DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1b

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_031746887.1 Gene:cacna1b / 100489231 -ID:- Length:2250 Species:Xenopus tropicalis


Alignment Length:2231 Identity:471/2231 - (21%)
Similarity:821/2231 - (36%) Gaps:621/2231 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   401 LFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAP 465
            :|..|...|:...|.:..:..||::.|...|       ::.::..|............|..:|..
 Frog    12 IFCFEAGIKIIALGFVFHKGSYLRNGWNVMD-------FVVVLTGILATAGTDFDLRTLRAVRVL 69

  Fly   466 RPLIM---IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNH 526
            |||.:   |..|:|.|| |:.|:.:         .:..:.|...|.:.::.::|::|: |:....
 Frog    70 RPLKLVSGIPSLQVVLK-SIMKAMV---------PLLQIGLLLFFAIVMFAIIGLEFYMGKFHKA 124

  Fly   527 CVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSY----VIGFNGFE 587
            |..::::     .|        :.|..|..:|       |..:|....|...|    ..|...|:
 Frog   125 CFSDDSD-----EP--------VGDFPCGEEP-------PARLCENGTFCRVYWKGPNFGITNFD 169

  Fly   588 DIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVIT------- 645
            :|..::.||:|..:.|||..|:|...|::.......||..:|...::.:.|:.:.|::       
 Frog   170 NILFAVLTVFQCITMEGWTDILYNTNDAVGYMWNWLYFIPLIIVGSFFMLNLVLGVLSGEFAKER 234

  Fly   646 ------ETFNEIRVQFQQMWGARGHIQ--KTAASQILSGNDTG---------WRLVTIDDNKHGG 693
                  ..|.::|.|.|......|:::  ..|...:|:..|..         .:..||..:|:  
 Frog   235 ERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKRATIKKSKN-- 297

  Fly   694 LAPETCHA----------------------------------------------ILRSPYFRMLV 712
               :..||                                              ::::..|...|
 Frog   298 ---DLIHAEEGDDHFNDICSVGSPFARSSLKSGKNESSSYLRRKEKMFRFFIRRMVKAQSFYWFV 359

  Fly   713 MSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKF 777
            :.|:..|.:..|.:   |..:|: ...|..||.|.||..|...|...|:|.||.|.|:..|.:.|
 Frog   360 LCVVALNTLCVAIV---HYNQPQ-WLTEALYYAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNCF 420

  Fly   778 ELLLAAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKASP---MLEGFVYKIFGPGKKLGSLII 835
            :..:..|:...:: ....|.   |::..:.||::|:.|.:.   .|...|..:....|.:.||:.
 Frog   421 DFGVIVGSIFEVIWAAVKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIVSLLF 485

  Fly   836 FTMCLLIISSSISMQLFCFLCDF------TKFESFPEAFMSMFQILTQEAWVEVM---DETMIRT 891
            .....:::.:.:.||||.....|      |.|::||.|.:::|||||.|.|..||   .|:....
 Frog   486 LLFLFIVVFALLGMQLFGGQFYFEEETRNTNFDTFPTAILTVFQILTGEDWNLVMYFGIESQGGV 550

  Fly   892 SKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNL----ELDEDIKKLKQL---KFREQSA-EIK 948
            ||.:  ...:|||:..||....:|::|:|:.:|||    ||.:|.:::::.   |...|.| |:.
 Frog   551 SKGM--FSCIYFIILTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEATNQKLALQKAKEVA 613

  Fly   949 ETLP-----FRLRIFEKFP-------------DSPQMTILHRIPNDFMLPKVRESFMKHFVIELE 995
            |..|     ..:..|.|..             :||.             |.|..:.:|..:....
 Frog   614 EVSPMSAANLSITAFVKQTQGAISRSSSVSNVNSPD-------------PSVCSAVIKTQLPAYP 665

  Fly   996 TEDSLVENCKR---PMSECWESN------VVFRKQKPVRIMNKTAKVRAAGSS------LRKLAI 1045
            :...|..:|.|   .|..|.:.|      |..::...:|..|..|...|..|.      ||....
 Frog   666 SAWELAPSCARHLHAMDPCKQQNSTKCRSVWEQRTSQIRKHNFRASCEALYSELEPEDRLRYATT 730

  Fly  1046 THIIND--SNNQRLML-----------------GDSAMLPVVGT------------------KGG 1073
            .|:..|  |:..|.:|                 ..:.:.||.|.                  .||
 Frog   731 LHLRPDMKSHMDRPLLVEPQDSTETKDGSPDAPAPNEIEPVPGVTTEPSARKQHRHRDRGEPNGG 795

