DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Cacna1a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_006530650.1 Gene:Cacna1a / 12286 MGIID:109482 Length:2464 Species:Mus musculus


Alignment Length:2391 Identity:507/2391 - (21%)
Similarity:832/2391 - (34%) Gaps:665/2391 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 GGGGGGSSATAAPSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGG--MGGMGG---------GAAA 284
            |.|||||              |...|.|||..||     .|.||  .||..|         ...|
Mouse   102 GAGGGGS--------------GPAAGVVVGAAGG-----RGAGGSRQGGQPGAQRMYKQSMAQRA 147

  Fly   285 AGMGICGGI-----SSTVG---------------SAAITGVPPIG-LGIATGIGNKIMLGRKQSL 328
            ..|.:...|     ..||.               :..||..||.. :.:||.|.|.|:|..:|.|
Mouse   148 RTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHL 212

  Fly   329 KGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQ--FIT 391
                       |::.                                .||.: ||....:  ||.
Mouse   213 -----------PDDD--------------------------------KTPMS-ERLDDTEPYFIG 233

  Fly   392 FASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKF 456
                     :|..|...|:...|....:..||::.|...|       ::.::..|...:......
Mouse   234 ---------IFCFEAGIKIVALGFAFHKGSYLRNGWNVMD-------FVVVLTGILATVGTEFDL 282

  Fly   457 SYLSIMRAPRPLIM---IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ 518
            ..|..:|..|||.:   |..|:|.|| |:.|:.|         .:..:.|...|.:.::.::|::
Mouse   283 RTLRAVRVLRPLKLVSGIPSLQVVLK-SIMKAMI---------PLLQIGLLLFFAILIFAIIGLE 337

  Fly   519 FF-GELKNHCVMNNTEYDLY---KRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSY 579
            |: |:....|....|: |:.   ..|..|..    |...|    .:|.:|.|        :....
Mouse   338 FYMGKFHTTCFEEGTD-DIQGESPAPCGTEE----PARTC----PNGTKCQP--------YWEGP 385

  Fly   580 VIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAID-SLPAWRAAFYFSTMIFFLAWLVKNVFIAV 643
            ..|...|::|..::.||:|..:.|||..::|.:.| |...|. ..||..:|...::.:.|:.:.|
Mouse   386 NNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWN-WLYFIPLIIIGSFFMLNLVLGV 449

  Fly   644 IT-------------ETFNEIRVQFQQMWGARGHIQ--KTAASQILSGNDT-----------GWR 682
            ::             ..|.::|.|.|......|:::  ..|...||:.::|           ..|
Mouse   450 LSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDVGALR 514

  Fly   683 LVTIDDNKHGGLAPETCH------AILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYER 741
            ..|:..:|...|.||...      |.:.||:.|..:.|..|.|.      ||.|....|..||.|
Mouse   515 RATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENS------TFFHKKERRMRFYIR 573

  Fly   742 -------------------------------------YYYIELVFTCLLDLETLFKIYCLGWRGY 769
                                                 .||.|.:|..|...|...|:|.||.|.|
Mouse   574 RMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPY 638

  Fly   770 YKHSIHKFELLLAAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPG 827
            :..|.:.|:..:..|:...:: .:..|.   |::..:.||::|:.|.:   ..|...|..:....
Mouse   639 FHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSM 703

  Fly   828 KKLGSLIIFTMCLLIISSSISMQLFCFLCDF------TKFESFPEAFMSMFQILTQEAWVEVMDE 886
            |.:.||:......:::.:.:.||||....:|      |.|::||.|.|::|||||.|.|.|||.:
Mouse   704 KSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYD 768

  Fly   887 TMIRTSKTLTPLV-AVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKET 950
            .:.........:| ::|||:..||....:|::|:|:.:|||...:::.|.:|.:  |::|..|..
Mouse   769 GIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE--EEAANQKLA 831

