DRSC/TRiP Functional Genomics Resources

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Protein Alignment na and SCN11A

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_016861136.1 Gene:SCN11A / 11280 HGNCID:10583 Length:1916 Species:Homo sapiens


Alignment Length:1839 Identity:381/1839 - (20%)
Similarity:698/1839 - (37%) Gaps:467/1839 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   320 IMLGRKQSLK--GGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFE 382
            ::|.||:::.  ..:..|..:||..|:...|....|:.|:   .|.:...|.:..|.:.|.    
Human   217 MVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLF---SMFIIGTVIINCVFMATG---- 274

  Fly   383 RYPSLQFITFASDTA---VTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIIL 444
              |:....:..:|.|   .|.::..|.:.|:..||.:..|..:|:|.|...|:.::....:|.|.
Human   275 --PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIP 337

  Fly   445 QIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVF--LKFSMPKSRINQI---FKRSSQQIYNVTLF 504
            .|  .::::|                :|..|||  ||.....||:..|   ..||.:::.||.:.
Human   338 GI--TIKLLP----------------LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIIL 384

  Fly   505 FLFFMSLYGLLGVQ-FFGELKNHCV------MNNTE-YD--LYKR---PILTINSLAIPDTFCSM 556
            ..|.:|::.|:|.| |.|.|...|:      ::|.| ||  ..|:   |...:..:.:.::.||:
Human   385 TFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSI 449

  Fly   557 DPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRA 621
            .    |:|....:  ..|:      .:..|::...|...:::..:|:.|..:..:.:.:...: :
Human   450 Q----YECKHTKI--NPDY------NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLY-S 501

  Fly   622 AFYFSTMIFFLAWLVKNVFIAVITETFN--------EIRVQFQQMWGARGHIQKTAASQILSGND 678
            .|:|..:||..::.:.|:.:||:|..:.        ||..:.:....|:..:::...:.:..|.|
Human   502 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGID 566

  Fly   679 TGWRLVTID---------------------------DNKHGGLAPETC----------------- 699
            .. .|.:::                           |...|..:.|.|                 
Human   567 RS-SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNL 630

  Fly   700 ----------------------------------------------------------------- 699
                                                                             
Human   631 SLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVL 695

  Fly   700 HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYI-ELVFTCLLDLETLFKIYC 763
            ..::..|:..:.:...|:.|   |..:..:|  ...:..:|:...| .||||.:...|...||..
Human   696 RTVMTDPFTELAITICIIIN---TVFLAMEH--HKMEASFEKMLNIGNLVFTSIFIAEMCLKIIA 755

  Fly   764 LGWRGYYKHSIHKFE---LLLAAGTTLHIV--PMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKI 823
            |....|::...:.|:   .||:....::.|  ...:|. |..|:||||.:|.|:.|.|...: ||
Human   756 LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPF-LRSFRVLRVFKLAKSWPTLNTLI-KI 818

  Fly   824 FGPG-KKLGSLIIFTMCLLIISSSISMQLF--CF-------LCDFT----------KFESFPEAF 868
            .|.. ..||||.:..:.::.|.|.:.||||  .|       ||:.|          ....|..:|
Human   819 IGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSF 883

  Fly   869 MSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILD-------NL 926
            :.:|:||..| |:|.|.|.| :.:...:.|..:.|||..:...|:||:||:|::|:       |.
Human   884 LVVFRILCGE-WIENMWECM-QEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNG 946

  Fly   927 ELDEDIKKLK-QL---KFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFM 987
            .|:.:.:|.| ||   :||.....::.||                                    
Human   947 NLEGEARKTKVQLALDRFRRAFCFVRHTL------------------------------------ 975

  Fly   988 KHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIIND- 1051
            :||             |.:   .|.:.|:  .:||.|          |.|.:.:...|..::.: 
Human   976 EHF-------------CHK---WCRKQNL--PQQKEV----------AGGCAAQSKDIIPLVMEM 1012

  Fly  1052 ---SNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPW------RVDQKKFGSRSIRRSVRSG 1107
               |..|. .||....:|          |:.| :.|...|      ..|..:|......:.:...
Human  1013 KRGSETQE-ELGILTSVP----------KTLG-VRHDWTWLAPLAEEEDDVEFSGEDNAQRITQP 1065

