Protein Alignment na and unc-77

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: NP_001293824.1
• Gene: unc-77 / 177379
• WormBaseID: WBGene00006809
• Length: 1867
• Species: Caenorhabditis elegans
• Alignment Length: 2036
• Identity: 871/2036 - (42%)
• Similarity: 1202/2036 - (59%)
• Gaps: 297/2036 - (14%)

  Fly   303 TGVP-----PIGLGIA-TGIGNKIMLGRKQSLKGGEP-FLADYGPEESLN--------------- 345
            ||.|     |..|.:| ..:.:..||.||.|...|.| ..|.:|..||:.
 Worm    13 TGRPKEMSAPTRLLVAKAAVLSSAMLARKNSSSRGAPGSAAGFGARESIAAISDMLSSQHKKPVR 77

  Fly   346 ----ESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEM 406
                ||..:||.        :::...:|:.:|.::||:|.|.:..|.:|..|:|.....:|..:.
 Worm    78 SSYVESDRVEWA--------LKIACTISMITVCIHTPRTIELFQPLNYIILAADFISVSIFMLDS 134

  Fly   407 IAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLS------IMRAP 465
            :.::|..|:...:..||.:.|.||...:.....:|.:|..:::::....|.:|:      .:|:.
 Worm   135 VLRIHYEGIFRCDSSYLSNRWSQFSVFISIIHLLSFLLHCYQLIDNFFPFLHLNYRAWYGAIRSI 199

  Fly   466 RPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFFGELKNHCVMN 530
            ||.|:||.:.:.:||.:||:||.|:.||||||:.||||||:|||:||.:.|:|.||.:..|||..
 Worm   200 RPFIIIRLIPLVVKFKLPKNRIEQLLKRSSQQVKNVTLFFVFFMTLYAIFGIQLFGRMDYHCVQP 264

  Fly   531 NTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNG-FEDIATSIF 594
            .|:.:     .:||..||||||.|:.:...||:|...||||::: |::...||.| |.|...|:|
 Worm   265 KTDPN-----NVTIMDLAIPDTMCAPEGIGGYECPAPMVCMQLN-LNAKGEGFYGMFNDFGASVF 323

  Fly   595 TVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMW 659
            |||.|||:||||:::|..:||||::.|..||.|:||||||||||||||||||||.||||||.:||
 Worm   324 TVYLAASEEGWVYVLYDCMDSLPSYLAFLYFCTLIFFLAWLVKNVFIAVITETFAEIRVQFSEMW 388

  Fly   660 ---------GARGHIQKTAASQILSGNDTGWRLVTIDDNKHGGLAPE----TCHAILRSPYFRML 711
                     |.|..::||         |.||||:.:|    |.:.||    ....:|||.||:..
 Worm   389 QKKEVTLDEGFRKKLEKT---------DDGWRLIRLD----GEVEPEGPKQKLQWMLRSMYFQCF 440

  Fly   712 VMSVILANGIVTATMTFKHD--GRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSI 774
            |:..::.|.|..|...::||  .:||..   .:|..|:.||.|.::|.:.||.|.|:|.:.:..|
 Worm   441 VIIFVVINAIGNAMFVYRHDETDKPRKY---NFYLFEVGFTILFNVECIIKILCYGFRNFIRRGI 502

  Fly   775 HKFELLLAAGTTLHIVPMFYPSG-LTYFQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLIIFTM 838
            .||||:|..|::|:.|..||... .||||..|::|||||||:||.||:|||.||||||.|:|||:
 Worm   503 FKFELILCLGSSLNCVKFFYERNYFTYFQTFRLLRLIKASPILEDFVWKIFSPGKKLGGLVIFTI 567

  Fly   839 CLLIISSSISMQLFCFLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYF 903
            ..:...|:||:|||..:.:...|.:||:||||||||:|||.|.:.:.|.:..|...|.||||:||
 Worm   568 AFICCYSAISLQLFYSVPNLHHFRTFPQAFMSMFQIITQEGWTDFVVEVLRATDDNLVPLVALYF 632

