DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and cacna1c

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	XP_021330579.1	Gene:	cacna1c / 170581	ZFINID:	ZDB-GENE-020129-1	Length:	2202	Species:	Danio rerio

Alignment Length:	2338	Identity:	502/2338 - (21%)
Similarity:	867/2338 - (37%)	Gaps:	740/2338 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 GGGHNNGAGLGPV--------VGGGGGGLNLL--------GGLGGMGGMGGGAAAAGMGICGGIS 294
            ||.:.:...|.||        ||||||.|.|.        ..|.....:.....|..||..|...
Zfish    42 GGSNYSSPSLAPVPSLNEDEHVGGGGGVLGLAPEHIPTPGAPLSWQAAIDAARQAKLMGTTGAPI 106

  Fly   295 STVGS---------------AAITGVPPIGLGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESL 344
            ||..|               :..:..||..|         :.|..|..::.....:.::.|.|
Zfish   107 STASSTQRKRQHYTKPKKQASTASTRPPRAL---------LCLTLKNPIRRACINIVEWKPFE-- 160

  Fly   345 NESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPK--------TFERYPSLQFITFASDTAVTLL 401
                         :..||.:.|.....:|.:..|:        ..||...|..|          :
Zfish   161 -------------IIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLI----------I 202

  Fly   402 FTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFE-VLEIVPK---------- 455
            ||.|...|:...|:|.....||::.|...|       :|.:::.:|. :||...|
Zfish   203 FTVEAFLKVIAYGLLCHPNAYLRNGWNLLD-------FIIVVVGLFSAILEQATKGDGGTSMGGK 260

  Fly   456 -----FSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYG 513
                 ...|...|..|||.::.        .:|..::  |.|.| :...:.::.|..||.:.:|.
Zfish   261 AAGFDVKALRAFRVLRPLRLVS--------GVPSLQVVLNSIIK-AMVPLLHIALLVLFVIIIYA 316

  Fly   514 LLGVQ-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMV--CMKMDF 575
            ::|:: |.|::...|....   |.:|..|  ......|   |:.....|..|||..:  ||
Zfish   317 IIGLELFMGKMHRTCFFYK---DGHKGHI--AEEKPAP---CAPSSAHGRHCSPPNITQCM---- 369

  Fly   576 LSSYVIGFNG-------FEDIATSIFTVYQAASQEGWVFIMYRAIDS----LPAWRAAFYFSTMI 629
                 :|:.|       |::.|.::.||:|..:.|||..::|...|:    || |   .||.:::
Zfish   370 -----MGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELP-W---VYFVSLV 425

  Fly   630 FFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDTG---WRLVT------ 685
            .|.::.|.|:.:.|::..|::.|.:.:    |||..||....|.|..:..|   |  :|
Zfish   426 IFGSFFVLNLVLGVLSGEFSKEREKAK----ARGDFQKLREKQQLEEDLKGYLDW--ITQAEDID 484

  Fly   686 -------IDDNK--------------------HGGLAPET------------------------- 698
                   :||:|                    .|.:..||
Zfish   485 PENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLC 549

  Fly   699 ---CHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRP------RDVFYERYYYIELVFTCLLD 754
               |.|.::|..|..||:.::..|   |.|:..:|..:|      :|:       ...|...|..
Zfish   550 RRKCRAAVKSNVFYWLVIFLVFLN---TLTIASEHHQQPEWLTNVQDI-------ANKVLLALFT 604

  Fly   755 LETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV----PMFYPSGLTYFQVLRVVRLIKAS-- 813
            .|.|.|:|.||.:.|:....::|:..:..|..|..:    .:..|.|::..:.:|::|:.|.:
Zfish   605 GEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRY 669

  Fly   814 -PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLF--CFLCDFTK---FESFPEAFMSMF 872
             ..|...|..:....:.:.||::.....:||.|.:.||||  .|..|.|:   |::||::.:::|
Zfish   670 WNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVF 734

