Protein Alignment na and Cacna1h

DIOPT Version :9

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_008765754.2
• Gene: Cacna1h / 114862
• RGDID: 68943
• Length: 2370
• Species: Rattus norvegicus
• Alignment Length: 2532
• Identity: 490/2532 - (19%)
• Similarity: 813/2532 - (32%)
• Gaps: 979/2532 - (38%)

  Fly   187 LGARQDAASALNSPTTIVNSGSGSGGGSSVAFGMQPQQQQQSLAGGGGGGSSATAAPSSGGGHNN 251
            |||...|      |...|.:...|.|.        |.:::|   ||.|.|..|..:|    |...
  Rat    15 LGASPPA------PAAPVRASPASPGA--------PGREEQ---GGSGSGVLAPESP----GTEC 58

  Fly   252 GAGLG-----PVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSAAITGVPPIGLG 311
            ||.||     ||                    ...|.||.:..|                   ||
  Rat    59 GADLGADEEQPV--------------------PYPALAATVFFC-------------------LG 84

  Fly   312 IATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKL----WVRRLMRLCALVSLTS 372
            ..|         |.:|                        |..:|    |...:..|..:::..:
  Rat    85 QTT---------RPRS------------------------WCLRLVCNPWFEHISMLVIMLNCVT 116

  Fly   373 VSLNTP-----KTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDA 432
            :.:..|     ...||...|:    |.|..:...|..||:.||...| |.|:..||.|.|.:.|.
  Rat   117 LGMFRPCEDVECRSERCSILE----AFDDFIFAFFAVEMVIKMVALG-LFGQKCYLGDTWNRLDF 176

  Fly   433 SMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMI------RFLRVFLKFSMPKSRINQIF 491
            .:|....:...|....|     ..|.:..:|..|||..|      |.|...|..::|
  Rat   177 FIVMAGMMEYSLDGHNV-----SLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLP-------- 228

  Fly   492 KRSSQQIYNVTL--FFLFFMSLYGLLGVQFF-GELKNHC------VMNNTEYDLYKRPILTINSL 547
                 .:.||.|  ||:||  ::|::|||.: |.|:|.|      |.||..  .:.||.......
  Rat   229 -----MLGNVLLLCFFVFF--IFGIVGVQLWAGLLRNRCFLDSAFVRNNNL--TFLRPYYQTEEG 284

  Fly   548 AIPDTFCSMDPDSG--------------YQCSPGM--------------------------VCMK 572
            ......||...|:|              .||:.|.                          ||..
  Rat   285 EENPFICSSRRDNGMQKCSHIPSRRELRVQCTLGWEAYGQPQAEDGGAGRNACINWNQYYNVCRS 349

  Fly   573 MDFLSSYVIGFNG---FEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAW 634
            .:|..     .||   |::|..:...::|..:.||||.|||..:|: .::....||..:|...::
  Rat   350 GEFNP-----HNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSF 408

  Fly   635 LVKNVFIAVITETFNEIRVQFQQMWGAR----------------------------GHI------ 665
            .:.|:.:.||...|:|.:.:..|:...:                            |||
  Rat   409 FMINLCLVVIATQFSETKQRENQLMREQRARYLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKR 473

  Fly   666 --------------QKTAASQILSGNDTGWR-------------LV------------------- 684
                          :|...|..:.|...|.|             ||
  Rat   474 RSLRLYARWQSRWRKKVDPSSTVHGQGPGRRPRRAGRRTASVHHLVYHHHHHHHHHYHFSHGGPR 538

  Fly   685 ------TIDDNK--------------HGGLAPETCHAI------LRSPYFRMLV-------MSVI 716
                  ...||:              ||....|:.|:|      :..|..|..|       .|:.
  Rat   539 RPSPEPGAGDNRLVRACAPPSPPSPGHGPPDSESVHSIYHADCHVEGPQERARVAHSIATAASLK 603

  Fly   717 LANGIVT---------------------------------------------------------- 723
            ||:|:.|
  Rat   604 LASGLGTMNYPTILPSGTVNSKGGTSSRPKGLRGAGAPGAAVHSPLSLGSPRPYEKIQHVVGEQG 668

