Protein Alignment na and nca-2

DIOPT Version :9

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: NP_498054.2
• Gene: nca-2 / 175674
• WormBaseID: WBGene00003558
• Length: 1785
• Species: Caenorhabditis elegans
• Alignment Length: 1747
• Identity: 839/1747 - (48%)
• Similarity: 1141/1747 - (65%)
• Gaps: 111/1747 - (6%)

  Fly   308 IGLGI--ATGIGNKIMLGRKQSLKG---------GEPF------LADYGPEESLNESADIEWVNK 355
            :||..  |..:...::..||.|:.|         ||..      :.:..|...:|:|.::  :::
 Worm     9 LGLSACRAAALSTTMLTRRKSSIDGTKTERNRRRGESIGGAFTDMINIEPTSIINKSTEL--LHE 71

  Fly   356 LWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEV 420
            .::|.::|:..|:|:.|:.|:||:|.:.:|.|.:|..|:|..|||:|..|....::..|:...:.
 Worm    72 RFLRDMVRVACLLSMISLCLHTPETIKMWPPLNYIILANDVIVTLIFIGEAAVTINQNGLFDNQN 136

  Fly   421 PYLKDHWCQFDASMVSFLWISIILQIFEVLEI-VPK-----FSYLSIMRAPRPLIMIRFLRVFLK 479
            .||:|.|.||:..::....:|.::.|:|:..| .|.     :.:|..:|:.||.|.:||:|..::
 Worm   137 SYLRDRWYQFEFFLLINHILSCVIHIYELCSIWFPALNFVYYPWLGALRSARPFIFLRFIRSIVR 201

  Fly   480 FSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFFGELKNHCVMNNTEYDLYKRPILTI 544
            |.:||:||..|.|||||||.|||:||:||:..|.::|||.||.|..|||:|.|:.:     .:||
 Worm   202 FKLPKNRIKLIIKRSSQQIQNVTIFFMFFVFSYAIMGVQLFGRLNYHCVVNGTDPN-----NVTI 261

  Fly   545 NSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNG-FEDIATSIFTVYQAASQEGWVFI 608
            ..||||||.||.....||:|...||||::. |.....||.| |.|.|:|:||||.||||||||::
 Worm   262 ADLAIPDTMCSQKGAGGYECPGNMVCMRLQ-LKPQEEGFYGQFSDFASSLFTVYLAASQEGWVYV 325

  Fly   609 MYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQI 673
            :|..:||||::.|.|||.|:||||||||||||||||||||.||||||.:||..|........:|.
 Worm   326 LYDCLDSLPSFLAFFYFVTLIFFLAWLVKNVFIAVITETFAEIRVQFSEMWQTREATTDHVYTQK 390

  Fly   674 LSGNDTGWRLVTIDD-NKHGGLAPETCHAILRSPYFRMLVMSVILANGIVTATMTFKHD--GRPR 735
            |..::.||:||.:|. |:.........|.|:.|..|:.::..:||||.|..||..|.||  .:.|
 Worm   391 LEKDEDGWKLVEVDKYNRAHSNNSLFLHTIVTSTAFQTVMQLLILANAIFHATFVFYHDESDQIR 455

  Fly   736 DVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGL-T 799
            .::   |||:|:.||.|.:.|.:.|||..||:.|.....|||:.:|..|::|:.:.:.|.:.: |
 Worm   456 KIW---YYYVEVGFTILFNTEVIIKIYAFGWKAYIARGQHKFDCILCVGSSLNAIWVLYETNIFT 517

  Fly   800 YFQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDFTKFESF 864
            ||||.|:.||||||||||.|||||||||||||.|:|||..|||::|:||:||||::....||.:|
 Worm   518 YFQVFRIARLIKASPMLEDFVYKIFGPGKKLGGLVIFTGILLIVTSAISLQLFCYVPKLNKFTNF 582

  Fly   865 PEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELD 929
            ..||||||||:|||.|.:|:.|.:...::...|.||:||:.|||.|||.||||||||||||||:|
 Worm   583 AVAFMSMFQIITQEGWTDVVIEILRACNEQAVPFVAIYFVAYHLLVTLFVLSLFVAVILDNLEMD 647

  Fly   930 EDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIE- 993
            |::||:||||.|||.. ||.|||.|||||.:||.:|.|..:.::.::|.|||:|:||.:.|..|
 Worm   648 EELKKVKQLKAREQDT-IKTTLPMRLRIFNRFPTAPTMVTMKKVSSEFPLPKIRDSFTRQFADEF 711

  Fly   994 LETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLM 1058
            :||.|..::...      ::...:...:.|.:....|..:|..|....|..:|.::.:||..|.:
 Worm   712 VETSDDTIQEIG------FKVRSMLSGRGPSKETRITTTIRHVGQLSNKTILTSMLTESNRNRAL 770

  Fly  1059 LGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGD 1123
            ..:|.......|:..         |.||..:.......|||..|.:  .|:|.|...|...||||
 Worm   771 FSESNQHLASLTRSN---------TSSKHGKSGALSTNSRSRTRGL--ASLKGKHMVEGFKENGD 824

  Fly  1124 IAAAPRANSGRARPH-DLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKIC 1187
            :  .|...:.:...| ::|.|.||.||..||:.||:.||::|||||.||.|||||.|||..|::|
 Worm   825 L--RPEDTARKVEKHGEIDFKALQMKRAHAEITRNRIEEEMRENHPMFDRPLFLVGRESSLRRMC 887

