Protein Alignment na and Cacna1a

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_006530650.1
• Gene: Cacna1a / 12286
• MGIID: 109482
• Length: 2464
• Species: Mus musculus
• Alignment Length: 2391
• Identity: 507/2391 - (21%)
• Similarity: 832/2391 - (34%)
• Gaps: 665/2391 - (27%)

  Fly   231 GGGGGGSSATAAPSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGG--MGGMGG---------GAAA 284
            |.|||||              |...|.|||..||     .|.||  .||..|         ...|
Mouse   102 GAGGGGS--------------GPAAGVVVGAAGG-----RGAGGSRQGGQPGAQRMYKQSMAQRA 147

  Fly   285 AGMGICGGI-----SSTVG---------------SAAITGVPPIG-LGIATGIGNKIMLGRKQSL 328
            ..|.:...|     ..||.               :..||..||.. :.:||.|.|.|:|..:|.|
Mouse   148 RTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHL 212

  Fly   329 KGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQ--FIT 391
                       |::.                                .||.: ||....:  ||.
Mouse   213 -----------PDDD--------------------------------KTPMS-ERLDDTEPYFIG 233

  Fly   392 FASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKF 456
                     :|..|...|:...|....:..||::.|...|       ::.::..|...:......
Mouse   234 ---------IFCFEAGIKIVALGFAFHKGSYLRNGWNVMD-------FVVVLTGILATVGTEFDL 282

  Fly   457 SYLSIMRAPRPLIM---IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ 518
            ..|..:|..|||.:   |..|:|.|| |:.|:.|         .:..:.|...|.:.::.::|::
Mouse   283 RTLRAVRVLRPLKLVSGIPSLQVVLK-SIMKAMI---------PLLQIGLLLFFAILIFAIIGLE 337

  Fly   519 FF-GELKNHCVMNNTEYDLY---KRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSY 579
            |: |:....|....|: |:.   ..|..|..    |...|    .:|.:|.|        :....
Mouse   338 FYMGKFHTTCFEEGTD-DIQGESPAPCGTEE----PARTC----PNGTKCQP--------YWEGP 385

  Fly   580 VIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAID-SLPAWRAAFYFSTMIFFLAWLVKNVFIAV 643
            ..|...|::|..::.||:|..:.|||..::|.:.| |...|. ..||..:|...::.:.|:.:.|
Mouse   386 NNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWN-WLYFIPLIIIGSFFMLNLVLGV 449

  Fly   644 IT-------------ETFNEIRVQFQQMWGARGHIQ--KTAASQILSGNDT-----------GWR 682
            ::             ..|.::|.|.|......|:::  ..|...||:.::|           ..|
Mouse   450 LSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDVGALR 514

  Fly   683 LVTIDDNKHGGLAPETCH------AILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYER 741
            ..|:..:|...|.||...      |.:.||:.|..:.|..|.|.      ||.|....|..||.|
Mouse   515 RATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENS------TFFHKKERRMRFYIR 573

  Fly   742 -------------------------------------YYYIELVFTCLLDLETLFKIYCLGWRGY 769
                                                 .||.|.:|..|...|...|:|.||.|.|
Mouse   574 RMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPY 638

  Fly   770 YKHSIHKFELLLAAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPG 827
            :..|.:.|:..:..|:...:: .:..|.   |::..:.||::|:.|.:   ..|...|..:....
Mouse   639 FHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSM 703

  Fly   828 KKLGSLIIFTMCLLIISSSISMQLFCFLCDF------TKFESFPEAFMSMFQILTQEAWVEVMDE 886
            |.:.||:......:::.:.:.||||....:|      |.|::||.|.|::|||||.|.|.|||.:
Mouse   704 KSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYD 768

  Fly   887 TMIRTSKTLTPLV-AVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKET 950
            .:.........:| ::|||:..||....:|::|:|:.:|||...:::.|.:|.:  |::|..|..
Mouse   769 GIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE--EEAANQKLA 831

