Protein Alignment na and SCN11A

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_047303334.1
• Gene: SCN11A / 11280
• HGNCID: 10583
• Length: 1916
• Species: Homo sapiens
• Alignment Length: 1839
• Identity: 381/1839 - (20%)
• Similarity: 698/1839 - (37%)
• Gaps: 467/1839 - (25%)

  Fly   320 IMLGRKQSLK--GGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFE 382
            ::|.||:::.  ..:..|..:||..|:...|....|:.|:   .|.:...|.:..|.:.|.
Human   217 MVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLF---SMFIIGTVIINCVFMATG---- 274

  Fly   383 RYPSLQFITFASDTA---VTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIIL 444
              |:....:..:|.|   .|.::..|.:.|:..||.:..|..:|:|.|...|:.::....:|.|.
Human   275 --PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIP 337

  Fly   445 QIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVF--LKFSMPKSRINQI---FKRSSQQIYNVTLF 504
            .|  .::::|                :|..|||  ||.....||:..|   ..||.:::.||.:.
Human   338 GI--TIKLLP----------------LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIIL 384

  Fly   505 FLFFMSLYGLLGVQ-FFGELKNHCV------MNNTE-YD--LYKR---PILTINSLAIPDTFCSM 556
            ..|.:|::.|:|.| |.|.|...|:      ::|.| ||  ..|:   |...:..:.:.::.||:
Human   385 TFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSI 449

  Fly   557 DPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRA 621
            .    |:|....:  ..|:      .:..|::...|...:::..:|:.|..:..:.:.:...: :
Human   450 Q----YECKHTKI--NPDY------NYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLY-S 501

  Fly   622 AFYFSTMIFFLAWLVKNVFIAVITETFN--------EIRVQFQQMWGARGHIQKTAASQILSGND 678
            .|:|..:||..::.:.|:.:||:|..:.        ||..:.:....|:..:::...:.:..|.|
Human   502 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGID 566

  Fly   679 TGWRLVTID---------------------------DNKHGGLAPETC----------------- 699
            .. .|.:::                           |...|..:.|.|
Human   567 RS-SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNL 630

  Fly   700 ----------------------------------------------------------------- 699
                                                                             
Human   631 SLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVL 695

  Fly   700 HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYI-ELVFTCLLDLETLFKIYC 763
            ..::..|:..:.:...|:.|   |..:..:|  ...:..:|:...| .||||.:...|...||..
Human   696 RTVMTDPFTELAITICIIIN---TVFLAMEH--HKMEASFEKMLNIGNLVFTSIFIAEMCLKIIA 755

  Fly   764 LGWRGYYKHSIHKFE---LLLAAGTTLHIV--PMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKI 823
            |....|::...:.|:   .||:....::.|  ...:|. |..|:||||.:|.|:.|.|...: ||
Human   756 LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPF-LRSFRVLRVFKLAKSWPTLNTLI-KI 818

  Fly   824 FGPG-KKLGSLIIFTMCLLIISSSISMQLF--CF-------LCDFT----------KFESFPEAF 868
            .|.. ..||||.:..:.::.|.|.:.||||  .|       ||:.|          ....|..:|
Human   819 IGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSF 883

  Fly   869 MSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILD-------NL 926
            :.:|:||..| |:|.|.|.| :.:...:.|..:.|||..:...|:||:||:|::|:       |.
Human   884 LVVFRILCGE-WIENMWECM-QEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNG 946

  Fly   927 ELDEDIKKLK-QL---KFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFM 987
            .|:.:.:|.| ||   :||.....::.||
Human   947 NLEGEARKTKVQLALDRFRRAFCFVRHTL------------------------------------ 975

  Fly   988 KHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIIND- 1051
            :||             |.:   .|.:.|:  .:||.|          |.|.:.:...|..::.:
Human   976 EHF-------------CHK---WCRKQNL--PQQKEV----------AGGCAAQSKDIIPLVMEM 1012

  Fly  1052 ---SNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPW------RVDQKKFGSRSIRRSVRSG 1107
               |..|. .||....:|          |:.| :.|...|      ..|..:|......:.:...
Human  1013 KRGSETQE-ELGILTSVP----------KTLG-VRHDWTWLAPLAEEEDDVEFSGEDNAQRITQP 1065

  Fly  1108 SIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDI-------KLLQAKRQQAEMRRNQRE---ED 1162
            ..: :|.||...||      .:..|.|.:..::|:       ..:|..|:::::.....|   .|
Human  1066 EPE-QQAYELHQEN------KKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTID 1123

