DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Cacna1d

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_006518538.1 Gene:Cacna1d / 12289 MGIID:88293 Length:2207 Species:Mus musculus


Alignment Length:2055 Identity:447/2055 - (21%)
Similarity:786/2055 - (38%) Gaps:617/2055 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   369 SLTSVSLNTP-----------KTFERYPSLQ----------FITFASDT-------------AVT 399
            :|..:|||.|           |.|:.:..|.          :|.|..|.             |..
Mouse   105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFL 169

  Fly   400 LLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEV-LEIVPK-------- 455
            ::||.|...|:...|:|.....|:::.|...|       ::.:|:.:|.| ||.:.|        
Mouse   170 IIFTVETFLKIIAYGLLLHPNAYVRNGWNLLD-------FVIVIVGLFSVILEQLTKETEGGNHS 227

  Fly   456 --------FSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMS 510
                    ...|...|..|||.::.        .:|..::  |.|.| :...:.::.|..||.:.
Mouse   228 SGKSGGFDVKALRAFRVLRPLRLVS--------GVPSLQVVLNSIIK-AMVPLLHIALLVLFVII 283

  Fly   511 LYGLLGVQ-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSP-GMVCMKM 573
            :|.::|:: |.|::...|...:::....:.|        .|..|..    :|.||:. |..|   
Mouse   284 IYAIIGLELFIGKMHKTCFFADSDIVAEEDP--------APCAFSG----NGRQCTANGTEC--- 333

  Fly   574 DFLSSYVIGFNG----FEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAF-YFSTMIFFLA 633
               .|..:|.||    |::.|.::.||:|..:.|||..::|...|:: .|...: ||.::|...:
Mouse   334 ---RSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAI-GWEWPWVYFVSLIILGS 394

  Fly   634 WLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQIL-----------------------S 675
            :.|.|:.:.|::..|::.|.:.:    |||..||....|.|                       .
Mouse   395 FFVLNLVLGVLSGEFSKEREKAK----ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEE 455

  Fly   676 GNDTGWRLVTIDDN---------------------------KHGGLAP----------------- 696
            |.:.|.|..::..:                           |..|.|.                 
Mouse   456 GGEEGKRNTSMPTSETESVNTENVSGEGETQGCCGTLWCWWKRRGAAKTGPSGCRRWGQAISKSK 520

  Fly   697 -------------ETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRP------RDVFYERY 742
                         ..|.|.::|..|..||:.::..|   |.|::.:|..:|      :|:..:  
Mouse   521 LSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLN---TLTISSEHYNQPDWLTQIQDIANK-- 580

  Fly   743 YYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAG----TTLHIVPMFYPSGLTYFQV 803
             .:..:|||    |.|.|:|.||.:.|:....::|:..:..|    |.|..:.:..|.|::.|:.
Mouse   581 -VLLALFTC----EMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRC 640

  Fly   804 LRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF----TK- 860
            :|::|:.|.:   ..|...|..:....|.:.||::.....:||.|.:.||||....:|    || 
Mouse   641 VRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKR 705

  Fly   861 --FESFPEAFMSMFQILTQEAWVEVMDETMIR----TSKTLTPLVAVYFILYHLFVTLIVLSLFV 919
              |::||:|.:::|||||.|.|..||.:.::.    :|..:  :|.:|||:..:....|:|::|:
Mouse   706 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGM--IVCIYFIILFICGNYILLNVFL 768

  Fly   920 AVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRE 984
            |:.:|||...|.:...     :::.||.||    |.:|..|                       |
Mouse   769 AIAVDNLADAESLNTA-----QKEEAEEKE----RKKIARK-----------------------E 801

  Fly   985 SFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHII 1049
            |               :||.|                      |...:|....:|..|:.|....
Mouse   802 S---------------LENKK----------------------NNKPEVNQIANSDNKVTIDDYQ 829

  Fly  1050 NDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQT 1114
            .|:.       |....|......|                                      ::.
Mouse   830 EDAE-------DKDPYPPCDVPVG--------------------------------------EEE 849

  Fly  1115 YEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPR 1179
            .|...:..::.|.||                  .|:.:|:...::...:.|...|     |::.:
Mouse   850 EEEEEDEPEVPAGPR------------------PRRISELNMKEKIAPIPEGSAF-----FILSK 891

  Fly  1180 ESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFET 1244
            .:..|..|.|:::.                      |.|..|:  |.::|     ||..::..|.
Mouse   892 TNPIRVGCHKLINH----------------------HIFTNLI--LVFIM-----LSSAALAAED 927

  Fly  1245 P----NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSF 1305
            |    ::|   :..|...:|.|....::|:.||:...|.|....|:.::....||:.:..||   
Mouse   928 PIRSHSFR---NTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS--- 986

  Fly  1306 LCWMPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEILLVSTLLILLMFI 1367
            |....:.....|..::|.:||.:||||....   :.|:.:.|:...|....|::|:|   ||.|:
Mouse   987 LVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT---LLQFM 1048