  Fly   951 LPFRLRIFEKFP-DSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSL----------VENC 1004
            |.....:.|..| .:..|:|  .:.......|..:|..:....|:..::.|          .|..
Mouse   832 LQKAKEVAEVSPLSAANMSI--AVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALYGDAAERW 894

  Fly  1005 KRPMSECWESNVVFRKQKPVRI------MNKTAKVRAAGSSLRKLA------------------- 1044
            ..|.:.....:|.....:|:.:      .|.|.|.||. .:||..|                   
Mouse   895 PTPYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAP-EALRPTARPRESARDPDARRAWPGSP 958

  Fly  1045 ------------------------ITHIINDSNNQRLMLGDS----------------------- 1062
                                    ..|...|::.:|...||:                       
Mouse   959 ERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRP 1023

  Fly  1063 ----------------AMLPVVGTKGGG--GLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGS- 1108
                            |..|.....|.|  |.:.: ...|..|...|:::   |..||....|| 
Mouse  1024 GDEPDDRPERRPRPRDATRPARAADGEGDDGERKR-RHRHGPPAHDDRER---RHRRRKENQGSG 1084

  Fly  1109 ----------------------IKLKQTYEHLMENGDIAAAPRANSGRARPHD---------LDI 1142
                                  :.|.:..:: |:|..:|....|:     |||         ...
Mouse  1085 VPVSGPNLSTTRPIQQDLGRQDLPLAEDLDN-MKNNKLATGEPAS-----PHDSLGHSGLPPSPA 1143

  Fly  1143 KL---------LQAKRQQAEMRR---------NQREEDLRENHPFFDTPLFLVPRESRFRK---- 1185
            |:         |....|.|..||         |.......||......|....|..::..:    
Mouse  1144 KIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEH 1208

  Fly  1186 -------ICQKIVHARYDARLK---DPLTGKERKVQ-----------------YKSL-------- 1215
                   .|..:.|........   |||..||.:.:                 |.|:        
Mouse  1209 MAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNP 1273

  Fly  1216 -----HNFLGLVTYLDWVMIFATTLSCISMMFETP-NYRVMDHPTLQIAEYGFVIFMSLELALKI 1274
                 |..|.| .|.:..::....:|.|::..|.| ......:..|:..:|.|....:.|:.:|:
Mouse  1274 LRRLCHYILNL-RYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKM 1337

  Fly  1275 LADGLFFTPKAYIKD---------VAAALDVFIYVVSTSFLCWMPLNIPTNS------AAQLLMI 1324
            :..||.....||.:|         |:.||..|.:..||.          .||      ..:.|.:
Mouse  1338 IDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTSSTR----------GNSKGKDINTIKSLRV 1392

  Fly  1325 LRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTIS 1389
            ||.:|||:....:|.::.|...:....|.:..:..:.:|.|||||...|||:.|:...|.|.:..
Mouse  1393 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKE 1457

  Fly  1390 RREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWL 1454
            ...||.|.::..             |........|.| ....|::||:..|:||||.|.:.:||.
Mouse  1458 FERDCRGKYLLY-------------EKNEVKARDREW-KKYEFHYDNVLWALLTLFTVSTGEGWP 1508

  Fly  1455 DVR----DVLIKAVGP----------VHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTAL-- 1503
            .|.    |...:..||          .:.||..::.|    ..:.:||.::|..:.|.....:  
Mouse  1509 QVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF----FFVNIFVALIIITFQEQGDKMMEE 1569

  Fly  1504 --LTVDQRRWCDLKKRLKIAQPL--HLPPRPDGRKIRAFTYDITQHII---FKRVIAVVVLINSM 1561
              |..::|...|....   |:||  |:|     :..::|.|.:.|.::   |:..|..::.:|::
Mouse  1570 YSLEKNERACIDFAIS---AKPLTRHMP-----QNKQSFQYRMWQFVVSPPFEYTIMAMIALNTI 1626

