DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1c

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_012814814.1 Gene:cacna1c / 100488055 XenbaseID:XB-GENE-991126 Length:2196 Species:Xenopus tropicalis


Alignment Length:2087 Identity:457/2087 - (21%)
Similarity:793/2087 - (37%) Gaps:581/2087 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   400 LLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFE-VLEIVPKFSYLSI-- 461
            ::||.|...|:...|:|.....||::.|...|       :|.:::.:|. :||...|....|.  
 Frog   196 IIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLD-------FIIVVVGLFSAILEQATKADGGSAIG 253

  Fly   462 -------MRAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGV 517
                   ::|.|...::|.||  |...:|..::  |.|.| :...:.::.|..||.:.:|.::|:
 Frog   254 GKGAGFDVKALRAFRVLRPLR--LVSGVPSLQVVLNSIIK-AMVPLLHIALLVLFVIIIYAIIGL 315

  Fly   518 Q-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTF-------CSMDPDSGYQCSPGMVCMKMD 574
            : |.|::...|......|               ||..       |:::.::|..|..|.:|.   
 Frog   316 ELFMGKMHKTCYYLTNGY---------------PDVLTEEEPSPCALESNNGRHCPNGTLCR--- 362

  Fly   575 FLSSYV---IGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLV 636
              |.:|   .|...|::.|.::.||:|..:.|||..::|...|::.......||.:::.|.::.|
 Frog   363 --SGWVGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPCVYFVSLVIFGSFFV 425

  Fly   637 KNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDTG---WRLVT------------- 685
            .|:.:.|::..|::.|.:.:    |||..||....|.|..:..|   |  :|             
 Frog   426 LNLVLGVLSGEFSKEREKAK----ARGDFQKLREKQQLEEDLKGYLDW--ITQAEDIDPENEDED 484

  Fly   686 IDDNKHGGLAPET------------------------------------------------CHAI 702
            ||:.|...::..|                                                |.|.
 Frog   485 IDEEKPRNMSMPTSETESVNTDNVGSGDVEEESCGVRLAHRISKSKFSRYWRRWNRFCRRKCRAA 549

  Fly   703 LRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWR 767
            ::|..|..||:.::..|   |.|:..:|..:| |...|.......|...|...|.|.|:|.||.:
 Frog   550 VKSNVFYWLVIFLVFLN---TLTIASEHYNQP-DWLTEVQDTANKVLLALFTAEMLLKMYSLGLQ 610

  Fly   768 GYYKHSIHKFELLLAAGTTLHIV----PMFYPSGLTYFQVLRVVRLIKAS---PMLEGFVYKIFG 825
            .|:....::|:..:..|..|..:    .:..|.|::..:.:|::|:.|.:   ..|...|..:..
 Frog   611 AYFVSLFNRFDCFIVCGGILETILVETRIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLN 675

  Fly   826 PGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF-------TKFESFPEAFMSMFQILTQEAWVEV 883
            ..:.:.||::.....:||.|.:.||||....:|       :.|::||:|.:::|||||.|.|..|
 Frog   676 SVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMLTRRSTFDNFPQALLTVFQILTGEDWNSV 740

  Fly   884 MDETMIRTSKTLTP--LVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAE 946
            |.:.::.......|  ||.:|||:..:....|:|::|:|:.:|||   .|.:.|...:..|:..:
 Frog   741 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNL---ADAESLTSAQKEEEEEK 802

  Fly   947 IKETL-----PFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKR 1006
            .::.|     |.:.:..|....||             :|.|.|:..|   |||:.          
 Frog   803 ERKKLARTASPEKKQENESLGKSP-------------VPAVEENKEK---IELKA---------- 841

  Fly  1007 PMSECWESNVVFRKQKPVRIMNKTAKVRAAGSS--LRKLAITHIINDSNNQRLMLGDSAMLPVVG 1069
                                      :.|.|.|  ..|:::.....:.|.::.....|...|   
 Frog   842 --------------------------ITADGESPPNTKISVEEFSTNENEEKTPYPSSNETP--- 877

  Fly  1070 TKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGR 1134
                                                         .|...|..::...|     |
 Frog   878 ---------------------------------------------GEEEEEEPEMPVGP-----R 892

  Fly  1135 ARP-HDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDAR 1198
            .|| .:|.||...|...:|                   :..|:...::|||..|.:||:......
 Frog   893 PRPLSELHIKEKAAPMPEA-------------------SAFFVFRSDNRFRVHCHRIVNNNIFTN 938

  Fly  1199 L--------------KDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRV 1249
            |              :||       |::.|..|  .::.|.|.|.....|:..:..:        
 Frog   939 LILFFILLSSISLAAEDP-------VRHNSFRN--QVLFYFDIVFTAIFTVEIVLKI-------- 986