  Fly  1368 FASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRF 1432
            ||..||||:.|:..||.|...|..|:|.|:|:         |....|...| ::..|:|.| ..|
Mouse  1049 FACIGVQLFKGKFYRCTDEAKSNPEECRGLFI---------LYKDGDVDSP-VVRERIWQN-SDF 1102

  Fly  1433 NFDNIGDAMLTLFEVLSFKGWLDVRDVLIKA-------VGPVH------AVYIHIYIFLGCMIGL 1484
            ||||:..||:.||.|.:|:||   ..:|.||       ||||:      :::..|||.:.....:
Mouse  1103 NFDNVLSAMMALFTVSTFEGW---PALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMM 1164

  Fly  1485 TLFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQPL--HLPPRPDGRKIRAFT 1539
            .:|||.||..:.| :|.     .:.:.|:|.|.        || |:||  ::|..|...|   |.
Mouse  1165 NIFVGFVIVTFQE-QGE-----KEYKNCELDKNQRQCVEYALK-ARPLRRYIPKNPYQYK---FW 1219

  Fly  1540 YDITQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRG 1603
            | :.....|:.::.|::::|::.|::. :.:.::..:.:.|::.|.|.||.||:|:|.|||.|:|
Mouse  1220 Y-VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKG 1283

  Fly  1604 YWQSRRNRYDLLVTVAGVI--------------W------IILQTIL------------------ 1630
            |:....|.:|.|:.:..:|              |      |::.:::                  
Mouse  1284 YFSDAWNTFDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPSESETIPLP 1348

  Fly  1631 ---------RNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSF----FIIFGMFLLV 1682
                     .|.:|..|..:..::|...:..:...::.|:.|    ..|||    ::...:.:|.
Mouse  1349 TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWT----FIKSFQALPYVALLIAMLF 1409

  Fly  1683 FFYALAGTILFGTVKYGEG--IGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGN 1745
            |.||:.|..:||.|...:.  |.|..||.:....|.:|||..|||.|.:||..|: ....|...:
Mouse  1410 FIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL-PGKLCDPDS 1473

  Fly  1746 NY---WETDCG-NFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQ 1806
            :|   .|..|| ||  :::||.:||::..::::||.||:||:||.  |...:.::|....:..|:
Mouse  1474 DYNPGEEYTCGSNF--AIVYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFK 1534

  Fly  1807 NTWNIVDIHQRG-------VIPVRRVKFIL---RLLKGRLECDPQKDRLLFKYMCYELDKLHNGE 1861
            ..|:..|...:|       |..:||::..|   :|...|:.|    .||:...|     .|::..
Mouse  1535 RIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVAC----KRLVAMNM-----PLNSDG 1590

  Fly  1862 DVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIR------------------ 1908
            .|.|:..:..|...::.|:....||:  |.||...::::...|.:::                  
Mouse  1591 TVMFNATLFALVRTALKIKTEGNLEQ--ANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGK 1653

  Fly  1909 ---TWL-------------EGCLKKIRAQNASKQQNSLIAGLRATNE-QPVMRP----NIQEDKA 1952
               |:|             :|.:.|..|:|.:   .:|.||||..:: .|.:|.    ::|:|:.
Mouse  1654 FYATFLIQDYFRKFKKRKEQGLVGKYPAKNTT---IALQAGLRTLHDIGPEIRRAISCDLQDDEP 1715

  Fly  1953 PLGAVDKSAISTISGAVAG-----------------------------ACPPTSDAFSPTFSSTE 1988
            .....::..:...:||:.|                             :.||.||...|.|....
Mouse  1716 EDSKPEEEDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSMPPASDTEKPLFPPAG 1780

  Fly  1989 NEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRGYAL 2053
            |   .|..:     .|:..||.....::|.|.......|....|.|.......||...|......
Mouse  1781 N---SGCHN-----HHNHNSIGKQAPTSTNANLNNANMSKAAHGKPPSIGNLEHVSENGHYSCKH 1837

  Fly  2054 NRSDSTGSSAGR-----KFLAPTSSDPQQRSTLSDKERLH 2088
            :|.....||..|     .::...|.|.|..:...:...:|
Mouse  1838 DRELQRRSSIKRTRYYETYIRSESGDEQFPTICREDPEIH 1877

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 74/340 (22%)
Ion_trans 734..927 CDD:278921 61/216 (28%)
Ion_trans 1240..1497 CDD:278921 83/276 (30%)
Ion_trans 1571..1793 CDD:278921 73/278 (26%)
Cacna1dXP_006518538.1 Ion_trans 125..417 CDD:366146 70/326 (21%)
Ion_trans 545..780 CDD:366146 69/246 (28%)
Ion_trans 905..1182 CDD:366146 92/334 (28%)
Ion_trans 1224..1523 CDD:366146 77/307 (25%)
GPHH 1532..1585 CDD:374878 14/61 (23%)
Ca_chan_IQ 1596..1667 CDD:370105 10/72 (14%)
CAC1F_C 1690..2206 CDD:374867 38/196 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.950

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