Protein Alignment na and Scn5a

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_006512056.1
• Gene: Scn5a / 20271
• MGIID: 98251
• Length: 2085
• Species: Mus musculus
• Alignment Length: 2119
• Identity: 429/2119 - (20%)
• Similarity: 750/2119 - (35%)
• Gaps: 664/2119 - (31%)

  Fly   331 GEPFLADYGPEES-------LNESADI---EWVNKLW-------VRR------------LMRLCA 366
            ||| |.|..|..|       ||:...|   ...|.|:       |||            ::.:|.
Mouse   142 GEP-LEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVRRAAVKILVHSLFSMLIMCT 205

  Fly   367 -LVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQF 430
             |.:...::.:.|..:.:|....|         |.::|.|.:.|:..||.......:|:|.|...
Mouse   206 ILTNCVFMAQHDPPPWTKYVEYTF---------TAIYTFESLVKILARGFCLHAFTFLRDPWNWL 261

  Fly   431 DASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSS 495
            |.|::             |:....:|..|..:.|.|...::|.|:.....|..|:.:..:. :|.
Mouse   262 DFSVI-------------VMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI-QSV 312

  Fly   496 QQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNTEYDLYKRPI----LTINSLAI----PD 551
            :::.:|.:..:|.:|::.|:|:| |.|.|::.||.|.||.:.....:    :..|||.:    |.
Mouse   313 KKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGIVWNSLDVYLNDPA 377

  Fly   552 TF-----------CSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGW 605
            .:           |....|:| .|..|..|:|......:  |:..|:..|.:...:::..:|:.|
Mouse   378 NYLLKNGTTDVLLCGNSSDAG-TCPEGYRCLKAGENPDH--GYTSFDSFAWAFLALFRLMTQDCW 439

  Fly   606 VFIMYRAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVITETF-----------NEIRVQ 654
            ..:..:.:      |:|     .:|..:||..::.:.|:.:||:...:           .|...:
Mouse   440 ERLYQQTL------RSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 498

  Fly   655 FQQMWGARGHIQKTAASQILSGNDTGWRLVTIDDNKHGGLAPET--------------------- 698
            ||:   |...::|...:..:.|.||    |:....:...|||.|
Mouse   499 FQE---AMEMLKKEHEALTIRGVDT----VSRSSLEMSPLAPVTNHERRSKRRKRLSSGTEDGGD 556

  Fly   699 --------------------CHAILRSPY-----------FR----------------------- 709
                                .|.:.|:..           ||
Mouse   557 DRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESES 621

  Fly   710 ----MLV----------------------------MSVILANGIVT--------ATMTFKHDGRP 734
                :||                            .|.:..||:|:        ||....|..||
Mouse   622 HRTSLLVPWPLRRPSTQGQPGFGTSAPGHVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSHLLRP 686

  Fly   735 ----------------------------RDVFYE------------------------------- 740
                                        .|.|.|
Mouse   687 IVLDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELEESHRKCPPC 751

  Fly   741 -----RYYYI------------------------------------------------------- 745
                 ::|.|
Mouse   752 WNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHYNMTAEFEEMLQV 816

  Fly   746 -ELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFE--LLLAAGTTLHIVPMFYPSGLTYFQVLRVV 807
             .||||.:...|..|||..|....|::...:.|:  :::.:...|.:..|...|.|..|::|||.
Mouse   817 GNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMGNLSVLRSFRLLRVF 881

  Fly   808 RLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF------------------- 852
            :|.|:.|.|...: ||.|.. ..||:|.:....::.|.:.:.||||
Mouse   882 KLAKSWPTLNTLI-KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPR 945

  Fly   853 CFLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSL 917
            ..:.||.      .||:.:|:||..| |:|.|.:.|..:.::|..||   |:|..:...|:||:|
Mouse   946 WHMMDFF------HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLV---FLLVMVIGNLVVLNL 1000

  Fly   918 FVAVIL-----DNLELDEDIKKLKQLKFREQSAEIKETLPFRLR--------IFEKFPDSPQMTI 969
            |:|::|     |||...::..::..|:.  ..|.|:..|.|..|        :..:.|..|....
Mouse  1001 FLALLLSSFSADNLTAPDEDGEMNNLQL--ALARIQRGLRFVKRTTWDFCCGLLRRRPKKPAALA 1063

  Fly   970 LH-RIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKV 1033
            .| ::|:....|:                       ..|..|       ..|..|.|...:..:.
Mouse  1064 THSQLPSCIAAPR-----------------------SPPPPE-------VEKAPPARKETRFEED 1098

  Fly  1034 RAAGSSLR--------KLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTIT----HSK 1086
            :..|....        .:|:..  :|:::|.....:|     :||:.....|.|.:..    |..
Mouse  1099 KRPGQGTPGDTEPVCVPIAVAE--SDTDDQEEDEENS-----LGTEEEESSKQQESQVVSGGHEP 1156

  Fly  1087 PWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQ 1151
            |  .:.:.:...|...|..:.:...:..::...|     |.|||......|.|     ..::...
Mouse  1157 P--QEPRAWSQVSETTSSEAEASTSQADWQQERE-----AEPRAPGCGETPED-----SYSEGST 1209

