DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Scn5a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_038936827.1 Gene:Scn5a / 25665 RGDID:3637 Length:2020 Species:Rattus norvegicus


Alignment Length:2139 Identity:424/2139 - (19%)
Similarity:731/2139 - (34%) Gaps:705/2139 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 GEPFLADYGPEES-------LNESADI---EWVNKLW-------VRR------------LMRLCA 366
            ||| |.|..|..|       ||:...|   ...|.|:       |||            ::.:|.
  Rat    78 GEP-LEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVRRAAVKILVHSLFSMLIMCT 141

  Fly   367 -LVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQF 430
             |.:...::.:.|..:.:|....|         |.::|.|.:.|:..||.......:|:|.|...
  Rat   142 ILTNCVFMAQHDPPPWTKYVEYTF---------TAIYTFESLVKILARGFCLHAFTFLRDPWNWL 197

  Fly   431 DASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSS 495
            |.|::             |:....:|..|..:.|.|...::|.|:.....|..|:.:..:. :|.
  Rat   198 DFSVI-------------VMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI-QSV 248

  Fly   496 QQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNTEYDLYKRPI----LTINSLAI----PD 551
            :::.:|.:..:|.:|::.|:|:| |.|.|::.||.|.||.:.....:    |..|||.:    |.
  Rat   249 KKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGLVWNSLDVYLNDPA 313

  Fly   552 TF-----------CSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGW 605
            .:           |....|:| .|..|..|:|......:  |:..|:..|.:...:::..:|:.|
  Rat   314 NYLLKNGTTDVLLCGNSSDAG-TCPEGYRCLKAGENPDH--GYTSFDSFAWAFLALFRLMTQDCW 375

  Fly   606 VFIMYRAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVITETFNE--------------- 650
            ..:..:.:      |:|     .:|..:||..::.:.|:.:||:...:.|               
  Rat   376 ERLYQQTL------RSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 434

  Fly   651 ----------------IR---------VQFQQMWGARGHIQKTAASQILS------GND------ 678
                            ||         ::...:.....|.:|:...:.||      |:|      
  Rat   435 FQEAMEMLKKEHEALTIRGVDTVSHSSLEMSPLAPVTNHERKSKRRKRLSSGTEDGGDDRLPKSD 499

  Fly   679 ----------------------------------------------------------------- 678
                                                                             
  Rat   500 SEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRTSLLV 564

  Fly   679 ------------------------TGWRLVTIDDN------------------------------ 689
                                    .|.|..|:|.|                              
  Rat   565 PWPLRHPSAQGQPGPGASAPGYVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSYLLRPMVLDRPP 629

  Fly   690 -------KHGG---LAP------------------------------------------------ 696
                   :.||   |.|                                                
  Rat   630 DTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQH 694

  Fly   697 ----ETC----------HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIEL 747
                |.|          ..::..|:..:.:...|:.|   |..|..:|.....: |.|......|
  Rat   695 YLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLN---TLFMALEHYNMTAE-FEEMLQVGNL 755

  Fly   748 VFTCLLDLETLFKIYCLGWRGYYKHSIHKFE--LLLAAGTTLHIVPMFYPSGLTYFQVLRVVRLI 810
            |||.:...|..|||..|....|::...:.|:  :::.:...|.:..|...|.|..|::|||.:|.
  Rat   756 VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMGNLSVLRSFRLLRVFKLA 820

  Fly   811 KASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF-------------------CFL 855
            |:.|.|...: ||.|.. ..||:|.:....::.|.:.:.||||                   ..:
  Rat   821 KSWPTLNTLI-KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPRWHM 884

  Fly   856 CDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVA 920
            .||.      .||:.:|:||..| |:|.|.:.|..:.::|..||   |:|..:...|:||:||:|
  Rat   885 MDFF------HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLV---FLLVMVIGNLVVLNLFLA 939

  Fly   921 VIL-----DNLELDEDIKKLKQLKFREQSAEIKETLPFRLR--------IFEKFPDSPQMTILH- 971
            ::|     |||...::..::..|:.  ..|.|:..|.|..|        |..:.|..|.....| 
  Rat   940 LLLSSFSADNLTAPDEDGEMNNLQL--ALARIQRGLRFVKRTTWDFCCGILRRRPKKPAALATHS 1002

  Fly   972 RIPNDFMLPKV-------------RESFMKH-------------------FVIELETEDSLVE-- 1002
            ::|:....|:.             :|:..:.                   .|.|.:|||...:  
  Rat  1003 QLPSCITAPRSPPPPEVEKVPPARKETRFEEDKRPGQGTPGDSEPVCVPIAVAESDTEDQEEDEE 1067

  Fly  1003 ---NCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAM 1064
               ..:...|:..||.||....:|.:.....::|....||                         
  Rat  1068 NSLGTEEESSKQQESQVVSGGHEPYQEPRAWSQVSETTSS------------------------- 1107

