DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and Ca-alpha1T

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster

Alignment Length:	2713	Identity:	506/2713 - (18%)
Similarity:	852/2713 - (31%)	Gaps:	1011/2713 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GSGG--AGGGGGGGGAGAVPGAAGAAGTGPITGASATAASGSSGSGGHHQHHHHSHPYSTSGINT 93
            |||.  |.|||..........||.......:.|.:.:|||.:..|..|.||....|
  Fly   766 GSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQH--------- 821

  Fly    94 PATASTSSSSGNSLTPQQQQQQQHPHHQSHHGHHYAHHQQHTHHHAPPHSHHPHPHPHGHPHSYP 158
                               |||||.:.|         .||....|:...:......|.|.|.|
  Fly   822 -------------------QQQQHQNQQ---------QQQQQQQHSSSDNTEQSLAPDGLPRS-- 856

  Fly   159 HLRHSQPASASQFSFNPSPGSSP-----------------------GNGLGLGARQDAASALNSP 200
               .|...|.:.....|. ||:.                       ||   ||......|...||
  Fly   857 ---SSLKKSTAHHQLKPE-GSAAEQKTILLKFPQQMIDSEQLILQLGN---LGKSHPCTSGFLSP 914

  Fly   201 TT--------------------IVNSGSGSGGGSSVAFGMQPQQQQQSLAGGGGGGSSATAAPSS 245
            .|                    .:|:...:.|.::..      ....:...|....::|.||..|
  Fly   915 PTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTV------APTVATVAGTAAAAAAAAATGS 973

  Fly   246 GGGHNNGAGLGPVVGGGGGG-----------------------LNLLGGLGGMGGMGGGAAAAGM 287
            |.|:||....|...|.|.||                       :||...:|.:.......:..|:
  Fly   974 GSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGI 1038

  Fly   288 ----------------------------------------------------------------- 287

  Fly  1039 HDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGA 1103

  Fly   288 -GICGGISSTVGSAAITGVPPIGLGIATGI-----------------------GNKIMLGRKQSL 328
             |....::||.|....|..|.....:..|.                       .|.....|....
  Fly  1104 EGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRS 1168

  Fly   329 KGG-------EP------FLADYGPEESLNESA---------------------------DIEWV 353
            :.|       ||      ::.||.....|.::|                           ...|:
  Fly  1169 RQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWI 1233

  Fly   354 NKLWVRRLMR---------LCALVSLTSVSL---NTPKTFERYPSLQFITFASDTAVTLLFTAEM 406
            .: ::|||:.         |..|::..|:.:   |.|      |.|..|...|:...:.:|..||
  Fly  1234 RR-YIRRLVEHKYFQQGILLAILINTLSMGIEYHNQP------PELTAIVETSNVVFSGIFAVEM 1291

  Fly   407 IAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKF---------SYLSIM 462
            :.|:    |..|...|:.:.:..||.          |:.|...:||...|         |.||::
  Fly  1292 LLKV----VAEGPFRYIANGFNVFDG----------IIVILSAIEICQTFMGNGTGGGGSGLSVL 1342

  Fly   463 RAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFF---LFFMSLYGLLGVQFFGELK 524
            |..|.|.:::.:|.     ||..| .|:|. ..:.:.||.:||   :.|:.::.:||:..||
  Fly  1343 RTFRLLRILKLVRF-----MPNLR-RQLFV-MLRTMDNVAVFFSLLVLFIFIFSILGMYLFG--- 1397

  Fly   525 NHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGY--QCS--------PGMVCMKMDFLSSY 579
                                      ..||....:||.  :|:        |...|.:
  Fly  1398 --------------------------GKFCKFLDESGLERECTCPEIISRHPQCECDR------- 1429

  Fly   580 VIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVI 644
                ..|.:|..:..||:|..:||.|..:::..::....| ||.||..::.|..:::.|:.:|::
  Fly  1430 ----KHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHW-AALYFVALMTFGNYVLFNLLVAIL 1489

  Fly   645 TETF----NEIRVQFQQMWGARGHIQK----TAASQILSG--------------NDT------GW 681
            .|.|    ||.|.:.|     |..::|    |.|.....|              ||:      .|
  Fly  1490 VEGFSSERNERREREQ-----RELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRW 1549

