Protein Alignment na and Cacna1e

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_011246211.1
• Gene: Cacna1e / 12290
• MGIID: 106217
• Length: 2466
• Species: Mus musculus
• Alignment Length: 2247
• Identity: 468/2247 - (20%)
• Similarity: 827/2247 - (36%)
• Gaps: 657/2247 - (29%)

  Fly   312 IATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLN 376
            :||.|.|.|:|..:|.|           ||:                          ..|.:|..
Mouse   243 LATIIANCIVLALEQHL-----------PED--------------------------DKTPMSRR 270

  Fly   377 TPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWIS 441
            ..|| |.|    ||.         :|..|...|:...|.:..:..||::.|...|..:|    :|
Mouse   271 LEKT-EPY----FIG---------IFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVV----LS 317

  Fly   442 IIL-------------------QIFEVLEIVPKFSYL-----SIMRAPRPLIMIRFLRVFLKFSM 482
            .||                   ::...|::|.....|     |||:|..||:.|..|
Mouse   318 GILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLL-------- 374

  Fly   483 PKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTINS 546
                                |||...|  :.::|::|: |:|...|.|||:
Mouse   375 --------------------LFFAILM--FAIIGLEFYSGKLHRACFMNNS-------------- 403

  Fly   547 LAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYR 611
             .|.:.|....|.....|..|..|  .|::... .|...|::|..::.||:|..:.|||..::|.
Mouse   404 -GILEGFDPPHPCGVQGCPAGYEC--KDWIGPN-DGITQFDNILFAVLTVFQCITMEGWTTVLYN 464

  Fly   612 AIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSG 676
            ..|:|.|.....||..:|...::.|.|:.:.|::..|.:.|.:.:.    |....|....|.:..
Mouse   465 TNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVEN----RRAFMKLRRQQQIER 525

  Fly   677 NDTGWR--------LVTIDDNKHGGL-----------------------APETC----------- 699
            ...|:|        ::..::||:.|.                       :.|.|
Mouse   526 ELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLA 590

  Fly   700 --------------------------HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVF 738
                                      ..:::|..|..:|:||:..|   ||.:...|..:|:.:.
Mouse   591 RASIKSTKVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALN---TACVAIVHHNQPQWLT 652

  Fly   739 YERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV-PMFYPS---GLT 799
            : ..||.|.:|..|..||...|:|.:|.|.|:..|.:.|:..:..|:...:| .:|.|.   |::
Mouse   653 H-LLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGIS 716

  Fly   800 YFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF--- 858
            ..:.||::|:.|.:   ..|...|..:....|.:.||:......:::.:.:.||||....:|
Mouse   717 VLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 781

  Fly   859 ---TKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLV--AVYFILYHLFVTLIVLSLF 918
               ..|::||.|.|::|||||.|.|.||| ...||:...::..:  |:|||:..||....:|::|
Mouse   782 TPSANFDTFPAAIMTVFQILTGEDWNEVM-YNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVF 845

  Fly   919 VAVILDNLELDEDIKKLKQLK---FREQSA--EIKETLPFRLRIFEKFPDSPQMTILHRIPNDFM 978
            :|:.:|||...:::.|.:|.:   |.::.|  :.||..|.      ..|:.|.:....|..:...
Mouse   846 LAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPM------SAPNMPSIERDRRRRHHMS 904

  Fly   979 L--PK---VRESFMKHFV-------------IELETEDSLVE---------NCKRPMSECWESNV 1016
            :  |:   :||...:|.:             :::.::::|.:         |...|:|.....|.
Mouse   905 MWEPRSSHLRERRRRHHMSVWEQRTSQLRRHMQMSSQEALNKEEAPPMNPLNPLNPLSPLNPLNA 969

  Fly  1017 ---VFRKQKPVR------IMNKTAKVRAAGSSLRKLAITHIINDSNNQR--LMLG--DSAMLP-- 1066
               ::|:.:|:.      .:.|..:.|.:.....|..|..:.:..:|||  |.||  :...||
Mouse   970 HPSLYRRPRPIEGLALGLGLEKCEEERISRGGSLKGDIGGLTSALDNQRSPLSLGKREPPWLPRS 1034

  Fly  1067 ------VVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIR------------------RSVRSG 1107
                  .:..:.||| ::..|.......|..|::...|.:|                  ||:..|
Mouse  1035 CHGNCDPIQQEAGGG-ETVVTFEDRARHRQSQRRSRHRRVRTEGKDSASASRSRSASQERSLDEG 1098

  Fly  1108 -SIK--------------------------LKQTYEHLMENG-------DIAAAP---------- 1128
             |::                          |::|...::..|       |.|..|
Mouse  1099 VSVEGEKEHEPHSSHRSKEPTIHEEERTQDLRRTNSLMVPRGSGLVGALDEAETPLVQPQPELEV 1163

  Fly  1129 -----------------------------------------RANSGRARPH---------DLD-- 1141
                                                     .||..:|...         |:|
Mouse  1164 GKDAALTEQEAEGSSEQALLGDVQLDVGRGISQSEPDLSCMTANMDKATTESTSVTVAIPDVDPL 1228

  Fly  1142 ------------------IKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRF----- 1183
                              :|..:.|.::.|:.:.::::..:.     :|...:||..|.|
Mouse  1229 VDSTVVNISNKTDGEASPLKEAETKEEEEEVEKKKKQKKEKR-----ETGKAMVPHSSMFIFSTT 1288

  Fly  1184 ---RKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETP 1245
               |:.|..||:.|                             |.:..::.....|.|::..|.|
Mouse  1289 NPIRRACHYIVNLR-----------------------------YFEMCILLVIAASSIALAAEDP 1324

