DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Scn9a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_001277603.1 Gene:Scn9a / 20274 MGIID:107636 Length:1984 Species:Mus musculus


Alignment Length:2116 Identity:420/2116 - (19%)
Similarity:751/2116 - (35%) Gaps:652/2116 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   326 QSLKGGEPFLADYGPEESLNESADIEWVN-------------------KLWVRRLMRLCALVSLT 371
            :.|:..:|:.||......||:...|...|                   |:.|..|..:..:.::.
Mouse    73 EPLEDLDPYYADKKTFIVLNKGKAIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTIL 137

  Fly   372 S----VSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDA 432
            :    ::::.|..:.:.....|         |.::|.|.:.|:..||...||..:|:|.|     
Mouse   138 TNCIFMTMSNPPDWTKNVEYTF---------TGIYTFESLIKILARGFCVGEFTFLRDPW----- 188

  Fly   433 SMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQ 497
                 .|:..::.:|..|   .:|..|..:.|.|...::|.|:........|:.:..:. :|.::
Mouse   189 -----NWLDFVVIVFAYL---TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI-QSVKK 244

  Fly   498 IYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPD---------- 551
            :.:|.:..:|.:|::.|:|:| |.|.||:.|...:.|.:   ..:.:|.|.|..:          
Mouse   245 LSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKDLEQN---ETLESIMSTAESEEELKRYFYYL 306

  Fly   552 ------TFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMY 610
                  ..|....||| ||..|..|:.......|  |:..|:....:...:::..:|:.|..:..
Mouse   307 EGSKDALLCGFSTDSG-QCPEGYECVTAGRNPDY--GYTSFDTFGWAFLALFRLMTQDYWENLYQ 368

  Fly   611 RAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVITETFNE-----------IRVQFQQM- 658
            :.:      |||     .:|..:||..::.:.|:.:||:...:.|           ..::|||| 
Mouse   369 QTL------RAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQML 427

  Fly   659 ----------------------------------------------------------------- 658
                                                                             
Mouse   428 DRLKKEQEEAEAIAAAAAEYTSLGRSRIMGLSESSSETSRLSSKSAKERRNRRKKKKQKLSSGEE 492

  Fly   659 ----------------------WGARGH------------------------IQKTAASQILS-- 675
                                  .|..||                        .::::.:.:.|  
Mouse   493 KGDDEKLSKSGSEESIRKKSFHLGVEGHHRAREKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFK 557

  Fly   676 --GNDTGWRLVTIDDN------------------------------------------------- 689
              |.|.|......||.                                                 
Mouse   558 GRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSPPVLPVNGKMHSAVD 622

  Fly   690 ----------------KHGGLAPET---------------------------CHAILRSPYFRML 711
                            .:|.|.||.                           ...:|..|:.|..
Mouse   623 CNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQR 687

  Fly   712 VMSVILANGIVTATMTFKHDGR--------------------PRDVFYERYYY-------IELVF 749
            .||   ...|:|.|:....:.|                    |..:.::::.|       ::|..
Mouse   688 AMS---RASILTNTVEELEESRQKCPPWWYRFAHTFLIWNCSPYWIKFKKFIYFIVMDPFVDLAI 749

  Fly   750 TCLLDLETLF---------------------------------KIYCLGWRGYYKHSIHKFELLL 781
            |..:.|.|||                                 |:..:....|::...:.|:.|:
Mouse   750 TICIVLNTLFMAMEHHPMTDEFKNVLAVGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLI 814

  Fly   782 AAGTTLHIVPMFYP-----SGLTYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCL 840
               .||.:|.:|..     |.|..|::|||.:|.|:.|.| ..:.||.|.. ..||:|.:....:
Mouse   815 ---VTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTLVLAII 875

  Fly   841 LIISSSISMQLF------CFLCDFTK--------FESFPEAFMSMFQILTQEAWVEVMDETMIRT 891
            :.|.:.:.||||      | :|...:        ...|..:|:.:|::|..| |:|.|.:.|...
Mouse   876 VFIFAVVGMQLFGKSYKEC-VCKINENCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVA 938

  Fly   892 SKTLTPLVAVYFILYHLFVTLIVLSLFVAVIL-----DNL---ELDEDIKKLK--QLKFREQSAE 946
            .:|:..:|   :::..:...|:||:||:|::|     |||   |.|.|...|:  ..:.:.....
Mouse   939 GQTMCLIV---YMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDTDANNLQIAVARIKRGINY 1000

  Fly   947 IKETL-PFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSE 1010
            :|:|| .|.|:.|.|.|...:.|.....||:     .||:::.:                |.::|
Mouse  1001 VKQTLREFILKSFSKKPKGSKDTKRTADPNN-----KRENYISN----------------RTLAE 1044

  Fly  1011 CWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGG 1075
            ..:.: .|.|:|.        |:....|||.|    ..:::::.|..:...|..:.|....|...
Mouse  1045 ISKDH-NFLKEKD--------KISGFSSSLDK----SFMDENDYQSFIHNPSLTVTVPIAPGESD 1096

  Fly  1076 LKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDL 1140
            |::..|...|.....|..|      .|..||.|.:.......|         |......|.|.:.
Mouse  1097 LENMNTEELSSDSDSDYSK------ERRNRSSSSECSTVDNPL---------PGEEEAEAEPINA 1146

  Fly  1141 DIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRES-------RFRKICQKIV-HARYDA 1197
            |..  :|......:||               .|...|..:|       ..||.|.:|| |:.:::
Mouse  1147 DEP--EACFTDGCVRR---------------FPCCQVNIDSGKGKVWWTIRKTCYRIVEHSWFES 1194

