Protein Alignment na and Scn9a

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: NP_001277603.1
• Gene: Scn9a / 20274
• MGIID: 107636
• Length: 1984
• Species: Mus musculus
• Alignment Length: 2116
• Identity: 420/2116 - (19%)
• Similarity: 751/2116 - (35%)
• Gaps: 652/2116 - (30%)

  Fly   326 QSLKGGEPFLADYGPEESLNESADIEWVN-------------------KLWVRRLMRLCALVSLT 371
            :.|:..:|:.||......||:...|...|                   |:.|..|..:..:.::.
Mouse    73 EPLEDLDPYYADKKTFIVLNKGKAIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTIL 137

  Fly   372 S----VSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDA 432
            :    ::::.|..:.:.....|         |.::|.|.:.|:..||...||..:|:|.|
Mouse   138 TNCIFMTMSNPPDWTKNVEYTF---------TGIYTFESLIKILARGFCVGEFTFLRDPW----- 188

  Fly   433 SMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQ 497
                 .|:..::.:|..|   .:|..|..:.|.|...::|.|:........|:.:..:. :|.::
Mouse   189 -----NWLDFVVIVFAYL---TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI-QSVKK 244

  Fly   498 IYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPD---------- 551
            :.:|.:..:|.:|::.|:|:| |.|.||:.|...:.|.:   ..:.:|.|.|..:
Mouse   245 LSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKDLEQN---ETLESIMSTAESEEELKRYFYYL 306

  Fly   552 ------TFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMY 610
                  ..|....||| ||..|..|:.......|  |:..|:....:...:::..:|:.|..:..
Mouse   307 EGSKDALLCGFSTDSG-QCPEGYECVTAGRNPDY--GYTSFDTFGWAFLALFRLMTQDYWENLYQ 368

  Fly   611 RAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVITETFNE-----------IRVQFQQM- 658
            :.:      |||     .:|..:||..::.:.|:.:||:...:.|           ..::||||
Mouse   369 QTL------RAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQML 427

  Fly   659 ----------------------------------------------------------------- 658
                                                                             
Mouse   428 DRLKKEQEEAEAIAAAAAEYTSLGRSRIMGLSESSSETSRLSSKSAKERRNRRKKKKQKLSSGEE 492

  Fly   659 ----------------------WGARGH------------------------IQKTAASQILS-- 675
                                  .|..||                        .::::.:.:.|
Mouse   493 KGDDEKLSKSGSEESIRKKSFHLGVEGHHRAREKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFK 557

  Fly   676 --GNDTGWRLVTIDDN------------------------------------------------- 689
              |.|.|......||.
Mouse   558 GRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSPPVLPVNGKMHSAVD 622

  Fly   690 ----------------KHGGLAPET---------------------------CHAILRSPYFRML 711
                            .:|.|.||.                           ...:|..|:.|..
Mouse   623 CNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQR 687

  Fly   712 VMSVILANGIVTATMTFKHDGR--------------------PRDVFYERYYY-------IELVF 749
            .||   ...|:|.|:....:.|                    |..:.::::.|       ::|..
Mouse   688 AMS---RASILTNTVEELEESRQKCPPWWYRFAHTFLIWNCSPYWIKFKKFIYFIVMDPFVDLAI 749

  Fly   750 TCLLDLETLF---------------------------------KIYCLGWRGYYKHSIHKFELLL 781
            |..:.|.|||                                 |:..:....|::...:.|:.|:
Mouse   750 TICIVLNTLFMAMEHHPMTDEFKNVLAVGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLI 814

  Fly   782 AAGTTLHIVPMFYP-----SGLTYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCL 840
               .||.:|.:|..     |.|..|::|||.:|.|:.|.| ..:.||.|.. ..||:|.:....:
Mouse   815 ---VTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTLVLAII 875

  Fly   841 LIISSSISMQLF------CFLCDFTK--------FESFPEAFMSMFQILTQEAWVEVMDETMIRT 891
            :.|.:.:.||||      | :|...:        ...|..:|:.:|::|..| |:|.|.:.|...
Mouse   876 VFIFAVVGMQLFGKSYKEC-VCKINENCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVA 938

  Fly   892 SKTLTPLVAVYFILYHLFVTLIVLSLFVAVIL-----DNL---ELDEDIKKLK--QLKFREQSAE 946
            .:|:..:|   :::..:...|:||:||:|::|     |||   |.|.|...|:  ..:.:.....
Mouse   939 GQTMCLIV---YMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDTDANNLQIAVARIKRGINY 1000

  Fly   947 IKETL-PFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSE 1010
            :|:|| .|.|:.|.|.|...:.|.....||:     .||:::.:                |.::|
Mouse  1001 VKQTLREFILKSFSKKPKGSKDTKRTADPNN-----KRENYISN----------------RTLAE 1044

  Fly  1011 CWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGG 1075
            ..:.: .|.|:|.        |:....|||.|    ..:::::.|..:...|..:.|....|...
Mouse  1045 ISKDH-NFLKEKD--------KISGFSSSLDK----SFMDENDYQSFIHNPSLTVTVPIAPGESD 1096

  Fly  1076 LKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDL 1140
            |::..|...|.....|..|      .|..||.|.:.......|         |......|.|.:.
Mouse  1097 LENMNTEELSSDSDSDYSK------ERRNRSSSSECSTVDNPL---------PGEEEAEAEPINA 1146

