DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and Scn10a

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	NP_001192250.1	Gene:	Scn10a / 20264	MGIID:	108029	Length:	1958	Species:	Mus musculus

Alignment Length:	2081	Identity:	436/2081 - (20%)
Similarity:	739/2081 - (35%)	Gaps:	617/2081 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 GEPFLADYGPEES-------LNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQ 388
            ||| |.|..|..|       |::|..|...:..|...|.....|:..|::.::....|..:.::.
Mouse    76 GEP-LEDLDPFYSTHRTFIVLDKSRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITVT 139

  Fly   389 FITFA-----------SDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISI 442
            .:...           .:.|.|:::|.|.:.|:..||....|..||:|.|...|.|:::..::..
Mouse   140 ILVNCVCMTRTDLPEKLEYAFTVVYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGA 204

  Fly   443 ILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLF 507
            .:.    |..:.......::||.:.:.:|..|:|.:...:          .|.:::.:||:..:|
Mouse   205 AID----LRGISGLRTFRVLRALKTVSVIPGLKVIVGALI----------HSVRKLADVTILTVF 255

  Fly   508 FMSLYGLLGVQFF-GELKNHCVMNNTE------------YDLYKRPILTINSLAIPDTFCSMDPD 559
            .:|::.|:|:|.| |.|||.|:.|.|:            .|::.:|..|      ....|....|
Mouse   256 CLSVFALVGLQLFKGNLKNKCIKNGTDPHKADNLSSEMAGDIFIKPGTT------DPLLCGNGSD 314

  Fly   560 SGYQCSPGMVCMKM----DFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWR 620
            :|: |....||.|.    ||      .:..|:..|.:..::::..:|:.|..:..:.:      |
Mouse   315 AGH-CPNDYVCRKTSDNPDF------NYTSFDSFAWAFLSLFRLMTQDSWERLYQQTL------R 366

  Fly   621 AA-----FYFSTMIFFLAWLVKNVFIAVIT----------------------------------- 645
            |:     .:|..:||..::.:.|:.:||:|
Mouse   367 ASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEEQSQATIAEIEAKEKKFKEALEVLQKEQEVL 431

  Fly   646 -----------------------------------------------ETFNEIRVQFQQMWGARG 663
                                                           :.:|:.|:.|..:...|.
Mouse   432 AALGIDTTSLYSHNGSPLAPKNANERRPRVKSRMSEGSTDDNRSLQSDPYNQRRMSFLGLSSGRR 496

  Fly   664 HI------------------------------QKTAASQILSGNDTG------------------ 680
            ..                              |::..|.||.|...|
Mouse   497 RASHSSVFHFRAPSQDVSFPDGILDDGVFHGDQESRRSSILLGRGAGQAGPLPRSPLPQSPNPGP 561

  Fly   681 ------------WRLVT-----------------------------------------IDDNKHG 692
                        ..|.|                                         |::.:..
Mouse   562 RRGEEGQRGVPTGELATGAPEGPALDAAGQKNFLSADYLNEPFRAQRAMSVVSIMTSVIEELEES 626

  Fly   693 GLAPETCHAILRSPY-----------FRMLV----------MSVILANGIVTATMTFKHDGRP-R 735
            .|....|...|...|           |:|::          :::.|...:.|..|..:|  .| .
Mouse   627 KLKCPPCLISLAQKYLIWECCPKWKKFKMVLFELVTDPFAELTITLCIVVNTVFMAMEH--YPMT 689

  Fly   736 DVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYP--SGL 798
            |.|........:|||....:|..|||.......|::...:.|:.::...:.|.:......  |.|
Mouse   690 DAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSTSKKGSLSVL 754

  Fly   799 TYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF-----C---- 853
            ..|::|||.:|.|:.|.| ..:.||.|.. ..||:|......::.|.:.:..||.     |
Mouse   755 RTFRLLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSENYGCRRDG 818

