DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Cacna1c

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_036021662.1 Gene:Cacna1c / 12288 MGIID:103013 Length:2245 Species:Mus musculus


Alignment Length:2420 Identity:515/2420 - (21%)
Similarity:904/2420 - (37%) Gaps:763/2420 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 TPQQQQQQQHPHHQSHH---GHHYAHHQQHTHHHAPPHSHHPHPHPHGHPHSYPHLRHSQPASAS 169
            ||..|....|...::..   |......|.:..:.:|..|::..|.|       .|...:..|:| 
Mouse    10 TPPYQPLSSHSSEETERKFKGKVVHEAQLNCFYISPGGSNYGSPRP-------AHANMNANAAA- 66

  Fly   170 QFSFNPSPGSSPGNGLGLGARQDAASALNSPTTIVNSGSGSGGGSSVAFGMQPQQQQQSLAGGGG 234
              ...|....:||..|...|..|||.....        .||.|.::::.....|:::|..    |
Mouse    67 --GLAPEHIPTPGAALSWQAAIDAARQAKL--------MGSAGNATISTVSSTQRKRQQY----G 117

  Fly   235 -----GGSSATAAPSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGIS 294
                 ||::||..|.:                      ||                    |..:.
Mouse   118 KPKKQGGTTATRPPRA----------------------LL--------------------CLTLK 140

  Fly   295 STVGSAAITGV--PPIGLGI-ATGIGNKIMLGRKQSLKGGEPFLADYGPEESLN-ESADIEWVNK 355
            :.:..|.|:.|  .|..:.| .|...|.:.|...      .||     ||:..| .::::|.|..
Mouse   141 NPIRRACISIVEWKPFEIIILLTIFANCVALAIY------IPF-----PEDDSNATNSNLERVEY 194

  Fly   356 LWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEV 420
            |::                                         ::||.|...|:...|:|....
Mouse   195 LFL-----------------------------------------IIFTVEAFLKVIAYGLLFHPN 218

  Fly   421 PYLKDHWCQFDASMVSFLWISIILQIFE-VLEIVPKFSYLSIM---------RAPRPLIMIRFLR 475
            .||::.|...|       :|.:::.:|. :||...|....:.:         :|.|...::|.||
Mouse   219 AYLRNGWNLLD-------FIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLR 276

  Fly   476 VFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNTEYDLY 537
              |...:|..::  |.|.| :...:.::.|..||.:.:|.::|:: |.|::...|      |:  
Mouse   277 --LVSGVPSLQVVLNSIIK-AMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTC------YN-- 330

  Fly   538 KRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNG-------FEDIATSIFT 595
            :..|:.:.:...|.. |:::...|.||..|.||..         |::|       |::.|.::.|
Mouse   331 QEGIIDVPAEEDPSP-CALETGHGRQCQNGTVCKP---------GWDGPKHGITNFDNFAFAMLT 385

  Fly   596 VYQAASQEGWVFIMYRAIDS----LPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQ 656
            |:|..:.|||..::|...|:    || |   .||.:::.|.::.|.|:.:.|::..|::.|.:.:
Mouse   386 VFQCITMEGWTDVLYWMQDAMGYELP-W---VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 446

  Fly   657 QMWGARGHIQKTAASQILSGNDTGW-----RLVTID-----------------------DNKHGG 693
                |||..||....|.|..:..|:     :...||                       |.|.|.
Mouse   447 ----ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNRGAPAGLHDQKKGK 507

  Fly   694 LA--------------PET---------------------------------------------C 699
            .|              .||                                             |
Mouse   508 FAWFSHSTETHVSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKC 572

  Fly   700 HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFT------CLLDLETL 758
            .|.::|..|..||:.::..|   |.|:..:|..:|       ::..|:..|      .|...|.|
Mouse   573 RAAVKSNVFYWLVIFLVFLN---TLTIASEHYNQP-------HWLTEVQDTANKALLALFTAEML 627