  Fly   724 ----------------------ATMT-----------------------------------FKHD 731
                                  .|:|                                   |..|
  Rat   669 LGRASSHLSGLSVPCPLPSPQAGTLTCELKSCPYCASALEDPEFEFSGSESGDSDAHGVYEFTQD 733

  Fly   732 -----------------------------------------------GRPRDVFYERYY------ 743
                                                           |:.|.:...:|:
  Rat   734 VRHGDCRDPVQQPHEVGTPGHSNERRRTPLRKASQPGGIGHLWASFSGKLRRIVDSKYFNRGIMA 798

  Fly   744 ------------YIE-------------LVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAA 783
                        |.|             :|||.:..||.|.|:...|..||.::..:.|:.::..
  Rat   799 AILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVV 863

  Fly   784 GTTLHIVPMFYPSGLTY---FQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLIIFTMCLLIISS 845
            .:...||.. ...||:.   |::|||::|::..|.|...:..:......:.:..:..|..:.|.|
  Rat   864 ISVWEIVGQ-ADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLMRTMDNVATFCMLLMLFIFIFS 927

  Fly   846 SISMQLFCFLCDFT-------------KFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTP 897
            .:.|.||.  |.|:             .|:|...|.:::|||||||.|..|:...|..||.
  Rat   928 ILGMHLFG--CKFSLKTDSGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS---- 986

  Fly   898 LVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFP 962
            ..|:||:....|...::.:|.||::::..:.:.|..       |..:.|.|.:.
  Rat   987 WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDAT-------RSDTDEDKTST----------- 1033

  Fly   963 DSPQMTILHRIPNDF-MLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRI 1026
                     ::..|| .|..:|.:.||.:.:.:.....|......|               |..|
  Rat  1034 ---------QLEGDFDKLRDLRATEMKMYSLAVTPNGHLEGRGSLP---------------PPLI 1074

  Fly  1027 MNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHS--KPWR 1089
            .:..|.......|...|.:.|.:.||...    ...::.|.:|.:     ||..::..|  .||.
  Rat  1075 THTAATPMPTPKSSPNLDVAHALLDSRRS----SSGSVDPQLGDQ-----KSLASLRSSPCTPWG 1130

  Fly  1090 VDQKKFGSRSIRRSV-RSGSIKLKQ---TYEHLM------ENGDIAAAPRANSG---------RA 1135
            .:......||...|: |:.|:|.:.   ..|.|:      ...|.|...|.::|         ||
  Rat  1131 PNSAGSSRRSSWNSLGRAPSLKRRSQCGERESLLSGEGKGSTDDEAEDSRPSTGTHPGASPGPRA 1195

  Fly  1136 RP----------------------------HDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDT 1172
            .|                            ||.:.::: |...:..:|.:..:||..|    ||.
  Rat  1196 TPLRRAESLDHRSTLDLCPPRPAALLPTKFHDCNGQMV-ALPSEFFLRIDSHKEDAAE----FDD 1255

  Fly  1173 ----------------------------PLFLVPRESRFRKICQKIV-HARYDARLKDPLTGKER 1208
                                        .|:|.|.::|.|..|||:: |..:|
  Rat  1256 DIEDSCCFRLHKVLEPYAPQWCRSRESWALYLFPPQNRLRVSCQKVIAHKMFD------------ 1308

  Fly  1209 KVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNY--RVMDHPTLQIAEYGFVIFMSLELA 1271
                   |..|        |.||   |:||::..|.|:.  ...:...|.::.|.|.....:|:.
  Rat  1309 -------HVVL--------VFIF---LNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVVEMM 1355

  Fly  1272 LKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAA--------QLLMILRCV 1328
            :|::|.||.:...||::.....||..:.:||.     :.:.:...||.        ::|.:||.:
  Rat  1356 VKVVALGLLWGEHAYLQSSWNVLDGLLVLVSL-----VDIIVAMASAGGAKILGVLRVLRLLRTL 1415

  Fly  1329 RPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARC---NDPTISR 1390
            ||||:.:..|.::.||..|....:.|..:..:......||...||||:.|:...|   :...|:.
  Rat  1416 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGTDTRNITT 1480