  Fly  1188 QKIVHARYDARLKDPLTGKERK--VQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETP----- 1245
            |.|.|:|:.....|   |:.||  .:||..|:||.::||:||.|:..|||||.||::|:|
 Worm   888 QLIAHSRHSYDQND---GQHRKHSNKYKQFHDFLAIMTYMDWTMVLVTTLSCCSMLWESPWPTTG 949

  Fly  1246 NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMP 1310
            ...:.::..||||||.||:.||.||.:|.:|:||||||||.:.||...|.:|||:.|..||.|||
 Worm   950 ENLIFNNFYLQIAEYIFVLVMSFELIVKCIANGLFFTPKALVTDVGDILTIFIYITSLMFLIWMP 1014

  Fly  1311 LNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQL 1375
            .:|..||.|||||:.|.:||||::.|:||:|:||.||||||:|||||:.||::|||||||:||||
 Worm  1015 NHIEINSWAQLLMVCRAMRPLRVYALIPHIRRVVVELCRGFREILLVTILLVVLMFIFASFGVQL 1079

  Fly  1376 YGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDE-SYPAMLVPRVWANPRRFNFDNIGD 1439
            .||:||.||||.|:.||:|.|::..::|||:|::....|. .:|:::|||||.|||.||||:||:
 Worm  1080 VGGKLASCNDPMITSRENCTGLYDVKLFVTRMEVYGKNDNLMHPSIIVPRVWTNPRNFNFDHIGN 1144

  Fly  1440 AMLTLFEVLSFKGWLDVRDVLIKAVGPVHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALL 1504
            |||.|||.||:|||..|||||....|....::||||:|:|||||||||||||:|||:||:|||||
 Worm  1145 AMLALFETLSYKGWNVVRDVLYLRHGAWAVLFIHIYVFIGCMIGLTLFVGVVVANYTENRGTALL 1209

  Fly  1505 TVDQRRWCDLKKRLKIAQPLHLPPR-PDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWI 1568
            |||||||.|||.|||:|||||:||: |:..|:|.:.||:|....||::.||:|::||..|.|.|.
 Worm  1210 TVDQRRWHDLKARLKMAQPLHVPPKPPESAKLRCYLYDLTTSRWFKQLFAVLVVVNSFTLVIPWN 1274

  Fly  1569 KGEVHTER-----LVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQT 1628
            ..|....:     |.::||:...:|.:|.::|.||||..|:|||||||.|.::|:.|:.||:...
 Worm  1275 VSEEQDRKTFLLCLTVISAICNILFTLECLLKMIAFTLSGFWQSRRNRIDFIITILGINWIVFHF 1339

  Fly  1629 ILR------------NDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLL 1681
            :.:            ..|:|.:|::|||||||||.|:.:|||||||||.:|:.:|.|||..||||
 Worm  1340 LFQLPAYFAGGITEWKRLTYTYGYLVVILRFFTIAGRKSTLKMLMLTVVMSMVRSSFIIAAMFLL 1404

  Fly  1682 VFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTL--G 1744
            |.|||.||.:|||.||||:.:|:..||.:....:.:|||.|||||||.||||||..||:|..  |
 Worm  1405 VLFYANAGVVLFGMVKYGQAVGKHVNFRNGREALVVLFRSVTGEDWNDIMHDCMRAPPFCNWHPG 1469

  Fly  1745 NNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTW 1809
            .:||:|||||:..:::|||:||:|||||||||||||||||||||||:|||||||||||||||..|
 Worm  1470 LSYWQTDCGNYVGAIVYFCSFYLIITYIVLNLLVAIIMENFSLFYSSEEDALLSYADIRNFQLVW 1534

  Fly  1810 NIVDIHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSY 1874
            |:|||.|:..||||||||:|||||||||.:.:.|.||||:||:|:::||||:||:||||:|||||
 Worm  1535 NMVDIEQKRSIPVRRVKFLLRLLKGRLEVNDESDGLLFKHMCHEMERLHNGDDVSFHDVLNMLSY 1599

  Fly  1875 RSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNE 1939
            |||||||:|||||||.|||.||::||||||.|||.|||.|||.|:|    ||.|:|  |..::..
 Worm  1600 RSVDIRKSLQLEELLQREELEYIIEEEVAKHTIRAWLENCLKNIKA----KQNNTL--GKMSSIG 1658

  Fly  1940 QPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDGSS 1996
            .....|..||            :.| .|.|.....|..|:......|.:.:.:.|:|
 Worm  1659 STFAFPQSQE------------VLT-KGVVLTEASPEEDSLQGDKGSGKKKAQRGNS 1702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	136/287 (47%)
		Ion_trans	734..927	CDD:278921	105/193 (54%)
		Ion_trans	1240..1497	CDD:278921	151/262 (58%)
		Ion_trans	1571..1793	CDD:278921	126/240 (53%)
nca-2	NP_498054.2	Ion_trans	95..371	CDD:278921	133/281 (47%)
		Ion_trans	444..649	CDD:278921	111/207 (54%)
		Ion_trans	959..1202	CDD:278921	148/242 (61%)
		Ion_trans	1288..1518	CDD:278921	125/229 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158342
Domainoid	1	1.000	339	1.000	Domainoid score	I582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21832
Inparanoid	1	1.050	1527	1.000	Inparanoid score	I41
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48327
OrthoDB	1	1.010	-	-		D16416at33208
OrthoFinder	1	1.000	-	-		FOG0004135
OrthoInspector	1	1.000	-	-		otm14300
orthoMCL	1	0.900	-	-		OOG6_104443
Panther	1	1.100	-	-	LDO	PTHR46141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	1	1.000	-	-		X3959
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940