DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Cacna1f

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_446153.2 Gene:Cacna1f / 114493 RGDID:621535 Length:1980 Species:Rattus norvegicus


Alignment Length:2198 Identity:475/2198 - (21%)
Similarity:814/2198 - (37%) Gaps:687/2198 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   236 GSSATAAPSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSA 300
            |...|..||..    ||.|.||                            ..|:|.| ..|||:.
  Rat     7 GKDTTPEPSPA----NGTGPGP----------------------------EWGLCPG-PPTVGTD 38

  Fly   301 AITGVPPIGLGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLC 365
            . :|        |:|:|..  ..|.|..|.....:|.                    .:|..|..
  Rat    39 T-SG--------ASGLGTP--RRRTQHNKHKTVVVAS--------------------AQRSPRAL 72

  Fly   366 ALVSLTS------VSLNTPKTFERYPSLQ----------FITFASDTAVT-------------LL 401
            ..::||:      :|:...|.|:....|.          :|.|..|.:.|             ::
  Rat    73 FCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVI 137

  Fly   402 FTAEMIAKMHIRG-VLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEV-LEIVP---------- 454
            ||.|.:.|:...| |||... |:::.|...|       :|.:::.:|.| ||..|          
  Rat   138 FTVETVLKIVAYGLVLHPSA-YIRNGWNLLD-------FIIVVVGLFSVLLEQGPGRPGDAPHTG 194

  Fly   455 ------KFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSL 511
                  ....|...|..|||.::.        .:|...|  |.|.| :...:.::.|..||.:.:
  Rat   195 GKPGGFDVKALRAFRVLRPLRLVS--------GVPSLHIVLNSIMK-ALVPLLHIALLVLFVIII 250

  Fly   512 YGLLGVQ-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCS---------- 565
            |.::|:: |.|.:...|....::.:..:.|....:|            .||..|:          
  Rat   251 YAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASS------------GSGRSCTLNQTECRGRW 303

  Fly   566 PGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDS----LPAWRAAFYFS 626
            ||...           |...|::...::.||:|..:.|||..::|...|:    || |   .||.
  Rat   304 PGPNG-----------GITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELP-W---VYFV 353

  Fly   627 TMIFFLAWLVKNVFIAVITETFN------EIRVQFQQM---------------W----------- 659
            :::.|.::.|.|:.:.|::..|:      :.|..||::               |           
  Rat   354 SLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELDLHD 418

  Fly   660 -------------GARGH------------------------IQKTAASQILSGNDTGWRLVT-- 685
                         |..||                        ...|::...|..:|||....|  
  Rat   419 PSVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSITDTPG 483

  Fly   686 IDDNKHGGLAPET-------------------------CHAILRSPYFRMLVMSVILANGIVTAT 725
            .:|.:.|.:|..|                         |...::|......|:.::..|   |.|
  Rat   484 DEDEEEGTMASCTLCLNKIMKTKVCRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLN---TLT 545

  Fly   726 MTFKHDGRPRDVFY-ERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAG----T 785
            :..:|.|:|  |:. :...|...|..||..:|.|.|:|.||...|.....::|:..:..|    |
  Rat   546 IASEHHGQP--VWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILET 608

  Fly   786 TLHIVPMFYPSGLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSI 847
            ||..|....|.|::..:.:|::|:.|.:   ..|...|..:....|.:.||::.....:||.|.:
  Rat   609 TLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL 673

  Fly   848 SMQLFCFLCDF----TK---FESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTP--LVAVYF 903
            .||||....:|    ||   |::||:|.:::|||||.|.|..||.:.::.......|  ||.|||
  Rat   674 GMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYF 738

  Fly   904 ILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMT 968
            |:..:....|:|::|:|:.:||| ...|....|. |.||:|:|               .:.||  
  Rat   739 IILFICGNYILLNVFLAIAVDNL-ASGDAGAAKD-KGREKSSE---------------GNPPQ-- 784

  Fly   969 ILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKV 1033
                 .|..::|..            |.||:                                  
  Rat   785 -----ENKVLVPGG------------ENEDT---------------------------------- 798

  Fly  1034 RAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSR 1098
                                                    .|.||:|    :.|...:::     
  Rat   799 ----------------------------------------EGTKSEG----AAPGMEEEE----- 814

  Fly  1099 SIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDL 1163
                         ::..|...|||         :|.       ::|||      |:...::...:
  Rat   815 -------------EEEEEEEEENG---------AGH-------VELLQ------EVVPKEKVVPI 844

  Fly  1164 RENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWV 1228
            .|...|     |.:.:.:..||.|..::|.                      |.|..|      :
  Rat   845 PEGSAF-----FCLSQTNPLRKACHTLIHH----------------------HVFTSL------I 876

  Fly  1229 MIFATTLSCISMMFETP----NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKD 1289
            ::| ..||.:|:..|.|    ::|  :| .|...:|.|....::|:.||:...|.|....::.:.
  Rat   877 LVF-IILSSVSLAAEDPIRAHSFR--NH-ILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRS 937

  Fly  1290 VAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGF 1351
            ....||  :.|||.|.:.: .::....|..::|.:||.:||||....   :.|:.:.|:...|..
  Rat   938 WFNLLD--LLVVSVSLISF-GIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 999