  Fly  1391 REDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLD 1455
            :.:|.....|                         |.. |::||||:|.|:::||.:.|..||::
  Rat  1481 KAECHAAHYR-------------------------WVR-RKYNFDNLGQALMSLFVLSSKDGWVN 1519

  Fly  1456 VRDVLIKAVG----------PVHAVYIHIYIFLGCMIGLTLFVGVVIANY----SENKGTALLTV 1506
            :....:.|||          |...:|...::.:.....|.:|||||:.|:    ...:.......
  Rat  1520 IMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRR 1584

  Fly  1507 DQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYD-----------ITQHIIFKRVIAVVVLINS 1560
            :::|...|::|.:...     |.|:.:: |.:..|           .|.|.: ...|..::.:|.
  Rat  1585 EEKRLRRLERRRRSTF-----PNPEAQR-RPYYADYSHTRRSIHSLCTSHYL-DLFITFIICLNV 1642

  Fly  1561 MLLSIT-WIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWI 1624
            :.:|:. :.:.:...|.|...:.|.|.|||.|..:|.:||..|.:::.|.|:.||.:.:..::.|
  Rat  1643 ITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSIMGI 1707

  Fly  1625 ILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFI--------IFGMFLL 1681
            .|:.|..|........::.|:|...|.   ..||:|.:..|:.......:        :..:|:|
  Rat  1708 ALEEIEMNAALPINPTIIRIMRVLRIA---RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFML 1769

  Fly  1682 VFF-YALAGTILFGTVKYG-----EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPY 1740
            :|| ||..|..|||.::..     ||:.|.|.|.:.......|||:.||::||.||.|.:.:
  Rat  1770 LFFIYAALGVELFGRLECSEDNPCEGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRE--- 1831

  Fly  1741 CTLGNNYWETDCGNFTASL--IYFCTFYVIITYIVLNLLVAIIMENFSLFYSNE---EDALLSYA 1800
            ||..:.:    |.::..:|  :||.||.::..::::|::||::|::  |..||:   |||.:. |
  Rat  1832 CTREDKH----CLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKH--LEESNKEAREDAEMD-A 1889

  Fly  1801 DIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL--------ECDPQKDRLLFKYMCYELDKL 1857
            :|.                         |.:.:|..        ...||:.:
  Rat  1890 EIE-------------------------LEMAQGSTAQPPPTAQPPSPQESQ------------- 1916

  Fly  1858 HNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQN 1922
                 .|..|..|:|..|.|.:.:.|.|
  Rat  1917 -----GTQPDTPNLLVVRKVSVSRMLSL------------------------------------- 1939

  Fly  1923 ASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGA-----VDKSAISTISGAVAGA-CPPTSDAFS 1981
                          .|:..:.||     .||..|     :.:..:.|.:|.|..| .||.....|
  Rat  1940 --------------PNDSYMFRP-----VAPAAAPHSHPLQEVEMETYTGPVTSAHSPPLEPRAS 1985

  Fly  1982 ---PTFSSTENEEKDG-------------SSSAVV---QLPHSET------SIAG---------- 2011
               |:.:|:.....|.             |.|.::   :..|||:      .:.|
  Rat  1986 FQVPSAASSPARVSDPLCALSPRGTPRSLSLSRILCRQEAMHSESLEGKVDDVGGDSIPDYTEPA 2050

  Fly  2012 ----TGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTS 2072
                |..::|||..:...|.    .|.:|: |.:|  |.|:|..: :|..:.|.....      :
  Rat  2051 ENMSTSQASTGAPRSPPCSP----RPASVR-TRKH--TFGQRCIS-SRPPTLGGDEAE------A 2101

  Fly  2073 SDPQQRSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQLAK----QRGGGGEATKSSSFFAQ 2130
            :||      :|:|..||||......:  |.||:.:....|.    ..|.|.:..:..|..||
  Rat  2102 ADP------ADEEVSHITSSAHPWPA--TEPHSPEASPTASPVKGTMGSGRDPRRFCSVDAQ 2155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	83/343 (24%)
		Ion_trans	734..927	CDD:278921	56/239 (23%)
		Ion_trans	1240..1497	CDD:278921	66/283 (23%)
		Ion_trans	1571..1793	CDD:278921	67/240 (28%)
Cacna1h	XP_008765754.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920