  Fly   951 LPFRLRIFEKFP-DSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSL----------VENC 1004
            |.....:.|..| .:..|:|  .:.......|..:|..:....|:..::.|          .|..
Mouse   832 LQKAKEVAEVSPLSAANMSI--AVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALYGDAAERW 894

  Fly  1005 KRPMSECWESNVVFRKQKPVRI------MNKTAKVRAAGSSLRKLA------------------- 1044
            ..|.:.....:|.....:|:.:      .|.|.|.||. .:||..|
Mouse   895 PTPYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAP-EALRPTARPRESARDPDARRAWPGSP 958

  Fly  1045 ------------------------ITHIINDSNNQRLMLGDS----------------------- 1062
                                    ..|...|::.:|...||:
Mouse   959 ERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRP 1023

  Fly  1063 ----------------AMLPVVGTKGGG--GLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGS- 1108
                            |..|.....|.|  |.:.: ...|..|...|:::   |..||....||
Mouse  1024 GDEPDDRPERRPRPRDATRPARAADGEGDDGERKR-RHRHGPPAHDDRER---RHRRRKENQGSG 1084

  Fly  1109 ----------------------IKLKQTYEHLMENGDIAAAPRANSGRARPHD---------LDI 1142
                                  :.|.:..:: |:|..:|....|:     |||         ...
Mouse  1085 VPVSGPNLSTTRPIQQDLGRQDLPLAEDLDN-MKNNKLATGEPAS-----PHDSLGHSGLPPSPA 1143

  Fly  1143 KL---------LQAKRQQAEMRR---------NQREEDLRENHPFFDTPLFLVPRESRFRK---- 1185
            |:         |....|.|..||         |.......||......|....|..::..:
Mouse  1144 KIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEH 1208

  Fly  1186 -------ICQKIVHARYDARLK---DPLTGKERKVQ-----------------YKSL-------- 1215
                   .|..:.|........   |||..||.:.:                 |.|:
Mouse  1209 MAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNP 1273

  Fly  1216 -----HNFLGLVTYLDWVMIFATTLSCISMMFETP-NYRVMDHPTLQIAEYGFVIFMSLELALKI 1274
                 |..|.| .|.:..::....:|.|::..|.| ......:..|:..:|.|....:.|:.:|:
Mouse  1274 LRRLCHYILNL-RYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKM 1337

  Fly  1275 LADGLFFTPKAYIKD---------VAAALDVFIYVVSTSFLCWMPLNIPTNS------AAQLLMI 1324
            :..||.....||.:|         |:.||..|.:..||.          .||      ..:.|.:
Mouse  1338 IDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTSSTR----------GNSKGKDINTIKSLRV 1392

  Fly  1325 LRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTIS 1389
            ||.:|||:....:|.::.|...:....|.:..:..:.:|.|||||...|||:.|:...|.|.:..
Mouse  1393 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKE 1457

  Fly  1390 RREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWL 1454
            ...||.|.::..             |........|.| ....|::||:..|:||||.|.:.:||.
Mouse  1458 FERDCRGKYLLY-------------EKNEVKARDREW-KKYEFHYDNVLWALLTLFTVSTGEGWP 1508

  Fly  1455 DVR----DVLIKAVGP----------VHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTAL-- 1503
            .|.    |...:..||          .:.||..::.|    ..:.:||.::|..:.|.....:
Mouse  1509 QVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF----FFVNIFVALIIITFQEQGDKMMEE 1569

  Fly  1504 --LTVDQRRWCDLKKRLKIAQPL--HLPPRPDGRKIRAFTYDITQHII---FKRVIAVVVLINSM 1561
              |..::|...|....   |:||  |:|     :..::|.|.:.|.::   |:..|..::.:|::
Mouse  1570 YSLEKNERACIDFAIS---AKPLTRHMP-----QNKQSFQYRMWQFVVSPPFEYTIMAMIALNTI 1626

