DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and Cacna1b

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	XP_006233631.1	Gene:	Cacna1b / 257648	RGDID:	628852	Length:	2359	Species:	Rattus norvegicus

Alignment Length:	2343	Identity:	488/2343 - (20%)
Similarity:	843/2343 - (35%)	Gaps:	655/2343 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 GAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSAAITGVPPIGLGIATGI 316
            |..||...||.|||....|  ||.||.||    .|.|               |:||
  Rat     5 GDELGGRYGGTGGGERARG--GGAGGAGG----PGQG---------------GLPP--------- 39

  Fly   317 GNKIMLGRKQSLKGGEPFLADYGPEE------SLNESADI---------------EW--VNKLWV 358
            |.:::.  |||:......:|.|.|..      ::|.|..:               ||  ...:.:
  Rat    40 GQRVLY--KQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMIL 102

  Fly   359 RRLMRLCALVSLTSVSLNTPKT--FERYPSLQ--FITFASDTAVTLLFTAEMIAKMHIRGVLHGE 419
            ..::..|.:::|.....:..||  .||....:  ||.         :|..|...|:...|.:..:
  Rat   103 ATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIG---------IFCFEAGIKIIALGFVFHK 158

  Fly   420 VPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM---IRFLRVFLKFS 481
            ..||::.|...|       ::.::..|............|..:|..|||.:   |..|:|.|| |
  Rat   159 GSYLRNGWNVMD-------FVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLK-S 215

  Fly   482 MPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTIN 545
            :.|:.:         .:..:.|...|.:.::.::|::|: |:....|..|:|:.:
  Rat   216 IMKAMV---------PLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAE---------- 261

  Fly   546 SLAIPDTFCSMDP-----DSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGW 605
              .:.|..|..:.     ||..:|        .::......|...|::|..:|.||:|..:.|||
  Rat   262 --PVGDFPCGKEAPARLCDSDTEC--------REYWPGPNFGITNFDNILFAILTVFQCITMEGW 316

  Fly   606 VFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVIT-------------ETFNEIRVQFQQ 657
            ..|:|...|:........||..:|...::.:.|:.:.|::             ..|.::|.|.|.
  Rat   317 TDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQI 381

  Fly   658 MWGARGHIQ---------------------------KTAASQILSGNDTGWRLVTIDDNK----- 690
            .....|:::                           |.||:: .|.||    |:..::.:
  Rat   382 ERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAATK-KSRND----LIHAEEGEDRFVD 441

  Fly   691 -------------HGGLAPETCHAILRSPYFRMLVMSVILAN----------GIVTATMTFKHDG 732
                         ..|....:.:...:...||.|:..::.|.          .:.|..:...|..
  Rat   442 LCAAGSPFARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVLCVVALNTLCVAMVHYN 506

  Fly   733 RPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV-PMFYPS 796
            :|:.: ....|:.|.||..|...|...|:|.||.|.|::.|.:.|:..:..|:...:| ....|.
  Rat   507 QPQRL-TTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPG 570

  Fly   797 ---GLTYFQVLRVVRLIKASP---MLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFL 855
               |::..:.||::|:.|.:.   .|...|..:....|.:.||:......:::.:.:.||||...
  Rat   571 TSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQ 635

  Fly   856 CDF------TKFESFPEAFMSMFQILTQEAWVEVM---DETMIRTSKTLTPLVAVYFILYHLFVT 911
            .:|      |.|::||.|.:::|||||.|.|..||   .|:....||.:  ..:.|||:..||..
  Rat   636 FNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGM--FSSFYFIVLTLFGN 698

  Fly   912 LIVLSLFVAVILDNL----ELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHR 972
            ..:|::|:|:.:|||    ||.:|.:::      |::|..|..|.....:.|..|.|.....:
  Rat   699 YTLLNVFLAIAVDNLANAQELTKDEEEM------EEAANQKLALQKAKEVAEVSPMSAANISI-- 755

