DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and Scn10a

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	NP_058943.2	Gene:	Scn10a / 29571	RGDID:	3629	Length:	1956	Species:	Rattus norvegicus

Alignment Length:	2047	Identity:	428/2047 - (20%)
Similarity:	747/2047 - (36%)	Gaps:	551/2047 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 GEPFLADYGPEES-------LNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQ 388
            ||| |.|..|..|       ||:|..|...:..|...|.....|:..|::.::....|..:.::.
  Rat    76 GEP-LEDLDPFYSTHRTFMVLNKSRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITIT 139

  Fly   389 FITFA-----------SDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISI 442
            .:...           .:...|:::|.|.:.|:..||....|..||:|.|...|.|:::..::..
  Rat   140 ILVNCVCMTRTDLPEKVEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGA 204

  Fly   443 ILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLF 507
            .:.    |..:.......::||.:.:.:|..|:|.:...:          .|.:::.:||:..:|
  Rat   205 AID----LRGISGLRTFRVLRALKTVSVIPGLKVIVGALI----------HSVRKLADVTILTVF 255

  Fly   508 FMSLYGLLGVQFF-GELKNHCVMNNT-------------EYDLYKRPILTINSLAIPDTFCSMDP 558
            .:|::.|:|:|.| |.|||.|:.|.|             || ::.:|..|      ....|....
  Rat   256 CLSVFALVGLQLFKGNLKNKCIRNGTDPHKADNLSSEMAEY-IFIKPGTT------DPLLCGNGS 313

  Fly   559 DSGYQCSPGMVCMKM----DFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAW 619
            |:|: |..|.||:|.    ||      .:..|:..|.:..::::..:|:.|..:..:.:
  Rat   314 DAGH-CPGGYVCLKTPDNPDF------NYTSFDSFAWAFLSLFRLMTQDSWERLYQQTL------ 365

  Fly   620 RAA-----FYFSTMIFFLAWLVKNVFIAVITETFN---------------------EIRVQFQQM 658
            ||:     .:|..:||..::.:.|:.:||:|..:.                     |:..:.|::
  Rat   366 RASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEEQSQATIAEIEAKEKKFQEALEVLQKEQEV 430

  Fly   659 WGARG----HIQKTAASQILSGNDTGWR--------LVTIDDNK--------------------- 690
            ..|.|    .:|..:.|.:.|.|....|        ..:.|||:
  Rat   431 LAALGIDTTSLQSHSGSPLASKNANERRPRVKSRVSEGSTDDNRSPQSDPYNQRRMSFLGLSSGR 495

  Fly   691 ----HGGL--------------------------------------------------------- 694
                ||.:
  Rat   496 RRASHGSVFHFRAPSQDISFPDGITDDGVFHGDQESRRGSILLGRGAGQTGPLPRSPLPQSPNPG 560

  Fly   695 -------------------APE------------TCHAILRSPYFRMLVMSVILANGIVTATMTF 728
                               |||            .....|..|:.....|||:   .|:|:.:..
  Rat   561 RRHGEEGQLGVPTGELTAGAPEGPALDTTGQKSFLSAGYLNEPFRAQRAMSVV---SIMTSVIEE 622

  Fly   729 KHDGR----PRDVFYERYYYI-------------------------------------------- 745
            ..:.:    |..:.:.:.|.|
  Rat   623 LEESKLKCPPCLISFAQKYLIWECCPKWRKFKMALFELVTDPFAELTITLCIVVNTVFMAMEHYP 687

  Fly   746 ------------ELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYP--S 796
                        .:|||....:|..|||.......|::...:.|:.::...:.|.:......  |
  Rat   688 MTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSASKKGSLS 752

  Fly   797 GLTYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF-----C-- 853
            .|..|::|||.:|.|:.|.|...: ||.|.. ..||:|......::.|.:.:..||.     |
  Rat   753 VLRTFRLLRVFKLAKSWPTLNTLI-KIIGNSVGALGNLTFILAIIVFIFALVGKQLLSEDYGCRK 816

  Fly   854 -------------FLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFIL 905
                         .:|||  |.|    |:.:|:||..| |:|.|...|..:.|:   :..:.|:.
  Rat   817 DGVSVWNGEKLRWHMCDF--FHS----FLVVFRILCGE-WIENMWVCMEVSQKS---ICLILFLT 871

  Fly   906 YHLFVTLIVLSLFVAVIL-----DNLELDEDIKKLKQLKF---------REQSAEIKETLPFRLR 956
            ..:...|:||:||:|::|     |||...||..::..|:.         ...|..|...:....|
  Rat   872 VMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQLALARIQVLGHRASRAIASYISSHCR 936

  Fly   957 IFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQ 1021
                                |..|||            ||:..:    |.|::.....|.:
  Rat   937 --------------------FRWPKV------------ETQLGM----KPPLTSSEAKNHI---- 961

  Fly  1022 KPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDS---AMLPVV-GTKGGGGLKSQGTI 1082
                   .|..|.||..:|.|.|::   :...|....:.|.   ..:|:. |......|:.....
  Rat   962 -------ATDAVSAAVGNLTKPALS---SPKENHGDFITDPNVWVSVPIAEGESDLDELEEDMEQ 1016

  Fly  1083 THSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIA-----AAPRANSGRARPHDLDI 1142
            .....|:.:..|.....:.:..:..:.:..::...:|.:.|:|     :..|.:|.:.....:|.
  Rat  1017 ASQSSWQEEDPKGQQEQLPQVQKCENHQAARSPASMMSSEDLAPYLGESWKRKDSPQVPAEGVDD 1081

