DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and Cacna1b

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	XP_006497689.1	Gene:	Cacna1b / 12287	MGIID:	88296	Length:	2351	Species:	Mus musculus

Alignment Length:	2382	Identity:	513/2382 - (21%)
Similarity:	877/2382 - (36%)	Gaps:	640/2382 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 GAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSAAITGVPPIGLGIATGI 316
            |..||...||.|||....|  ||.||.||    .|.|               |:||
Mouse     5 GDELGGRYGGTGGGERARG--GGAGGAGG----PGQG---------------GLPP--------- 39

  Fly   317 GNKIMLGRKQSLKGGEPFLADYGPEE------SLNESADI---------------EW--VNKLWV 358
            |.:::.  |||:......:|.|.|..      ::|.|..:               ||  ...:.:
Mouse    40 GQRVLY--KQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMIL 102

  Fly   359 RRLMRLCALVSLTSVSLNTPKT--FERYPSLQ--FITFASDTAVTLLFTAEMIAKMHIRGVLHGE 419
            ..::..|.:::|.....:..||  .||....:  ||.         :|..|...|:...|.:..:
Mouse   103 ATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIG---------IFCFEAGIKIIALGFVFHK 158

  Fly   420 VPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM---IRFLRVFLKFS 481
            ..||::.|...|       ::.::..|............|..:|..|||.:   |..|:|.|| |
Mouse   159 GSYLRNGWNVMD-------FVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLK-S 215

  Fly   482 MPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTIN 545
            :.|:.:         .:..:.|...|.:.::.::|::|: |:....|..|:|:.:
Mouse   216 IMKAMV---------PLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDTE---------- 261

  Fly   546 SLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMY 610
              .:.|..|..||.: .||.....|  .::......|...|::|..:|.||:|..:.|||..|:|
Mouse   262 --PVGDFPCGKDPPA-RQCDGDTEC--REYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILY 321

  Fly   611 RAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVIT-------------ETFNEIRVQFQQMWGAR 662
            ...|:........||..:|...::.:.|:.:.|::             ..|.::|.|.|......
Mouse   322 NTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELN 386

  Fly   663 GHIQ---------------------------KTAASQILSGNDTGWRLVTIDDNKHG-----GLA 695
            |:::                           |.||:: .|.||    |:..::.:..     .:.
Mouse   387 GYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAATK-KSRND----LIHAEEGEDRFVDLCAVG 446

  Fly   696 PETCHAILR------SPYFR--------------------MLVMSVILANGIVTATMTFKHDGRP 734
            .....|.|:      |.|||                    .:|:.|:..|.:..|.:   |..:|
Mouse   447 SPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMV---HYNQP 508

  Fly   735 RDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV-PMFYPS-- 796
            :.: ....|:.|.||..|...|...|:|.||.|.|::.|.:.|:..:..|:...:| ....|.
Mouse   509 QRL-TTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTS 572

  Fly   797 -GLTYFQVLRVVRLIKASP---MLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCD 857
             |::..:.||::|:.|.:.   .|...|..:....|.:.||:......:::.:.:.||||....:
Mouse   573 FGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN 637

  Fly   858 F------TKFESFPEAFMSMFQILTQEAWVEVM---DETMIRTSKTLTPLVAVYFILYHLFVTLI 913
            |      |.|::||.|.:::|||||.|.|..||   .|:....||.:  ..:.|||:..||....
Mouse   638 FQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGM--FSSFYFIVLTLFGNYT 700

  Fly   914 VLSLFVAVILDNL----ELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIP 974
            :|::|:|:.:|||    ||.:|.:::      |::|..|..|.....:.|..|.|.....:
Mouse   701 LLNVFLAIAVDNLANAQELTKDEEEM------EEAANQKLALQKAKEVAEVSPMSAANISI---- 755

  Fly   975 NDFMLPKVRESFMKHFVIELETEDSLVE-NCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGS 1038
                     .:|:|.....:....|:.. |..|..:.....:|..::...:|:.|..|...|..|
Mouse   756 ---------AAFVKQTRGTVSRSSSVSSVNSPRQQNSAKARSVWEQRASQLRLQNLRASCEALYS 811

