DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Scn4a

DIOPT Version :10

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_037310.2 Gene:Scn4a / 25722 RGDID:3636 Length:1840 Species:Rattus norvegicus


Alignment Length:1936 Identity:423/1936 - (21%)
Similarity:738/1936 - (38%) Gaps:448/1936 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   355 KLWVRRLMRLCALVSLTS----VSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGV 415
            |:.:..|..:..::::.:    ::::.|.::.::....|         |.::|.|.:.||..||.
  Rat   126 KVLIHALFSMFIMITILTNCVFMTMSNPPSWSKHVEYTF---------TGIYTFESLIKMLARGF 181

  Fly   416 LHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKF 480
            ...:..:|:|.|...|.|:::..:::             :|..|..:.|.|...::|.|:.....
  Rat   182 CIDDFTFLRDPWNWLDFSVITMAYVT-------------EFVDLGNISALRTFRVLRALKTITVI 233

  Fly   481 SMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCV-----MNNTEYDLYKR 539
            ...|:.:..:. :|.:::.:|.:..:|.:|::.|:|:| |.|.|:..||     ||:|....|..
  Rat   234 PGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPMNDTNTTWYGN 297

  Fly   540 PILTIN-------------------SLAIPDTF-----------------------CSMDPDSGY 562
            .....|                   |.|...||                       |....|:|:
  Rat   298 DTWYSNDTWYGNDTWYINDTWNSQESWAGNSTFDWEAYINDEGNFYFLEGSNDALLCGNSSDAGH 362

  Fly   563 QCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA----- 622
             |..|..|:|.....:|  |:..::..:.:...:::..:|:.|..:....:      |||     
  Rat   363 -CPEGYECIKAGRNPNY--GYTSYDTFSWAFLALFRLMTQDYWENLFQLTL------RAAGKTYM 418

  Fly   623 FYFSTMIFFLAWLVKNVFIAVITETF---NEIRV--------QFQQMWGA----RGHIQKTAASQ 672
            .:|..:||..::.:.|:.:||:...:   ||..:        :||||...    :..::|..|:|
  Rat   419 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDQEKEEEFQQMLEKYKKHQEEVEKAKAAQ 483

  Fly   673 ILSGNDTGWRLVTIDDNKHGGL----------------------------APETC--------HA 701
            .|...:......|.:.:.:|.|                            |.:.|        |.
  Rat   484 ALESGEEADGDPTHNKDCNGSLDASGEKGPPRPSCSADSAISDAMEELEEAHQKCPPWWYKCAHK 548

  Fly   702 IL----RSPYFR------MLVMSVILANGIV------TATMTFKHDGRPRDVFYERYYYI-ELVF 749
            :|    .:|:.:      ::||...:..||.      |..|..:|  .|....::....: .|||
  Rat   549 VLIWNCCAPWVKFKHIIYLIVMDPFVDLGITICIVLNTLFMAMEH--YPMTEHFDNVLSVGNLVF 611

  Fly   750 TCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYP-----SGLTYFQVLRVVRL 809
            |.:...|.:.|:..:....|::...:.|:..:   .||.:|.:...     |.|..|::|||.:|
  Rat   612 TGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFI---VTLSLVELGLANVQGLSVLRSFRLLRVFKL 673

  Fly   810 IKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF--------CFL---CDFTKF- 861
            .|:.|.| ..:.||.|.. ..||:|.:....::.|.:.:.||||        |.:   |:..:: 
  Rat   674 AKSWPTL-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIASDCNLPRWH 737

  Fly   862 -ESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVIL-- 923
             ..|..:|:.:|:||..| |:|.|.:.|....:.:...|   |::..:...|:||:||:|::|  
  Rat   738 MNDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTV---FLMVMVIGNLVVLNLFLALLLSS 798

  Fly   924 ---DNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRES 985
               |:|...::..::..|:.  ....||..:.|                    ...|:|..:|..
  Rat   799 FSADSLAASDEDGEMNNLQI--AIGRIKWGIGF--------------------AKTFLLGLLRGK 841

  Fly   986 FM--KHFVIELETEDSLVENCKR--PMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAIT 1046
            .:  |..::.|.......||.:.  |..|..|.....::.|...|:|.........||:.   :.
  Rat   842 ILSPKEIILSLGEPGGAGENAEESTPEDEKKEPPPEDKELKDNHILNHVGLTDGPRSSIE---LD 903

  Fly  1047 HIINDSNNQRLMLGDSAMLPVVGTKGGGGLKS-QGTITHSKPWRVDQKKFGSRSIRRSVRSGSIK 1110
            | :|..||..|.:    .:|:...:....:.: :.|...|:|  .|.||               .
  Rat   904 H-LNFINNPYLTI----HVPIASEESDLEMPTEEETDAFSEP--EDIKK---------------P 946

  Fly  1111 LKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLF 1175
            |:..|:     |:.:....|:   .:|.:.|                  .|:..|.:|..:.|  
  Rat   947 LQPLYD-----GNSSVCSTAD---YKPPEED------------------PEEQAEENPEGEQP-- 983

  Fly  1176 LVPRESRFRKICQKIVHARYDARLKDPLTGKE------RKVQYKSL-HNFLGLVTYLDWVMIFAT 1233
                |..|.:.|.|    |......|...|:.      |:..:|.: ||      :.:..::|..
  Rat   984 ----EECFTEACVK----RCPCLYVDISQGRGKMWWTLRRACFKIVEHN------WFETFIVFMI 1034

