DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Scn11a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_062138.1 Gene:Scn11a / 29701 RGDID:3630 Length:1765 Species:Rattus norvegicus


Alignment Length:1870 Identity:391/1870 - (20%)
Similarity:701/1870 - (37%) Gaps:478/1870 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   320 IMLGRKQ-----SLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLC-ALVSLTSVSLNTP 378
            ::|.:|:     |.|.....|..:.|..||.....:..|..:::     :| .:::...::.:..
  Rat    92 MVLNKKRTIYRFSAKRALFILGPFNPLRSLMIRISVHSVFSMFI-----ICTVIINCMFMANSME 151

  Fly   379 KTFER-YPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISI 442
            ::|:. .|...||.         ::..|.:.|:..||.:..|..:|:|.|...|..::.    :.
  Rat   152 RSFDNDIPEYVFIG---------IYILEAVIKILARGFIVDEFSFLRDPWNWLDFIVIG----TA 203

  Fly   443 ILQIFEVLEI-VPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFL 506
            |...|...:: :.......:.||.:.:.:|..|:|.:...:          ||.:::.:|.:..|
  Rat   204 IATCFPGSQVNLSALRTFRVFRALKAISVISGLKVIVGALL----------RSVKKLVDVMVLTL 258

  Fly   507 FFMSLYGLLGVQ-FFGELKNHCVMNN------TEYDLYKRPILTINSLAIPDTFCSMDPDSGYQC 564
            |.:|::.|:|.| |.|.|...|:.:|      :..|.:::. .......:..|:....|     |
  Rat   259 FCLSIFALVGQQLFMGILNQKCIKHNCGPNPASNKDCFEKE-KDSEDFIMCGTWLGSRP-----C 317

  Fly   565 SPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMI 629
            ..|..|.|.......  .:..|::...|...:::..:|:.|. .:||.|.........|:|..:|
  Rat   318 PNGSTCDKTTLNPDN--NYTKFDNFGWSFLAMFRVMTQDSWE-RLYRQILRTSGIYFVFFFVVVI 379

  Fly   630 FFLAWLVKNVFIAVITETFNE-----------IRVQFQQ--------------MWGARGHI---- 665
            |..::.:.|:.:||:|..:.|           ....||:              |...|..:    
  Rat   380 FLGSFYLLNLTLAVVTMAYEEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRSSLNSLQ 444

  Fly   666 -------------QKTAASQILSGNDTGWRLVTIDDNKHGGLAPETCHAILR------------- 704
                         .||..|..:.|:.|. :....|........|:......|             
  Rat   445 ASSFSPKKRKFFGSKTRKSFFMRGSKTA-QASASDSEDDASKNPQLLEQTKRLSQNLPVDLFDEH 508

  Fly   705 -SPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYY------------------------- 743
             .|..|...:|.:   .|:|.||      :.::.|.|..:                         
  Rat   509 VDPLHRQRALSAV---SILTITM------QEQEKFQEPCFPCGKNLASKYLVWDCSPQWLCIKKV 564

  Fly   744 --------YIELVFTCLLDLETLF---------------------------------KIYCLGWR 767
                    :.||..|..:.:.|:|                                 ||..|...
  Rat   565 LRTIMTDPFTELAITICIIINTVFLAVEHHNMDDNLKTILKIGNWVFTGIFIAEMCLKIIALDPY 629

  Fly   768 GYYKHSIHKFELLLAAGTTLHIVPMFY-------PSGLTYFQVLRVVRLIKASPMLEGFVYKIFG 825
            .|::|..:.|:.::|   .|.:..:.|       .|.|...:||||.:|.|:.|.|...: ||.|
  Rat   630 HYFRHGWNVFDSIVA---LLSLADVLYNTLSDNNRSFLASLRVLRVFKLAKSWPTLNTLI-KIIG 690

  Fly   826 PG-KKLGSLIIFTMCLLIISSSISMQLFCFLCDFTKF-----------------ESFPEAFMSMF 872
            .. ..||:|.:....::.|.|.:.|:||     .|||                 ::|..:|:.:|
  Rat   691 HSVGALGNLTVVLTIVVFIFSVVGMRLF-----GTKFNKTAYATQERPRRRWHMDNFYHSFLVVF 750

  Fly   873 QILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILD---NLELDEDIK- 933
            :||..| |:|.|...|  .....:||..:.|:|..:...|:||:||:|::|:   |.|.|..:: 
  Rat   751 RILCGE-WIENMWGCM--QDMDGSPLCIIVFVLIMVIGKLVVLNLFIALLLNSFSNEEKDGSLEG 812

  Fly   934 KLKQLKFREQSAEIKETLPFRLRIFEKF-------PDSPQMTILHRIPNDFMLPK-VRESFMKHF 990
            :.::.|.:......:....|.|...:.|       .:||:             || ..|||..  
  Rat   813 ETRKTKVQLALDRFRRAFSFMLHALQSFCCKKCRRKNSPK-------------PKETTESFAG-- 862

  Fly   991 VIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQ 1055
                |.:||::.:. ||..|......::..|              ||:.|..||  .:.:|..  
  Rat   863 ----ENKDSILPDA-RPWKEYDTDMALYTGQ--------------AGAPLAPLA--EVEDDVE-- 904

  Fly  1056 RLMLGDSAMLPV----VGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRS---------- 1106
              ..|:...||.    .|.:.|........:|......|:.:.|....:..|::|          
  Rat   905 --YCGEGGALPTSQHSAGVQAGDLPPETKQLTSPDDQGVEMEVFSEEDLHLSIQSPRKKSDAVSM 967

