DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1e

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_017949086.2 Gene:cacna1e / 100488514 XenbaseID:XB-GENE-1012852 Length:2393 Species:Xenopus tropicalis


Alignment Length:2089 Identity:437/2089 - (20%)
Similarity:776/2089 - (37%) Gaps:569/2089 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   283 AAAGMGICGGISSTVG----SAAITGVP--PIGLGIATGIGNKIMLGRKQSLKGGEPF------- 334
            |..|..:.|.:||..|    |..:.|.|  |:|...|.. .:|....|..:|....|.       
 Frog   158 ARFGEAVTGRLSSADGGSERSKTLQGSPAAPVGTQAAFK-QSKAQRARTMALYNPIPVRQNCFTV 221

  Fly   335 ---LADYGPEESLNESAD--IEW--VNKLWVRRLMRLCALVSL---------TSVSLNTPKTFER 383
               |..:|.:..:.:.|.  |:|  ...:.:..::..|.:::|         |.:|....|| |.
 Frog   222 NRSLFIFGEDNIIRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPGDDKTPMSRRLEKT-EP 285

  Fly   384 YPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIIL---- 444
            |    ||.         :|..|...|:...|::..:..||::.|...|..:|    :|.||    
 Frog   286 Y----FIG---------IFCFEAGIKIVALGLVFHKGSYLRNGWNVMDFIVV----LSGILATAG 333

  Fly   445 ---------------QIFEVLEIVPKFSYL-----SIMRAPRPLIMIRFLRVFLKFSMPKSRINQ 489
                           ::...|::|.....|     |||:|..||:.|..|               
 Frog   334 THFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLL--------------- 383

  Fly   490 IFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTINSLAIPDTF 553
                         |||...|  :.::|::|: |:|...|..||:..:|                 
 Frog   384 -------------LFFAILM--FAIIGLEFYSGKLHKACYRNNSGMEL----------------- 416

  Fly   554 CSMDP---------DSGYQC----SPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGW 605
            ..|||         .:||:|    .|.             .|...|::|..::.||:|..:.|||
 Frog   417 DPMDPPHPCGVPRCPAGYECKEWIGPN-------------DGITQFDNILFAVLTVFQCITMEGW 468

  Fly   606 VFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVIT-------------ETFNEIRVQFQ- 656
            ..::|...|:|.|.....||..:|...::.|.|:.:.|::             ..|.::|.|.| 
 Frog   469 TTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQI 533

  Fly   657 --QMWGARGHIQK--------------TAASQIL-------------------------SGNDTG 680
              ::.|.|..|.|              |:|.::|                         |...|.
 Frog   534 ERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKRSRTEAMNRDSTEDHCVDISSVGTP 598

  Fly   681 WRLVTIDDNKHGG---------LAPETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRD 736
            ....:|...|..|         |...:...:::|..|..:|:.|:..|....|.:.........:
 Frog   599 LARASIKSTKMDGASYFRHKEKLLRVSVRHMIKSQVFYWMVLGVVALNTFCVAIVHHNQTLWLSN 663

  Fly   737 VFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV-PMFYPS---G 797
            |.    ||.|.:|..|..:|..||:|.:|.|.|:..|.:.|:..:..|:...:: .:|.|.   |
 Frog   664 VL----YYAEFLFLGLFLVEMAFKMYGMGPRLYFHSSFNCFDCGVTIGSIFEVLWAIFRPGTSFG 724

  Fly   798 LTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF- 858
            ::..:.||::|:.|.:   ..|...|..:....|.:.||:......:::.:.:.|||:....:| 
 Frog   725 ISVLRALRLLRIFKITKYWASLRNLVVSLMNSMKSIISLLFLLFLFIVVFALLGMQLYGGRFNFN 789

  Fly   859 -----TKFESFPEAFMSMFQILTQEAWVEVM-----DETMIRTSKTLTPLVAVYFILYHLFVTLI 913
                 ..|::||.|.|::|||||.|.|.|||     .:..:|:..    ..::|||:..||....
 Frog   790 DGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVRSGM----WSSIYFIVLTLFGNYT 850

