Protein Alignment na and NALCN

DIOPT Version :9

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_024305104.1
• Gene: NALCN / 259232
• HGNCID: 19082
• Length: 1786
• Species: Homo sapiens
• Alignment Length: 1754
• Identity: 972/1754 - (55%)
• Similarity: 1223/1754 - (69%)
• Gaps: 93/1754 - (5%)

  Fly   318 NKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFE 382
            |..||.||||.:.....:.|:||:|||:::|||.|:||.||..|:|:||::|:.||.:|||.|||
Human    17 NLSMLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMTFE 81

  Fly   383 RYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIF 447
            .||.||::||..||.:..|:||||||||||||::.|:..|:||.||.||..||..||:|::||:|
Human    82 HYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVF 146

  Fly   448 EVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLY 512
            |:.:||.:.|...::|.||||||||..|::.:|.:|::||..|.|||.:||::|::|.|||:.||
Human   147 EIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLY 211

  Fly   513 GLLGVQFFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMD--F 575
            |:||||.||....|||:|:|     |...:|.||||||||.||.:.:.||||.||..||.::  .
Human   212 GILGVQMFGTFTYHCVVNDT-----KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLG 271

  Fly   576 LSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVF 640
            ||...:|::||.:|.|||||||:|||||||||:|||||||.|.||:.|||.|:||||||||||||
Human   272 LSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVF 336

  Fly   641 IAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDT-GWRLVTIDDNKHGGLAPETCHAILR 704
            ||||.|||.|||||||||||:|.....||.:|:...:.. ||:||.:|.||..|.||.....::|
Human   337 IAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMR 401

  Fly   705 SPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGY 769
            |..|.|.::|::..:.||.|:..:|.:...|.  |:.:|..|:.||.|.|||.|.||:|||:.||
Human   402 SSVFHMFILSMVTVDVIVAASNYYKGENFRRQ--YDEFYLAEVAFTVLFDLEALLKIWCLGFTGY 464

  Fly   770 YKHSIHKFELLLAAGTTLHIVPMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLI 834
            ...|:|||||||..|||||:.|..|.|..|||||||||||||.||.||.|||||||||||||||:
Human   465 ISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLV 529

  Fly   835 IFTMCLLIISSSISMQLFCFLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLV 899
            :||..|||:.|:||:|:|||:.:..:|.:||.||||||||||||.||:|||:|:........|:|
Human   530 VFTASLLIVMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVV 594

  Fly   900 AVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDS 964
            |:||||||||.|||:|||||||||||||||||:|||||||..|.:|:.||.||.|||||||||:.
Human   595 AIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNR 659

  Fly   965 PQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLV----------ENCKRPMSECWESNVVFR 1019
            |||..:.::|:||.:||:||||||.| |:.:.:|:..          .:|........|.|
Human   660 PQMVKISKLPSDFTVPKIRESFMKQF-IDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIEDN---- 719

  Fly  1020 KQKPVRIMNKTAKVRAAGSSLRKLAITHIIND---------SNNQRLMLGDS------------- 1062
            |....::......:||.....::.|:|.|::.         |....|.||.|
Human   720 KYIDQKLRKSVFSIRARNLLEKETAVTKILSKRPLPTSSPISIRCCLYLGRSHCHSSGVRACTRQ 784

  Fly  1063 AMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAA 1127
            .||.  |:..|...|.:..:  |....:.|::   ||:|....|..|...::.|.|.::
Human   785 RMLS--GSFEGQPAKERSIL--SVQHHIRQER---RSLRHGSNSQRISRGKSLETLTQD------ 836

  Fly  1128 PRANSGR---ARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQK 1189
             .:|:.|   |:..|.:||::|.|::||||:|..:||:||||||:||.|||:|.||.|||..|:.
Human   837 -HSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRV 900

  Fly  1190 IVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPT 1254
            :|.||::|...||:||..:..:|..|::.||||||||||||..|..||||||||:|..|||..||
Human   901 VVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMHAPT 965

