DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and Cacna1g

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	XP_011246988.1	Gene:	Cacna1g / 12291	MGIID:	1201678	Length:	2392	Species:	Mus musculus

Alignment Length:	2441	Identity:	492/2441 - (20%)
Similarity:	817/2441 - (33%)	Gaps:	845/2441 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 GLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSA--AITGVPPIGLGIATGI 316
            |.|....|.......|..|.|.||..|.         |......|||  ...|:|...|.
Mouse     7 GAGAEESGQPRSFTQLNDLSGAGGRQGP---------GSTEKDPGSADSEAEGLPYPALA----- 57

  Fly   317 GNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTP--- 378
                            |.:..|..::|...|..:..|...|..|:..|..|::..::.:..|
Mouse    58 ----------------PVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCED 106

  Fly   379 --KTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWIS 441
              ...:|...||    |.|..:...|..||:.||...|:. |:..||.|.|.:.|    .|:.|:
Mouse   107 IACDSQRCRILQ----AFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLD----FFIVIA 162

  Fly   442 IILQIFEVLEIVPKFSYLSIMRAPRPLIMI------RFLRVFLKFSMPKSRINQIFKRSSQQIYN 500
            .:|:....|:.| .||.:..:|..|||..|      |.|...|..::|             .:.|
Mouse   163 GMLEYSLDLQNV-SFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP-------------MLGN 213

  Fly   501 VTL--FFLFFMSLYGLLGVQFF-GELKNHCVMNNT-----EYDL---YK---------------- 538
            |.|  ||:||  ::|::|||.: |.|:|.|.:...     ..||   |:
Mouse   214 VLLLCFFVFF--IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLEPYYQTENEDESPFICSQPRE 276

  Fly   539 ------RPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMD-FLSSYVIG----FNG---FEDI 589
                  |.:.|:.........|.:|.:: |..|....|:..: :.::...|    |.|   |::|
Mouse   277 NGMRSCRSVPTLRGEGGGGPPCGLDYEA-YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNI 340

  Fly   590 ATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQ 654
            ..:...::|..:.||||.|||..:|: .::....||..:|...::.:.|:.:.||...|:|.:.:
Mouse   341 GYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR 404

  Fly   655 FQQMW-------------------------------------GARGHIQKTAASQILSG------ 676
            ..|:.                                     .||...|.:.|..:.:|
Mouse   405 ESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAVGVRAGLLSSPV 469

  Fly   677 ---------------------------------------------------------NDTGWRLV 684
                                                                     |.:.|.::
Mouse   470 ARGGQEPQPSGSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRVPRASPEIQDRDANGSRWLML 534

  Fly   685 ------------------------------------------------TIDDNK----------- 690
                                                            |:...|
Mouse   535 PPPSTPTPSGGPPRGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPP 599

  Fly   691 ---------------------------------------------------------------HG 692
                                                                           .|
Mouse   600 EMLKDKALVEVAPSPGPPTLTSFNIPPGPFSSMHKLLETQSTGESVGACHSSCKISSPCSKADSG 664

  Fly   693 GLAPETC----------------------------------HAILRSPY---------------- 707
            ...|::|                                  |:.||.|:
Mouse   665 ACGPDSCPYCARTGAGEPESADHEMPDSDSEAVYEFTQDAQHSDLRDPHRRRRPSLGPDAEPSSV 729

  Fly   708 ----------FRMLVMSVILANGIV------TATMTFKHDGRPRDVFYERYYYIELVFTCLLDLE 756
                      ||.:|.|.....||:      |.:|..::..:|.:: ........:|||.|..||
Mouse   730 LAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEEL-TNALEISNIVFTSLFALE 793

  Fly   757 TLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTY---FQVLRVVRLIKASPMLEG 818
            .|.|:...|..||.|:..:.|:.::...:...||.. ...||:.   |:::||::|::..|.|:.
Mouse   794 MLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-QGGGLSVLRTFRLMRVLKLVRFLPALQR 857