  Fly  1163 LRENHPFFDTPLFLVPRESRFRKI---------CQKIVHARYDARLKDP--LTGKERKVQYKSLH 1216
            |::...:...   :||::...|.:         |..:     |.| |.|  :....||..|:.:.
Human  1124 LQDGFGWLPE---MVPKKQPERCLPKGFGCCFPCCSV-----DKR-KPPWVIWWNLRKTCYQIVK 1179

  Fly  1217 NFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQ----IAEYGFVIFMSLELALKILAD 1277
            :     ::.:..:||...||..:::||  :..:.:.|.:|    ..:..|.....||:.||.:|.
Human  1180 H-----SWFESFIIFVILLSSGALIFE--DVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAF 1237

  Fly  1278 GLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRK 1342
            |.    ..|.......||..|.:||.:.|    :|:   ...:....||.:||||..:....|:.
Human  1238 GF----GKYFTSAWCCLDFIIVIVSVTTL----INL---MELKSFRTLRALRPLRALSQFEGMKV 1291

  Fly  1343 VVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKM 1407
            ||..|......||.|..:.::...:|...||..:.|:..:|.:.|.|       |....:...|.
Human  1292 VVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDS-------VINYTIITNKS 1349

  Fly  1408 KLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVHA--- 1469
            :...|...          |.| ::.||||:|:|.|.|.:|.:||||:   |::..||.....
Human  1350 QCESGNFS----------WIN-QKVNFDNVGNAYLALLQVATFKGWM---DIIYAAVDSTEKEQQ 1400

  Fly  1470 ----------VYIHIYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLK 1519
                      :|..::|..|....|.||:||:|.|:::.:     ....:|.:|:::.:..|:|.
Human  1401 PEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLG 1465

  Fly  1520 IAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSM-LLSITWIKGEVHTERLVIVSAV 1583
            ..:|....||| ..|.:...:||....||..:|..::::|.: :::.::.:.:.....|..::.|
Human  1466 SKKPQKPIPRP-LNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWV 1529

  Fly  1584 LTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL 1645
            ...:|.:|.::|..|.. :.|:.:..|.:|.:|.:..::..::.| |.|.....|.   |.:|.|
Human  1530 FVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVSTMIST-LENQEHIPFPPTLFRIVRL 1592

  Fly  1646 ----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRA 1706
                |...:......::.|:..:.:|:...|.|...:||::|.||:.|...|..|....||....
Human  1593 ARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIF 1657

  Fly  1707 NFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITY 1771
            ||.:..:.:..||:|.|...|:.::...:.....|    |....:|.....:..||.::.:|...
Human  1658 NFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESC----NSSSENCHLPGIATSYFVSYIIISFL 1718

  Fly  1772 IVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFI-------- 1828
            ||:|:.:|:|:|||:......||. |...|...|...|...|        ....:||
Human  1719 IVVNMYIAVILENFNTATEESEDP-LGEDDFDIFYEVWEKFD--------PEATQFIKYSALSDF 1774

  Fly  1829 -------LRLLKGRLECDPQKDRLLFKYMCYEL-----DKLHNGEDVTFHDVINML-SYRSVDIR 1880
                   ||:.|      |.|    ::::..:|     |:|| ..|:.|.....:| ....:|..
Human  1775 ADALPEPLRVAK------PNK----YQFLVMDLPMVSEDRLH-CMDILFAFTARVLGGSDGLDSM 1828

  Fly  1881 KALQLEELLAREEFEYLVE 1899
            ||:..|:.:.....:.|.|
Human  1829 KAMMEEKFMEANPLKKLYE 1847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	68/321 (21%)
		Ion_trans	705..927	CDD:459842	71/254 (28%)
		Ion_trans	1224..1497	CDD:459842	74/289 (26%)
		Ion_trans	1545..1793	CDD:459842	57/255 (22%)
SCN11A	XP_047303334.1	Ion_trans	253..534	CDD:459842	67/320 (21%)
		Ion_trans	701..945	CDD:459842	70/252 (28%)
		Na_trans_assoc	951..1176	CDD:461936	53/316 (17%)
		Ion_trans	1180..1442	CDD:459842	74/300 (25%)
		Na_channel_gate	1434..1486	CDD:240441	10/52 (19%)
		Ion_trans	1507..1740	CDD:459842	53/238 (22%)