  Fly  1108 SIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDI-------KLLQAKRQQAEMRRNQRE---ED 1162
            ..: :|.||...||      .:..|.|.:..::|:       ..:|..|:::::.....|   .|
Human  1066 EPE-QQAYELHQEN------KKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTID 1123

  Fly  1163 LRENHPFFDTPLFLVPRESRFRKI---------CQKIVHARYDARLKDP--LTGKERKVQYKSLH 1216
            |::...:...   :||::...|.:         |..:     |.| |.|  :....||..|:.:.
Human  1124 LQDGFGWLPE---MVPKKQPERCLPKGFGCCFPCCSV-----DKR-KPPWVIWWNLRKTCYQIVK 1179

  Fly  1217 NFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQ----IAEYGFVIFMSLELALKILAD 1277
            :     ::.:..:||...||..:::||  :..:.:.|.:|    ..:..|.....||:.||.:|.
Human  1180 H-----SWFESFIIFVILLSSGALIFE--DVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAF 1237

  Fly  1278 GLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRK 1342
            |.    ..|.......||..|.:||.:.|    :|:   ...:....||.:||||..:....|:.
Human  1238 GF----GKYFTSAWCCLDFIIVIVSVTTL----INL---MELKSFRTLRALRPLRALSQFEGMKV 1291

  Fly  1343 VVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKM 1407
            ||..|......||.|..:.::...:|...||..:.|:..:|.:.|.|       |....:...|.
Human  1292 VVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDS-------VINYTIITNKS 1349

  Fly  1408 KLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVHA--- 1469
            :...|...          |.| ::.||||:|:|.|.|.:|.:||||:   |::..||.....   
Human  1350 QCESGNFS----------WIN-QKVNFDNVGNAYLALLQVATFKGWM---DIIYAAVDSTEKEQQ 1400

  Fly  1470 ----------VYIHIYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLK 1519
                      :|..::|..|....|.||:||:|.|:::.:     ....:|.:|:::.:..|:|.
Human  1401 PEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLG 1465

  Fly  1520 IAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSM-LLSITWIKGEVHTERLVIVSAV 1583
            ..:|....||| ..|.:...:||....||..:|..::::|.: :::.::.:.:.....|..::.|
Human  1466 SKKPQKPIPRP-LNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWV 1529

  Fly  1584 LTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL 1645
            ...:|.:|.::|..|.. :.|:.:..|.:|.:|.:..::..::.| |.|.....|.   |.:|.|
Human  1530 FVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVSTMIST-LENQEHIPFPPTLFRIVRL 1592

  Fly  1646 ----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRA 1706
                |...:......::.|:..:.:|:...|.|...:||::|.||:.|...|..|....||....
Human  1593 ARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIF 1657

  Fly  1707 NFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITY 1771
            ||.:..:.:..||:|.|...|:.::...:.....|    |....:|.....:..||.::.:|...
Human  1658 NFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESC----NSSSENCHLPGIATSYFVSYIIISFL 1718

  Fly  1772 IVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFI-------- 1828
            ||:|:.:|:|:|||:......||. |...|...|...|...|        ....:||        
Human  1719 IVVNMYIAVILENFNTATEESEDP-LGEDDFDIFYEVWEKFD--------PEATQFIKYSALSDF 1774

  Fly  1829 -------LRLLKGRLECDPQKDRLLFKYMCYEL-----DKLHNGEDVTFHDVINML-SYRSVDIR 1880
                   ||:.|      |.|    ::::..:|     |:|| ..|:.|.....:| ....:|..
Human  1775 ADALPEPLRVAK------PNK----YQFLVMDLPMVSEDRLH-CMDILFAFTARVLGGSDGLDSM 1828

  Fly  1881 KALQLEELLAREEFEYLVE 1899
            ||:..|:.:.....:.|.|
Human  1829 KAMMEEKFMEANPLKKLYE 1847

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 66/309 (21%)
Ion_trans 734..927 CDD:278921 66/225 (29%)
Ion_trans 1240..1497 CDD:278921 70/273 (26%)
Ion_trans 1571..1793 CDD:278921 53/228 (23%)
SCN11AXP_016861136.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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