back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and Scn2a

DIOPT Version :10

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	NP_001092768.1	Gene:	Scn2a / 110876	MGIID:	98248	Length:	2006	Species:	Mus musculus

Alignment Length:	2162	Identity:	425/2162 - (19%)
Similarity:	745/2162 - (34%)	Gaps:	719/2162 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 LKGGE--PFLADYG--PEESLN---ESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYP 385
            |:.|:  ||:  ||  |.|.::   |..|..::||              .|.:.||..|...|:.
Mouse    56 LEAGKSLPFI--YGDIPPEMVSEPLEDLDPYYINK--------------KTFIVLNKGKAISRFS 104

  Fly   386 SLQ-------------------------------------FITFAS--------DTAVTLLFTAE 405
            :..                                     |:|.::        :...|.::|.|
Mouse   105 ATSALYILTPFNPIRKLAIKILVHSLFNVLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFE 169

  Fly   406 MIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM 470
            .:.|:..||....:..:|:|.|...|.::::|.:::             :|..|..:.|.|...:
Mouse   170 SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT-------------EFVNLGNVSALRTFRV 221

  Fly   471 IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVM---NN 531
            :|.|:........|:.:..:. :|.:::.:|.:..:|.:|::.|:|:| |.|.|:|.|:.   :|
Mouse   222 LRALKTISVIPGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDN 285

  Fly   532 TEYDL----YKRPILTINSLAIPDT--------------------------FCSMDPDSGYQCSP 566
            :.:::    :....|..|..|...|                          .|....|:| ||..
Mouse   286 STFEINITSFFNNSLDWNGTAFNRTMNMFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAG-QCPE 349

  Fly   567 GMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----FYFS 626
            |.:|:|.....:|  |:..|:..:.:..::::..:|:.|..:....:      |||     .:|.
Mouse   350 GYICVKAGRNPNY--GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL------RAAGKTYMIFFV 406

  Fly   627 TMIFFLAWLVKNVFIAVITETFNE-----------IRVQFQQMW--------------------- 659
            .:||..::.:.|:.:||:...:.|           ...:||||.
Mouse   407 LVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAES 471

  Fly   660 ----GARG----HIQKTAASQILSGND-------------------------------------- 678
                ||.|    ....:.||::.|.::
Mouse   472 RDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQAGEEEKEDAVRKSASEDSIRKKG 536

  Fly   679 -----TGWRLV----------------------------------------------------TI 686
                 .|.||.                                                    |.
Mouse   537 FRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFKGRVKDIGSENDFADDEHSTF 601

  Fly   687 DDN-----------KHGGLAPET-------------------------CHAI------------- 702
            :||           :||...|..                         |:.:
Mouse   602 EDNDSRRDSLFVPHRHGERRPSNVSQASRASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSP 666

  Fly   703 -----------------------------LRSPYFRMLVMSVILANGIVTATMTFKHDGRPR--- 735
                                         |..|..|...||:.   .|:|.||....:.|.:
Mouse   667 VGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSMA---SILTNTMEELEESRQKCPP 728

  Fly   736 ------------------------------DVF-----------------YERYYYIE------- 746
                                          |.|                 .|.|...|
Mouse   729 CWYKFANMCLIWDCCKPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLS 793

  Fly   747 ---LVFTCLLDLETLFKIYCL--------GWRGY--YKHSIHKFELLLAAGTTLHIVPMFYPSGL 798
               ||||.:...|...||..:        ||..:  :..|:...||.||....|.:        |
Mouse   794 VGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSV--------L 850

  Fly   799 TYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF--------CF 854
            ..|::|||.:|.|:.|.| ..:.||.|.. ..||:|.:....::.|.:.:.||||        |.
Mouse   851 RSFRLLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 914

  Fly   855 L---CDFTKF--ESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIV 914
            :   |:..::  ..|..:|:.:|::|..| |:|.|.:.|....:|:...|   |::..:...|:|
Mouse   915 ISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTV---FMMVMVIGNLVV 975

  Fly   915 LSLFVAVIL-----DNLELDEDIKKLKQLKF---REQSAEIKETLPFRLRIFEKFPDSPQMTILH 971
            |:||:|::|     |||...:|..::..|:.   |.|..
Mouse   976 LNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKG-------------------------- 1014

  Fly   972 RIPNDFMLPKVRESFMKHFVIELETEDSL--VENCKRPMSECWESNVVFRKQKPVRIM---NKTA 1031
               .||:..|:||...|.||.:.:..|.:  :|:.......|..::......|.:..:   |.|.
Mouse  1015 ---IDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTT 1076

