Protein Alignment na and Cacna1d

DIOPT Version :9

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_017455544.1
• Gene: Cacna1d / 29716
• RGDID: 70973
• Length: 2207
• Species: Rattus norvegicus
• Alignment Length: 2204
• Identity: 472/2204 - (21%)
• Similarity: 822/2204 - (37%)
• Gaps: 671/2204 - (30%)

  Fly   220 MQPQQQQQSLAGGGGGGSSATAAPSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAA 284
            ||.|:|||.........:..|..|.||.        ||..........:|.....:.......||
  Rat    10 MQHQRQQQEDHANEANYARGTRLPISGE--------GPTSQPNSSKQTVLSWQAAIDAARQAKAA 66

  Fly   285 AGMGICGGISSTVGSAAITGVPPIGLGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESAD 349
            ..|.              |..||       .:|:.....|:|           |...:....|::
  Rat    67 QTMS--------------TSAPP-------PVGSLSQRKRQQ-----------YAKSKKQGNSSN 99

  Fly   350 IEWVNKLWVRRLMRLCALVSLTSVSLNTP-----------KTFERYPSLQ----------FITFA 393
                     .|..|     :|..:|||.|           |.|:.:..|.          :|.|.
  Rat   100 ---------SRPAR-----ALFCLSLNNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFP 150

  Fly   394 SDT-------------AVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQ 445
            .|.             |..::||.|...|:...|:|.....|:::.|...|       ::.:|:.
  Rat   151 EDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLD-------FVIVIVG 208

  Fly   446 IFEV-LEIVPK----------------FSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRI--NQIF 491
            :|.| ||.:.|                ...|...|..|||.::.        .:|..::  |.|.
  Rat   209 LFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVS--------GVPSLQVVLNSII 265

  Fly   492 KRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCS 555
            | :...:.::.|..||.:.:|.::|:: |.|::...|...:::....:.|        .|..|..
  Rat   266 K-AMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDP--------APCAFSG 321

  Fly   556 MDPDSGYQCSP-GMVCMKMDFLSSYVIGFNG----FEDIATSIFTVYQAASQEGWVFIMYRAIDS 615
                :|.||:. |..|      .|..:|.||    |::.|.::.||:|..:.|||..::|...|:
  Rat   322 ----NGRQCAANGTEC------RSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 376

  Fly   616 LPAWRAAF-YFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQIL----- 674
            : .|...: ||.::|...::.|.|:.:.|::..|::.|.:.:    |||..||....|.|
  Rat   377 I-GWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAK----ARGDFQKLREKQQLEEDLK 436

  Fly   675 ------------------SGNDTGWRLVTIDDN---------------------------KHGGL 694
                              .|.:.|.|..::..:                           |..|.
  Rat   437 GYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGETQGCCGSLWCWWKRRGA 501

  Fly   695 AP------------------------------ETCHAILRSPYFRMLVMSVILANGIVTATMTFK 729
            |.                              ..|.|.::|..|..||:.::..|   |.|::.:
  Rat   502 AKTGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLN---TLTISSE 563

  Fly   730 HDGRP------RDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAG---- 784
            |..:|      :|:..:   .:..:|||    |.|.|:|.||.:.|:....::|:..:..|
  Rat   564 HYNQPDWLTQIQDIANK---VLLALFTC----EMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITE 621

  Fly   785 TTLHIVPMFYPSGLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSS 846
            |.|..:.:..|.|::.|:.:|::|:.|.:   ..|...|..:....|.:.||::.....:||.|.
  Rat   622 TILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSL 686

  Fly   847 ISMQLFCFLCDF----TK---FESFPEAFMSMFQILTQEAWVEVMDETMIR----TSKTLTPLVA 900
            :.||||....:|    ||   |::||:|.:::|||||.|.|..||.:.::.    :|..:  :|.
  Rat   687 LGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGM--IVC 749

  Fly   901 VYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSP 965
            :|||:..:....|:|::|:|:.:|||...|.:...     :::.||.||    |.:|..|
  Rat   750 IYFIILFICGNYILLNVFLAIAVDNLADAESLNTA-----QKEEAEEKE----RKKIARK----- 800

  Fly   966 QMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKT 1030
                              ||               :||.|                      |..
  Rat   801 ------------------ES---------------LENKK----------------------NNK 810

  Fly  1031 AKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKF 1095
            .:|....:|..|:.|.....::.       |....|......|
  Rat   811 PEVNQIANSDNKVTIDDYQEEAE-------DKDPYPPCDVPVG---------------------- 846

  Fly  1096 GSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQRE 1160
                            ::..|...:..::.|.||                  .|:.:|:...::.
  Rat   847 ----------------EEEEEEEEDEPEVPAGPR------------------PRRISELNMKEKI 877

  Fly  1161 EDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYL 1225
            ..:.|...|     |::.:.:..|..|.|:::.                      |.|..|:  |
  Rat   878 APIPEGSAF-----FILSKTNPIRVGCHKLINH----------------------HIFTNLI--L 913

