DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Scn8a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_062139.2 Gene:Scn8a / 29710 RGDID:3638 Length:1978 Species:Rattus norvegicus


Alignment Length:1905 Identity:388/1905 - (20%)
Similarity:655/1905 - (34%) Gaps:657/1905 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   367 LVSLTSVSLNTPKTFERY---PSLQ----------------------------------FITFAS 394
            |...|.|.||..||..|:   |:|.                                  |:||::
  Rat    89 LTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSN 153

  Fly   395 --------DTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLE 451
                    :...|.::|.|.:.|:..||.......:|:|.|...|.|::             ::.
  Rat   154 PPEWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVI-------------MMA 205

  Fly   452 IVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLG 516
            .|.:|..|..:.|.|...::|.|:........|:.:..:. :|.:::.:|.:..:|.:|::.|:|
  Rat   206 YVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIG 269

  Fly   517 VQ-FFGELKNHCVM-----------NNT------EYDLYKRPILTINSLAIPDTFCSMDPDSGYQ 563
            :| |.|.|:|.||:           |.|      ||...|.....:..:..| ..|....|:| |
  Rat   270 LQLFMGNLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEP-LLCGNSSDAG-Q 332

  Fly   564 CSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----F 623
            |..|..|||.....:|  |:..|:..:.:...:::..:|:.|..:....:      |||     .
  Rat   333 CPEGFQCMKAGRNPNY--GYTSFDTFSWAFLALFRLMTQDYWENLYQLTL------RAAGKTYMI 389

  Fly   624 YFSTMIFFLAWLVKNVFIAVITETFNE----------------------IRVQFQQMWGA----- 661
            :|..:||..::.:.|:.:||:...:.|                      ::.|.::...|     
  Rat   390 FFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATS 454

  Fly   662 -------------------------------------RGHIQKTAASQILSGNDTG--------- 680
                                                 |...:|....::..|.:.|         
  Rat   455 AGTVSEDAIEEEGEDGVGSPRSSSELSKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSE 519

  Fly   681 ---------WRL----------------------------------------------------- 683
                     :||                                                     
  Rat   520 SEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFA 584

  Fly   684 --------------------------------------------------------VTIDDN--- 689
                                                                    .|:|.|   
  Rat   585 DDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVV 649

  Fly   690 ------KH-GGLAPET------------------------------------------------- 698
                  .| |.|.||.                                                 
  Rat   650 SLIGPGSHIGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQ 714

  Fly   699 ------------------CH-----------AILRSPYFRMLVMSVILANGIVTATMTFKHDGRP 734
                              ||           .|:..|:..:.:...|:.|   |..|..:|  .|
  Rat   715 RKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLN---TLFMAMEH--HP 774

  Fly   735 RDVFYERYYYI-ELVFTCLLDLETLFKIYCL--------GWRGY--YKHSIHKFELLLAAGTTLH 788
            ....:|....: .||||.:...|...|:..:        ||..:  :..|:...||.||....|.
  Rat   775 MTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLS 839

  Fly   789 IVPMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF 852
            :        |..|::|||.:|.|:.|.| ..:.||.|.. ..||:|.:....::.|.:.:.||||
  Rat   840 V--------LRSFRLLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 895

  Fly   853 ------CFLCDFTK--------FESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYF 903
                  | :|...:        ...|..:|:.:|::|..| |:|.|.:.|....:.:..:|   |
  Rat   896 GKSYKEC-VCKINQECKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIV---F 955

  Fly   904 ILYHLFVTLIVLSLFVAVIL-----DNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPD 963
            ::..:...|:||:||:|::|     |||...:|..::..|                         
  Rat   956 MMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNL------------------------- 995

  Fly   964 SPQMTILHRIPNDFMLPKVR-ESFMKHFVIELETEDSLVENCKRPMSECWES------------- 1014
              |:::: ||.......||: .:||:....:.|.::      .:|:.|.:|.             
  Rat   996 --QISVI-RIKKGVAWTKVKVHAFMQAHFKQREADE------VKPLDELYEKKANCIANHTGVDI 1051

  Fly  1015 --NVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDS-----NNQRLMLGDSAMLPV-VGTK 1071
              |..|:|       |........|||:.|    :||::.     ||..|    :..:|: ||..
  Rat  1052 HRNGDFQK-------NGNGTTSGIGSSVEK----YIIDEDHMSFINNPNL----TVRVPIAVGES 1101

  Fly  1072 GGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRAR 1136
            ....|.::...:.|.|       .||:.          ||..|              .::.|.. 
  Rat  1102 DFENLNTEDVSSESDP-------EGSKD----------KLDDT--------------SSSEGST- 1134