  Fly  1074 G------------------------------GLKSQG---------------------------- 1080
            |                              |.|..|                            
 Frog   796 GRENGNHNGDSGSNDREERQRQHRSRSKEEDGSKETGRGERNRSQERGKRHHRRASPEDGTEREH 860

  Fly  1081 ----TITHSKPWRVD--------QKKFGSRSIRRS------VRSGSIKLKQTYEHLMENGDIAAA 1127
                |..||    .|        |...|.:..|:|      .|||:.:.:.|.....|||:  ..
 Frog   861 RRHRTHRHS----ADRQGKEGNGQPPSGGKGERKSRHRGGGSRSGNREGEGTNRGTGENGE--EP 919

  Fly  1128 PRA---NSGRA-RPHDLDIKLLQAKRQQAEM-------RRNQREEDL-----------------R 1164
            ||:   |..:| ..:|.:.|......:.||.       |.|:.|.:|                 :
 Frog   920 PRSRHRNRHKALSTYDTEDKKENKDGESAEKEHRNHRPRENRNESELPPGGLQQLAEQPEDADNQ 984

  Fly  1165 EN-------HP----FFDTPLFLV--PRESRFRKICQKIVHARYDAR------LKDPLT--GKER 1208
            :|       ||    ..:.|:.:.  |.||    ....|.:..:|.:      ::|.||  |.::
 Frog   985 KNVNRMALPHPERSSTINIPVTITAPPGES----AVIPINNVDFDGKSEEKKEMEDDLTKNGPKQ 1045

  Fly  1209 KVQYKSL-------------HNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHP---TLQI 1257
            .:.|.|:             |..:.| .|.:.|::....||.|::..|.|..  .|.|   .|:.
 Frog  1046 ILPYSSMFIFSTTNPVRRLCHYIVNL-RYFEMVILVVIALSSIALAAEDPVQ--ADAPRNDVLKY 1107

  Fly  1258 AEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYV----VSTSFLCWMPLNIPTN-S 1317
            .:|.|....:.|:.:|::..||.....:|.:|:...|| ||.|    |:.:|..::..|...: :
 Frog  1108 MDYIFTGVFTFEMVIKMIDLGLLLHSGSYFRDLWNILD-FIVVSGALVAFAFSSFVGGNKGKDLN 1171

  Fly  1318 AAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLAR 1382
            ..:.|.:||.:|||:....:|.::.|...:....|.:|.:..:.:|.|||||...|||:.|:...
 Frog  1172 TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGKFFY 1236

  Fly  1383 CNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEV 1447
            |.|.:....:||.|.::..             |:.......|.| ....|::||:..|:||||.|
 Frog  1237 CTDESKDLEKDCRGEYLNY-------------ENNDVRAQAREW-KKYEFHYDNVLWALLTLFTV 1287

  Fly  1448 LSFKGWLDVR----DVLIKAVGPV----------HAVYIHIYIFLGCMIGLTLFVGVVIANYSEN 1498
            .:.:||.:|.    |...:..||.          :.||..::.|    ..:.:||.::|..:.| 
 Frog  1288 STGEGWPNVLKHSVDATYEDQGPTPGFRMEISIFYVVYFVVFPF----FFVNIFVALIIITFQE- 1347

  Fly  1499 KGTALLTVDQRRWCDLKKRLKI-------AQPL--HLPPRPDGRKIRAFTYDITQHII---FKRV 1551
            :|..:::.     |.|:|..:.       |:||  ::|     :..::|.|.:.:.::   |:..
 Frog  1348 QGDKVMSE-----CSLEKNERACIDFAISAKPLTRYMP-----QNRQSFQYKMWRFVVSPPFEYF 1402

  Fly  1552 IAVVVLINSMLLSITWIKG-EVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLL 1615
            |.|::.:|:::|.:.:... :.:.:.|..::.:.|.:|.:|.::|.|||....|::...|.:| .
 Frog  1403 IMVMIALNTIVLMMKFYGAPQTYEDMLKCLNIIFTSMFSLECILKIIAFGVLNYFRDAWNVFD-F 1466

  Fly  1616 VTVAGVIWIILQTILRN-----DLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFII 1675
            |||.|.|..||.|.:.:     :||:...|...  |...:..:..|:::|:.|...|.....::.
 Frog  1467 VTVLGSITDILVTEIADTENFINLSFLRLFRAA--RLIKLLRQGYTIRILLWTFVQSFKALPYVC 1529