  Fly   759 FKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV----PMFYPSGLTYFQVLRVVRLIKAS---PML 816
            .|:|.||.:.|:....::|:..:..|..|..:    .:..|.|::..:.:|::|:.|.:   ..|
Mouse   628 LKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSL 692

  Fly   817 EGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF-------TKFESFPEAFMSMFQI 874
            ...|..:....:.:.||::.....:||.|.:.||||....:|       :.|::||::.:::|||
Mouse   693 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQI 757

  Fly   875 LTQEAWVEVMDETMIRTSKTLTP--LVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQ 937
            ||.|.|..||.:.::.......|  ||.:|||:..:....|:|::|:|:.:|||   .|.:.|..
Mouse   758 LTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNL---ADAESLTS 819

  Fly   938 LKFREQSAEIKETL--PFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSL 1000
            .:..|:..:.::.|  |.|..       ||:                                  
Mouse   820 AQKEEEEEKERKKLARPARTA-------SPE---------------------------------- 843

  Fly  1001 VENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAML 1065
                              :||:   :|.|.|                 :.:|..:::        
Mouse   844 ------------------KKQE---VMEKPA-----------------VEESKEEKI-------- 862

  Fly  1066 PVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRA 1130
                     .|||......|.|                    :.|:........||.|  .:|.:
Mouse   863 ---------ELKSITADGESPP--------------------TTKINMDDLQPSENED--KSPHS 896

  Fly  1131 NSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENH------PFFD-TPLFLVPRESRFRKICQ 1188
            |...|...|         .::.||....|...|.|.|      |..: :..|:....:|||..|.
Mouse   897 NPDTAGEED---------EEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCH 952

  Fly  1189 KIVHARYDARL--------------KDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCIS 1239
            :||:......|              :||       ||:.|..|.  ::.|.|   |..||:..|.
Mouse   953 RIVNDTIFTNLILFFILLSSISLAAEDP-------VQHTSFRNH--ILFYFD---IVFTTIFTIE 1005

  Fly  1240 MMFETPNYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTS 1304
            :..:          .|..|:|.|....:||:.||:.|.|.|....::.::....||  :.|||.|
Mouse  1006 IALK----------ILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILD--LLVVSVS 1058

  Fly  1305 FLCW----MPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEILLVSTLLI 1362
            .:.:    ..:|:     .::|.:||.:||||....   :.|:.:.|:...|....|::|:|   
Mouse  1059 LISFGIQSSAINV-----VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT--- 1115

  Fly  1363 LLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWA 1427
            ||.|:||..||||:.|:|..|:|.:.....:|.|.:          :|....|....::.||.|.
Mouse  1116 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY----------ITYKDGEVDHPIIQPRSWE 1170

  Fly  1428 NPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV-------GPVH------AVYIHIYIFLG 1479
            | .:|:|||:..||:.||.|.:|:||   .::|.:::       ||::      :::..|||.:.
Mouse  1171 N-SKFDFDNVLAAMMALFTVSTFEGW---PELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIII 1231

  Fly  1480 CMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQPL--HLPPRPDGRK 1534
            ....:.:|||.||..:.| :|.     .:.:.|:|.|.        || |:||  ::|......|
Mouse  1232 AFFMMNIFVGFVIVTFQE-QGE-----QEYKNCELDKNQRQCVEYALK-ARPLRRYIPKNQHQYK 1289

  Fly  1535 IRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLV--IVSAVLTFVFVVEVVMKNI 1597
            :    :.:.....|:.::.|::|:|::.|::... |:....::.  |::.:.|.:|.||:::|.|
Mouse  1290 V----WYVVNSTYFEYLMFVLILLNTICLAMQHY-GQSCLFKIAMNILNMLFTGLFTVEMILKLI 1349

  Fly  1598 AFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFF-------------GFMV------- 1642
            ||.|:||:....|.:|.|:.:..:|.:||     ::.:::|             |.:|       
Mouse  1350 AFKPKGYFSDPWNVFDFLIVIGSIIDVIL-----SETNHYFCDAWNTFDALIVVGSIVDIAITEV 1409

