DRSC/TRiP Functional Genomics Resources

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Protein Alignment na and cacna1a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_031755311.1 Gene:cacna1a / 100492135 XenbaseID:XB-GENE-1013831 Length:2302 Species:Xenopus tropicalis


Alignment Length:2261 Identity:482/2261 - (21%)
Similarity:822/2261 - (36%) Gaps:658/2261 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   401 LFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSY--LSIMR 463
            :|..|...|:...|....:..||::.|...|       ::.::..|  |....|:|..  |..:|
 Frog    41 IFCFETGIKIIALGFAFHKGSYLRNGWNIMD-------FVVVLSGI--VASTGPEFDLRTLRAVR 96

  Fly   464 APRPLIM---IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELK 524
            ..|||.:   |..|:|.|| |:.|:.|         .:..:.|...|.:.::.::|:.|: |:..
 Frog    97 VLRPLKLVSGIPSLQVVLK-SIMKAMI---------PLLQIGLLLFFAILIFAIIGLDFYIGKFH 151

  Fly   525 NHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNG---F 586
            ..|      ||:....|.       .:..|..| .|..:|.....|     ||.:....||   |
 Frog   152 TSC------YDMAGEDIR-------EEVLCGND-SSSRRCPENTQC-----LSKWEGPNNGITQF 197

  Fly   587 EDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAF---YFSTMIFFLAWLVKNVFIAVIT--- 645
            ::|..:|.||:|..:.|||..|:|.:.|   .:.:||   ||..:|...::.:.|:.:.|::   
 Frog   198 DNILFAILTVFQCITMEGWTDILYYSND---VFGSAFNWLYFIPLIIIGSFFMLNLVLGVLSGEF 259

  Fly   646 ----------ETFNEIRVQFQQMWGARGHIQKTAASQILSGNDT-----------GWRLVTIDDN 689
                      ..|.::|.|.|......|:::..:.::::...|.           ..|..||..|
 Frog   260 AKERERVENRRAFMKLRRQQQIERELNGYMEWISKAEVILAEDDSDIEQRLPYDGALRRPTIKKN 324

  Fly   690 KHGGL-APETCHAI-----LRSPYFRMLVMSVILAN----------------------------- 719
            |...| |.|...||     :.||:.|..:.|..:.|                             
 Frog   325 KTELLNAEEGEEAIGDIASVGSPFARASIKSAKMENSSYMHKKERRIRFLIRRMVKTQAFYWVVL 389

  Fly   720 GIV---TATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLL 781
            |:|   |..:...|.|:. |...|..||.|.:|..|...|...|:|.||.|.|:..|.:.|:..:
 Frog   390 GLVALNTLCVAIVHYGQD-DRLSEFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCAV 453

  Fly   782 AAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMC 839
            ..|:...:| .|..|.   |::..:.||::|:.|.:   ..|...|..:....|.:.||:.....
 Frog   454 ITGSIFEVVWAMVKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVISLLSSMKSIISLLFLLFL 518

  Fly   840 LLIISSSISMQLFCFLCDF------TKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPL 898
            .:::.:.:.||||....:|      |.|::||.|.|::|||||.|.|..||.:.:.......|.:
 Frog   519 FIVVFALLGMQLFGGQFNFDEKTPATNFDTFPAAIMTVFQILTGEDWNAVMYDGIKSQGGVKTGM 583

  Fly   899 V-AVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQ-------LKFREQSA-EIKETLPF- 953
            | ::|||:..||....:|::|:|:.:|||...:::.|.:|       .|...|.| |:.|..|. 
 Frog   584 VFSIYFIILTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLAMQKAKEVAEVSPLS 648

  Fly   954 --RLRIFEKFPDSPQ---MTILHRIPND--------------------------FMLPKVRESFM 987
              .:.|..|.....|   |::..:..|:                          ||.|.|:....
 Frog   649 ATNMSIAAKEQQKNQKTSMSVWEQRTNEIRRQNLMNSREALYSELDPEERWKLSFMRPDVKTHLD 713

  Fly   988 KHFVIELE---------------------------TEDSL-----------------VENCKRPM 1008
            :..|::.:                           .||.|                 .|..:||.
 Frog   714 RPLVVDPQENRNNNTNKTRPGEGRNPIEQRLSQQRAEDYLRKQARFQERGGRGYDMGQEPGRRPR 778

