEH-----GDNELELGHDEIL-------ADGLIKKG 1144

  Fly  1081 TITHSKPWRV---DQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDI 1142
             |.......|   |..:|   :|...:::...| |..|.:...:.|.|:.....|.:.||...:.
  Fly  1145 -IKEQTQLEVAIGDGMEF---TIHGDMKNNKPK-KSKYLNNATDDDTASINSYGSHKNRPFKDES 1204

  Fly  1143 KLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQK-------IVHARYDARLK 1200
            ....|:..:.|.:|:..:|||.            :..|......|::       |:|| :|..:.
  Fly  1205 HKGSAETMEGEEKRDASKEDLG------------LDEELDEEGECEEGPLDGDIIIHA-HDEDIL 1256

  Fly  1201 DP----------------LTGKERKVQYKSLHNFLGLVT-------YLDWVMIFATTLSCISMMF 1242
            |.                |.|.:....::...| |.|.|       |.:..:|....:|.:::..
  Fly  1257 DEYPADCCPDSYYKKFPILAGDDDSPFWQGWGN-LRLKTFQLIENKYFETAVITMILMSSLALAL 1320

  Fly  1243 ETPNYRVMDHPTLQIAEYG----FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVST 1303
            |  :..:...|.||...|.    |.:...||:.:|.||.|.    |.|..:....||..|.:||.
  Fly  1321 E--DVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF----KVYFTNAWCWLDFVIVMVSL 1379

  Fly  1304 SFLCWMPLNIPTN-------SAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLL 1361
                   :|...:       .|.:.:..||.:||||..:.:..||.||..|.:....|..|..:.
  Fly  1380 -------INFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVC 1437

  Fly  1362 ILLMFIFASYGVQLYGGRLARCND--------PTISRREDCVGVFMRRVFVTKMKLTPGPDESYP 1418
            ::...|||..||||:.|:..:|.|        ..|..|..|                  ..|:|
  Fly  1438 LIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNAC------------------ESENY- 1483

  Fly  1419 AMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKA----VGPVHAVYIHIYIF-- 1477
                  .|.| ...|||::|:|.|.||:|.:||||:.:.:..|.:    ..|:....|::|::
  Fly  1484 ------TWVN-SAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFV 1541

  Fly  1478 ----LGCMIGLTLFVGVVIANYSENKGTA------LLTVDQRRWCDLKKRLKIAQPLHLPPRPDG 1532
                .|....|.||:||:|.|::|.|..|      .:|.||:::.:..|::...:||...|||..
  Fly  1542 FFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRW 1606

  Fly  1533 RKIRAFTYDITQHIIFKRVIAVVVLINSMLLSI-TWIKGEVHTERLVIVSAVLTFVFVVEVVMKN 1596
            |. :|..::|.....|..:|.:.:.:|...::: .:...:.:...|..::|:...:|..|.::|.
  Fly  1607 RP-QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI 1670

  Fly  1597 IAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKM-- 1659
            .|.... |:....|.:|::|.:..::.::|..|:.   .||..  ..:||...:......|::
  Fly  1671 FALRYH-YFIEPWNLFDVVVVILSILGLVLSDIIE---KYFVS--PTLLRVVRVAKVGRVLRLVK 1729

  Fly  1660 -------LMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAM 1717
                   |:..:.:|:...|.|...:||::|.:|:.|...|..||...||....||.:....:.:
  Fly  1730 GAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMIL 1794

  Fly  1718 LFRIVTGEDWNKIMHDCMVQPPYCTLGNN--YWETDCGNFTASLIYFCTFYVIITYIVLNLLVAI 1780
            ||::.|...|:.:: |.::....|...:|  .:..:||:.|..:.:..::.||...||:|:.:|:
  Fly  1795 LFQMSTSAGWDGVL-DAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAV 1858

  Fly  1781 IMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLECDPQKDRL 1845
            |:||:|....:.::.|.. .|...:...|...|......|...::...|.:|:..|:.....
  Fly  1859 ILENYSQATEDVQEGLTD-DDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPN--- 1919

  Fly  1846 LFKYMCYELD-KLHNGEDVTFHDVINMLSYRSVDIRKALQLE------ELLAREEFE-YLVEEEV 1902
              ||....:| .:..|:.:...|:::.|: :....||...:|      |:.||.:.| |   |.|
  Fly  1920 --KYKIISMDIPICRGDLMYCVDILDALT-KDFFARKGNPIEETGEIGEIAARPDTEGY---EPV 1978

  Fly  1903 AKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQE---------DKAPLGAVD 1958
            :....|...|.|.:.|  |:|.::..:...|..:      ..|:...         |.||..|.|
  Fly  1979 SSTLWRQREEYCARLI--QHAWRKHKARGEGGGS------FEPDTDHGDGGDPDAGDPAPDEATD 2035

  Fly  1959 KSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATAT 2023
            ..|.:...|:|.|.....:||          :|.:.:|.       .|.:.|...::|..||..|
  Fly  2036 GDAPAGGDGSVNGTAEGAADA----------DESNVNSP-------GEDAAAAAAAAAAAAAAGT 2083

  Fly  2024 GTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSD 2083
            .|:...|.|            :.|::...|..||...:..|.|.:..:.| |...|..:|
  Fly  2084 TTAGSPGAG------------SAGRQTAVLVESDGFVTKNGHKVVIHSRS-PSITSRTAD 2130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	55/306 (18%)
		Ion_trans	734..927	CDD:278921	59/335 (18%)
		Ion_trans	1240..1497	CDD:278921	76/285 (27%)
		Ion_trans	1571..1793	CDD:278921	53/232 (23%)
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	55/302 (18%)
		Na_trans_cytopl	515..648	CDD:288761	7/132 (5%)
		Ion_trans	835..1028	CDD:278921	40/201 (20%)
		Na_trans_assoc	1054..1296	CDD:284034	58/328 (18%)
		Ion_trans	1318..1571	CDD:278921	78/291 (27%)
		Na_channel_gate	1561..1613	CDD:240441	15/52 (29%)
		Ion_trans	1636..1871	CDD:278921	53/241 (22%)
		GPHH	1880..1930	CDD:293510	9/54 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439094
Domainoid	1	1.000	91	1.000	Domainoid score	I1740
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.870