  Fly   914 VLSLFVAVILDNLELDEDIKKLKQLK---FREQSA--EIKETLPF----------------RLRI 957
            :|::|:|:.:|||...:::.|.:|.:   |.::.|  :.||..|.                .|.|
 Frog   851 LLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNASCIEKERRKRHTLSI 915

  Fly   958 FEKFP---------------DSPQMTILHRIPNDFMLPKVRESFMKHFVIELETED--------- 998
            :|:..               .|.::..|:  |:..:..|.:|:..::...|...:|         
 Frog   916 WEQRTSQLRRHIQMSSQEALQSEELAALN--PHSSIYRKTKEAAEQNTEKEEVHQDAKLAIDPVE 978

  Fly   999 ------------SLVENCKRPM----SECWESN------VVFRKQKPVRIMNKTAKVRAAGSSLR 1041
                        :|.||.::..    ||..|.|      .:.|:|...|  ::..:||..|..  
 Frog   979 GPPEGEGSPSNRNLRENWRQKSRHGNSENTEPNGTTPEEAMRRRQSQRR--SRHRRVRTEGRE-- 1039

  Fly  1042 KLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGL---KSQGTITHSK-----PWR--VDQKKFG 1096
                    ..||...........|..|..:.|..:   ||.|.....|     |.:  :..:...
 Frog  1040 --------QCSNPNSTSASREGGLDKVSAEDGRTIPEEKSNGEAKEVKGVDDEPLKICISSRNCE 1096

  Fly  1097 SRSIR--------------RSVRS------------------GSIKLKQTYEHLMENGDIAAAPR 1129
            .|:||              :.|.|                  |||:.:::     .|....:.|.
 Frog  1097 DRNIRTLGCEGIALNDTPLQDVNSQEKDSSPPDLDCSEQALLGSIQSQES-----PNPTSCSLPD 1156

  Fly  1130 ANSGRAR--------------PHDLDIKLLQAKR------------QQAEMRRNQREEDLRENHP 1168
            .:|...|              |.|..:..:...|            ::.|...:..|..::....
 Frog  1157 VSSSTERVTESTVITLPDTGMPTDCTVVQMSEGRDGEVNFGSSQQEKEEEEAEDGEERTIKRKEK 1221

  Fly  1169 FFDTPLFLVPRESR--------FRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYL 1225
            ..::|..:||..|.        .||:|..||:.|                             |.
 Frog  1222 LLESPKAIVPYSSMLIFSSTNPIRKVCHYIVNLR-----------------------------YF 1257

  Fly  1226 DWVMIFATTLSCISMMFETPNYRVMD-HPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKD 1289
            :..::.....|.|::..|.|.....| :..|:..:|.|....:.|:.:|::..||.....:|.:|
 Frog  1258 EMSILLVIAASSIALAAEDPVLTNSDRNKVLRYFDYVFTGVFTFEMIIKMIDQGLILHEGSYFRD 1322

  Fly  1290 VAAALDVFIYVVSTSFLCWMPLNIPTNSAAQL-----LMILRCVRPLRIFTLVPHMRKVVYELCR 1349
            :...|| |:.||.......:...:.||....:     |.:||.:|||:....:|.::.|...:..
 Frog  1323 LWNILD-FVVVVGALIAFALANVLGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVN 1386

  Fly  1350 GFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPD 1414
            ..|.:..:..:..|.|||||...|||:.|:...|.|.:....::|:|.::              |
 Frog  1387 SLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKETEKECIGSYI--------------D 1437

  Fly  1415 ESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGPVH------A 1469
            .....|.|.|.......|::|||..|:||||.|.:.:||..|.    |:..:..||..      :
 Frog  1438 HEKNKMEVKRREWKRHDFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDITEEDRGPSRSNRMEMS 1502

  Fly  1470 VYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKRLKI-------AQPL--H 1525
            ::..||..:.....:.:||.::|..:.| :|..::     ..|.|:|..:.       |:||  :
 Frog  1503 IFYVIYFVVFPFFFVNIFVALIIITFQE-QGDKMM-----EECSLEKNERACIDFAISAKPLTRY 1561

  Fly  1526 LPPRPDGRKIRAFTYDITQHII---FKRVIAVVVLINSMLLSITWIKGEVHTERLVI--VSAVLT 1585
            :|     :....|.|.:...::   |:..|..::.:|:::|.:.:.... :|..|.:  ::...|
 Frog  1562 MP-----QNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAP-YTYELALKYLNIAFT 1620

  Fly  1586 FVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIIL-QTILRNDLSYFFGFMVVI--LRF 1647
            .:|.:|.::|.|||....|::...|.:|.:..:..:..||| .:.|.|..|:...|:.:.  .|.
 Frog  1621 MLFSLECILKIIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSSFNMSFLKLFRAARL 1685

  Fly  1648 FTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEG--IGRRANFGS 1710
            ..:..:..|:::|:.|...|.....::...:.:|.|.||:.|..:||.::..|.  |.|..||.|
 Frog  1686 IKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIRLEEDSHINRHNNFRS 1750

  Fly  1711 PVTGVAMLFRIVTGEDWNKIMHDCMVQ---PPYCTLGNNYWETD-CGNFTASLIYFCTFYVIITY 1771
            ..:.:.:|||..|||.|.:||..|:..   .|..:..:.:.|.: ||...| .:||.:|....::
 Frog  1751 FFSSLMLLFRSATGEAWQEIMLSCLSDKGCEPDTSAASGHNENERCGTELA-YVYFVSFIFFCSF 1814

  Fly  1772 IVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL 1836
            ::|||.||:||:||.  |...:.::|....:..|...|...|....|.||.:.:..::|::...|
 Frog  1815 LMLNLFVAVIMDNFE--YLTRDSSILGPHHLDEFVRIWAEYDRAACGRIPYKDMYKLVRVISPPL 1877

  Fly  1837 ----ECDPQKDRLLFKYMCYELDKLHN--GEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFE 1895
                .|.       ::..|..|..::.  .||:|.|....:::.    ||.||.::......:.:
 Frog  1878 GLGENCP-------YRVACKRLVLMNMPVSEDMTVHFTSTLMAL----IRTALDIKIAKGGADRQ 1931

  Fly  1896 YLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPV------------------ 1942
            .| :.|:.|..:..|          .|.|::...|:..:...::..|                  
 Frog  1932 QL-DSELQKDILAIW----------PNLSQKMIDLLVPMPRASDLTVGKIYAAMMIMDYYKQSKA 1985

  Fly  1943 --MRPNIQEDK-APL------GAVDKSAIS-----------TISGAVAGACPPTS-----DAFSP 1982
              .|..::|.| ||:      .|:.:..:|           |:||  .|..|..|     :.|.|
 Frog  1986 KKQRQQLEEQKNAPMFQRMEASALPEEILSNAKALPYLQQDTLSG--LGGFPSLSPLSPEEVFQP 2048

  Fly  1983 TFSSTENEE 1991
            .....|.||
 Frog  2049 PCLDGEEEE 2057

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 70/331 (21%)
Ion_trans 734..927 CDD:278921 58/210 (28%)
Ion_trans 1240..1497 CDD:278921 67/272 (25%)
Ion_trans 1571..1793 CDD:278921 65/232 (28%)
cacna1eXP_017949086.2 Ion_trans 244..519 CDD:395416 72/352 (20%)
Ion_trans 632..871 CDD:395416 65/246 (26%)
Ion_trans 1255..1485 CDD:395416 63/273 (23%)
Ion_trans 1579..1836 CDD:395416 69/260 (27%)
GPHH 1845..1898 CDD:407139 11/59 (19%)
Ca_chan_IQ 1909..1982 CDD:400901 12/87 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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