  Fly   973 IPNDFMLPKVRESFMKHFVIELETEDSLVE-NCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAA 1036
                       .:|:|.....:....|:.. |..|..:.....:|..::...:|:.|..|...|.
  Rat   756 -----------AAFVKQTRGTVSRSSSVSSVNSPRQQNSAKARSVWEQRASQLRLQNLRASCEAL 809

  Fly  1037 GSS------LRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGL------------------- 1076
            .|.      ||..:..|:..|.....    |.   |:|...|..||
  Rat   810 YSEMDPEERLRYASTRHVRPDMKTHM----DR---PLVVEPGRDGLRGPAGNKSKPEGTEATEGA 867

  Fly  1077 -------------------------------KSQGTITHSKPWRVDQKKFGSRSI---------- 1100
                                           |::.|.|.::..|...::..|:..
  Rat   868 DPPRRHHRHRDRDKTSASTPAGGEQDRTDCPKAESTETGAREERARPRRSHSKEAPGADTQVRCE 932

  Fly  1101 --RRSVRSGS--------IKLKQTYEH---------------LMENGDIAA-------APRANSG 1133
              ||..|.||        .:..:.:.|               |:..|:..|       .||....
  Rat   933 RSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGKEGTAPVLVPKGERRARHRGPRTGPRETEN 997

  Fly  1134 RARP-------HDLDIKLLQAKRQQAEMRRNQREEDLR-ENHPFFDTPLFLVPRESR-------- 1182
            ...|       |.:...|...:|:.||...|..|.|.. .||.         |:|.|
  Rat   998 SEEPTRRHRAKHKVPPTLEPPEREVAEKESNVVEGDKETRNHQ---------PKEPRCDLEAIAV 1053

  Fly  1183 --------FRKIC-QKIVHARYDA-----------RLKDP---------LTG------------- 1205
                    ....| ||:.....||           :..||         |||
  Rat  1054 TGVGSLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLTGPPGEATVVPSANT 1118

  Fly  1206 ---------KERK------------VQYKSLH------------NFLGLVTYLDWVMIFATTLSC 1237
                     ||.:            |.|.|:.            :::..:.|.:.|::....||.
  Rat  1119 DLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSS 1183

  Fly  1238 ISMMFETP----NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFI 1298
            |::..|.|    ::|   :..|:..:|.|....:.|:.:|::..||...|.||.:|:...|| ||
  Rat  1184 IALAAEDPVRTDSFR---NNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILD-FI 1244

  Fly  1299 YV----VSTSFLCWM------PLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKE 1353
            .|    |:.:|..:|      .:|     ..:.|.:||.:|||:....:|.::.|...:....|.
  Rat  1245 VVSGALVAFAFSSFMGGSKGKDIN-----TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKN 1304

  Fly  1354 ILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYP 1418
            :|.:..:.:|.|||||...|||:.|:...|.|.:.....||.|.::             ..|...
  Rat  1305 VLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYL-------------DYEKEE 1356

  Fly  1419 AMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGP----------VHA 1469
            ....||.| ....|::||:..|:||||.|.:.:||..|.    |...:..||          .:.
  Rat  1357 VEAQPRQW-KKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYV 1420

  Fly  1470 VYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKRLKI-------AQPL--H 1525
            ||..::.|    ..:.:||.::|..:.| :|..:::.     |.|:|..:.       |:||  :
  Rat  1421 VYFVVFPF----FFVNIFVALIIITFQE-QGDKVMSE-----CSLEKNERACIDFAISAKPLTRY 1475

  Fly  1526 LPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTE-RLVIVSAVLTFVFV 1589
            :|......:.:.:|:.::..  |:..|..::.:|:::|.:.:.......| .|..::.|.|.:|.
  Rat  1476 MPQNKQSFQYKTWTFVVSPP--FEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFS 1538

  Fly  1590 VEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTIL---RNDLSYFFGFMVVILRFFTIT 1651
            :|.::|.|||....|::...|.:| .|||.|.|..||.|.:   .|.::..|..:....|...:.
  Rat  1539 LECILKIIAFGVLNYFRDAWNVFD-FVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLL 1602

