DRSC/TRiP Functional Genomics Resources

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Protein Alignment na and Cacna1s

DIOPT Version :10

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_001074492.1 Gene:Cacna1s / 12292 MGIID:88294 Length:1852 Species:Mus musculus


Alignment Length:2000 Identity:444/2000 - (22%)
Similarity:773/2000 - (38%) Gaps:549/2000 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   400 LLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLE-----IVPKFSYL 459
            ::|:.|...|:...|.|..:..||:..|...|..:|.....::||:...:::     :..|.:.|
Mouse    95 IVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNIIQTNTAPMSSKGAGL 159

  Fly   460 SIMRAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-G 521
            .: :|.|...::|.||  |...:|..::  |.||| :...::::.|..||.:.:|.::|::.| |
Mouse   160 DV-KALRAFRVLRPLR--LVSGVPSLQVVLNSIFK-AMLPLFHIALLVLFMVIIYAIIGLELFKG 220

  Fly   522 ELKNHCVMNNTEYDLYKRPILTI-NSLAIPDTFCSMDPDSGYQCS-PGMVCMKMDFLSSYVIGFN 584
            ::...|....|:.      :.|: |....|   |:. ..||..|: .|..|..         |:.
Mouse   221 KMHKTCYFIGTDI------VATVENEKPSP---CAR-TGSGRPCTINGSECRG---------GWP 266

  Fly   585 G-------FEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIA 642
            |       |::...|:.||||..|.|||..::|...|::.......||.|:|...::.:.|:.:.
Mouse   267 GPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLG 331

  Fly   643 VITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDTGW-------RLVTIDDNKHGGLAPE--- 697
            |::..|.:.|.:.:    :||..||....|.|..:..|:       .::.:||.:.|.|:.:   
Mouse   332 VLSGEFTKEREKAK----SRGTFQKLREKQQLEEDLRGYMSWITQGEVMDVDDLREGKLSLDEGG 392

  Fly   698 -------------------------------TCHAILRSPYFRMLVMSVILANGIVTATMTFKHD 731
                                           .||.:::|..|..||:.::..|   |.::..:|.
Mouse   393 SDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSKVFYWLVILIVALN---TLSIASEHH 454

  Fly   732 GRP------RDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV 790
            .:|      :||       ...|...|..:|.|.|:|.||.|.|:....::|:..:.....|.|:
Mouse   455 NQPLWLTHLQDV-------ANRVLLTLFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEIL 512

  Fly   791 PM----FYPSGLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSIS 848
            .:    ..|.|::..:.:|::||.|.:   ..|...|..:....:.:.||::.....:||.:.:.
Mouse   513 LVESGAMSPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLG 577

  Fly   849 MQLFCFLCDF-------TKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTP--LVAVYFI 904
            ||||....||       :.|::||:|.:|:||:||.|.|..||...::.......|  ||.:|||
Mouse   578 MQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPTYPGVLVCIYFI 642

  Fly   905 LYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTI 969
            :..:....|:|::|:|:.:|||...|.:...::.|..|:.         |.::.:..||      
Mouse   643 ILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERK---------RRKMSKGLPD------ 692

  Fly   970 LHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVR 1034
                                                                       |:.:.|
Mouse   693 -----------------------------------------------------------KSEEER 698

  Fly  1035 AAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRS 1099
            |        .:|..:...:                       |.:|..|.:| .::|:       
Mouse   699 A--------TVTKKLEQKS-----------------------KGEGIPTTAK-LKIDE------- 724

  Fly  1100 IRRSVRSGSIKLKQTYEHLMENGDIAAAPRAN-SGRARPHDLDIKLLQAKRQQAEMRRNQREEDL 1163
                ..|...::|..|            |.|: .|.....:.:|.:....|..||::..::...:
Mouse   725 ----FESNVNEVKDPY------------PSADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPI 773

  Fly  1164 RENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWV 1228
            .|...|     |:....::.|.:|.:||:|.:                            :.:::
Mouse   774 PEASSF-----FIFSPTNKIRVLCHRIVNATW----------------------------FTNFI 805

  Fly  1229 MIFATTLSCISMMFETP-NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAA 1292
            ::| ..||..::..|.| ....|.:..|:..:|.|....::|:.||:...|.|....::.::...
Mouse   806 LLF-ILLSSAALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFN 869

  Fly  1293 ALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEI 1354
            .||:.:..||   |..|.|.....|..::|.:||.:||||....   :.|:.:.|:...|....|
Mouse   870 ILDLLVVAVS---LISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 931

  Fly  1355 LLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPA 1419
            :||:|   ||.|:||..||||:.|:...|||.:....|:|.|.:    ::.|        :..|.
Mouse   932 VLVTT---LLQFMFACIGVQLFKGKFYSCNDLSKMTEEECRGYY----YIYK--------DGDPT 981

  Fly  1420 M--LVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV-------GPVH------A 1469
            .  |.||.|.: ..|:|||:..||::||.|.:|:||   ..:|.||:       |||:      |
Mouse   982 QIELRPRQWIH-NDFHFDNVLSAMMSLFTVSTFEGW---PQLLYKAIDSNEEDTGPVYNNRVEMA 1042

  Fly  1470 VYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQPL-- 1524
            ::..|||.|.....:.:|||.||..:.|...|      :.:.|:|.|.        || |:||  
Mouse  1043 IFFIIYIILIAFFMMNIFVGFVIVTFQEQGET------EYKNCELDKNQRQCVQYALK-ARPLRC 1100