  Fly  1039 S------LRKLAITHIIND-------------------------SNNQRLMLGDSAMLP------ 1066
            .      ||..:..|:..|                         |..:.....:||.||
Mouse   812 EMDPEERLRYASTRHVRPDMKTHMDRPLVVEPGRDGLRGPVGSKSKPEGTEATESADLPRRHHRH 876

  Fly  1067 -------VVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSI------------RRSVRSGS---- 1108
                   .....||...:::.|.|.::..|...::..|:..            ||..|.||
Mouse   877 RDRDKTSATAPAGGEQDRTESTETGAREERARPRRSHSKETPGADTQVRCERSRRHHRRGSPEEA 941

  Fly  1109 ----IKLKQTYEHLMENGDIAAAP----------RANSGRARP----------------HDLDIK 1143
                .:..:.:.|..::.....||          |....|..|                |.:...
Mouse   942 TEREPRRHRAHRHAQDSSKEGTAPVLVPKGERRARHRGPRTGPREAENNEEPTRRHRARHKVPPT 1006

  Fly  1144 LLQAKRQQAEMRRNQREEDLR-ENH----PFFDT---------PLFLVPRESRFRKICQKIVHA- 1193
            |...:|:.||...|..|.|.. .||    |..|.         ||.::| .:..:|:.::...|
Mouse  1007 LQPPEREAAEKESNAVEGDKETRNHQPKEPHCDLEAIAVTGVGPLHMLP-STCLQKVDEQPEDAD 1070

  Fly  1194 ------RYDARLKDP---------LTG----------------------KERK------------ 1209
                  |..::..||         |||                      ||.:
Mouse  1071 NQRNVTRMGSQPSDPSTTVHVPVTLTGPPGETPVVPSGNMNLEGQAEGKKEAEADDVLRRGPRPI 1135

  Fly  1210 VQYKSLH------------NFLGLVTYLDWVMIFATTLSCISMMFETP----NYRVMDHPTLQIA 1258
            |.|.|:.            :::..:.|.:.|::....||.|::..|.|    ::|   :..|:..
Mouse  1136 VPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFR---NNALKYM 1197

  Fly  1259 EYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYV----VSTSFLCWM------PLNI 1313
            :|.|....:.|:.:|::..||...|.||.:|:...|| ||.|    |:.:|..:|      .:|
Mouse  1198 DYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILD-FIVVSGALVAFAFSSFMGGSKGKDIN- 1260

  Fly  1314 PTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGG 1378
                ..:.|.:||.:|||:....:|.::.|...:....|.:|.:..:.:|.|||||...|||:.|
Mouse  1261 ----TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1321

  Fly  1379 RLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLT 1443
            :...|.|.:.....||.|.::             ..|.......||.| ....|::||:..|:||
Mouse  1322 KFFYCTDESKELERDCRGQYL-------------DYEKEEVEAQPRQW-KKYDFHYDNVLWALLT 1372

  Fly  1444 LFEVLSFKGWLDVR----DVLIKAVGP----------VHAVYIHIYIFLGCMIGLTLFVGVVIAN 1494
            ||.|.:.:||..|.    |...:..||          .:.||..::.|    ..:.:||.::|..
Mouse  1373 LFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPF----FFVNIFVALIIIT 1433

  Fly  1495 YSENKGTALLTVDQRRWCDLKKRLKI-------AQPL--HLPPRPDGRKIRAFTYDITQHIIFKR 1550
            :.| :|..:::.     |.|:|..:.       |:||  ::|......:.:.:|:.::..  |:.
Mouse  1434 FQE-QGDKVMSE-----CSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPP--FEY 1490

  Fly  1551 VIAVVVLINSMLLSITWIKGEVHTE-RLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDL 1614
            .|..::.:|:::|.:.:.......| .|..::.|.|.:|.:|.::|.|||....|::...|.:|
Mouse  1491 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVFD- 1554

  Fly  1615 LVTVAGVIWIILQTIL---RNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIF 1676
            .|||.|.|..||.|.:   .|.::..|..:....|...:..:..|:::|:.|...|.....::..
Mouse  1555 FVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCL 1619