  Fly  1226 DWVMIFATTLSCISMMFETP----NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAY 1286
            .::|     ||..::..|.|    ::|   :..|...:|.|....::|:.||:...|.|....|:
  Rat   914 VFIM-----LSSAALAAEDPIRSHSFR---NTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAF 970

  Fly  1287 IKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELC 1348
            .::....||:.:..||   |....:.....|..::|.:||.:||||....   :.|:.:.|:...
  Rat   971 CRNYFNLLDMLVVGVS---LVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1032

  Fly  1349 RGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGP 1413
            |....|::|:|   ||.|:||..||||:.|:..||.|...|..|:|.|:|:         |....
  Rat  1033 RTIGNIMIVTT---LLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI---------LYKDG 1085

  Fly  1414 DESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKA-------VGPVH--- 1468
            |...| ::..|:|.| ..|||||:..||:.||.|.:|:||   ..:|.||       ||||:
  Rat  1086 DVDSP-VVRERIWQN-SDFNFDNVLSAMMALFTVSTFEGW---PALLYKAIDSNGENVGPVYNYR 1145

  Fly  1469 ---AVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQ 1522
               :::..|||.:.....:.:|||.||..:.| :|.     .:.:.|:|.|.        || |:
  Rat  1146 VEISIFFIIYIIIVAFFMMNIFVGFVIVTFQE-QGE-----KEYKNCELDKNQRQCVEYALK-AR 1203

  Fly  1523 PL--HLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTERLVIVSAVL 1584
            ||  ::|..|...|   |.| :.....|:.::.|::::|::.|::. :.:.::..:.:.|::.|.
  Rat  1204 PLRRYIPKNPYQYK---FWY-VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVF 1264

  Fly  1585 TFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVI--------------W------IILQTI 1629
            |.||.||:|:|.|||.|:||:....|.:|.|:.:..:|              |      |::.::
  Rat  1265 TGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSV 1329

  Fly  1630 L---------------------------RNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVS 1667
            :                           .|.:|..|..:..::|...:..:...::.|:.|
  Rat  1330 VDIAITEVNPSDSENIPLPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWT---- 1390

  Fly  1668 VCKSF----FIIFGMFLLVFFYALAGTILFGTVKYGEG--IGRRANFGSPVTGVAMLFRIVTGED 1726
            ..|||    ::...:.:|.|.||:.|..:||.|...:.  |.|..||.:....|.:|||..|||.
  Rat  1391 FIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEA 1455

  Fly  1727 WNKIMHDCMVQPPYCTLGNNY---WETDCG-NFTASLIYFCTFYVIITYIVLNLLVAIIMENFSL 1787
            |.:||..|: ....|...::|   .|..|| ||  :::||.:||::..::::||.||:||:||.
  Rat  1456 WQEIMLACL-PGKLCDPDSDYNPGEEYTCGSNF--AIVYFISFYMLCAFLIINLFVAVIMDNFD- 1516

  Fly  1788 FYSNEEDALLSYADIRNFQNTWNIVDIHQRG-------VIPVRRVKFIL---RLLKGRLECDPQK 1842
             |...:.::|....:..|:..|:..|...:|       |..:||::..|   :|...|:.|
  Rat  1517 -YLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVAC---- 1576

  Fly  1843 DRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTI 1907
            .||:...|     .|::...|.|:..:..|...::.|:....||:  |.||...::::...|.::
  Rat  1577 KRLVAMNM-----PLNSDGTVMFNATLFALVRTALKIKTEGNLEQ--ANEELRAVIKKIWKKTSM 1634

  Fly  1908 R---------------------TWL-------------EGCLKKIRAQNASKQQNSLIAGLRATN 1938
            :                     |:|             :|.:.|..|:|.:   .:|.||||..:
  Rat  1635 KLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTT---IALQAGLRTLH 1696

  Fly  1939 E-QPVMRP----NIQEDKAPLGAVDKSAISTISGAVAG--------------------------- 1971
            : .|.:|.    ::|:|:......::..:...:||:.|
  Rat  1697 DIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNGALLGNYVNHVNSDRRESLQQTNTTHRPLHVQ 1761

  Fly  1972 --ACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPP 2034
              :.||.||...|.|....|        :|....|:..||.....::|.|.......|....|..
  Rat  1762 RPSIPPASDTEKPLFPPAGN--------SVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKR 1818

  Fly  2035 TVQSTARHVMTVGKRGYALNRSDSTGSSAGR-----KFLAPTSSDPQQRSTLSDKERLH 2088
            .......||...|...|..:|.....||..|     .::...|.|.|..:...:...:|
  Rat  1819 PSIGDLEHVSENGHYSYKHDRELQRRSSIKRTRYYETYIRSESGDEQLPTICREDPEIH 1877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	74/340 (22%)
		Ion_trans	734..927	CDD:278921	61/216 (28%)
		Ion_trans	1240..1497	CDD:278921	83/276 (30%)
		Ion_trans	1571..1793	CDD:278921	73/278 (26%)
Cacna1d	XP_017455544.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920