  Fly   904 ILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMT 968
            :.||||||||||||||||||||||:||::||:|||:.||.:..::.|||:|||:|||||..|||.
 Worm   633 VAYHLFVTLIVLSLFVAVILDNLEMDEELKKVKQLRAREATTSMRSTLPWRLRVFEKFPTRPQMA 697

  Fly   969 ILHRIPNDFMLPKVRESFMKHFVIE--LETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTA 1031
            .:.:..:||.:||||.||...|.::  |||.|.:            ||:..|    |.|||....
 Worm   698 AMRKADSDFPMPKVRGSFTHQFAVDHSLETTDVI------------ESDFEF----PKRIMKSAG 746

  Fly  1032 K---------VRAAGSSLRKLAITHIINDSNNQRLMLGDS-AMLPVVGTKGGGGLKSQGTITHSK 1086
            |         .|..||:..:.::.:::..|:..|..|.:| :.||..       .:|.|::...|
 Worm   747 KRKISKSGLTFRQIGSTSLRCSLNNLLEMSDRTRQSLSNSLSFLPHF-------TRSSGSLYPRK 804

  Fly  1087 PWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIA----AAPRANSGRARPHDLDIKLLQA 1147
            ......:....:.::.:||:     || :....||||::    :||:.|   |:..::||:.||.
 Worm   805 DALPKSRSMTGKFLQTAVRN-----KQ-FNMYSENGDLSRPSDSAPKKN---AKQGEIDIRALQQ 860

  Fly  1148 KRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQY 1212
            |||.||:.||:.|||:||||||||.|||||.|.|:.|:.|:|:||::||::......|.:.|.::
 Worm   861 KRQLAEITRNRIEEDMRENHPFFDRPLFLVGRASQLREFCKKMVHSKYDSQDDGTNGGAKTKKRF 925

  Fly  1213 KSLHNFLGLVTYLDWVMIFATTLSCISMMFETP-----NYRVMDHPTLQIAEYGFVIFMSLELAL 1272
            |.:...:|::.|:||.|...|.:|||||:||:|     ...||::..|||::|.||:.|:.||.:
 Worm   926 KEIRALIGIMPYIDWAMATVTIVSCISMLFESPWPTTGENLVMNNGYLQISDYFFVLSMTFELCV 990

  Fly  1273 KILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLV 1337
            ||:|:||||||||.::||...:::|||..|..||.|||.::..||.||.|||.|.:|||||:|||
 Worm   991 KIIANGLFFTPKAVVRDVGGVMNLFIYFTSVIFLAWMPKHVEINSLAQFLMICRAMRPLRIYTLV 1055

  Fly  1338 PHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRV 1402
            ||:|:||.|..|||||||||:.|:|::||||||:|||:.||:||.|||||:|.||:|.|||.:::
 Worm  1056 PHIRRVVLEFFRGFKEILLVTILMIVVMFIFASFGVQIVGGKLAACNDPTVSSRENCTGVFWQKL 1120

  Fly  1403 FVTKMKLTPGPDES-YPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGP 1466
            |||::::.....|: :|.::|||||.|||.||||::|:|||.|||.||||||..:||:|....||
 Worm  1121 FVTRLEVYGKDTEAMHPKIMVPRVWTNPRNFNFDHVGNAMLALFETLSFKGWNVIRDILWSRHGP 1185

  Fly  1467 VHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKRLKIAQPLHLPPRP- 1530
            ...|:||||:|:|||||||||||||||||::|:||||||||||||.|||.|||:|||||:||:|
 Worm  1186 WAVVFIHIYVFIGCMIGLTLFVGVVIANYTQNRGTALLTVDQRRWHDLKARLKMAQPLHVPPKPS 1250

  Fly  1531 DGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIV------SAVLTFVFV 1589
            :..::|...||:|....|.:..|::|::||..|.|.| ..|...:|...|      :|.:..:||
 Worm  1251 ESARLRTKLYDLTMSRWFNQAFALLVVLNSFTLVIPW-NVEEEEQRATYVFTVTALAAFMNMLFV 1314