  Fly  1137 PHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKD 1201
               :||     |.:..|:...|.||.|..:..|.:..:      .|| |.||        ..:::
  Rat  1135 ---IDI-----KPEVEEVPVEQPEEYLDPDACFTEGCV------QRF-KCCQ--------VNIEE 1176

  Fly  1202 PLTGKERKVQYKSL-----HNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQ-IAEY 1260
            .| ||...:..|:.     ||      :.:..:||...||..::.||  :..:....|:: |.||
  Rat  1177 GL-GKSWWILRKTCFLIVEHN------WFETFIIFMILLSSGALAFE--DIYIEQRKTIRTILEY 1232

  Fly  1261 G---FVIFMSLELALKILADGL--FFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQ 1320
            .   |.....||:.||..|.|.  |||      :....||..|..||...|....|......|.:
  Rat  1233 ADKVFTYIFILEMLLKWTAYGFVKFFT------NAWCWLDFLIVAVSLVSLIANALGYSELGAIK 1291

  Fly  1321 LLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCND 1385
            .|..||.:||||..:....||.||..|......|:.|..:.::...||:..||.|:.|:...|.:
  Rat  1292 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFN 1356

  Fly  1386 PT---------ISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAM 1441
            .|         ::.:.||            .||..|......       |.|. :.||||:|...
  Rat  1357 ETSEIRFEIDIVNNKTDC------------EKLMEGNSTEIR-------WKNV-KINFDNVGAGY 1401

  Fly  1442 LTLFEVLSFKGWLDVRDVLIKAVGPVHA------VYIHIY----IFLGCMIGLTLFVGVVIANYS 1496
            |.|.:|.:||||:|:....:.:..|...      :|::||    |..|....|.||:||:|.|::
  Rat  1402 LALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1466

  Fly  1497 ENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVV 1556
            :.|     ....:|.:|:::.:..|:|...:|....||| ..||:...:|......|..||.:::
  Rat  1467 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-LNKIQGIVFDFVTQQAFDIVIMMLI 1530

  Fly  1557 LINSMLLSITWIKGEVHTER------LVIVSAVLTFVFVVEVVMKNIAFTPRGY-----WQSRRN 1610
            .:|.:.:.:     |..|:.      |..::.|....|..|.|:|  .|..|.|     |    |
  Rat  1531 CLNMVTMMV-----ETDTQSKQMENILYWINLVFVIFFTCECVLK--MFALRHYYFTIGW----N 1584

  Fly  1611 RYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGKHTTLKMLMLTVGVSV 1668
            .:|.:|.:..::.:.|..|:.   .||..   |.|:.|    |...:......::.|:..:.:|:
  Rat  1585 IFDFVVVILSIVGMFLADIIE---KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1646

  Fly  1669 CKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHD 1733
            ...|.|...:||::|.:::.|...|..||:..||....||.:....:..||:|.|...|:.::..
  Rat  1647 PALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLP 1711

  Fly  1734 CMVQPPYCTLGNNY----WETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEED 1794
            .:.:||.|:|...:    ::.||||.:..:.:|.::.:|...||:|:.:|||:||||:  :.||.
  Rat  1712 ILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSV--ATEES 1774

  Fly  1795 A-LLSYADIRNFQNTWNIVD 1813
            | .||..|...|...|...|
  Rat  1775 ADPLSEDDFETFYEIWEKFD 1794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 73/370 (20%)
Ion_trans 734..927 CDD:278921 58/223 (26%)
Ion_trans 1240..1497 CDD:278921 79/281 (28%)
Ion_trans 1571..1793 CDD:278921 63/243 (26%)
Scn8aNP_062139.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..62
I. /evidence=ECO:0000305 114..442 65/351 (19%)
Ion_trans 131..421 CDD:395416 65/313 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..530 5/83 (6%)
Na_trans_cytopl 504..700 CDD:403218 12/195 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..597 0/20 (0%)
II. /evidence=ECO:0000305 733..1005 73/318 (23%)
Ion_trans 750..963 CDD:395416 55/231 (24%)
Na_trans_assoc 989..1190 CDD:399489 55/305 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1146 13/80 (16%)
III. /evidence=ECO:0000305 1178..1493 93/349 (27%)
Ion_trans 1195..1471 CDD:395416 86/309 (28%)
Na_channel_gate 1463..1515 CDD:240441 12/52 (23%)
IV. /evidence=ECO:0000305 1502..1799 82/310 (26%)
Ion_trans 1520..1774 CDD:395416 68/269 (25%)
GPHH 1786..1833 CDD:407139 3/9 (33%)
IQ 1892..1913 CDD:197470
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1923..1978
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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