DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Scn11a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_017168851.1 Gene:Scn11a / 24046 MGIID:1345149 Length:1782 Species:Mus musculus


Alignment Length:1868 Identity:396/1868 - (21%)
Similarity:700/1868 - (37%) Gaps:472/1868 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   320 IMLGRKQ-----SLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPK 379
            ::|.:|:     |.|.....|..:.|..|......:..|..:::     :|.::.......|...
Mouse   109 MVLNKKRTIYRFSAKRALFILGPFNPIRSFMIRISVHSVFSMFI-----ICTVIINCMFMANNSS 168

  Fly   380 TFER----YPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWI 440
            ...|    .|...||.         ::..|.:.|:..||.:..|..||:|.|...|..::.    
Mouse   169 VDSRPSSNIPEYVFIG---------IYVLEAVIKILARGFIVDEFSYLRDPWNWLDFIVIG---- 220

  Fly   441 SIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFF 505
            :.|...|    :..|.:.||.:|..|   ::|.|:.....|..|..:..:. ||.:::.:|.:..
Mouse   221 TAIAPCF----LGNKVNNLSTLRTFR---VLRALKAISVISGLKVIVGALL-RSVKKLVDVMVLT 277

  Fly   506 LFFMSLYGLLGVQ-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGY------- 562
            ||.:|::.|:|.| |.|.|...|:.::.      .|    |:.:..|.|...:....:       
Mouse   278 LFCLSIFALVGQQLFMGILSQKCIKDDC------GP----NAFSNKDCFVKENDSEDFIMCGNWL 332

  Fly   563 ---QCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFY 624
               .|..|..|.|..|...|  .:..|:....|...:::..:|:.|. .:||.|.........|:
Mouse   333 GRRSCPDGSTCNKTTFNPDY--NYTNFDSFGWSFLAMFRVMTQDSWE-KLYRQILRTSGIYFVFF 394

  Fly   625 FSTMIFFLAWLVKNVFIAVITETFNE-----------IRVQFQQ--------------------- 657
            |..:||..::.:.|:.:||:|..:.|           ....||:                     
Mouse   395 FVVVIFLGSFYLLNLTLAVVTMAYEEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRTS 459

  Fly   658 ---------------MWGA--------RGHIQKTAASQILSGNDTGWR----------------- 682
                           .:|:        ||  .|||.:......|...:                 
Mouse   460 LNSLQASSFSPKKRKFFGSKTRKSFFMRG--SKTARASASDSEDDASKNPQLLEQTKRLSQNLPV 522

  Fly   683 ----------------------LVTIDDNKHG---------GLA----------PETC-----HA 701
                                  .:|:.:.:..         .||          |..|     ..
Mouse   523 ELFDEHVDPLHRQRALSAVSILTITMQEQEKSQEPCFPCGKNLASKYLVWECSPPWLCIKKVLQT 587

  Fly   702 ILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGW 766
            |:..|:..:.:...|:.|.:..|......|...:|:.....:    |||.:...|...||..|..
Mouse   588 IMTDPFTELAITICIIVNTVFLAMEHHNMDNSLKDILKIGNW----VFTGIFIAEMCLKIIALDP 648

  Fly   767 RGYYKHSIHKFELLLAAGTTLHIVPMFYP-----SGLTYFQVLRVVRLIKASPMLEGFVYKIFGP 826
            ..|::|..:.|:.::|..:...:  :|:.     |.|...:||||.:|.|:.|.|...: ||.|.
Mouse   649 YHYFRHGWNIFDSIVALVSLADV--LFHKLSKNLSFLASLRVLRVFKLAKSWPTLNTLI-KIIGH 710

  Fly   827 G-KKLGSLIIFTMCLLIISSSISMQLF-------CFLCDFTKFES--------FPEAFMSMFQIL 875
            . ..||:|.:....::.|.|.:.|:||       |    .|..||        |..:|:.:|:||
Mouse   711 SVGALGNLTVVLTIVVFIFSVVGMRLFGAKFNKTC----STSPESLRRWHMGDFYHSFLVVFRIL 771

  Fly   876 TQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKF 940
            ..| |:|.|.|.|.....  :||..:.|:|..:...|:||:||:|::|::...:|        |.
Mouse   772 CGE-WIENMWECMQEMEG--SPLCVIVFVLIMVVGKLVVLNLFIALLLNSFSNEE--------KD 825

  Fly   941 REQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDF-MLPKVRESFMKHFVIELETEDSLVENC 1004
            .....|.::|   ::::           .|.|....| .:.:..::|.                |
Mouse   826 GNPEGETRKT---KVQL-----------ALDRFSRAFYFMARALQNFC----------------C 860

  Fly  1005 KRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVG 1069
            ||    |...|    ..||     ..|....||.|                    .|:|.|    
Mouse   861 KR----CRRQN----SPKP-----NEATESFAGES--------------------RDTATL---- 888

  Fly  1070 TKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGS--IKLKQTYEHLMENGDIAAAPRAN- 1131
                          .::.|    |::.|.....:.::|:  ..|.:..:.:...|:..|:|.:. 
Mouse   889 --------------DTRSW----KEYDSEMTLYTGQAGAPLAPLAKEEDDMECCGECDASPTSQP 935

  Fly  1132 SGRARPHDLDIK------------------------LLQAKRQQ---AEMRRNQREEDLRENHPF 1169
            |..|:..||.:|                        .:|:.|::   |.|.......||  |..|
Mouse   936 SEEAQACDLPLKTKRLPSPDDHGVEMEVFSEEDPNLTIQSARKKSDAASMLSECSTIDL--NDIF 998