  Fly   854 -----------FLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYH 907
                       .:|||  |.|    |:.:|:||..| |:|.|...|         .|:..:|...
Mouse   819 ISVWNGERLRWHMCDF--FHS----FLVVFRILCGE-WIENMWVCM---------EVSQDYICLT 867

  Fly   908 LFVT------LIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQ 966
            ||:|      |:||:||:|::|::...|       .|...|...|: ..|...|...:.|.....
Mouse   868 LFLTVMVLGNLVVLNLFIALLLNSFSAD-------NLTAPEDDGEV-NNLQVALARIQVFGHRAS 924

  Fly   967 MTILHRIPNDFML--PKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNK 1029
            ..|...|.:...|  |||            ||:..:    |.|::.|...|.:           .
Mouse   925 RAITSYIRSHCRLRWPKV------------ETQLGM----KPPLTSCKAENHI-----------A 962

  Fly  1030 TAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGT-ITHSKPWRVDQK 1093
            |..|.||..:|.|.|:                           ||..::.|. ||....|
Mouse   963 TDAVNAAVGNLAKPAL---------------------------GGPKENHGDFITDPNVW----- 995

  Fly  1094 KFGSRSIRRSVRSGSI---KLKQTYEHLMENGDIAAAPRA--------------NSGRARPHDL- 1140
                  :...:..|..   :|::..||..::.....:|:.              .:.|:.|..:
Mouse   996 ------VSVPIAEGESDLDELEEDVEHASQSSWQEESPKGQQELLQQVQKCEDHQAARSPPSGMS 1054

  Fly  1141 --DIKLLQAKRQQAEMRRNQR----------------------EEDLR---ENHPFFDTPLFLVP 1178
              |:.....:|.|.|  .:.|                      ||.||   |.....|.|....|
Mouse  1055 SEDLAPYLGERWQRE--ESPRVPAEGVDDTSSSEGSTVDCPDPEEILRKIPELAEELDEPDDCFP 1117

  Fly  1179 RESRFRKICQKIVHARYDARLKDP-LTG-KERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMM 1241
            .....|..|.|:..:::      | .|| :.||..|:.:.:     ::.:..:||...||..::.
Mouse  1118 EGCTRRCPCCKVNTSKF------PWATGWQVRKTCYRIVEH-----SWFESFIIFMILLSSGALA 1171

  Fly  1242 FETPNYRVMDHPTLQ-IAEYG---FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVS 1302
            || .|| :.:.|.:: :.||.   |......|:.||.:|.|.    |.|..:....||..|..:|
Mouse  1172 FE-DNY-LEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWLDFLIVNIS 1230

  Fly  1303 TSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFI 1367
            .:.|....|.....::.:.|..||.:||||..:....||.||..|......|:.|..:.::...|
Mouse  1231 LTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLI 1295

  Fly  1368 FASYGVQLYGGRLARC-----------NDPTISRREDC-----VGVFMRRVFVTKMKLTPGPDES 1416
            |:..||.|:.|:.:||           |...::.:.||     .|.|.
Mouse  1296 FSIMGVNLFAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNTGHFF----------------- 1343

  Fly  1417 YPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDV-------RDVLIKAVGP--VHAVYI 1472
                     |.|. :.||||:....|.|.:|.:||||:|:       ||:..:   |  ..::|:
Mouse  1344 ---------WVNV-KVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSRDINSQ---PNWEESLYM 1395

  Fly  1473 HIY----IFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPP 1528
            ::|    |..|....|.|||||:|.|:::.|     ....:|.:|:::.:..|:|...:|....|
Mouse  1396 YLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKIRGQDIFMTEEQKKYYNAMKKLGSKKPQKPIP 1460