  Fly   819 FVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLF-C---------FLCDFTKFESFPEAFMSMFQ 873
            .:..:......:.:..:..|..:.|.|.:.|.|| |         .|.|...|:|...|.:::||
Mouse   858 QLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQ 922

  Fly   874 ILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKK---- 934
            |||||.|.:|:...|..||.    ..|:|||....|...::.:|.||::::..:.:|..|:
Mouse   923 ILTQEDWNKVLYNGMASTSS----WAALYFIALMTFGNYVLFNLLVAILVEGFQAEEIGKREDTS 983

  Fly   935 ----LKQLKFREQSAEIKETLPFRLRIFEKFPD--SPQM-------------------------- 967
                ..||....|..:..::        |..||  ||.:
Mouse   984 GQLSCIQLPVNSQGGDATKS--------ESEPDFFSPSVDGDGDRKKRLALVALGEHSELRKSLL 1040

  Fly   968 --TILHRIPNDFMLPK-----VRESF----------------MKHFVIELETEDSLVENCKRPMS 1009
              .|:|.......|||     |.|:.                ..|.  |:::..|...:...|.|
Mouse  1041 PPLIIHTAATPMSLPKSSSTGVGEALGSGSRRTSSSGSAEPGTAHH--EMKSPPSARSSPHSPWS 1103

  Fly  1010 --ECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKG 1072
              ..|.|.                  |::.:||.:.......:.|..:|.:|            .
Mouse  1104 AASSWTSR------------------RSSRNSLGRAPSLKRRSPSGERRSLL------------S 1138

  Fly  1073 GGGLKSQGTITHSK-----PWRVDQKKFGSRSIRRSVRSGSIKLKQTY----------------E 1116
            |.|.:||.....|:     |...|.:..|  |:.|..:| |..|..|.                |
Mouse  1139 GEGQESQDEEESSEEDRASPAGSDHRHRG--SLEREAKS-SFDLPDTLQVPGLHRTASGRSSASE 1200

  Fly  1117 HLMENGDIAAAPRANSGRARPHDLD-------IKLLQAKRQQAEMRRNQ----REEDLRENHPFF 1170
            |...||..|:...|.:.||....||       ..|.:.:|.:|.:|...    ||.|
Mouse  1201 HQDCNGKSASGRLARTLRADDPPLDGDDGDDEGNLSKGERLRAWVRARLPACCRERD-------- 1257

  Fly  1171 DTPLFLVPRESRFRKICQKIV-HARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATT 1234
            ....::.|.:||||.:|.:|: |..:|                   |..|        |:||
Mouse  1258 SWSAYIFPPQSRFRLLCHRIITHKMFD-------------------HVVL--------VIIF--- 1292

  Fly  1235 LSCISMMFETPNYRVMDHPT----LQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALD 1295
            |:||::..|.|  ::..|..    |.::.|.|......|:.:|::|.|..|..:||::.....||
Mouse  1293 LNCITIAMERP--KIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLD 1355

  Fly  1296 VFIYVVST-SFLCWMPLNIPTNSAAQL--LMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLV 1357
            ..:.::|. ..|..|..:..|.....|  |.:||.:||||:.:....::.||..|....|.|..:
Mouse  1356 GLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNI 1420

  Fly  1358 STLLILLMFIFASYGVQLYGGRLARC---NDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPA 1419
            ..:......||...||||:.|:...|   :...|:.:.||.                  :.||.
Mouse  1421 VVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCA------------------EASYR- 1466

  Fly  1420 MLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVG----------PVHAVYIHI 1474
                  |.. .::||||:|.|:::||.:.|..||:|:....:.|||          |...:|...
Mouse  1467 ------WVR-HKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFIS 1524

  Fly  1475 YIFLGCMIGLTLFVGVVIANY-----SENKGTALLTVDQR-RWCDLKKRLKIAQPLHL------- 1526
            ::.:.....|.:|||||:.|:     .:.:..|....::| :..:.|:|.|..|...|
Mouse  1525 FLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLKRLEKKRRSKEKQMADLMLDDVIA 1589

