DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and Cacna1g

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	XP_008766207.2	Gene:	Cacna1g / 29717	RGDID:	68942	Length:	2388	Species:	Rattus norvegicus

Alignment Length:	2428	Identity:	498/2428 - (20%)
Similarity:	822/2428 - (33%)	Gaps:	823/2428 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 GLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSA--AITGVPPIGLGIATGI 316
            |.|....|.......|..|.|.||..|.         |......|||  ...|:|...|.
  Rat     7 GAGAEESGQPRSFTQLNDLSGAGGRQGP---------GSTEKDPGSADSEAEGLPYPALA----- 57

  Fly   317 GNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTP--- 378
                            |.:..|..::|...|..:..|...|..|:..|..|::..::.:..|
  Rat    58 ----------------PVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCED 106

  Fly   379 --KTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWIS 441
              ...:|...||    |.|..:...|..||:.||...|:. |:..||.|.|.:.|    .|:.|:
  Rat   107 IACDSQRCRILQ----AFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLD----FFIVIA 162

  Fly   442 IILQIFEVLEIVPKFSYLSIMRAPRPLIMI------RFLRVFLKFSMPKSRINQIFKRSSQQIYN 500
            .:|:....|:.| .||.:..:|..|||..|      |.|...|..::|             .:.|
  Rat   163 GMLEYSLDLQNV-SFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP-------------MLGN 213

  Fly   501 VTL--FFLFFMSLYGLLGVQFF-GELKNHCVMNNT-----EYDL---YK---------------- 538
            |.|  ||:||  ::|::|||.: |.|:|.|.:...     ..||   |:
  Rat   214 VLLLCFFVFF--IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLEPYYQTENEDESPFICSQPRE 276

  Fly   539 ------RPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMD-FLSSYVIG----FNG---FEDI 589
                  |.:.|:.........||:|.:: |..|....|:..: :.::...|    |.|   |::|
  Rat   277 NGMRSCRSVPTLRGEGGGGPPCSLDYET-YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNI 340

  Fly   590 ATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEI--- 651
            ..:...::|..:.||||.|||..:|: .::....||..:|...::.:.|:.:.||...|:|.
  Rat   341 GYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR 404

  Fly   652 --------RVQF-----------------QQMWGARGHIQKTAASQILS---------------- 675
                    ||:|                 :::.....:|.:.||.::..
  Rat   405 ESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAIGVRAGLLSSPV 469

  Fly   676 --------------------------------------GNDT-----------------GWRLV- 684
                                                  ||.|                 ..||:
  Rat   470 ARSGQEPQPSGSCTRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRVPRASPEIQDRDANGSRRLML 534

  Fly   685 ------------------------------------------------TIDDNK----------- 690
                                                            |:...|
  Rat   535 PPPSTPTPSGGPPRGAESVHSFYHADCHLEPVRCQAPPPRCPSEASGRTVGSGKVYPTVHTSPPP 599

  Fly   691 -----------------------------------------------------------HGGLAP 696
                                                                       .|...|
  Rat   600 EILKDKALVEVAPSPGPPTLTSFNIPPGPFSSMHKLLETQSTGACHSSCKISSPCSKADSGACGP 664

  Fly   697 ETC----------------------------------HAILRSPY-------------------- 707
            ::|                                  |:.||.|:
  Rat   665 DSCPYCARTGAGEPESADHVMPDSDSEAVYEFTQDAQHSDLRDPHSRRRQRSLGPDAEPSSVLAF 729

  Fly   708 -------FRMLVMSVILANGIV------TATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLF 759
                   ||.:|.|.....||:      |.:|..::..:|.:: ........:|||.|..||.|.
  Rat   730 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEEL-TNALEISNIVFTSLFALEMLL 793

  Fly   760 KIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTY---FQVLRVVRLIKASPMLEGFVY 821
            |:...|..||.|:..:.|:.::...:...||.. ...||:.   |:::||::|::..|.|:..:.
  Rat   794 KLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-QGGGLSVLRTFRLMRVLKLVRFLPALQRQLV 857