  Fly  1170 FDTPLFLVPRESR---FRK------ICQKIVHARYDARLKDP--LTGKERKVQYKSLHNFLGLVT 1223
            .:....:.|::..   |.|      :|.|.:      :.|.|  |....||..|:.:.:     :
Mouse   999 RNLQKTVSPQKQPDRCFPKGLSCIFLCCKTI------KKKSPWVLWWNLRKTCYQIVKH-----S 1052

  Fly  1224 YLDWVMIFATTLSCISMMFETPNY--RVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAY 1286
            :.:..:||...||..:::||..|.  |......|:..:..|.....||:.||.:|.|.    :.|
Mouse  1053 WFESFIIFVILLSSGALIFEDVNLPSRPQVEKLLKCTDNIFTFIFLLEMILKWVAFGF----RKY 1113

  Fly  1287 IKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGF 1351
            .......||..|.|||...|    .|:|.   .:....||.:||||..:....|:.||..|....
Mouse  1114 FTSAWCWLDFLIVVVSGLSL----TNLPN---LKSFRNLRALRPLRALSQFEGMKVVVNALMSAI 1171

  Fly  1352 KEILLVSTLLILLMFIFASYGVQLYGGRLARC-NDPTISRREDCVGVFMRRVFVTKMKLTPGPDE 1415
            ..||.|..:.::...||...||..:.|:..|| |...|::..:...|               |::
Mouse  1172 PAILNVLLVCLIFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNV---------------PNQ 1221

  Fly  1416 SYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGP---------VHA-V 1470
            | ..::....|..| ..||||:|:|.|.|.:|.::|||||:.:..:.:.|.         ::| :
Mouse  1222 S-QCLVSNYTWKVP-NVNFDNVGNAYLALLQVATYKGWLDIMNAAVDSRGKDEQPAFEANLYAYL 1284

  Fly  1471 YIHIYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRP 1530
            |..::|..|....|.||:||:|.|:::.:     ....:|.:|:::.:..|:|...:|....|||
Mouse  1285 YFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKISGQDIFMTEEQKKYYNAMKKLGTKKPQKPIPRP 1349

  Fly  1531 DGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLV--IVSAVLTFVFVVEVV 1593
             ..|.:||.:|:....:|. ||.:.:::.:|::.:...:|:.:..:.:  |::.|...:|.||.:
Mouse  1350 -LNKCQAFVFDLVTSQVFD-VIILGLIVTNMIIMMAESEGQPNEVKKIFDILNIVFVVIFTVECL 1412

  Fly  1594 MKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVIL----RFFTITGKH 1654
            :|..|.. :.|:.:..|.:|.:|.|..:|..::..:..:::.....|.:|.|    |...:....
Mouse  1413 IKVFALR-QHYFTNGWNLFDCVVVVLSIISTLVSGLENSNVFPPTLFRIVRLARIGRILRLVRAA 1476

  Fly  1655 TTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLF 1719
            ..::.|:..:.:|:...|.|...:||::|.||:.|...|..||.|.||....||.:....:..||
Mouse  1477 RGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMNWFSKVKRGSGIDDIFNFDTFSGSMLCLF 1541

  Fly  1720 RIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMEN 1784
            :|.|...|:.:::..:.....|   |:..:..|.....:::||.::.:|...||:|:.:|:|:||
Mouse  1542 QITTSAGWDALLNPMLESKASC---NSSSQESCQQPQIAIVYFVSYIIISFLIVVNMYIAVILEN 1603

  Fly  1785 FSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFI---------------LRLLKG 1834
            |:......||. |...|...|...|...|        ....:||               ||:.| 
Mouse  1604 FNTATEESEDP-LGEDDFEIFYEIWEKFD--------PEATQFIQYSSLSDFADALPEPLRVAK- 1658

  Fly  1835 RLECDPQKDRLLFKYMCYEL-----DKLHNGEDVTFHDVINMLSYRS-VDIRKALQLEELLAREE 1893
                 |.:    |:::..:|     |:|| ..||.|.....:|...| :|..||:..|:.:....
Mouse  1659 -----PNR----FQFLMMDLPMVMGDRLH-CMDVLFAFTTRVLGNSSGLDTMKAMMEEKFMEANP 1713

  Fly  1894 FEYLV-----------EEEVAKMTIRTWLEGCLKKIRAQNASKQQNSL 1930
            |:.|.           |||.|.:..|.:.....|.|:.:...:..:||
Mouse  1714 FKKLYEPIVTTTKRKEEEECAAVIQRAYRRHMEKMIKLKLKGRSSSSL 1761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 65/306 (21%)
Ion_trans 734..927 CDD:278921 60/213 (28%)
Ion_trans 1240..1497 CDD:278921 75/269 (28%)
Ion_trans 1571..1793 CDD:278921 54/227 (24%)
Scn11aXP_017168851.1 Ion_trans 145..424 CDD:366146 67/317 (21%)
Ion_trans 591..825 CDD:366146 66/255 (26%)
Na_trans_assoc 830..1047 CDD:368948 51/309 (17%)
Ion_trans 1051..1315 CDD:366146 79/296 (27%)
Na_channel_gate 1307..1359 CDD:240441 12/52 (23%)
Ion_trans 1363..1612 CDD:366146 59/253 (23%)
GPHH 1623..1670 CDD:374878 10/64 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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