  Fly  1562 LLSITWIKGEVHTER-LVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWII 1625
            :|.:.:....|..|. |.:.:.|.|.:|.:|.|:|.:||....|::...|.:| .|||.|.|..|
Mouse  1627 VLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFD-FVTVLGSITDI 1690

  Fly  1626 LQTILRN-----DLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFY 1685
            |.|...|     :||:...|...  |...:..:..|:::|:.|...|.....::...:.:|.|.|
Mouse  1691 LVTEFGNPNNFINLSFLRLFRAA--RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1753

  Fly  1686 ALAGTILFGTVKY-GEG---------IGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPY 1740
            |:.|..:||.:.. ||.         |....||.:....:.:|||..|||.|:.||..|:...| 
Mouse  1754 AIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP- 1817

  Fly  1741 CTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNF 1805
            |...:.....||||..| ..||.:|..:.::::|||.||:||:||.  |...:.::|....:..:
Mouse  1818 CDKNSGILTADCGNEFA-YFYFVSFIFLCSFLMLNLFVAVIMDNFE--YLTRDSSILGPHHLDEY 1879

  Fly  1806 QNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQK---DRLLFKYMCYELD-KLHNGED 1862
            ...|...|....|.|..:.:..:||::...|    :| |.:   .|||      .:| .:.:...
Mouse  1880 VRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKC-PHRVACKRLL------RMDLPVADDNT 1937

  Fly  1863 VTFHDVINMLSYRSVDIRKA------------LQLEEL-----LAREEFEYLVEEE--------- 1901
            |.|:..:..|...::||:.|            |:.|.:     |:::..:.||...         
Mouse  1938 VHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGK 2002

  Fly  1902 --VAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAIST 1964
              .|.|.:..:.:...||::|....:            |..|:|...: |..:|         :.
Mouse  2003 IYAAMMIMEYYRQSKAKKLQAMREEQ------------NRTPLMFQRM-EPPSP---------TQ 2045

  Fly  1965 ISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGL 2029
            ..|....|.|.|.........:.|...|: |.|.|.|.........||.|...|.......|.  
Mouse  2046 EGGPSQNALPSTQLDPGGGLMAHEGGMKE-SPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQ-- 2107

  Fly  2030 GVGPPTVQSTARHVMTVGKRGYALNRSDS------TGSSAGRKFLAPTSSDPQQR--------ST 2080
                |..||.....|  |..||    |||      .|.:.........:.:.::|        ||
Mouse  2108 ----PNSQSVEMREM--GTDGY----SDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLST 2162

  Fly  2081 LSDKERLHITSQQRKKNSMTTLPHAGQLGQLA-------------KQRGGGGEATKSSSF--FAQ 2130
            :||      ||..::..|:.. |.|.:|...:             ::|...|..|...|.  :..
Mouse  2163 ISD------TSPMKRSASVLG-PKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTD 2220

  Fly  2131 LNSEIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGGHGGHGEHQMHHHH 2181
            :::.:|    ..::....:..|.........|......|..|..|..||||
Mouse  2221 VDTGLG----TDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHH 2267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 63/303 (21%)
Ion_trans 734..927 CDD:278921 62/243 (26%)
Ion_trans 1240..1497 CDD:278921 68/286 (24%)
Ion_trans 1571..1793 CDD:278921 73/237 (31%)
Cacna1aXP_006530650.1 Ion_trans 188..462 CDD:366146 72/361 (20%)
Ion_trans 579..817 CDD:366146 59/237 (25%)
PHA03247 <895..1277 CDD:223021 57/392 (15%)
Ion_trans 1285..1520 CDD:366146 63/258 (24%)
Ion_trans 1610..1869 CDD:366146 77/265 (29%)
GPHH 1878..1931 CDD:374878 13/59 (22%)
Ca_chan_IQ 1942..2015 CDD:370105 11/72 (15%)
PHA03307 2046..>2460 CDD:223039 51/246 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.950

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