  Fly  1143 KLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDP-LTG- 1205
               .:..:.:.:.....||.||:.....|.   |...:..|.:.|.:..........|.| .||
  Rat  1082 ---TSSSEGSTVDCPDPEEILRKIPELADD---LDEPDDCFTEGCTRRCPCCNVNTSKSPWATGW 1140

  Fly  1206 KERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQ-IAEYG---FVIFM 1266
            :.||..|:.:.:     ::.:..:||...||..::.|| .|| :.:.|.:: :.||.   |....
  Rat  1141 QVRKTCYRIVEH-----SWFESFIIFMILLSSGALAFE-DNY-LEEKPRVKSVLEYTDRVFTFIF 1198

  Fly  1267 SLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPL 1331
            ..|:.||.:|.|.    |.|..:....||..|..:|.:.|....|.....::.:.|..||.:|||
  Rat  1199 VFEMLLKWVAYGF----KKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRALRPL 1259

  Fly  1332 RIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARC-----------ND 1385
            |..:....||.||..|......|:.|..:.::...||:..||.|:.|:.::|           |.
  Rat  1260 RALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSKCVDTRNNPFSNVNS 1324

  Fly  1386 PTISRREDC-----VGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLF 1445
            ..::.:.:|     .|.|.                          |.|. :.||||:....|.|.
  Rat  1325 TMVNNKSECHNQNSTGHFF--------------------------WVNV-KVNFDNVAMGYLALL 1362

  Fly  1446 EVLSFKGWLDVRDVLIKAVGPVHA-----------VYIHIYIFLGCMIGLTLFVGVVIANYSENK 1499
            :|.:||||:|:....:.: |.:::           :|..::|..|....|.|||||:|.|:::.|
  Rat  1363 QVATFKGWMDIMYAAVDS-GEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQK 1426

  Fly  1500 -----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLIN 1559
                 ....:|.:|:::.:..|:|...:|....||| ..|.:.|.:||.....|..:|.|::.:|
  Rat  1427 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-LNKYQGFVFDIVTRQAFDIIIMVLICLN 1490

  Fly  1560 SMLLSI-TWIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIW 1623
            .:.:.: |..:||..|:.|..::.....||..|.|||..|.. :.|:.:..|.:|.:|.:..:..
  Rat  1491 MITMMVETDEQGEEKTKVLGRINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVILSIGS 1554

  Fly  1624 IILQTILRNDLSYFFGFMVVILRFFTI----------TGKHTTLKMLMLTVGVSVCKSFFIIFGM 1678
            ::...||::..:||...:..::|...|          .|..|.|..||:    |:...|.|...:
  Rat  1555 LLFSAILKSLENYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMM----SLPALFNIGLLL 1615

  Fly  1679 FLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCM-VQPPYC- 1741
            ||::|.|::.|...|..|....||....||.:....:..||:|.|...|:.::...: ..||||
  Rat  1616 FLVMFIYSIFGMASFANVVDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1680

  Fly  1742 -TLGN-NYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRN 1804
             .|.| |....:||:....:|:|.|:.:|...||:|:.:|:|:|||:: .:.|....||..|...
  Rat  1681 PNLPNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFNV-ATEESTEPLSEDDFDM 1744

  Fly  1805 FQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMCYEL---DKLHNGEDVTFH 1866
            |..||...|......|....:......|.|.|.. |:.::.:...|...|   ||:| ..|:.|.
  Rat  1745 FYETWEKFDPEATQFIAFSALSDFADTLSGPLRI-PKPNQNILIQMDLPLVPGDKIH-CLDILFA 1807

  Fly  1867 DVINMLSYRSVDIRKALQLEELLAREEFEYLVEE------EVAKMTIRTWLEGCLKKIRAQNASK 1925
            ...|:|.       ::.:|:.|....|.:::...      |....|:| |.:..|.....|.|.:
  Rat  1808 FTKNVLG-------ESGELDSLKTNMEEKFMATNLSKASYEPIATTLR-WKQEDLSATVIQKAYR 1864

  Fly  1926 QQNSLIAGLRATNEQPVMRPNIQEDKAPL------------GAVDKSAISTISGAVAGACPPTSD 1978
            .. .|...|..:|...|  |..:||...|            |..|||     ..|.|.:.||:.|
  Rat  1865 SY-MLHRSLTLSNTLHV--PRAEEDGVSLPGEGYVTFMANSGLPDKS-----ETASATSFPPSYD 1921

  Fly  1979 A----------FSPTFSSTENEE----KDGSS 1996
            :          .:|: ||.:||:    |:|:|
  Rat  1922 SVTRGLSDRANINPS-SSMQNEDEVAAKEGNS 1952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	64/335 (19%)
		Ion_trans	734..927	CDD:278921	58/276 (21%)
		Ion_trans	1240..1497	CDD:278921	72/287 (25%)
		Ion_trans	1571..1793	CDD:278921	65/235 (28%)
Scn10a	NP_058943.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..54
		I. /evidence=ECO:0000305	116..404		65/321 (20%)
		Ion_trans	129..406	CDD:395416	63/310 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..484		8/42 (19%)
		Na_trans_cytopl	<482..614	CDD:403218	10/134 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..581		0/43 (0%)
		II. /evidence=ECO:0000305	646..910		58/274 (21%)
		Ion_trans	663..893	CDD:395416	53/240 (22%)
		Na_trans_assoc	903..1148	CDD:399489	47/300 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1008..1094		9/88 (10%)
		III. /evidence=ECO:0000305	1141..1450		83/347 (24%)
		Ion_trans	1152..1428	CDD:395416	77/314 (25%)
		Na_channel_gate	1420..1472	CDD:240441	12/52 (23%)
		IV. /evidence=ECO:0000305	1459..1758		86/305 (28%)
		Ion_trans	1476..1733	CDD:395416	71/262 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1906..1956		16/53 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920