  Fly  1141 DIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRES-------RFRKICQKIV-HARYDA 1197
            |..  :|......:||               .|...|..:|       ..||.|.:|| |:.:::
Mouse  1147 DEP--EACFTDGCVRR---------------FPCCQVNIDSGKGKVWWTIRKTCYRIVEHSWFES 1194

  Fly  1198 RLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQ-IAEYG 1261
                                          .::....||..::.||  :..:....|:: |.||.
Mouse  1195 ------------------------------FIVLMILLSSGALAFE--DIYIEKKKTIKIILEYA 1227

  Fly  1262 ---FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLM 1323
               |.....||:.||.:|.|.    |.|..:....||..|..||...|....|........:.|.
Mouse  1228 DKIFTYIFILEMLLKWVAYGY----KTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLR 1288

  Fly  1324 ILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPT- 1387
            .||.:||||..:....||.||..|......|:.|..:.::...||:..||.|:.|:...|.:.|
Mouse  1289 TLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTD 1353

  Fly  1388 --------ISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPR----RFNFDNIGDA 1440
                    ::.|.:|..:.                         .|..|.|    :.||||:|..
Mouse  1354 GSRFSVSQVANRSECFALM-------------------------NVSGNVRWKNLKVNFDNVGLG 1393

  Fly  1441 MLTLFEVLSFKGWLDVRDVLIKAVG----PVHA------VYIHIYIFLGCMIGLTLFVGVVIANY 1495
            .|:|.:|.:||||:|:....:.:|.    |::.      :|..|:|..|....|.||:||:|.|:
Mouse  1394 YLSLLQVATFKGWMDIMYAAVDSVNVNAQPIYEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF 1458

  Fly  1496 SENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVV 1555
            ::.|     ....:|.:|:::.:..|:|...:|....||| |.|.:...:|:..:..|...|.|:
Mouse  1459 NQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-GNKFQGCIFDLVTNQAFDITIMVL 1522

  Fly  1556 VLINSMLLSITWIKGEVHTERLVIVSAVLTFVFVV----EVVMKNIAFTPRGY-----WQSRRNR 1611
            :.:|.:.:   .::.|..|:.:..|...:..||::    |.|:|.|:.  |.|     |    |.
Mouse  1523 ICLNMVTM---MVEKEGQTDYMSFVLYWINVVFIILFTGECVLKLISL--RHYYFTVGW----NI 1578

  Fly  1612 YDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGKHTTLKMLMLTVGVSVC 1669
            :|.:|.:..::.:.|..::.   .||..   |.|:.|    |...:......::.|:..:.:|:.
Mouse  1579 FDFVVVILSIVGMFLAEMIE---KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1640

  Fly  1670 KSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDC 1734
            ..|.|...:||::|.||:.|...|..||...||....||.:....:..||:|.|...|:.::...
Mouse  1641 ALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1705

  Fly  1735 M-VQPPYCT-----LGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEE 1793
            : ..||.|.     .|::. |.||||.:..:.||.::.:|...:|:|:.:|:|:||||: .:.|.
Mouse  1706 LNSAPPDCDPKKVHPGSSV-EGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSV-ATEES 1768

  Fly  1794 DALLSYADIRNFQNTWNIVDIHQRGVIPVRRVK-FILRLLKGRLECDPQKDRLLFKYMCYELD-K 1856
            ...||..|...|...|...|......|...::. |...|....|...|.|.:|:      .:| .
Mouse  1769 TEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLI------AMDLP 1827

  Fly  1857 LHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYL------VEEEVAKMTIR------- 1908
            :.:|:.:...|::...:.|.  :.::.:::.|.::.|..::      |..|....|::
Mouse  1828 MVSGDRIHCLDILFAFTKRV--LGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVS 1890

  Fly  1909 -TWLEGCLKKIRAQNASKQQNSLIA--GLR---ATNEQPVMRPNIQEDKAPLGAVDKSAISTISG 1967
             |.::...::.|.:...|..:|:..  |.|   ..|::.::..|:.|:.:| ...|.:| ||||
Mouse  1891 ATIIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLPNKEDIVFDNVNENSSP-EKTDATA-STIS- 1952

  Fly  1968 AVAGACPPTSDA--------FSPTFSSTENEEKDGS 1995
                  ||:.|:        :....:..|::|||.|
Mouse  1953 ------PPSYDSVTKPDQEKYETDKTEKEDKEKDES 1982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	63/329 (19%)
		Ion_trans	705..927	CDD:459842	68/309 (22%)
		Ion_trans	1224..1497	CDD:459842	77/299 (26%)
		Ion_trans	1545..1793	CDD:459842	68/269 (25%)
Scn9a	NP_001277603.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..55
		I. /evidence=ECO:0000305	112..410		65/332 (20%)
		Ion_trans	125..410	CDD:459842	63/319 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..540		3/81 (4%)
		Na_trans_cytopl	534..693	CDD:463401	15/161 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..609		0/34 (0%)
		II. /evidence=ECO:0000305	725..988		63/271 (23%)
		Ion_trans	742..955	CDD:459842	48/221 (22%)
		Na_trans_assoc	981..1185	CDD:461936	53/269 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1039		7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1089..1145		14/70 (20%)
		III. /evidence=ECO:0000305	1178..1486		87/368 (24%)
		Ion_trans	1189..1464	CDD:459842	79/335 (24%)
		Na_channel_gate	1456..1508	CDD:240441	12/52 (23%)
		IV. /evidence=ECO:0000305	1495..1793		81/312 (26%)
		Ion_trans	1512..1768	CDD:459842	68/269 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1933..1984		17/59 (29%)