  Fly  1590 VEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIIL---------------QTILRNDLSYFFG 1639
            :|:::|.||:|..|:|||||||.|||:||.|||||.|               |..|:. .:|.||
 Worm  1315 IEIILKVIAYTFSGFWQSRRNRVDLLITVFGVIWIFLHFFVALPSSKIDVDVQVELKK-FTYTFG 1378

  Fly  1640 FMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGR 1704
            ::|||||||||..:::|||||||||.:|:.:|||||..:||||.|||..|.|||..||||..:.:
 Worm  1379 YLVVILRFFTIASRNSTLKMLMLTVIMSMFRSFFIITALFLLVLFYAYTGVILFPMVKYGMAVSK 1443

  Fly  1705 RANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYC--TLGNNYWETDCGNFTASLIYFCTFYV 1767
            ..||.:....:.:|||.:||||||.||||||...|:|  ..|.||||||||||..::||||:||:
 Worm  1444 HVNFRTASEALVVLFRCLTGEDWNDIMHDCMRSAPFCYWNEGMNYWETDCGNFYGAIIYFCSFYL 1508

  Fly  1768 IITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLL 1832
            ||||||.|||||:||||||||||:|||||||||||||||..||:||..|:..|||.||||:||||
 Worm  1509 IITYIVRNLLVAVIMENFSLFYSSEEDALLSYADIRNFQYVWNMVDQEQKRTIPVERVKFLLRLL 1573

  Fly  1833 KGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYL 1897
            |||||.||:|||:|||:||||:::|||||:|:||||:.|||||||||||:|||||||.|||.|::
 Worm  1574 KGRLEVDPEKDRILFKHMCYEMERLHNGEEVSFHDVLYMLSYRSVDIRKSLQLEELLQREELEFI 1638

  Fly  1898 VEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAI 1962
            :||||||.||||||||||:|:|  |.|::                               |...:
 Worm  1639 IEEEVAKQTIRTWLEGCLRKMR--NPSQK-------------------------------DAEGV 1670

  Fly  1963 STISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSET--------SIAGTGSSATGA 2019
            ....|.            .|...|:      |.||    :.|.||        :|.|      .:
 Worm  1671 LPFGGG------------HPVIHSS------GHSS----ISHEETVAQRLRFENIRG------DS 1707

  Fly  2020 ATATGTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTG--SSAGRKFLAPTSSDPQQRSTLS 2082
            .....|.|.....||.::..|   ....:||...:....||  ..|.|||:..:||:.:|
 Worm  1708 VDTEETESSEEETPPPIRKKA---AVKNRRGSIPDVLSRTGLFQEAARKFMVGSSSEKKQ----- 1764

  Fly  2083 DKERLHITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAA 2147
                    .:.|...::..||....    ::.|.|.|:   ..:|..|||    .:..|.:..
 Worm  1765 --------VKSRSPETVQLLPKRAN----SEIRKGSGQ---PKNFHLQLN----VYDLPDVEE-- 1808

  Fly  2148 AAAALHGYGHGHGHGHGGHGGHGGHGE----------HQMHHHHGGALGSPSAMMSQMIGGSGKL 2202
                                    .||          ...:..|...:.:||..:....|....|
 Worm  1809 ------------------------RGEDSPFSPKNLSDDFNGEHSPLVITPSLPVPPTHGSPRPL 1849

  Fly  2203 LPFNNQANAVYEVHDWWQEQV 2223
            :|    .....::..||...|
 Worm  1850 MP----CETTKDIEKWWNSLV 1866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	126/299 (42%)
		Ion_trans	705..927	CDD:459842	112/224 (50%)
		Ion_trans	1224..1497	CDD:459842	162/278 (58%)
		Ion_trans	1545..1793	CDD:459842	139/270 (51%)
unc-77	NP_001293824.1	Ion_trans	87..383	CDD:459842	128/309 (41%)
		Ion_trans	434..660	CDD:459842	115/228 (50%)
		Ion_trans	936..1214	CDD:459842	160/277 (58%)
		Ion_trans	1265..1534	CDD:459842	139/270 (51%)