  Fly  1009 SECWESNVVFRKQKPVRIMNKTAKV--------------RAAGSSLRKLAITHIINDSNNQRLML 1059
            .:  |.::: |..:.:.:.::|.::              |..||...:........|.:::|...
 Frog   779 IK--EQDII-RDGQDLGMQDRTGEMDGGIRPPQDPHRRHRGGGSKESRSGSPLPRGDGDHRRHRP 840

  Fly  1060 -----------------------GDSAMLPVVGTKG-----GGGLKSQG--------------TI 1082
                                   |.....|..|..|     |||.:|:|              :.
 Frog   841 HRRTGEDNEDAGGGGGGGGRGGGGGGDRRPRHGRDGMRVREGGGGESEGPEGERRRRHRHAAQST 905

  Fly  1083 THSKPWRVDQKKFGSR----------------SIRRSVRSGSIKLKQTYEHLMENGD-------I 1124
            ..|...|.|:::...|                |..|.::..|.:..|..:  .||.|       :
 Frog   906 YESDAKRDDRERRHRRRKEPTAPTPGSGGPNLSTTRPIQDRSRQENQNQQ--PENMDNIRNTKLV 968

  Fly  1125 AAAPRANSG------------------------------RARPH--------------------- 1138
            .:.|.|..|                              |..||                     
 Frog   969 TSEPPAGGGVGGLNHSPAKIGNHTNCANNNSVPTGNATPRRTPHPTNSGPPPSAPDPSHTFSNPT 1033

  Fly  1139 ------------DLDI----------------KLLQAK---RQQAEMRRNQREEDLRENHPFFDT 1172
                        .:||                |::...   ::..|.:..:.::|..|..|....
 Frog  1034 ETAKGTKTTEHTTVDIPPPFPPPVENAIGQANKIVAVSPLPKKDDEKKEEEEDDDDGEKGPKPMP 1098

  Fly  1173 P---LFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATT 1234
            |   :|::...:..|::|..||..|                             |.:..::....
 Frog  1099 PYSSMFILSTTNPLRRLCHYIVTMR-----------------------------YFEMCILMVIA 1134

  Fly  1235 LSCISMMFETPNYRVMDHP---TLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDV 1296
            :|.|::..|.|..  .|.|   .|:..:|.|....:.|:.:|::..||.....||.:|:...|| 
 Frog  1135 MSSIALAAEDPVQ--PDAPRNNVLRYFDYVFTGVFTFEMVIKMVDLGLILHQGAYFRDLWNFLD- 1196

  Fly  1297 FIYV----VSTSFLCWMPLNIPTN----------SAAQLLMILRCVRPLRIFTLVPHMRKVVYEL 1347
            ||.|    |:.:|        .:|          |..:.|.:||.:|||:....:|.::.|...:
 Frog  1197 FIVVCGALVAFAF--------SSNQRGGSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCV 1253

  Fly  1348 CRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPG 1412
            ....|.:|.:..:.:|.|||||...|||:.|:...|.|.:...:.||.|.::  |:         
 Frog  1254 VNSLKNVLNILIVYMLFMFIFAVVAVQLFKGKFFYCTDESKEFQRDCRGEYL--VY--------- 1307

  Fly  1413 PDESYPAMLVPRVWANPRR-----FNFDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGP-- 1466
             |:|       .|.|..|.     |::||:..|:||||.|.:.:||.||.    |...:..||  
 Frog  1308 -DKS-------EVKAQKREWKKWPFHYDNVLWALLTLFTVSTGEGWPDVLRHSVDATYEDQGPRP 1364

  Fly  1467 --------VHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTAL----LTVDQRRWCDLKKRLK 1519
                    .:.||..::.|    ..:.:||.::|..:.|.....:    |..::|...|....  
 Frog  1365 GFRMEMSIFYVVYFVVFPF----FFVNIFVALIIITFQEQGDKIMEEYSLEKNERACIDFAIS-- 1423

  Fly  1520 IAQPL--HLPPRPDGRKIRAFTYDITQHII---FKRVIAVVVLINSMLLSITWIKGEVHTERLVI 1579
             |:||  |:|     :..::|.|.:.|.::   |:..|..::.:|:::|.:.: .|..:|...|:
 Frog  1424 -AKPLTRHMP-----QNKQSFQYRMWQFVVSPPFEYTIMALIALNTIVLMMKF-HGSSNTYENVL 1481