  Fly  1652 GKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEG--IGRRANFGSPVTG 1714
            .:..|:::|:.|...|.....::...:.:|.|.||:.|..:||.:...:|  |.|..||.:.:..
  Rat  1603 RQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDGTSINRHNNFRTFLQA 1667

  Fly  1715 VAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWE-----TDCGNFTASLIYFCTFYVIITYIVL 1774
            :.:|||..|||.|::||..|        |||...:     ::||:..| ..||.:|..:.::::|
  Rat  1668 LMLLFRSATGEAWHEIMLSC--------LGNRACDPHANASECGSDFA-YFYFVSFIFLCSFLML 1723

  Fly  1775 NLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL--- 1836
            ||.||:||:||.  |...:.::|....:..|...|...|....|.|....:..:|:.:...|
  Rat  1724 NLFVAVIMDNFE--YLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLG 1786

  Fly  1837 -ECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEE 1900
             :|..   |:.:|.: ..::...:.||:|.|....:::.    ||.||:: :|......::..:.
  Rat  1787 KKCPA---RVAYKRL-VRMNMPISNEDMTVHFTSTLMAL----IRTALEI-KLAPAGTKQHQCDA 1842

  Fly  1901 EVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAV-------- 1957
            |:.|.....|            |:..|.:|          .::.|..:.|:..:|.|
  Rat  1843 ELRKEISSVW------------ANLPQKTL----------DLLVPPHKPDEMTVGKVYAALMIFD 1885

  Fly  1958 ----DKSAISTISGAVAGACP--PTSDAFSPTFSSTENEEKDGSSSAVVQL-PHSETSIAGTGSS 2015
                :|:.......|..|...  |.| .|.|..::.|..:......|.|.| ..|.||::..|:.
  Rat  1886 FYKQNKTTRDQTHQAPGGLSQMGPVS-LFHPLKATLEQTQPAVLRGARVFLRQKSATSLSNGGAI 1949

  Fly  2016 AT-----------------------GAATATGTSSGLGVGPP---TVQSTARHVMTVGKRGYALN 2054
            .|                       .|....|.|:.:.||.|   .|....:::...|..|....
  Rat  1950 QTQESGIKESLSWGTQRTQDVLYEARAPLERGHSAEIPVGQPGALAVDVQMQNMTLRGPDGEPQP 2014

  Fly  2055 RSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTL---PHAGQLGQLAKQRG 2116
            ..:|.|.:|....||..:......|.:              |.|::||   ||..||......|
  Rat  2015 GLESQGRAASMPRLAAETQPAPNASPM--------------KRSISTLAPRPHGTQLCNTVLDR- 2064

  Fly  2117 GGGEATKSSSFFAQLNSEIGQFHY-----------------PTINAAAAAAALHGYGHGHGHGHG 2164
                         ...|::...|:                 |:::.....|.....|.|..||.|
  Rat  2065 -------------PPPSQVSHHHHHRCHRRRDKKQRSLEKGPSLSVDTEGAPSTAAGSGLPHGEG 2116

  Fly  2165 GHG 2167
            ..|
  Rat  2117 STG 2119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	60/306 (20%)
		Ion_trans	734..927	CDD:278921	61/212 (29%)
		Ion_trans	1240..1497	CDD:278921	73/284 (26%)
		Ion_trans	1571..1793	CDD:278921	69/232 (30%)
Cacna1b	XP_006233631.1	Ion_trans	112..367	CDD:278921	59/300 (20%)
		Ion_trans	500..721	CDD:278921	64/223 (29%)
		Ion_trans	1186..1448	CDD:278921	75/289 (26%)
		Ion_trans	1511..1742	CDD:278921	70/242 (29%)
		GPHH	1750..1814	CDD:293510	13/67 (19%)
		Ca_chan_IQ	1816..1890	CDD:285917	15/100 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920