  Fly  1255 LQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAA 1319
            ||||||.||||||:||.|||:||||||||.|.|:|....:|:|||:||..||||||.|:|..|.|
Human   966 LQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGA 1030

  Fly  1320 QLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCN 1384
            ||||:|||:||||||.|||.|||||.||..|||||.|||.||:.||.:|||:||||:.|:||:||
Human  1031 QLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCN 1095

  Fly  1385 DPTISRREDCVGVFMRRVFVTK---MKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFE 1446
            ||.|.|||||.|:|...|.|:|   :||.||  |..|...|||||||||.|||||:|:|||.|||
Human  1096 DPNIIRREDCNGIFRINVSVSKNLNLKLRPG--EKKPGFWVPRVWANPRNFNFDNVGNAMLALFE 1158

  Fly  1447 VLSFKGWLDVRDVLIKAVGPVHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRW 1511
            |||.|||::||||:|..|||:|.:|||:::||||||||||||||||||::|||||||||||||||
Human  1159 VLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRW 1223

  Fly  1512 CDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTER 1576
            .|||.|||||||||||||||....||..||||||..|||.||::||..|:|||:.|...:..|..
Human  1224 EDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP 1288

  Fly  1577 LVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFM 1641
            |..:|.|.||:||:||.||.||.:|.|:|||||||||||||..||:|::|...|.|..:|..|..
Human  1289 LATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGAC 1353

  Fly  1642 VVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRA 1706
            |::.|||:|.|||.|||||:|||.||:.||||||.|||||:..||.||.:|||||||||.|.|.|
Human  1354 VIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHA 1418

  Fly  1707 NFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGN-NYWETDCGNFTASLIYFCTFYVIIT 1770
            ||.|....:.:||||||||||||||||||||||:||... .||.|||||:..:|:|||:|||||.
Human  1419 NFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIA 1483

  Fly  1771 YIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGR 1835
            ||:||||||||:||||||||.|||.||||.|:|:||..||:||..:.||||..||||:||||:||
Human  1484 YIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGR 1548

  Fly  1836 LECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEE 1900
            ||.|..||:||||:||||:::||||.|||||||::|||||||||||:||||||||||:.||.:||
Human  1549 LEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1613

  Fly  1901 EVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMR----PNIQEDKAPLGAVDKSA 1961
            ||||.|||.||:.|||:|||:  .:|..|:|..||.:.:|.:.|    |:|:..:.   :.|.:|
Human  1614 EVAKQTIRMWLKKCLKRIRAK--QQQSCSIIHSLRESQQQELSRFLNPPSIETTQP---SEDTNA 1673

  Fly  1962 ISTISGAVAGACPPTS---DAFSPTFSSTENEEKDGSSSAVVQ-------LPHSETSIAGTGSS 2015
            .|..:...    |.||   ...|||.|......:|.:.:...|       ||.:...|:.:.||
Human  1674 NSQDNSMQ----PETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQWRLPSAPKPISHSVSS 1733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	165/282 (59%)
		Ion_trans	734..927	CDD:278921	124/192 (65%)
		Ion_trans	1240..1497	CDD:278921	177/259 (68%)
		Ion_trans	1571..1793	CDD:278921	143/222 (64%)
NALCN	XP_024305104.1	Ion_trans	55..350	CDD:306908	173/299 (58%)
		Ion_trans	402..622	CDD:306908	132/221 (60%)
		Ion_trans	935..1209	CDD:306908	189/275 (69%)
		Ion_trans	1257..1506	CDD:306908	156/248 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144610
Domainoid	1	1.000	391	1.000	Domainoid score	I785
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21832
Inparanoid	1	1.050	1832	1.000	Inparanoid score	I63
Isobase	1	0.950	-	0	Normalized mean entropy	S4294
OMA	1	1.010	-	-		QHG48327
OrthoDB	1	1.010	-	-		D16416at33208
OrthoFinder	1	1.000	-	-		FOG0004135
OrthoInspector	1	1.000	-	-		oto89339
orthoMCL	1	0.900	-	-		OOG6_104443
Panther	1	1.100	-	-	LDO	PTHR46141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	1	1.000	-	-		X3959
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890