  Fly  1677 GMFLLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPP 1739
            .:.:|.|.||:.|..:||.:...:  .|.|..||.:.:..:.:|||..|||.|::||..|
Mouse  1620 LIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSC----- 1679

  Fly  1740 YCTLGNNYWE-----TDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSY 1799
               |||...:     ::||:..| ..||.:|..:.::::|||.||:||:||.  |...:.::|..
Mouse  1680 ---LGNRACDPHANASECGSDFA-YFYFVSFIFLCSFLMLNLFVAVIMDNFE--YLTRDSSILGP 1738

  Fly  1800 ADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQKDRLLFKYMCYELDKLHNG 1860
            ..:..|...|...|....|.|....:..:|:.:...|    :|..   |:.:|.: ..::...:.
Mouse  1739 HHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPA---RVAYKRL-VRMNMPISN 1799

  Fly  1861 EDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWL-------------- 1911
            ||:|.|....:::.    ||.||:: :|......::..:.|:.|.....|.
Mouse  1800 EDMTVHFTSTLMAL----IRTALEI-KLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLLVPPH 1859

  Fly  1912 ---EGCLKKIRA---------QNASKQQN--------------SLIAGLRATNEQ---PVMRPNI 1947
               |..:.|:.|         ||.:.:..              ||...|:||.||   .|:|
Mouse  1860 KPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR--- 1921

  Fly  1948 QEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDG--SSSAVVQLPHS-ETSI 2009
               .|.:....|||.|..:|   ||..........:.|......:|.  .:.|.::..|| |..:
Mouse  1922 ---GARVFLRQKSATSLSNG---GAIQTQESGIKESLSWGTQRTQDALYEARAPLERGHSAEIPV 1980

  Fly  2010 AGTGSSATGAATATGTSSGL-GVGPPTVQSTARHV--------MTVGKRGYALNRSDSTGSSAGR 2065
            ..:|:.|........|..|. |...|.::|..|..        .........:.||.||
Mouse  1981 GQSGTLAVDVQMQNMTLRGPDGEPQPGLESQGRAASMPRLAAETQPAPNASPMKRSIST------ 2039

  Fly  2066 KFLAPTSSDPQQRSTLSDK-----------ERLHITSQQRKKNSMTT------------------ 2101
              |||.....|..||:.|:           .|.| ..:.:|:.|:..
Mouse  2040 --LAPRPHGTQLCSTVLDRPPPSQASHHHHHRCH-RRRDKKQRSLEKGPSLSVDPEGAPSTAAGP 2101

  Fly  2102 -LPHAGQLGQLA------KQRGGGGEATKSSSFFAQLNSEIGQFH-------------------Y 2140
             ||| |: |..|      ::||...|..:.||    .:||..:|:                   :
Mouse  2102 GLPH-GE-GSTACRRDRKQERGRSQERRQPSS----SSSEKQRFYSCDRFGSREPPQLMPSLSSH 2160

  Fly  2141 PTINAAAAAAALHGYGHGHGHGH-----GGHGGHGGHGEHQM 2177
            ||...||...|.|..|.|..:|.     .|....|..|..|:
Mouse  2161 PTSPTAALEPAPHPQGSGSVNGSPLMSTSGASTPGRGGRRQL 2202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	62/301 (21%)
		Ion_trans	734..927	CDD:278921	61/212 (29%)
		Ion_trans	1240..1497	CDD:278921	73/284 (26%)
		Ion_trans	1571..1793	CDD:278921	68/232 (29%)
Cacna1b	XP_006497689.1	Ion_trans	94..367	CDD:366146	63/313 (20%)
		Ion_trans	482..721	CDD:366146	68/244 (28%)
		Granin	<936..>1041	CDD:279595	20/104 (19%)
		Ion_trans	1161..1395	CDD:366146	70/256 (27%)
		Ion_trans	1485..1734	CDD:366146	72/262 (27%)
		GPHH	1743..1796	CDD:374878	10/56 (18%)
		Ca_chan_IQ	1808..1882	CDD:370105	11/78 (14%)
		PHA03307	1959..>2326	CDD:223039	55/259 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920