  Fly  1643 -------------------VILRFFTITGKHTTLKMLMLTVGV-----SVCKSF----FIIFGMF 1679
                               :.:.||.:......:|:|....|:     :..|||    ::...:.
Mouse  1410 HPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIV 1474

  Fly  1680 LLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCM------- 1735
            :|.|.||:.|..:||.:...:  .|.|..||.:....|.:|||..|||.|..||..||       
Mouse  1475 MLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1539

  Fly  1736 -VQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSY 1799
             .:|...|.|    ||.||: :.::.||.:||::..::::||.||:||:||.  |...:.::|..
Mouse  1540 ESEPSNSTEG----ETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGP 1597

  Fly  1800 ADIRNFQNTWNIVDIHQRG-------VIPVRRVKFIL---RLLKGRLECDPQKDRLLFKYMCYEL 1854
            ..:..|:..|...|...:|       |..:||::..|   :|...|:.|    .||:...|    
Mouse  1598 HHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVAC----KRLVSMNM---- 1654

  Fly  1855 DKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLV--------------------- 1898
             .|::...|.|:..:..|...::.|:....||:  |.||...::                     
Mouse  1655 -PLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKKIWKRTSMKLLDQVVPPAGD 1716

  Fly  1899 -EEEVAKMTIRTWLEGCLKKIRAQNAS------KQQN--SLIAGLRATNE-QPVMRPNIQEDKAP 1953
             |..|.|......::...:|.:.:...      .|:|  ||.||||..:: .|.:|..|..|...
Mouse  1717 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTA 1781

  Fly  1954 LGAVDKSAISTISGAV-------AGACPPT------SDA---FSPTFSSTE--NEEKDGSSSAVV 2000
            ...:||:....:|.|.       ||.....      ||:   |..||::..  :..|.|::.|..
Mouse  1782 EEELDKAMKEAVSAASEDDIFRRAGGLFGNHVTYYQSDSRGNFPQTFATQRPLHINKTGNNQADT 1846

  Fly  2001 QLPHSE---------TSIAGTGSSA---TGAATATG-----------TSSGLGVGPP-----TVQ 2037
            :.|..|         :|.:.|||:|   ....||.|           .|:..|.|||     .||
Mouse  1847 ESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHGPPLSPAVRVQ 1911

  Fly  2038 STARHVMTVGKRGYALNRSDSTGSSAGRKFL------------APTSSDPQQRST----LSDKER 2086
            ..|..:.:  ||.::   .:|.|::..::..            |...|:|...||    ..:.|.
Mouse  1912 EAAWKLSS--KRCHS---RESQGATVNQEIFPDETRSVRMSEEAEYCSEPSLLSTDMFSYQEDEH 1971

  Fly  2087 LHITSQQRKKNSMTTLP-----HAGQLGQ--------LAKQRGGGGEATKSSSF----------- 2127
            ..:|..:..|..:...|     .:..||:        |.:|:..||:.::.::.           
Mouse  1972 RQLTCPEEDKREIQPSPKRSFLRSASLGRRASFHLECLKRQKDQGGDISQKTALPLHLVHHQALA 2036

  Fly  2128 FAQLNSEIGQFHYPT 2142
            .|.|:..:.:.|.||
Mouse  2037 VAGLSPLLQRSHSPT 2051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 66/304 (22%)
Ion_trans 734..927 CDD:278921 55/214 (26%)
Ion_trans 1240..1497 CDD:278921 75/276 (27%)
Ion_trans 1571..1793 CDD:278921 72/281 (26%)
Cacna1cXP_036021662.1 Ion_trans 153..446 CDD:395416 79/376 (21%)
Ion_trans 578..819 CDD:395416 66/253 (26%)
Ion_trans 957..1254 CDD:395416 90/348 (26%)
Ion_trans 1296..1593 CDD:395416 78/309 (25%)
GPHH 1602..1655 CDD:407139 14/61 (23%)
Ca_chan_IQ 1666..1737 CDD:400901 10/72 (14%)
CAC1F_C 1759..2194 CDD:407123 64/298 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.950

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