  Fly  1352 KEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDES 1416
            ..|::|:|   ||.|:||..||||:.|:...|.|......::|.|.|:         :.|..|.|
  Rat  1000 GNIMIVTT---LLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFL---------IYPDGDVS 1052

  Fly  1417 YPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV-------GPVH------ 1468
            .| ::..|:|.| ..|||||:..||:.||.|.:|:||   ..:|.||:       ||::      
  Rat  1053 RP-LVRERLWVN-SDFNFDNVLSAMMALFTVSTFEGW---PALLYKAIDAHAEDEGPIYNYHVEI 1112

  Fly  1469 AVYIHIYIFLGCMIGLTLFVGVVIANY----SENKGTALLTVDQRRWCDLKKRLKIAQPL--HLP 1527
            :|:..:||.:.....:.:|||.||..:    .:......|..:||: | ::..|| ||||  ::|
  Rat  1113 SVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQ-C-VEYALK-AQPLRRYIP 1174

  Fly  1528 PRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTER-------LVIVSAVLT 1585
            ..|...::.|    ......|:.::.:::|:|::.|::.      |.|:       :.|::.|.|
  Rat  1175 KNPHQYRVWA----TVNSAAFEYLMFLLILLNTVALAMQ------HYEQTAPFNYAMDILNMVFT 1229

  Fly  1586 FVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTI-------------LRNDLSYF 1637
            .:|.||:|:|.|||.|:.|:....|.:|.|:.|..|:.|.:..:             .|..:::|
  Rat  1230 GLFTVEMVLKIIAFKPKHYFADAWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFF 1294

  Fly  1638 FGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSF----FIIFGMFLLVFFYALAGTILFGTVKY 1698
            ..|.|  :|...:..|...::.|:.|    ..|||    ::...:.::.|.||:.|..:||.|..
  Rat  1295 RLFRV--MRLVKLLSKGEGIRTLLWT----FIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVAL 1353

  Fly  1699 GEG--IGRRANFGSPVTGVAMLFRIVTGEDWNKIM------HDCMVQPPYCTLGNNYWETDCG-N 1754
            .:|  |.|..||.:....|.:|||..|||.|.:||      :.|   .|....|... |..|| |
  Rat  1354 QDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRC---DPESDFGPGE-EFTCGSN 1414

  Fly  1755 FTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGV 1819
            |  :::||.:|:::..::::||.||:||:||.  |...:.::|....:..|:..|:..|...:|.
  Rat  1415 F--AIVYFISFFMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFKRIWSEYDPGAKGR 1475

  Fly  1820 IPVRRVKFILRLLK-----GRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDI 1879
            |....|..:||.::     |:| |   ..|:..|.:......|::...|||:..:..|...|:.|
  Rat  1476 IKHLDVVALLRRIQPPLGFGKL-C---PHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLRI 1536

  Fly  1880 RKALQLEELLAREEFEYLV--------------------EEE--VAKMTIRTWLEGCLKKIRAQN 1922
            :....|::  |.:|...::                    |||  |.|......::...:|.|   
  Rat  1537 KTEGNLDQ--ANQELRMVIKKIWKRIKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFR--- 1596

  Fly  1923 ASKQQNSLIAGLRATNEQPVMRPNIQ--EDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFS 1985
             .:::..|:.....|:...|::..::  :|   ||...:.|:                    |:.
  Rat  1597 -RRKEKGLLGADAPTSTSSVLQAGLRSLQD---LGPEIRQAL--------------------TYD 1637

  Fly  1986 STENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRG 2050
            :.|.||::.::....:...:|.: ..|...:..:......:|.:.|..|..:.....:.|     
  Rat  1638 TEEEEEEEEAAGQEAEEEEAENN-PETYKDSIDSQPQAQWNSRISVSLPVKEKLPDSLST----- 1696

  Fly  2051 YALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNS---MTTLPHAGQLGQLA 2112
               ..||..|       :||.|..|         ..|...||..:::|   |.|:|..|.. ||.
  Rat  1697 ---GPSDDDG-------VAPNSRQP---------SGLQAGSQPHRRSSGVFMFTIPEEGST-QLK 1741

  Fly  2113 KQRG--GGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGHGHGH 2163
            ..:|  ...|..:...:...|:.:.|....|.:      ...| :...|.:||
  Rat  1742 GVQGQDNQNEEQEVPDWTPNLDEQAGMPSNPVL------LPPH-WSQQHVNGH 1787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 71/344 (21%)
Ion_trans 734..927 CDD:278921 65/209 (31%)
Ion_trans 1240..1497 CDD:278921 80/280 (29%)
Ion_trans 1571..1793 CDD:278921 74/254 (29%)
Cacna1fNP_446153.2 Ion_trans 91..383 CDD:395416 69/335 (21%)
Ion_trans 532..763 CDD:395416 72/236 (31%)
Ion_trans 869..1106 CDD:395416 79/288 (27%)
Ion_trans 1188..1451 CDD:395416 78/282 (28%)
GPHH 1460..1513 CDD:407139 13/56 (23%)
Ca_chan_IQ 1524..1595 CDD:400901 11/72 (15%)
CAC1F_C 1618..1977 CDD:407123 40/226 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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