  Fly  1676 FGMFLLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQP 1738
            ..:.:|.|.||:.|..:||.:...:  .|.|..||.:....:.:|||..|||.|::||..|:...
 Frog  1530 LLIAMLFFIYAIIGMQVFGNIALSDDSSINRHNNFRTFFQALMLLFRSATGEGWHEIMLSCLSNR 1594

  Fly  1739 PYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIR 1803
            | |...:...:.:||:..| ..||.:|..:.::::|||.||:||:||.  |...:.::|....:.
 Frog  1595 P-CDPRSGNTKEECGSDFA-YFYFVSFIFLCSFLMLNLFVAVIMDNFE--YLTRDSSILGPHHLD 1655

  Fly  1804 NFQNTWNIVD------IHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMCYELDKLHNGED 1862
            .|...|...|      ||.:.:..:.||  |...|.....|   ..|:.:|.: ..::...:..|
 Frog  1656 EFIRVWAEYDPAACCRIHYKDMYNLLRV--IAPPLGLGKRC---PSRVAYKRL-VRMNMPISDTD 1714

  Fly  1863 VTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWL---------------- 1911
            :|.|....:::.    ||.||.: :|.:....::..:.|:.|.....|.                
 Frog  1715 LTVHFTSTLMAL----IRTALDI-KLASGGIKQHECDAELRKEVSSVWPNLSQKTLDLLVPPHKP 1774

  Fly  1912 -EGCLKKIRA---------QNASKQQN--------------SLIAGLRAT-----NEQPVMRPNI 1947
             |..:.|:.|         ||.:.:..              ||...|:||     |.:..:|   
 Frog  1775 DELTVGKVYAALMIFDFYKQNKNNRDQSHPQSGVLSQTGTVSLFQPLKATLEPFGNSKMFIR--- 1836

  Fly  1948 QEDKAPL---GAVDKSAISTISGAVAGACP-------PTSDAFSPTFSSTENEEKDGSSSAVVQL 2002
            |:..|.|   |.|....:.....:..|..|       |.|.||....|...:.:::|..|..::.
 Frog  1837 QKSSASLNNGGLVPDQDMGIRESSSWGTQPATDPFSTPRSTAFQRGHSEEIHAQRNGKQSVEMKQ 1901

  Fly  2003 PHSETSIAG---TGSSATGAAT------------ATGTSSGLGVGP--PTVQSTARHV--MTVGK 2048
            .....|..|   ||..:.|.|.            :...|.|.|..|  |......|.|  :|..:
 Frog  1902 IGQTLSNGGEHPTGLESQGRAVSMPRLAAETHPRSRAPSPGNGYLPSIPDTSPMKRSVSTLTPPQ 1966

  Fly  2049 RG----YAL----------------------------------------NRSDSTGSSAGRKFLA 2069
            |.    |:|                                        :|....|.|..||...
 Frog  1967 RAQLYEYSLERVPPERTHQHHHRCHRRKERKQKSTERSPQSEDADAPTRDRKHERGRSQERKQQP 2031

  Fly  2070 PTSSDPQQRSTLSDKERLHITSQQRK-KNSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNS 2133
            |:||: :||....|:.....:...|: .:|..|.|.|||  ..:..|.|.|.|:.|         
 Frog  2032 PSSSE-KQRFYSCDRYGSRDSGHPRQCDHSRATSPSAGQ--DHSTHRQGSGSASGS--------- 2084

  Fly  2134 EIGQFHYPTINAAAAAAALHG 2154
                   |.:.::.|:....|
 Frog  2085 -------PRLTSSGASTPCRG 2098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 54/273 (20%)
Ion_trans 734..927 CDD:278921 62/212 (29%)
Ion_trans 1240..1497 CDD:278921 70/278 (25%)
Ion_trans 1571..1793 CDD:278921 66/228 (29%)
cacna1bXP_031746887.1 Ion_trans 9..238 CDD:395416 52/262 (20%)
Ion_trans 352..591 CDD:395416 70/244 (29%)
PRK12678 747..>927 CDD:237171 26/185 (14%)
Ion_trans 1072..1306 CDD:395416 67/250 (27%)
Ion_trans 1396..1647 CDD:395416 71/257 (28%)
GPHH 1656..1709 CDD:407139 12/58 (21%)
Ca_chan_IQ 1721..1795 CDD:400901 11/78 (14%)
PHA03307 1911..>2139 CDD:223039 41/207 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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