  Fly   873 QILTQEAWVEVMDETMIRTSKTLTP--LVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKL 935
            ||||.|.|..||.:.::.......|  ||.:|||:..:....|:|::|:|:.:|||...|.:...
Zfish   735 QILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSA 799

  Fly   936 KQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSL 1000
            :  |..|:..|.|:                    |.|..:    |:.|::..|.   .||.|
Zfish   800 Q--KEEEEEKERKK--------------------LARTAS----PEKRQNSEKP---PLEDE--- 832

  Fly  1001 VENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAML 1065
                              :|::.:.:.:.|:......::  |:.|.....:.|.::
Zfish   833 ------------------KKEEKIELKSITSDGETPTAT--KINIDEYTGEDNEEK--------- 868

  Fly  1066 PVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRA 1130
                                .|:.|:....|                   |...|..::...|
Zfish   869 --------------------NPYPVNDFPAG-------------------EDDEEEPEMPVGP-- 892

  Fly  1131 NSGRARP-HDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHAR 1194
               |.|| .|:.:|.......||:                   ..|:....::||.:|.|||:
Zfish   893 ---RPRPLSDIQLKEKAVPMPQAK-------------------AFFIFSPSNKFRVLCHKIVN-- 933

  Fly  1195 YDARLKDPLTGKERKVQYKSLHN-FLGLVTYLDWVMIFATTLSCISMMFETP----NYRVMDHPT 1254
                                 || |..|:       :|...||.||:..|.|    ::|   :..
Zfish   934 ---------------------HNIFTNLI-------LFFILLSSISLAAEDPVKNDSFR---NQI 967

  Fly  1255 LQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVS--TSFLCWMPLNIPTNS 1317
            |..|:|.|....::|:.||:.|.|.|....::.::....||:.:..||  :|.:....:|:
Zfish   968 LGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINV---- 1028

  Fly  1318 AAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGR 1379
             .::|.:||.:||||....   :.|:.:.|:...|....|::|::   ||.|:||..||||:.|:
Zfish  1029 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTS---LLQFMFACIGVQLFKGK 1089

  Fly  1380 LARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTL 1444
            ...|.|.:...:.:|.|.::    :.|......|:::      .|.|.| ..||||::...|:.|
Zfish  1090 FFYCTDTSKQTQAECRGAYI----LYKDGNVGKPEKA------QRSWEN-SDFNFDDVLQGMMAL 1143

  Fly  1445 FEVLSFKGWLDVRDVLIKA-------VGPVH------AVYIHIYIFLGCMIGLTLFVGVVIANYS 1496
            |.|.:|:||   ..:|.:|       |||::      :::..|||.:.....:.:|||.||..:.
Zfish  1144 FAVSTFEGW---PGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1205

  Fly  1497 ENKGTALLTVDQRRWCDLKKR--------LKIAQPL--HLPPRPDGRKIRAFTYDITQHIIFKRV 1551
            | :|.     .:.:.|:|.|.        || |:||  ::|..|...|:    :.:.....|:.:
Zfish  1206 E-QGE-----QEYKNCELDKNQRQCVEYALK-ARPLRRYIPKNPYQYKV----WYVVNSTYFEYL 1259

  Fly  1552 IAVVVLINSMLLSITWI-KGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLL 1615
            :..::|:|::.|::... :.:...:.:.|::.:.|.:|.||:::|.|||.||||:....|.:|.|
Zfish  1260 MFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRGYFSDPWNVFDFL 1324

  Fly  1616 VTVAGVIWIILQTI------------------LRND-----LSYFFGFMVVILRFFTITGKHTTL 1657
            :.:..:|.:||..|                  |:|.     :|..|..:..::|...:..:...:
Zfish  1325 IVIGSIIDVILSEINPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGI 1389

  Fly  1658 KMLMLTVGVSVCKSF----FIIFGMFLLVFFYALAGTILFGTVKYGEG--IGRRANFGSPVTGVA 1716
            :.|:.|    ..|||    ::...:.:|.|.||:.|..:||.:...:.  |.|..||.:....|.
Zfish  1390 RTLLWT----FIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINRNNNFQTFPQAVL 1450

  Fly  1717 MLFRIVTGEDWNKIMHDCMVQPPYCTLGN--NYWETDCGNFTASLIYFCTFYVIITYIVLNLLVA 1779
            :|||..|||.|.:||..|....| |..|:  |:...|||:..| :.||.:||::..::::||.||
Zfish  1451 LLFRCATGEAWQEIMLACSPNRP-CEKGSEINHSSEDCGSHFA-IFYFVSFYMLCAFLIINLFVA 1513

  Fly  1780 IIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRG-------VIPVRRVKFIL---RLLKG 1834
            :||:||.  |...:.::|....:..|:..|...|...:|       |..:||::..|   :|...
Zfish  1514 VIMDNFD--YLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPH 1576

  Fly  1835 RLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLV- 1898
            |:.|    .||:...|     .|::...|.|:..:..|...::.|:....||:  |.||...:|
Zfish  1577 RVAC----KRLVSMNM-----PLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIVK 1630

  Fly  1899 -------------------EEEV------AKMTIRTWL--------EGCLKKIRAQNASKQQNSL 1930
                               ::||      |...|:.:.        :|.:.||..:.|.    ||
Zfish  1631 KIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKIPPKTAL----SL 1691

  Fly  1931 IAGLRATNEQ-PVMRPNIQEDKAPLGAVDKSAISTI-------------SGAVAG---------- 1971
            .||||..::. |.:|..|..|......::::...|:             ||.:.|
Zfish  1692 QAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRVKRSGGLFGNHVNYYHQSD 1756

  Fly  1972 ---ACPPTSDAFSP---TFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLG 2030
               :.|.:.....|   :.|.:..|.:..|...:|....:.:|.:.:||:| ....|..|:.|..
Zfish  1757 GHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNA-NINNANNTAIGHR 1820

  Fly  2031 VGPPTVQS----TARHVMTV----------GKRGY---ALNRSDSTGS----------------- 2061
            ...|||.:    |...:.|:          .||..   ...||||:.|
Zfish  1821 YPKPTVSTVDGQTGPPLTTIPLPRPTWCFPNKRSCFYDTFMRSDSSDSRLPIIRREEASTDETYD 1885

  Fly  2062 ---------------------------------SAG-----------RKFLAPTS---------- 2072
                                             ..|           |.||.||:
Zfish  1886 ETFLDERDQAMLSMDMLEFQDEESKQLAPMVEAEVGEERRPWQSPRRRAFLCPTALGRRSSFHLE 1950

  Fly  2073 -------SDPQQRSTLSDKERLHITSQQ-----------RKKNSMT------TLPHAGQLGQLAK 2113
                   .|..|::.|.    ||:...|           |:.:|.|      :.|.|...|
Zfish  1951 CLRKHNRPDVSQKTALP----LHLVHHQALAVAGLSPLLRRSHSPTLFTRLCSTPPASPSG---- 2007

  Fly  2114 QRGGGGEA--------TKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGG 2168
             |.|||..        .:.|..:.:|||.:     |::|.::          .:...:|.|.|
Zfish  2008 -RSGGGPCYQPVPSLRLEGSGSYEKLNSSM-----PSVNCSS----------WYSDSNGNHSG 2054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	72/320 (23%)
		Ion_trans	734..927	CDD:278921	57/212 (27%)
		Ion_trans	1240..1497	CDD:278921	74/278 (27%)
		Ion_trans	1571..1793	CDD:278921	73/252 (29%)
cacna1c	XP_021330579.1	Ion_trans	156..452	CDD:306908	77/357 (22%)
		Ion_trans	559..798	CDD:306908	67/248 (27%)
		Ion_trans	934..1211	CDD:306908	85/314 (27%)
		Ion_trans	1253..1527	CDD:306908	77/281 (27%)
		GPHH	1528..1598	CDD:318993	17/78 (22%)
		Ca_chan_IQ	1600..1671	CDD:312334	12/72 (17%)
		CAC1F_C	1694..2129	CDD:318975	67/386 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950