  Fly   822 KIFGPGKKLGSLIIFTMCLLIISSSISMQLF-C---------FLCDFTKFESFPEAFMSMFQILT 876
            .:......:.:..:..|..:.|.|.:.|.|| |         .|.|...|:|...|.:::|||||
  Rat   858 VLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILT 922

  Fly   877 QEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKK------- 934
            ||.|.:|:...|..||.    ..|:|||....|...::.:|.||::::..:.:|..|:
  Rat   923 QEDWNKVLYNGMASTSS----WAALYFIALMTFGNYVLFNLLVAILVEGFQAEEIGKREDASGQL 983

  Fly   935 -LKQLKFREQSAEIKETLPFRLRIFEKFPD--SPQM----------------------------T 968
             ..||....|..:..::        |..||  ||.:                            .
  Rat   984 SCIQLPVNSQGGDATKS--------ESEPDFFSPSVDGDGDRKKRLALVALGEHAELRKSLLPPL 1040

  Fly   969 ILHRIPNDFMLPK-----VRESF----------------MKHFVIELETEDSLVENCKRPMS--E 1010
            |:|.......|||     |.|:.                ..|.  |:::..|...:...|.|  .
  Rat  1041 IIHTAATPMSLPKSSSTGVGEALGSGSRRTSSSGSAEPGAAHH--EMKSPPSARSSPHSPWSAAS 1103

  Fly  1011 CWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGG 1075
            .|.|.                  |::.:||.:.......:.|..:|.:|            .|.|
  Rat  1104 SWTSR------------------RSSRNSLGRAPSLKRRSPSGERRSLL------------SGEG 1138

  Fly  1076 LKSQGTITHSK-----PWRVDQKKFGSRSIRRSVRSGSIKLKQTY----------------EHLM 1119
            .:||.....|:     |...|.:..|  |:.|..:| |..|..|.                ||..
  Rat  1139 QESQDEEESSEEDRASPAGSDHRHRG--SLEREAKS-SFDLPDTLQVPGLHRTASGRSSASEHQD 1200

  Fly  1120 ENGDIAAAPRANSGRARPHDLD-------IKLLQAKRQQAEMRRNQ----REEDLRENHPFFDTP 1173
            .||..|:...|.:.|.....||       ..|.:.:|.||.:|...    ||.|        ...
  Rat  1201 CNGKSASGRLARTLRTDDPQLDGDDDNDEGNLSKGERIQAWVRSRLPACCRERD--------SWS 1257

  Fly  1174 LFLVPRESRFRKICQKIV-HARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSC 1237
            .::.|.:||||.:|.:|: |..:|                   |..|        |:||   |:|
  Rat  1258 AYIFPPQSRFRLLCHRIITHKMFD-------------------HVVL--------VIIF---LNC 1292

  Fly  1238 ISMMFETPNYRVMDHPT----LQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFI 1298
            |::..|.|  ::..|..    |.::.|.|......|:.:|::|.|..|..:||::.....||..:
  Rat  1293 ITIAMERP--KIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1355

  Fly  1299 YVVST-SFLCWMPLNIPTNSAAQL--LMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTL 1360
            .::|. ..|..|..:..|.....|  |.:||.:||||:.:....::.||..|....|.|..:..:
  Rat  1356 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVI 1420

  Fly  1361 LILLMFIFASYGVQLYGGRLARC---NDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLV 1422
            ......||...||||:.|:...|   :...|:.:.||.                  :.||.
  Rat  1421 CCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCA------------------EASYR---- 1463

  Fly  1423 PRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVG----------PVHAVYIHIYIF 1477
               |.. .::||||:|.|:::||.:.|..||:|:....:.|||          |...:|...::.
  Rat  1464 ---WVR-HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1524

  Fly  1478 LGCMIGLTLFVGVVIANY-----SENKGTALLTVDQR-RWCDLKKRLKIAQPLHL---------- 1526
            :.....|.:|||||:.|:     .:.:..|....::| |..:.|:|.|..|...|
  Rat  1525 IVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMADLMLDDVIASGS 1589