  Fly  1525 HLPPRPDGRKIRAFTYDITQHI---IFKRVIAVVVLINSMLLSITWIKGEVH---TERLVIVSAV 1583
            ::|..|       :.|.:...:   .|:.::..::::|::.|      |..|   :|::..:|.:
Mouse  1101 YIPKNP-------YQYQVWYVVTSSYFEYLMFALIMLNTICL------GMQHYNQSEQMNHISDI 1152

  Fly  1584 L----TFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTI--------------- 1629
            |    |.:|.:|:|:|.|||.||||:....|.:|.|:.:..:|.:||..|               
Mouse  1153 LNVAFTIIFTLEMVLKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGG 1217

  Fly  1630 ----------LRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGV-----SVCKSF----FII 1675
                      .|...::|..|.|:.|           :|:|....||     :..|||    ::.
Mouse  1218 GCGNVDPDESARISSAFFRLFRVMRL-----------VKLLNRAEGVRTLLWTFIKSFQALPYVA 1271

  Fly  1676 FGMFLLVFFYALAGTILFGTVKYGEG--IGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQP 1738
            ..:.:|.|.||:.|..:||.:...:|  |.|..||.:....|.:|||..|||.|.:|:..|. ..
Mouse  1272 LLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACS-YG 1335

  Fly  1739 PYCTLGNNY---WETDCG-NFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSY 1799
            ..|...::|   .|..|| ||  :..||.:||::..::::||.||:||:||.  |...:.::|..
Mouse  1336 KLCDPESDYAPGEEHTCGTNF--AYYYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGP 1396

  Fly  1800 ADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLK----------GRLECDPQKDRLLFKYMCYEL 1854
            ..:..|:..|...|...:|.|....|..:||.::          .|:.|    .||:...|    
Mouse  1397 HHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVAC----KRLVGMNM---- 1453

  Fly  1855 DKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIR 1919
             .|::...|||:..:..|      :|.||:::   ....||...||          |...:|||.
Mouse  1454 -PLNSDGTVTFNATLFAL------VRTALKIK---TEGNFEQANEE----------LRAIIKKIW 1498

  Fly  1920 AQNASKQQNSLI----------------------------------------------AGLRATN 1938
            .:.:.|..:.:|                                              ||||...
Mouse  1499 KRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQIQAGLRTIE 1563

  Fly  1939 EQPVMRPNIQE------------DKAPLGAVDKSAISTISGAVAG----------ACPPTSDAFS 1981
            |:..  |.|..            ::|.:.|..:..|...:|.:.|          :.||......
Mouse  1564 EEAA--PEIHRAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQR 1626

  Fly  1982 P-TFSSTENEEKDGSSSAVVQLPHSETS--IAGTGSSATGAATATGTSSGLGVGPPTVQSTARHV 2043
            | .|:..|.||.: |...:...|.:..:  :|...::...|..|.|.||..  ..|...|.....
Mouse  1627 PLQFAEIEMEELE-SPVFLEDFPQNPGTHPLARANTNNANANVAYGNSSHR--NNPVFSSICYER 1688

  Fly  2044 MTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLP--HAG 2106
            ..:|:....:.|........       .:|.|..||.: ||.:..:|.:...:..:...|  ..|
Mouse  1689 EFLGEADMPVTREGPLSQPC-------RASGPHSRSHV-DKLKRPMTQRGMPEGQVPPSPCQVTG 1745

  Fly  2107 QLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINA----AAAAAAL 2152
            ...:...|:.|.|   .:|.|....||...:.|.|..:|    |.|.|.|
Mouse  1746 AKAEHPVQKEGKG---PTSRFLETPNSRNFEEHVPRNSAHRCTAPATAML 1792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 361..654 CDD:459842 65/270 (24%)
Ion_trans 705..927 CDD:459842 66/243 (27%)
Ion_trans 1224..1497 CDD:459842 86/291 (30%)
Ion_trans 1545..1793 CDD:459842 81/297 (27%)
Cacna1sNP_001074492.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 63/264 (24%)
Ion_trans 50..345 CDD:459842 65/272 (24%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 1/2 (50%)
Binding to the beta subunit. /evidence=ECO:0000269|PubMed:28351836 357..374 3/16 (19%)
II. /evidence=ECO:0000305 418..664 67/255 (26%)
Ion_trans 431..672 CDD:459842 68/250 (27%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..712 10/141 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 6/37 (16%)
III. /evidence=ECO:0000305 768..1068 94/355 (26%)
Ion_trans 798..1075 CDD:459842 89/333 (27%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 32/98 (33%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 1/2 (50%)
IV. /evidence=ECO:0000305 1105..1384 80/305 (26%)
Ion_trans 1117..1392 CDD:459842 81/296 (27%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 2/2 (100%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 21/69 (30%)
Phenylalkylamine binding. /evidence=ECO:0000250 1349..1392 18/46 (39%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 18/45 (40%)
GPHH 1401..1454 CDD:465306 13/61 (21%)
Ca_chan_IQ 1464..1536 CDD:462591 14/90 (16%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q13698 1522..1542 0/19 (0%)
CAC1F_C 1557..1840 CDD:465298 53/251 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1702..1721 4/26 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1727..1762 6/37 (16%)
Blue background indicates that the domain is not in the aligned region.

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