  Fly  1152 AEMRRN--------QREEDLRENHPFFD------TPLFLVPRES-------RFRKICQKIVHARY 1195
            |:|...        ...||:::....|.      .|..:|....       |.||.|.:||.
Mouse  1210 ADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQAPGKVWWRLRKTCYRIVE--- 1271

  Fly  1196 DARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQI-AE 1259
                                |      ::.:..:||...||..::.||  :..:.:..|::: .|
Mouse  1272 --------------------H------SWFETFIIFMILLSSGALAFE--DIYLEERKTIKVLLE 1308

  Fly  1260 YG---FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQL 1321
            |.   |.....||:.||.:|.|.    |.|..:....||..|..||...|....|........:.
Mouse  1309 YADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1369

  Fly  1322 LMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDP 1386
            |..||.:||||..:....||.||..|......|:.|..:.::...||:..||.|:.|:..||.:.
Mouse  1370 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1434

  Fly  1387 T----------ISRREDCVGVFMR-RVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDA 1440
            |          ::.:.:|....:. .::.||:|:                       ||||:|..
Mouse  1435 TEGDLPLNYTIVNNKSECESFNVTGELYWTKVKV-----------------------NFDNVGAG 1476

  Fly  1441 MLTLFEVLSFKGWLDVRDVLIKAVGPVHA----------VYIHIYIFLGCMIGLTLFVGVVIANY 1495
            .|.|.:|.:||||:|:....:.:.|....          :|..::|..|....|.||:||:|.|:
Mouse  1477 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNF 1541

  Fly  1496 SENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVV 1555
            ::.|     ....:|.:|:::.:..|:|...:|....||| ..|.:.|.:||.....|...|..:
Mouse  1542 NQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-LNKYQGFIFDIVTKQAFDVTIMFL 1605

  Fly  1556 VLINSMLLSITWIKGEVHTERLVIVSAV-LTFV--FVVEVVMKNIAFTPRGYWQSRRNRYDLLVT 1617
            :.:|.:.:.:.  ..:...|::.|::.: |.||  |..|.::| :|.....|:.:..|.:|.:|.
Mouse  1606 ICLNMVTMMVE--TDDQSPEKVNILAKINLLFVAIFTGECIVK-MAALRHYYFTNSWNIFDFVVV 1667

  Fly  1618 VAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGKHTTLKMLMLTVGVSVCKSFFII 1675
            :..::..:|..|::   .|||.   |.|:.|    |...:......::.|:..:.:|:...|.|.
Mouse  1668 ILSIVGTVLSDIIQ---KYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIG 1729

  Fly  1676 FGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCM-VQPP 1739
            ..:||::|.|::.|...|..||:..||....||.:....:..||:|.|...|:.::...: ..||
Mouse  1730 LLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPP 1794

  Fly  1740 YC--TLGN-NYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYAD 1801
            ||  .|.| |....:||:....:::|.|:.:|...||:|:.:|||:||||: .:.|....||..|
Mouse  1795 YCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSV-ATEESTEPLSEDD 1858

  Fly  1802 IRNFQNTWNIVDIHQRGVIPVRRVKFI---------------LRLLKGRLECDPQKDRLLFKYMC 1851
            ...|...|...|        ....:||               ||:.|      |.:..|:
Mouse  1859 FDMFYEIWEKFD--------PEATQFIEYLALSDFADALSEPLRIAK------PNQISLI----- 1904

  Fly  1852 YELD-KLHNGEDVTFHDVINMLSYR------SVDIRKALQLEELL-----AREEFEYLV------ 1898
             .:| .:.:|:.:...|::...:.|      .:|..| :|:||..     ::..:|.:.
Mouse  1905 -NMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALK-IQMEEKFMAANPSKISYEPITTTLRRK 1967

  Fly  1899 EEEVAKMTIRTWLEGCLKKIRAQNAS---KQQNSLIAGLRATNEQP----------VMRPNIQED 1950
            .|||:...|:......|.:...::||   :||    ||....:::.          :|..|....
Mouse  1968 HEEVSATVIQRAFRRHLLQRSVKHASFLFRQQ----AGSSGLSDEDAPEREGLIAYMMNENFSRR 2028

  Fly  1951 KAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTEN 1989
            ..||.:   |:||:.|      .||:.|  |.|.::::|
Mouse  2029 SGPLSS---SSISSTS------FPPSYD--SVTRATSDN 2056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	65/329 (20%)
		Ion_trans	705..927	CDD:459842	78/442 (18%)
		Ion_trans	1224..1497	CDD:459842	76/297 (26%)
		Ion_trans	1545..1793	CDD:459842	68/261 (26%)
Scn5a	XP_006512056.1	Ion_trans	195..488	CDD:459842	64/324 (20%)
		Na_trans_cytopl	574..732	CDD:463401	18/157 (11%)
		Ion_trans	781..994	CDD:459842	51/223 (23%)
		Na_trans_assoc	1020..1268	CDD:461936	47/298 (16%)
		Ion_trans	1272..1547	CDD:459842	78/309 (25%)
		Na_channel_gate	1539..1591	CDD:240441	12/52 (23%)
		Ion_trans	1596..1850	CDD:459842	68/260 (26%)