  Fly  1580 --VSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRN---DLSYFFG 1639
              .:.|.|.:|.:|.::|.:||....|::...|.:| .|||.|.|..|:.|.|.:   :||:...
 Frog  1482 KTFNMVFTSLFSLECLLKIMAFGAPNYFRDAWNIFD-FVTVLGSITDIVVTELWDSIINLSFLRL 1545

  Fly  1640 FMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGE---- 1700
            |...  |...:..:..|:::|:.|...|.....::...:.:|.|.||:.|..:||.:...|    
 Frog  1546 FRAA--RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDEEDDD 1608

  Fly  1701 -GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCT 1764
             .|....||.:....:.:|||..|||.|::||..|:...| |.:|:...|.:||:..| ..||.:
 Frog  1609 TAITEHNNFRNFFQALMLLFRSATGEAWHEIMLSCLSGRP-CDVGSGLKEKECGSEFA-YFYFVS 1671

  Fly  1765 FYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKF-- 1827
            |..:.::::|||.||:||:||.  |...:.::|....:..:...|...|....|     |:|:  
 Frog  1672 FIFLCSFLMLNLFVAVIMDNFE--YLTRDSSILGPHHLDEYVRVWAEYDPAAWG-----RMKYTD 1729

  Fly  1828 ---ILRLLKGRL----ECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKA--- 1882
               :|||:...|    :|..   |:.:|.:......:.:...|.|:..:..|...::||:.|   
 Frog  1730 LYEMLRLISPPLGLGKKCPA---RVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGG 1791

  Fly  1883 ---LQLEELLARE-----------EFEYLVEEE-----------VAKMTIRTWLEGCLKKIRAQN 1922
               .|::..|.:|           ..:.||...           .|.|.:..:.:...|:::|..
 Frog  1792 ADKQQMDSQLRKEMMAIWPNMSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKRLQALQ 1856

  Fly  1923 ASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSST 1987
            ..:.:..|:.       |.:..|:..:| .|||      |:.:..:.||           .....
 Frog  1857 EEQNRTPLMF-------QRMEPPSPTQD-GPLG------INALPSSQAG-----------EMGLP 1896

  Fly  1988 ENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRGYA 2052
            |...|: |.|.:.|.........||.|... |.|...|:|    .|.:.||.  .:..:|:.||:
 Frog  1897 EGGMKE-SQSWMTQRAQQMFQKTGTWSPER-ARTQENTNS----WPNSQQSV--EMSDMGRDGYS 1953

  Fly  2053 LNRSDSTGSSAGRKFLAP-TSSDPQQR-------STLSDKERLHITSQQRKKNSMTTLPHAGQLG 2109
            .:.........||....| ..:|.|||       |.||.     ||.....|.|.:.|.|:...|
 Frog  1954 DSEQYLVMEGHGRAASMPRLPADNQQRRKTRTRGSNLST-----ITDGSPMKRSASMLGHSQSKG 2013

  Fly  2110 ---------------------QLAKQRGGGGEATKSSSFFAQLNSEIG--------QFHYPTINA 2145
                                 |..::| |...:.:|.:.:..|.|.:|        ....||...
 Frog  2014 IRLDEYSLERVTPEEGPRHGHQRRRER-GHRVSDRSLTRYVDLESGLGTELSTTTQSCDLPTEER 2077

  Fly  2146 AAAAAALHGYGHGHGHGHGGHGGHGGHGEHQMHHHHGGA------LGSPSA 2190
            .......|.:.|.|.|.|              ||||...      .|.||:
 Frog  2078 GRTRDRKHHHHHHHHHHH--------------HHHHPSTERERLEYGRPSS 2114

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 64/277 (23%)
Ion_trans 734..927 CDD:278921 62/206 (30%)
Ion_trans 1240..1497 CDD:278921 76/292 (26%)
Ion_trans 1571..1793 CDD:278921 69/231 (30%)
cacna1aXP_031755311.1 Ion_trans 1..267 CDD:395416 62/266 (23%)
Ion_trans 382..620 CDD:395416 68/238 (29%)
Ion_trans 1123..1358 CDD:395416 72/293 (25%)
Ion_trans 1448..1700 CDD:395416 74/259 (29%)
GPHH 1709..1762 CDD:407139 12/60 (20%)
Ca_chan_IQ 1773..1846 CDD:400901 11/72 (15%)
PHA03307 2112..>2292 CDD:223039 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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