  Fly   682 R--------------LVTIDDNKHGG--LAPETCHAILRSPYFRMLVMSVILANGIVTATMTFKH 730
            |              ::....|.|..  |.|...:.|...|    ...:...|:|...|:.....
  Fly  1550 RSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELP----ASSAAPSASGTSGASAPGDR 1610

  Fly   731 D---------GRPRDVFYERYYYIELVFTCLLDLET-----------------LFKIYCLGWRGY 769
            :         .|.||...||            |.|.                 |.|.|.:..|..
  Fly  1611 ERDRDRDRDRERDRDRDRER------------DREAGGGGKEEGAQHAKPRGGLKKTYSIKERRS 1663

  Fly   770 YKHSIHKFELLLAAG--TTLHIVPMFYPS-----GLTYFQ-------------VLR--------- 805
            ....:.|..|.....  ||....|...||     |:::.|             :||
  Fly  1664 EAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQ 1728

  Fly   806 --------VVRLIKASPMLEGFVYKIFGP---GKKLGSLIIFTMCLLIISSSISMQLFCFLCDFT 859
                    .:.||..||:|......|...   |..:|..:..|     ..||.||. ...:.|.:
  Fly  1729 RSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPST-----AGSSSSMH-SVIIDDIS 1787

  Fly   860 KFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILD 924
            |..|                           ::...||                   ::|..|..
  Fly  1788 KSSS---------------------------STAAATP-------------------IYVPTISS 1806

  Fly   925 NLELDEDIKKLKQLKF-REQSAEIKETLPFR----------LRIFEKFPDSPQMTILHRIPNDFM 978
            ..:.......|..:.. .....||..|...|          ....|:.|.:|
  Fly  1807 TADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAP------------- 1858

  Fly   979 LPKVRESFMKHF-----------VIELETED-----SLVENCKRPMSECWESNVVFR-KQKPVRI 1026
             |..:.||.:..           .:.|.|:|     :|....:|...|..|...:.. ......:
  Fly  1859 -PPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLL 1922

  Fly  1027 MNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWR-- 1089
            .|..|.|..:.|..::   |:.::..|:.|.:....:    :|:...|..::...|.:|:.::
  Fly  1923 RNSNAVVSGSSSGTKE---TNRLSPQNSIRRLSNTLS----IGSGPVGSRRASACIFNSQVYQNL 1980

  Fly  1090 ---------VDQKKFGSRSI----------------RRSVRSGSIKL-----KQTYEHLMENGDI 1124
                     ..|::..|..:                |:|:...:.|:     .::|.:|.|..::
  Fly  1981 NQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNM 2045

  Fly  1125 ------AAAPRANS-----GRARPHDLDIKLLQAKRQQAEMRR---------NQREEDLRENHPF 1169
                  |...|.||     .:.|..:.:::.||...||..:::         .|:::.|:::...
  Fly  2046 LQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLS 2110

  Fly  1170 FD-----------------------------TP-----------LFLVPRESRFRKICQKIVHAR 1194
            .|                             ||           |::.|.::|||:||...|:.:
  Fly  2111 KDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQK 2175

  Fly  1195 YDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNY--RVMDHPTLQI 1257
                                         :.|.|::....|:||::..|.||.  ...:...|..
  Fly  2176 -----------------------------WFDNVVLLFIALNCITLAMERPNIPPSSTERLFLAT 2211

  Fly  1258 AEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQL- 1321
            |.|.|.:..::|:.:|::|.|:|:...||.......:|..:..:|...|.   :::.:.|:.::
  Fly  2212 ANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLL---MSLISESSPRIF 2273

  Fly  1322 -----LMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLA 1381
                 ..:||.:||||:....|.::.||..|....:.|..:..:......||...||||:.|...
  Fly  2274 GILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFY 2338

  Fly  1382 RC---NDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLT 1443
            .|   |...:...::|     ||:        ||           .||.| |::|||::|.|:::
  Fly  2339 YCEGENIKGVRNADEC-----RRI--------PG-----------NVWTN-RKYNFDDLGKALMS 2378