  Fly  1198 RLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQ-IAEYG 1261
                                          .::....||..::.||  :..:....|:: |.||.
Mouse  1195 ------------------------------FIVLMILLSSGALAFE--DIYIEKKKTIKIILEYA 1227

  Fly  1262 ---FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLM 1323
               |.....||:.||.:|.|.    |.|..:....||..|..||...|....|........:.|.
Mouse  1228 DKIFTYIFILEMLLKWVAYGY----KTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLR 1288

  Fly  1324 ILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPT- 1387
            .||.:||||..:....||.||..|......|:.|..:.::...||:..||.|:.|:...|.:.| 
Mouse  1289 TLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTD 1353

  Fly  1388 --------ISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPR----RFNFDNIGDA 1440
                    ::.|.:|..:.                         .|..|.|    :.||||:|..
Mouse  1354 GSRFSVSQVANRSECFALM-------------------------NVSGNVRWKNLKVNFDNVGLG 1393

  Fly  1441 MLTLFEVLSFKGWLDVRDVLIKAVG----PVHA------VYIHIYIFLGCMIGLTLFVGVVIANY 1495
            .|:|.:|.:||||:|:....:.:|.    |::.      :|..|:|..|....|.||:||:|.|:
Mouse  1394 YLSLLQVATFKGWMDIMYAAVDSVNVNAQPIYEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF 1458

  Fly  1496 SENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVV 1555
            ::.|     ....:|.:|:::.:..|:|...:|....||| |.|.:...:|:..:..|...|.|:
Mouse  1459 NQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-GNKFQGCIFDLVTNQAFDITIMVL 1522

  Fly  1556 VLINSMLLSITWIKGEVHTERLVIVSAVLTFVFVV----EVVMKNIAFTPRGY-----WQSRRNR 1611
            :.:|.:.:   .::.|..|:.:..|...:..||::    |.|:|.|:.  |.|     |    |.
Mouse  1523 ICLNMVTM---MVEKEGQTDYMSFVLYWINVVFIILFTGECVLKLISL--RHYYFTVGW----NI 1578

  Fly  1612 YDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGKHTTLKMLMLTVGVSVC 1669
            :|.:|.:..::.:.|..::.   .||..   |.|:.|    |...:......::.|:..:.:|:.
Mouse  1579 FDFVVVILSIVGMFLAEMIE---KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1640

  Fly  1670 KSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDC 1734
            ..|.|...:||::|.||:.|...|..||...||....||.:....:..||:|.|...|:.::...
Mouse  1641 ALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1705

  Fly  1735 M-VQPPYCT-----LGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEE 1793
            : ..||.|.     .|::. |.||||.:..:.||.::.:|...:|:|:.:|:|:||||: .:.|.
Mouse  1706 LNSAPPDCDPKKVHPGSSV-EGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSV-ATEES 1768

  Fly  1794 DALLSYADIRNFQNTWNIVDIHQRGVIPVRRVK-FILRLLKGRLECDPQKDRLLFKYMCYELD-K 1856
            ...||..|...|...|...|......|...::. |...|....|...|.|.:|:      .:| .
Mouse  1769 TEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLI------AMDLP 1827

  Fly  1857 LHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYL------VEEEVAKMTIR------- 1908
            :.:|:.:...|::...:.|.  :.::.:::.|.::.|..::      |..|....|::       
Mouse  1828 MVSGDRIHCLDILFAFTKRV--LGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVS 1890

  Fly  1909 -TWLEGCLKKIRAQNASKQQNSLIA--GLR---ATNEQPVMRPNIQEDKAPLGAVDKSAISTISG 1967
             |.::...::.|.:...|..:|:..  |.|   ..|::.::..|:.|:.:| ...|.:| |||| 
Mouse  1891 ATIIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLPNKEDIVFDNVNENSSP-EKTDATA-STIS- 1952

  Fly  1968 AVAGACPPTSDA--------FSPTFSSTENEEKDGS 1995
                  ||:.|:        :....:..|::|||.|
Mouse  1953 ------PPSYDSVTKPDQEKYETDKTEKEDKEKDES 1982

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 62/313 (20%)
Ion_trans 734..927 CDD:278921 60/260 (23%)
Ion_trans 1240..1497 CDD:278921 75/283 (27%)
Ion_trans 1571..1793 CDD:278921 64/243 (26%)
Scn9aNP_001277603.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55
I. /evidence=ECO:0000305 112..410 65/332 (20%)
Ion_trans 147..410 CDD:278921 62/297 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..540 3/81 (4%)
Na_trans_cytopl 487..606 CDD:288761 9/118 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..609 0/34 (0%)
II. /evidence=ECO:0000305 725..988 63/271 (23%)
Ion_trans 760..955 CDD:278921 42/203 (21%)
Na_trans_assoc 981..1185 CDD:284034 53/269 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1039 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1089..1145 14/70 (20%)
III. /evidence=ECO:0000305 1178..1486 87/368 (24%)
Ion_trans 1224..1464 CDD:278921 72/268 (27%)
Na_channel_gate 1456..1508 CDD:240441 12/52 (23%)
IV. /evidence=ECO:0000305 1495..1793 81/312 (26%)
Ion_trans 1530..1768 CDD:278921 64/251 (25%)
GPHH 1780..1835 CDD:293510 12/60 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1933..1984 17/59 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.