  Fly  1246 NYRVMD-HPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWM 1309
            .....: :..|:..:|.|....:.|:.:|::..||.....:|.:|:...|| |:.||.......:
Mouse  1325 VLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILD-FVVVVGALVAFAL 1388

  Fly  1310 PLNIPTNSAAQL-----LMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFA 1369
            ...:.||....:     |.:||.:|||:....:|.::.|...:....|.:..:..:..|.|||||
Mouse  1389 ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFA 1453

  Fly  1370 SYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVP-RVWANPRRFN 1433
            ...|||:.|:...|.|.:....::|:|.::              |.....|.|. |.|.. ..|:
Mouse  1454 VIAVQLFKGKFFYCTDSSKDTEKECIGNYV--------------DHEKNKMEVKGREWKR-HEFH 1503

  Fly  1434 FDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGPVH------AVYIHIYIFLGCMIGLTLFV 1488
            :|||..|:||||.|.:.:||..|.    ||..:..||..      :::..:|..:.....:.:||
Mouse  1504 YDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1568

  Fly  1489 GVVIANYSENKGTALLTVDQRRWCDLKKRLKI-------AQPL--HLPPRPDGRKIRAFTYDITQ 1544
            .::|..:.| :|..::     ..|.|:|..:.       |:||  ::|     :....|.|.:..
Mouse  1569 ALIIITFQE-QGDKMM-----EECSLEKNERACIDFAISAKPLTRYMP-----QNRHTFQYRVWH 1622

  Fly  1545 HII---FKRVIAVVVLINSMLLSITWIKGEVHTE-RLVIVSAVLTFVFVVEVVMKNIAFTPRGYW 1605
            .::   |:..|..::.:|:::|.:.:.......| .|..::...|.||.:|.|:|.|||....|:
Mouse  1623 FVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYF 1687

  Fly  1606 QSRRNRYDLLVTVAGVIWIIL-QTILRNDLSYFFGFMVVI--LRFFTITGKHTTLKMLMLTVGVS 1667
            :...|.:|.:..:..:..||| .:.|.|...:...|:.:.  .|...:..:..|:::|:.|...|
Mouse  1688 RDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQS 1752

  Fly  1668 VCKSFFIIFGMFLLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKI 1730
            .....::...:.:|.|.||:.|..:||.:|..|  .|.|..||.|....:.:|||..|||.|.:|
Mouse  1753 FKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEI 1817

  Fly  1731 MHDCMVQ---PPYCTLGNNYWETD-CGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSN 1791
            |..|:.:   .|..|..:...|:: ||...| .:||.:|....::::|||.||:||:||.  |..
Mouse  1818 MLSCLGEKGCEPDTTAPSGQNESERCGTDLA-YVYFVSFIFFCSFLMLNLFVAVIMDNFE--YLT 1879

  Fly  1792 EEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQKDRLLFKYMCY 1852
            .:.::|....:..|...|...|....|.|....:..:|.|:...|    .| |.|       :.|
Mouse  1880 RDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRC-PSK-------VAY 1936

  Fly  1853 ELDKLHN---GEDVTFH--DVINMLSYRSVDIRKA------------LQLEEL-----LAREEFE 1895
            :...|.|   .||:|.|  ..:..|...::||:.|            ||.|.|     |:::..:
Mouse  1937 KRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLD 2001

  Fly  1896 YLVE----------EEVAKMTIRTWLEGCLKKIRAQNASKQQNS--------------LIAGLRA 1936
            .||.          :..|.|.|..:.:....|.:.|...:|:|:              :||..:|
Mouse  2002 LLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKA 2066

  Fly  1937 TNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAG---------------ACPPTSD-------- 1978
            .       |.:|:|          .:|.:||. :|               ||...:|
Mouse  2067 L-------PYLQQD----------PVSGLSGR-SGYPSMSPLSPQEIFQLACMDPADDGQFQEQQ 2113

  Fly  1979 ----AFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQST 2039
                |..|..|..::.:   ||:..:.||......||:|.::        :...|.:.|..|...
Mouse  2114 SLVNAQEPEVSELKSVQ---SSNHGIYLPPDTQEHAGSGRAS--------SMPRLTMDPQVVTDP 2167

  Fly  2040 ARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLPH 2104
            :..     :|.::..|...:.||...:|....||:    :|...:.|.:.:|.:...:.:.:  .
Mouse  2168 SSM-----RRSFSTIRDKRSNSSWLEEFSMERSSE----NTYKSRRRSYHSSLRLSAHRLNS--D 2221

  Fly  2105 AGQLGQLAKQRGGGGEATKS-------SSFFAQLNSE 2134
            :|....  ..|.||.|..:|       |...::.|||
Mouse  2222 SGHKSD--THRSGGRERGRSKERKHLLSPDVSRCNSE 2256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	71/317 (22%)
		Ion_trans	705..927	CDD:459842	71/236 (30%)
		Ion_trans	1224..1497	CDD:459842	70/289 (24%)
		Ion_trans	1545..1793	CDD:459842	72/260 (28%)
Cacna1e	XP_011246211.1	Ion_trans	235..509	CDD:459842	81/368 (22%)
		Ion_trans	622..861	CDD:459842	72/243 (30%)
		Ion_trans	1302..1536	CDD:459842	65/278 (23%)
		Ion_trans	1626..1883	CDD:459842	72/259 (28%)
		GPHH	1892..1945	CDD:465306	14/60 (23%)
		Ca_chan_IQ	1955..2031	CDD:462591	14/75 (19%)