  Fly  1444 LFEVLSFKGWLDVRDVLIKAVG----PV------HAVYIHIYIFLGCMIGLTLFVGVVIANY--- 1495
            ||.:.|..||:::....:.|||    |:      ..:|...:|.|.....|.:|||||:.|:
  Fly  2379 LFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRC 2443

  Fly  1496 --SENKGTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLI 1558
              .:.|...:....:|.....|||.::.:|   |...:....|.|.:::.....|...||.|:.:
  Fly  2444 REEQEKEEKIRRAAKRALQMEKKRRRMHEP---PYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGL 2505

  Fly  1559 NSMLLSITWIK---GEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAG 1620
            |.:.:::.:.|   |..:.  |.|.:...|.||::|..||.:|...:.|.:.|.|:.|:.:.:..
  Fly  2506 NVVTMAMEYYKMPSGLKYA--LKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLS 2568

  Fly  1621 VIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSV-----------CKSFFI 1674
            ::.|:|:. |..:..........|:|...:......||:|.:..|:..           ..:..:
  Fly  2569 IVGIVLEE-LETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGL 2632

  Fly  1675 IFGMFLLVFFYALAGTILFGTVKYG-----EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDC 1734
            :|  |||.|.:|..|..|||.::..     :|:|..|:|.:.......|||:.||::||.||.|
  Fly  2633 LF--FLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKD- 2694

  Fly  1735 MVQPPYCTLGNNYWETD------CGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEE 1793
                   ||.:|..:..      |.:...:.|:|..|.::..::::|::||::|::....:...|
  Fly  2695 -------TLRDNCDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQME 2752

  Fly  1794 DALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMCYELDKLH 1858
            |                                                          |||
  Fly  2753 D----------------------------------------------------------ELD--- 2756

  Fly  1859 NGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNA 1923
                                  ..::||..|.||: |:..|:::           |.:...||:.
  Fly  2757 ----------------------MEVELERELVREQ-EFAQEQKL-----------CQQLAEAQSK 2787

  Fly  1924 SKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAI-STISGAVAGACPPTSDAFSPTFSST 1987
            :           |...:|:         |.:.::.|:.| ||          |:.|...|..|..
  Fly  2788 A-----------AAPPRPL---------AKVKSLPKNFIYST----------PSLDKKFPAVSGV 2822

  Fly  1988 ENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGP--PTVQ------------- 2037
            .|...  :|||...|  ::.:.||:|.:|.||..|     |.|.||  .|||
  Fly  2823 NNPSL--TSSAATNL--NQVATAGSGGAAPGAVPA-----GSGAGPRRQTVQYFQQPPQSMLGGL 2878

  Fly  2038 STARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDP-----------QQRSTLS-----DKER 2086
            |.|....|:..:.......:..|...|.|      |.|           ::|..||     |::.
  Fly  2879 SLAEMGGTLTPQALGARLGEPFGGGGGNK------SGPRRQSYWQINPIRKRGVLSKERSLDEQA 2937

  Fly  2087 LHITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEA--TKSSSFFAQLNSEIGQFHYPTINAAAAA 2149
            :...:.:.|:.|..:||             .||:|  .:..:.|..|.|:
  Fly  2938 IRRRNLEAKRTSCDSLP-------------WGGDALDCRRGTIFESLESD--------------- 2974

  Fly  2150 AALHGYGHGHGHGHGGHGGHGGHGEHQMHHHHGGALGSPSAMMSQMIG 2197
                |.|.|.|...||.||.||...:.:.......:|.     |:|.|
  Fly  2975 ----GGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGH-----SEMDG 3013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	69/309 (22%)
		Ion_trans	734..927	CDD:278921	41/249 (16%)
		Ion_trans	1240..1497	CDD:278921	71/282 (25%)
		Ion_trans	1571..1793	CDD:278921	57/243 (23%)
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921
		Ion_trans	1261..1495	CDD:278921	66/301 (22%)
		Ion_trans	2192..2448	CDD:278921	71/283 (25%)
		Ion_trans	2510..2728	CDD:278921	55/230 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439093
Domainoid	1	1.000	91	1.000	Domainoid score	I1740
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.850