  Fly  1562 LLSITWIKGEVHTER-LVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWII 1625
            :|.:.:....|..|. |.:.:.|.|.:|.:|.|:|.:||....|::...|.:| .|||.|.|..|
Mouse  1627 VLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFD-FVTVLGSITDI 1690

  Fly  1626 LQTILRN-----DLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFY 1685
            |.|...|     :||:...|...  |...:..:..|:::|:.|...|.....::...:.:|.|.|
Mouse  1691 LVTEFGNPNNFINLSFLRLFRAA--RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1753

  Fly  1686 ALAGTILFGTVKY-GEG---------IGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPY 1740
            |:.|..:||.:.. ||.         |....||.:....:.:|||..|||.|:.||..|:...|
Mouse  1754 AIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP- 1817

  Fly  1741 CTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNF 1805
            |...:.....||||..| ..||.:|..:.::::|||.||:||:||.  |...:.::|....:..:
Mouse  1818 CDKNSGILTADCGNEFA-YFYFVSFIFLCSFLMLNLFVAVIMDNFE--YLTRDSSILGPHHLDEY 1879

  Fly  1806 QNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQK---DRLLFKYMCYELD-KLHNGED 1862
            ...|...|....|.|..:.:..:||::...|    :| |.:   .|||      .:| .:.:...
Mouse  1880 VRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKC-PHRVACKRLL------RMDLPVADDNT 1937

  Fly  1863 VTFHDVINMLSYRSVDIRKA------------LQLEEL-----LAREEFEYLVEEE--------- 1901
            |.|:..:..|...::||:.|            |:.|.:     |:::..:.||...
Mouse  1938 VHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGK 2002

  Fly  1902 --VAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAIST 1964
              .|.|.:..:.:...||::|....:            |..|:|...: |..:|         :.
Mouse  2003 IYAAMMIMEYYRQSKAKKLQAMREEQ------------NRTPLMFQRM-EPPSP---------TQ 2045

  Fly  1965 ISGAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGL 2029
            ..|....|.|.|.........:.|...|: |.|.|.|.........||.|...|.......|.
Mouse  2046 EGGPSQNALPSTQLDPGGGLMAHEGGMKE-SPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQ-- 2107

  Fly  2030 GVGPPTVQSTARHVMTVGKRGYALNRSDS------TGSSAGRKFLAPTSSDPQQR--------ST 2080
                |..||.....|  |..||    |||      .|.:.........:.:.::|        ||
Mouse  2108 ----PNSQSVEMREM--GTDGY----SDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLST 2162

  Fly  2081 LSDKERLHITSQQRKKNSMTTLPHAGQLGQLA-------------KQRGGGGEATKSSSF--FAQ 2130
            :||      ||..::..|:.. |.|.:|...:             ::|...|..|...|.  :..
Mouse  2163 ISD------TSPMKRSASVLG-PKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTD 2220

  Fly  2131 LNSEIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGGHGGHGEHQMHHHH 2181
            :::.:|    ..::....:..|.........|......|..|..|..||||
Mouse  2221 VDTGLG----TDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHH 2267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	63/315 (20%)
		Ion_trans	705..927	CDD:459842	71/272 (26%)
		Ion_trans	1224..1497	CDD:459842	71/302 (24%)
		Ion_trans	1545..1793	CDD:459842	77/266 (29%)
Cacna1a	XP_006530650.1	Ion_trans	188..462	CDD:459842	72/361 (20%)
		Ion_trans	579..817	CDD:459842	59/237 (25%)
		PHA03247	<895..1277	CDD:223021	57/392 (15%)
		Ion_trans	1285..1520	CDD:459842	63/258 (24%)
		Ion_trans	1610..1869	CDD:459842	77/265 (29%)
		GPHH	1878..1931	CDD:465306	13/59 (22%)
		Ca_chan_IQ	1941..2018	CDD:462591	11/76 (14%)
		PHA03307	2046..>2460	CDD:223039	51/246 (21%)