  Fly  1527 --------------PPRPDGRKIRAFTYDI-TQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTE 1575
                          |...|..:.|...:.: |.|.: ...|..|:.:|.:.:::. :.:.::..|
Mouse  1590 SGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYL-DLFITGVIGLNVVTMAMEHYQQPQILDE 1653

  Fly  1576 RLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGF 1640
            .|.|.:.:.|.:||:|.|.|.:||..|.::|.|.|:.||.:.:..::.|.|:.|   :::.....
Mouse  1654 ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI---EVNASLPI 1715

  Fly  1641 MVVILRFFTITGKHTTLKMLMLTVGV-----SVCKSFFIIFG---MFLLVFF-YALAGTILFGTV 1696
            ...|:|...:......||:|.:.||:     :|.::...:..   :|:|:|| :|..|..|||.:
Mouse  1716 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1780

  Fly  1697 KYG-----EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFT 1756
            :..     ||:||.|.|.:.......|||:.||::||.||.|        ||.:...|:.|.|..
Mouse  1781 ECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD--------TLRDCDQESTCYNTV 1837

  Fly  1757 ASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSN---EEDALLSYADIRNFQNT---------- 1808
            .|.|||.:|.:...::::|:::|::|::  |..||   :|:|.|. |::.....|
Mouse  1838 ISPIYFVSFVLTAQFVLVNVVIAVLMKH--LEESNKEAKEEAELE-AELELEMKTLSPQPHSPLG 1899

  Fly  1809 ----WNIVD------------IHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMCYELDKL 1857
                |..|:            .|....|......|.|         :...||.||
Mouse  1900 SPFLWPGVEGVNSPDSPKPGAPHTTAHIGAASSGFSL---------EHPTDRQLF---------- 1945

  Fly  1858 HNGEDVTFHDVINMLSYRSVDIRKALQLEEL------------------------LAREEFEYLV 1898
                     |.|::|...|::....| ::||                        ||..|...|.
Mouse  1946 ---------DTISLLIQGSLEGELKL-MDELAGPGGQPSAFPSAPSPGDSDPQIPLAEMEALSLT 2000

  Fly  1899 EEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLG----AVDK 1959
            .|.|::       ..|...:...:.....::|:.....:|    |.|:.:|...|||    .|.|
Mouse  2001 SEIVSE-------PSCSLALTDDSLPDDTHTLLLSALESN----MVPHTEEGPVPLGPDLLTVRK 2054

  Fly  1960 SAISTI-----------SGAVA-------GACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSE 2006
            |.:|..           :|:.|       |...|  .|.|.:..|..::..|  :|.::|||...
Mouse  2055 SGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGLP--KAQSGSILSVHSQPAD--TSCILQLPKDA 2115

  Fly  2007 TSIAGTGSSATGAATATGTSSGLGVGPP--------------TVQSTARHVMTVGKRGYALNRSD 2057
            ..:.....:.|..|...       :.||              .:::.:..|..:|.|...|  |:
Mouse  2116 HYLLQPHGAPTWGAIPK-------LPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLL--SE 2171

  Fly  2058 STGSSA----GRKFLAPTSSDPQQRSTLSDKERLHI 2089
            .:|.|.    ...|...:|...||||....|...||
Mouse  2172 VSGPSCPLTRSSSFWGGSSIQVQQRSGSQSKVSKHI 2207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	81/332 (24%)
		Ion_trans	734..927	CDD:278921	56/205 (27%)
		Ion_trans	1240..1497	CDD:278921	70/281 (25%)
		Ion_trans	1571..1793	CDD:278921	69/238 (29%)
Cacna1g	XP_011246988.1	Ion_trans	80..406	CDD:366146	85/352 (24%)
		Ion_trans	746..972	CDD:366146	61/231 (26%)
		Ion_trans	1280..1552	CDD:366146	80/329 (24%)
		Ion_trans	1622..1863	CDD:366146	69/252 (27%)
		PHA03307	2110..>2389	CDD:223039	23/107 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920