  Fly  1529 RPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSI-TWIKGEVHTERLVIVSAVLTFVFVVEV 1592
            || ..|.:.|.:||.....|..:|..::.:|.:.:.: |..:.|..|:.|..::.....||..|.
Mouse  1461 RP-LNKYQGFVFDIVTRQAFDIIIMALICLNMITMMVETDNQSEEKTKVLGRINQFFVAVFTGEC 1524

  Fly  1593 VMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTI------- 1650
            |||..|.. :.|:.:..|.:|.:|.:..:..::...||.:..|||...::.::|...|
Mouse  1525 VMKMFALR-QYYFTNGWNVFDFIVVILSISSLLFSAILSSLESYFSPTLLRVIRLARIGRILRLI 1588

  Fly  1651 ---TGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPV 1712
               .|..|.|..||:    |:...|.|...:||::|.|::.|...|..|....||....||.:..
Mouse  1589 RAAKGIRTLLFALMM----SLPALFNIGLLLFLVMFIYSIFGMASFANVIDEAGIDDMFNFKTFG 1649

  Fly  1713 TGVAMLFRIVTGEDWNKIMHDCM-VQPPYC---TLGNNYWETDCGNFTASLIYFCTFYVIITYIV 1773
            ..:..||:|.|...|:.::...: ..||||   ...:|..:.:||:....:::|.|:.:|...||
Mouse  1650 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNRPNSNGSKGNCGSPAVGILFFTTYIIISFLIV 1714

  Fly  1774 LNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLEC 1838
            :|:.:|:|:|||:: .:.|....||..|...|..||...|......|....:......|.|.|..
Mouse  1715 VNMYIAVILENFNV-ATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRI 1778

  Fly  1839 DPQKDRLLFKYMCYEL---DKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEE 1900
             |:.::.:...|...|   ||:| ..|:.|....|:|.       ::.:|:.|....|.:::...
Mouse  1779 -PKPNQNILIQMDLPLVPGDKIH-CLDILFAFTKNVLG-------ESGELDSLKTNMEEKFMATN 1834

  Fly  1901 ------EVAKMTIRTWLEGCLKKI--RAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPL--- 1954
                  |....|:|...|.....|  :|......|.||:.      ..|:..|..:||...|
Mouse  1835 LSKASYEPIATTLRCKQEDISATIIQKAYRNYMLQRSLML------SNPLHVPRAEEDGVSLPRE 1893

  Fly  1955 -----------GAVDKSAISTISGAVAGACPPTSDAFS---------PTFSSTENEE----KDGS 1995
                       |..|||     ..|.|.:.||:.|:.:         .|.||.:||:    |:|.
Mouse  1894 GYVTFMANDNGGLPDKS-----ETASATSFPPSYDSVTRGLSDRANISTSSSMQNEDEVTAKEGK 1953

  Fly  1996 S 1996
            |
Mouse  1954 S 1954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	64/395 (16%)
		Ion_trans	734..927	CDD:278921	59/222 (27%)
		Ion_trans	1240..1497	CDD:278921	77/289 (27%)
		Ion_trans	1571..1793	CDD:278921	63/235 (27%)
Scn10a	NP_001192250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..54
		I. /evidence=ECO:0000305	116..404		64/320 (20%)
		Ion_trans	147..406	CDD:278921	61/291 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..483		0/38 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..583		4/43 (9%)
		II. /evidence=ECO:0000305	646..910		69/290 (24%)
		Ion_trans	681..893	CDD:278921	61/230 (27%)
		Na_trans_assoc	903..1148	CDD:284034	57/318 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1006..1094		11/89 (12%)
		III. /evidence=ECO:0000305	1141..1450		88/349 (25%)
		Ion_trans	1170..1428	CDD:278921	78/293 (27%)
		Na_channel_gate	1420..1472	CDD:240441	12/52 (23%)
		IV. /evidence=ECO:0000305	1459..1758		82/305 (27%)
		Ion_trans	1494..1733	CDD:278921	64/244 (26%)
		GPHH	1743..1800	CDD:293510	13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1901..1958		17/59 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920