  Fly  1065 LPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPR 1129
                         ..|..|....|:.:||                                ..|:
  Rat  1108 -------------EAGASTSQADWQQEQK--------------------------------TEPQ 1127

  Fly  1130 ANSGRARPHDLDIKLLQAKRQQAEMRRN--------QREEDLRENHPFFD------TPLFLVPRE 1180
            |......|.|     ..::...|:|...        ...||:::....|.      .|..:|...
  Rat  1128 APGCGETPED-----SYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTT 1187

  Fly  1181 S-------RFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCI 1238
            .       |.||.|.:||.                       |      ::.:..:||...||..
  Rat  1188 QSPGKVWWRLRKTCYRIVE-----------------------H------SWFETFIIFMILLSSG 1223

  Fly  1239 SMMFETPNYRVMDHPTLQI-AEYG---FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIY 1299
            ::.||  :..:.:..|::: .||.   |.....||:.||.:|.|.    |.|..:....||..|.
  Rat  1224 ALAFE--DIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLIV 1282

  Fly  1300 VVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILL 1364
            .||...|....|........:.|..||.:||||..:....||.||..|......|:.|..:.::.
  Rat  1283 DVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIF 1347

  Fly  1365 MFIFASYGVQLYGGRLARCNDPT----------ISRREDCVGVFMR-RVFVTKMKLTPGPDESYP 1418
            ..||:..||.|:.|:..||.:.|          ::.:.:|....:. .::.||:|:         
  Rat  1348 WLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKV--------- 1403

  Fly  1419 AMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVHA----------VYIH 1473
                          ||||:|...|.|.:|.:||||:|:....:.:.|....          :|..
  Rat  1404 --------------NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFV 1454

  Fly  1474 IYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGR 1533
            ::|..|....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|...:|....||| ..
  Rat  1455 VFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-LN 1518

  Fly  1534 KIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIVSAV-LTFV--FVVEVVMK 1595
            |.:.|.:||.....|...|..::.:|.:.:.:.  ..:...|::.|::.: |.||  |..|.::|
  Rat  1519 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE--TDDQSPEKVNILAKINLLFVAIFTGECIVK 1581

  Fly  1596 NIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGK 1653
             :|.....|:.:..|.:|.:|.:..::..:|..|::   .|||.   |.|:.|    |...:...
  Rat  1582 -MAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQ---KYFFSPTLFRVIRLARIGRILRLIRG 1642

  Fly  1654 HTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAML 1718
            ...::.|:..:.:|:...|.|...:||::|.|::.|...|..||:..||....||.:....:..|
  Rat  1643 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCL 1707

  Fly  1719 FRIVTGEDWNKIMHDCM-VQPPYC--TLGN-NYWETDCGNFTASLIYFCTFYVIITYIVLNLLVA 1779
            |:|.|...|:.::...: ..||||  .|.| |....:||:....:::|.|:.:|...||:|:.:|
  Rat  1708 FQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIA 1772

  Fly  1780 IIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVI--------------PVRRVK---- 1826
            ||:||||: .:.|....||..|...|...|...|......|              |:|..|    
  Rat  1773 IILENFSV-ATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAKPNQI 1836

  Fly  1827 -----------------------FILRLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDV 1868
                                   |..|:|....|.|..|.::..|:|.      .|...:::..:
  Rat  1837 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMA------ANPSKISYEPI 1895

  Fly  1869 INMLSYRSVDIRKALQLEELLAREEF-EYLVEEEV--AKMTIRTWLEGCLKKIRAQNASKQQNSL 1930
            ...|.      ||..::...:.:..| .:|::..|  |....|....|  ..:..::|.::: .|
  Rat  1896 TTTLR------RKHEEVSATVIQRAFRRHLLQRSVKHASFLFRQQAGG--SGLSDEDAPERE-GL 1951

  Fly  1931 IAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTEN 1989
            ||.:        |..|.....|||.:   |:||:.|      .||:.|  |.|.::::|
  Rat  1952 IAYM--------MNGNFSRRSAPLSS---SSISSTS------FPPSYD--SVTRATSDN 1991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 66/345 (19%)
Ion_trans 734..927 CDD:278921 62/219 (28%)
Ion_trans 1240..1497 CDD:278921 72/281 (26%)
Ion_trans 1571..1793 CDD:278921 65/235 (28%)
Scn5aXP_038936827.1 Ion_trans 131..424 CDD:395416 66/324 (20%)
Na_trans_cytopl 484..668 CDD:403218 12/183 (7%)
Ion_trans 717..930 CDD:395416 59/227 (26%)
Na_trans_assoc 956..1203 CDD:399489 47/323 (15%)
Ion_trans 1207..1482 CDD:395416 78/309 (25%)
Na_channel_gate 1474..1526 CDD:240441 12/52 (23%)
Ion_trans 1531..1785 CDD:395416 68/260 (26%)
GPHH 1797..1844 CDD:407139 7/46 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.