  Fly  1234 TLSCISMMFE---TPNYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALD 1295
            .||..::.||   ....||: ...|:.|:..|.....||:.||.:|.|.    |.|..:....||
  Rat  1035 LLSSGALAFEDIYIEQRRVI-RTILEYADKVFTYIFILEMLLKWVAYGF----KVYFTNAWCWLD 1094

  Fly  1296 VFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTL 1360
            ..|..||...|....|........:.|..||.:||||..:....||.||..|......|:.|..:
  Rat  1095 FLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLV 1159

  Fly  1361 LILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRV 1425
            .::...||:..||.|:.|:...|.:.|.|.|.|             :.:.....|....|...:|
  Rat  1160 CLIFWLIFSIMGVNLFAGKFYYCVNTTTSERFD-------------ISVVNNKSECESLMYTGQV 1211

  Fly  1426 -WANPRRFNFDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGPVHAV------YIHIYIFLG 1479
             |.|. :.|:||:|...|:|.:|.:||||:|:.    |...|...|.:.|      |..|:|..|
  Rat  1212 RWMNV-KVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPDYEVNLYMYLYFVIFIIFG 1275

  Fly  1480 CMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFT 1539
            ....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|...:|....|||. .||:...
  Rat  1276 SFFTLNLFIGVIIDNFNQQKKKFGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQ-NKIQGMV 1339

  Fly  1540 YDITQHIIFKRVIAVVVLINSMLLSI-TWIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRG 1603
            ||.....:|...|.:::.:|.:.:.: |..:.::..:.|..::.|...:|..|.|:|  .|..|.
  Rat  1340 YDFVTKQVFDISIMILICLNMVTMMVETDDQSQLKVDILYNINMVFIIIFTGECVLK--MFALRH 1402

  Fly  1604 Y-----WQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGKHTT 1656
            |     |    |.:|.:|.:..::.:.|..:::   .||..   |.|:.|    |...:......
  Rat  1403 YYFTIGW----NIFDFVVVILSIVGLALSDLIQ---KYFVSPTLFRVIRLARIGRVLRLIRGAKG 1460

  Fly  1657 LKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRI 1721
            ::.|:..:.:|:...|.|...:||::|.|::.|...|..||...||....||.:....:..||.|
  Rat  1461 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEI 1525

  Fly  1722 VTGEDWNKIMHDCMVQ-PPYC--TL---GNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAI 1780
            .|...|:.:::..:.. ||.|  ||   |.|. ..||||.:..:.:||::.:|...||:|:.:||
  Rat  1526 TTSAGWDGLLNPILNSGPPDCDPTLENPGTNV-RGDCGNPSIGICFFCSYIIISFLIVVNMYIAI 1589

  Fly  1781 IMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLE-CDPQKDR 1844
            |:|||:: .:.|....||..|...|..||...|......|...|:...:..|:..|: ..|.|  
  Rat  1590 ILENFNV-ATEESSEPLSEDDFEMFYETWEKFDPDATQFIDYSRLSDFVDTLQEPLKIAKPNK-- 1651

  Fly  1845 LLFKYMCYEL-----DKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAK 1904
              .|.:..:|     ||:|                 .:||..||..|.|....|.:.|      |
  Rat  1652 --IKLITLDLPMVPGDKIH-----------------CLDILFALTKEVLGDSGEMDAL------K 1691

  Fly  1905 MTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTIS--- 1966
            .|:.       :|..|.|.||.....|.......::.|....||  :|....:.:.::...|   
  Rat  1692 QTME-------EKFMAANPSKVSYEPITTTLKRKQEEVCAIKIQ--RAYRRHLLQRSVKQASYMY 1747

  Fly  1967 -----GAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTS 2026
                 |...|| |......:.|.:.....||:|..   ||....|...:...:..|.....|.:|
  Rat  1748 RHSQDGNGDGA-PEKEGLLANTMNKMYGHEKEGDG---VQSQGEEEKASTEDAGPTVEPKPTSSS 1808

  Fly  2027 -SGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQ 2076
             :.|...||.                                |.|:||.||
  Rat  1809 DTALTPSPPP--------------------------------LPPSSSPPQ 1827

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 361..654 CDD:459842 65/360 (18%)
Ion_trans 705..927 CDD:459842 63/258 (24%)
Ion_trans 1224..1497 CDD:459842 82/286 (29%)
Ion_trans 1545..1793 CDD:459842 68/266 (26%)
Scn4aNP_037310.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..63
I. /evidence=ECO:0000305 113..448 64/353 (18%)
Ion_trans 130..451 CDD:459842 65/352 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..522 6/40 (15%)
II. /evidence=ECO:0000305 554..826 67/283 (24%)
Ion_trans 571..784 CDD:459842 52/222 (23%)
Na_trans_assoc 810..1019 CDD:461936 49/291 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..884 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 925..983 15/100 (15%)
III. /evidence=ECO:0000305 1006..1319 90/337 (27%)
Ion_trans 1023..1297 CDD:459842 85/298 (29%)
Na_channel_gate 1289..1341 CDD:240441 12/52 (23%)
Important for rapid channel inactivation. /evidence=ECO:0000269|PubMed:28012039 1303..1305 0/1 (0%)
IV. /evidence=ECO:0000305 1328..1626 83/309 (27%)
Ion_trans 1346..1602 CDD:459842 69/266 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1775..1840 18/88 (20%)
Blue background indicates that the domain is not in the aligned region.

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