  Fly  1107 ----GSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENH 1167
                .:|.|...:.:|.:    ..:|:....|..|..|....|..|..:                
  Rat   968 LSECSTIDLNDIFRNLQK----TVSPKKQPDRCFPKGLSCHFLCHKTDK---------------- 1012

  Fly  1168 PFFDTPLFLVPRES------RFRKICQKIV-HARYDARLKDPLTGKERKVQYKSLHNFLGLVTYL 1225
                       |:|      ..||.|.:|| |:.:::                            
  Rat  1013 -----------RKSPWVLWWNIRKTCYQIVKHSWFES---------------------------- 1038

  Fly  1226 DWVMIFATTLSCISMMFETPNY--RVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIK 1288
              .:||...||..:::||..|.  |......|:..:..|.....||:.||.:|.|.    :.|..
  Rat  1039 --FIIFVILLSSGALIFEDVNLPSRPQVEKLLRCTDNIFTFIFLLEMILKWVAFGF----RRYFT 1097

  Fly  1289 DVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKE 1353
            .....||..|.|||...|    :|:|   :.:....||.:||||..:....|:.|||.|......
  Rat  1098 SAWCWLDFLIVVVSVLSL----MNLP---SLKSFRTLRALRPLRALSQFEGMKVVVYALISAIPA 1155

  Fly  1354 ILLVSTLLILLMFIFASYGVQLYGGRLARCNDPT----------ISRREDCVGVFMRRVFVTKMK 1408
            ||.|..:.::...:|...||.|:.|:..||.:.|          :..|..|              
  Rat  1156 ILNVLLVCLIFWLVFCILGVNLFSGKFGRCINGTDINMYLDFTEVPNRSQC-------------- 1206

  Fly  1409 LTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLI----KAVGP--- 1466
                 :.|..:..||:|       ||||:|:|.|.|.:|.::||||::.:..:    |...|   
  Rat  1207 -----NISNYSWKVPQV-------NFDNVGNAYLALLQVATYKGWLEIMNAAVDSREKDEQPDFE 1259

  Fly  1467 --VHA-VYIHIYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQP 1523
              ::| :|..::|..|....|.||:||:|.|:::.:     ....:|.:|:::.:..|:|...:|
  Rat  1260 ANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGTKKP 1324

  Fly  1524 LHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLL---SITWIKGEVHTERLVIVSAVLT 1585
            ....||| ..|.:||.:|:....:|..:|..::::|.:::   |....|....|..::.::.|: 
  Rat  1325 QKPIPRP-LNKCQAFVFDLVTSQVFDVIILGLIVLNMIIMMAESADQPKDVKKTFDILNIAFVV- 1387

  Fly  1586 FVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSY-FFGFMVVIL---- 1645
             :|.:|.::|..|.. :.|:.:..|.:|.:|.|..:|..::..:..:|:|: ...|.||.|    
  Rat  1388 -IFTIECLIKVFALR-QHYFTNGWNLFDCVVVVLSIISTLVSRLEDSDISFPPTLFRVVRLARIG 1450

  Fly  1646 RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGS 1710
            |...:......::.|:..:.:|:...|.|...:||::|.||:.|...|..||.|.||....||.:
  Rat  1451 RILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMSWFSKVKKGSGIDDIFNFET 1515

  Fly  1711 PVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLN 1775
            ....:..||:|.|...|:.:::..:....:|   |:..:..|.....:::||.::.:|...||:|
  Rat  1516 FTGSMLCLFQITTSAGWDTLLNPMLEAKEHC---NSSSQDSCQQPQIAVVYFVSYIIISFLIVVN 1577

  Fly  1776 LLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFI-------LRLLK 1833
            :.:|:|:|||:......||. |...|...|...|...|......|....:...       ||:.|
  Rat  1578 MYIAVILENFNTATEESEDP-LGEDDFEIFYEVWEKFDPEASQFIQYSALSDFADALPEPLRVAK 1641

  Fly  1834 GRLECDPQKDRLLFKYMCYEL-----DKLHNGEDVTFHDVINMLSYRS-VDIRKALQLEELLARE 1892
                  |.|    |:::..:|     |:|| ..||.|.....:|...| :|..|.:..|:.:...
  Rat  1642 ------PNK----FQFLVMDLPMVMGDRLH-CMDVLFAFTTRVLGDSSGLDTMKTMMEEKFMEAN 1695

  Fly  1893 EFEYLV----------EEE----VAKMTIRTWLEGCLK-KIRAQNASKQQ 1927
            .|:.|.          |||    |.:...|..:|..:| :::.:::|..|
  Rat  1696 PFKKLYEPIVTTTKRKEEEQGAAVIQRAYRKHMEKMVKLRLKDRSSSSHQ 1745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 57/300 (19%)
Ion_trans 734..927 CDD:278921 62/286 (22%)
Ion_trans 1240..1497 CDD:278921 76/278 (27%)
Ion_trans 1571..1793 CDD:278921 56/226 (25%)
Scn11aNP_062138.1 I. /evidence=ECO:0000305 115..403 62/324 (19%)
Ion_trans 160..404 CDD:278921 55/275 (20%)
II. /evidence=ECO:0000305 554..820 63/277 (23%)
Ion_trans 589..807 CDD:278921 56/229 (24%)
Na_trans_assoc 812..1029 CDD:284034 48/287 (17%)
III. /evidence=ECO:0000305 1022..1319 89/363 (25%)
Ion_trans 1051..1297 CDD:278921 76/282 (27%)
Na_channel_gate 1289..1341 CDD:240441 12/52 (23%)
IV. /evidence=ECO:0000305 1328..1619 75/298 (25%)
Ion_trans 1363..1595 CDD:278921 58/237 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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