  Fly  1032 KVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFG 1096
            .  ..|||:.|    :::::|:....:...|..:.|....|....::..|           ::|.
Mouse  1077 S--GIGSSVEK----YVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT-----------EEFS 1124

  Fly  1097 SRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREE 1161
            |.|   .:.....||..|........||.|........|.|                      ||
Mouse  1125 SES---DMEESKEKLNATSSSEGSTVDIGAPAEGEQPEAEP----------------------EE 1164

  Fly  1162 DLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSL-HNFLGLVTYL 1225
            .|.....|.:..:       |..|.||..:...     |..|....||..||.: ||      :.
Mouse  1165 SLEPEACFTEDCV-------RKFKCCQISIEEG-----KGKLWWNLRKTCYKIVEHN------WF 1211

  Fly  1226 DWVMIFATTLSCISMMFETPNYRVMDHPT----LQIAEYGFVIFMSLELALKILADGLFFTPKAY 1286
            :..::|...||..::.||  :..:....|    |:.|:..|.....||:.||.:|.|.    :.|
Mouse  1212 ETFIVFMILLSSGALAFE--DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QMY 1270

  Fly  1287 IKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGF 1351
            ..:....||..|..||...|....|......|.:.|..||.:||||..:....||.||..|....
Mouse  1271 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAI 1335

  Fly  1352 KEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPT---------ISRREDCVGVFMRRVFVTKM 1407
            ..|:.|..:.::...||:..||.|:.|:...|.:.|         ::...:|..:.
Mouse  1336 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALI--------- 1391

  Fly  1408 KLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDV-------RDVLIKAVG 1465
                  :.:..|.     |.|. :.||||:|...|:|.:|.:||||:|:       |:|.::
Mouse  1392 ------ESNQTAR-----WKNV-KVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ--- 1441

  Fly  1466 PVHA------VYIHIYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLK 1519
            |.:.      :|..|:|..|....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|.
Mouse  1442 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG 1506

  Fly  1520 IAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSI-TWIKGEVHTERLVIVSAV 1583
            ..:|....||| ..|.:...:|.....:|...|.:::.:|.:.:.: |..:.:..|..|..::.|
Mouse  1507 SKKPQKPIPRP-ANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1570

  Fly  1584 LTFVFVVEVVMKNIAFTPRGY-----WQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---F 1640
            ...:|..|.|:|.|:.  |.|     |    |.:|.:|.:..::.:.|..::.   .||..   |
Mouse  1571 FIVLFTGECVLKLISL--RHYYFTIGW----NIFDFVVVILSIVGMFLAELIE---KYFVSPTLF 1626

  Fly  1641 MVVIL----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEG 1701
            .|:.|    |...:......::.|:..:.:|:...|.|...:||::|.||:.|...|..||...|
Mouse  1627 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVG 1691

  Fly  1702 IGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQ-PPYCTLGNNY----WETDCGNFTASLIY 1761
            |....||.:....:..||:|.|...|:.::...:.. ||.|....::    .:.||||.:..:.:
Mouse  1692 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPEKDHPGSSVKGDCGNPSVGIFF 1756

  Fly  1762 FCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDA-LLSYADIRNFQNTWNIVDIHQRGVI----- 1820
            |.::.:|...:|:|:.:|:|:||||:  :.||.| .||..|...|...|...|......|
Mouse  1757 FVSYIIISFLVVVNMYIAVILENFSV--ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKL 1819

  Fly  1821 -----------------PVRRVKFILRLLKG-RLEC-DPQKDRLLFKYM------CYELDKLH-- 1858
                             .|:.:...|.::.| |:.| |     :||.:.      ..|:|.|.
Mouse  1820 SDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD-----ILFAFTKRVLGESGEMDALRIQ 1879

  Fly  1859 --------NGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCL 1915
                    |...|::..:...|..:..:: .|:.::....|    ||::::|.|::
Mouse  1880 MEERFMASNPSKVSYEPITTTLKRKQEEV-SAIVIQRAYRR----YLLKQKVKKVS--------- 1930

  Fly  1916 KKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAI--STISGAVAGACPPTSD 1978
             .|..::..|:...      ...::.::...:.|:..|    :|:.:  ||.|       ||:.|
Mouse  1931 -SIYKKDKGKEDEG------TPIKEDIITDKLNENSTP----EKTDVTPSTTS-------PPSYD 1977

  Fly  1979 AFSPTFSSTENEEKDGS 1995
              |.|....|..|||.|
Mouse  1978 --SVTKPEKEKFEKDKS 1992

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.