  Fly  1527 -----------PPRPDGRKIRAFTYDI-TQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTERLV 1578
                       |...|..:.|...:.: |.|.: ...|..|:.:|.:.:::. :.:.::..|.|.
  Rat  1590 SASAASEAQCKPYYSDYSRFRLLVHHLCTSHYL-DLFITGVIGLNVVTMAMEHYQQPQILDEALK 1653

  Fly  1579 IVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVV 1643
            |.:.:.|.:||.|.|.|.:||..|.::|.|.|:.||.:.:..::.|.|:.|   :::........
  Rat  1654 ICNYIFTVIFVFESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI---EVNASLPINPT 1715

  Fly  1644 ILRFFTITGKHTTLKMLMLTVGV-----SVCKSFFIIFG---MFLLVFF-YALAGTILFGTVKYG 1699
            |:|...:......||:|.:.||:     :|.::...:..   :|:|:|| :|..|..|||.::..
  Rat  1716 IIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD 1780

  Fly  1700 -----EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASL 1759
                 ||:||.|.|.:.......|||:.||::||.||.|        ||.:...|:.|.|...|.
  Rat  1781 ETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD--------TLRDCDQESTCYNTVISP 1837

  Fly  1760 IYFCTFYVIITYIVLNLLVAIIMENFSLFYSN---EEDALLSYADIRNFQNT------------- 1808
            |||.:|.:...::::|:::|::|::  |..||   :|:|.|. |::.....|
  Rat  1838 IYFVSFVLTAQFVLVNVVIAVLMKH--LEESNKEAKEEAELE-AELELEMKTLSPQPHSPLGSPF 1899

  Fly  1809 -W------NIVDIHQRGV----------------IPVRRVKF--ILRLLKGRLECDPQKDRLLFK 1848
             |      |..|..:.|.                .|..|..|  |..|::|.||.:       .|
  Rat  1900 LWPGVEGVNSPDSPKPGAPHTTAHIGAASGFSLEHPTDRQLFDTISLLIQGSLEGE-------LK 1957

  Fly  1849 YMCYELDKL--HNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWL 1911
            .|    |:|  ..|:...|....::     .|....:.|.|:.|......:|.|
  Rat  1958 LM----DELAGPGGQPSAFPSAPSL-----GDSDPQIPLAEMEALSLTSEIVSE----------- 2002

  Fly  1912 EGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLG----AVDKSAISTI------- 1965
            ..|...:...:.....::|:.....:|    |.|:.:|...|||    .|.||.:|..
  Rat  2003 PSCSLALTDDSLPDDTHTLLLSALESN----MVPHPEEVPVPLGPDLLTVRKSGVSRTHSLPNDS 2063

  Fly  1966 ----SGAVA-------GACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGA 2019
                :|:.|       |...|  .|.|.:..|..::..|  :|.::|||.....:.....:.|..
  Rat  2064 YMCRNGSTAERSLGHRGWGLP--KAQSGSILSVHSQPAD--TSCILQLPKDVHYLLQPHGAPTWG 2124

  Fly  2020 ATATGTSSGLGVGPP--------------TVQSTARHVMTVGKRGYALNRSDSTGSSA----GRK 2066
            |...       :.||              .:::.:..|..:|.|...|  |:.:|.|.    ...
  Rat  2125 AIPK-------LPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLL--SEVSGPSCPLTRSSS 2180

  Fly  2067 FLAPTSSDPQQRSTLSDKERLHI 2089
            |...:|...||||.:..|...||
  Rat  2181 FWGGSSIQVQQRSGIQSKVSKHI 2203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	83/343 (24%)
		Ion_trans	734..927	CDD:278921	56/205 (27%)
		Ion_trans	1240..1497	CDD:278921	70/281 (25%)
		Ion_trans	1571..1793	CDD:278921	69/238 (29%)
Cacna1g	XP_008766207.2	Ion_trans	80..406	CDD:395416	86/352 (24%)
		Ion_trans	743..969	CDD:395416	61/231 (26%)
		Ion_trans	1277..1549	CDD:395416	80/329 (24%)
		Ion_trans	1619..1860	CDD:395416	69/252 (27%)
		PHA03307	2119..>2370	CDD:223039	20/94 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920