  Fly  1250 MDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCW----MP 1310
                 |..|:|.|....:||:.||:.|.|.|....::.::....||  :.|||.|.:.:    ..
 Frog   987 -----LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILD--LLVVSVSLISFGIQSSA 1044

  Fly  1311 LNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYG 1372
            :|:     .::|.:||.:||||....   :.|:.:.|:...|....|::|:|   ||.|:||..|
 Frog  1045 INV-----VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT---LLQFMFACIG 1101

  Fly  1373 VQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNI 1437
            |||:.|:|..|.|.:.....:|.|.::         .....|.|.| |:|.|.|.| .:|:|||:
 Frog  1102 VQLFKGKLYSCTDSSKITEAECKGKYI---------TYKDGDVSQP-MIVDRSWEN-SKFDFDNV 1155

  Fly  1438 GDAMLTLFEVLSFKGWLDVRDVLIKA-------VGPVH------AVYIHIYIFLGCMIGLTLFVG 1489
            ..||:.||.|.:|:||   .::|.:|       |||::      :::..|||.:.....:.:|||
 Frog  1156 LSAMMALFTVSTFEGW---PELLYRAIDSHTEDVGPIYNHRVEISIFFIIYIIIIAFFMMNIFVG 1217

  Fly  1490 VVIANYSENKGTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYD-----ITQHIIFK 1549
            .||..:.| :|.     .:.:.|:|.|..:......|..||..|.|....|.     :.....|:
 Frog  1218 FVIVTFQE-QGE-----QEYKNCELDKNQRQCVEYALKARPLRRYIPKNQYQYKVWYVVNSTYFE 1276

  Fly  1550 RVIAVVVLINSMLLSITWIKGEVH-------TERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQS 1607
            .::.|::|:|::.|::.      |       .|.:.|::.:.|.:|.||:::|.|||.|:||:..
 Frog  1277 YLMFVLILLNTICLAMQ------HYGQSCSFKEAMNILNMLFTGLFTVEMILKLIAFKPKGYFSD 1335

  Fly  1608 RRNRYDLLVTVAGVIWIILQTILRNDLSYFF-------------GFMV----------------- 1642
            ..|.:|.|:.:..|:.:||     ::.:::|             |.:|                 
 Frog  1336 PWNVFDFLIVIGSVVDVIL-----SETNHYFCDAWNTFDALIVVGSIVDIAITELNPGEHAQCSS 1395

  Fly  1643 ---------VILRFFTITGKHTTLKMLMLTVGV-----SVCKSF----FIIFGMFLLVFFYALAG 1689
                     :.:.||.:......:|:|....|:     :..|||    ::...:.:|.|.||:.|
 Frog  1396 SMNVEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIG 1460

  Fly  1690 TILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDC 1752
            ..:||.:...:  .|.|..||.:....|.:|||..|||.|.:||..|:...| |...:...|..|
 Frog  1461 MQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPSKP-CAPESETSEEKC 1524

  Fly  1753 GNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQR 1817
            |: :.::.||.:||::..::::||.||:||:||.  |...:.::|....:..|:..|...|...:
 Frog  1525 GS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFKRIWAEYDPEAK 1586

  Fly  1818 G-------VIPVRRVKFIL---RLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINML 1872
            |       |..:||::..|   :|...|:.|    .||:...|     .|::...|.|:..:..|
 Frog  1587 GRIKHLDVVTLLRRIQPPLGFGKLCPHRVAC----KRLVAMNM-----PLNSDGTVMFNATLFAL 1642

  Fly  1873 SYRSVDIRKALQLEELLAREEFEYLV----------------------EEEVAKMTIRTWLEGCL 1915
            ...|:.|:....||:  |.||...::                      |..|.|......::...
 Frog  1643 VRTSLCIKTDGNLEQ--ANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYF 1705

  Fly  1916 KKIRAQNAS------KQQN--SLIAGLRATNE-QPVMRPNIQEDKAPLGAVDKSAISTISGAV-- 1969
            :|.:.:...      .|:|  ||.||||..:: .|.:|..|..|......:||:....:|.|.  
 Frog  1706 RKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASED 1770

  Fly  1970 -----AGAC---------PPTSDAFSPTFSSTE----NEEKDG-------SSSAVVQLPHSETSI 2009
                 ||..         .....||..||::..    |:...|       |...:|....:.:|.
 Frog  1771 DIFRRAGGLFGNHVGYYQSEVRSAFPQTFTTQRPLHINKTSGGPGDLDSPSHEKLVDSTFTPSSY 1835

  Fly  2010 AGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTV-GKRGYALNRSD---STGSSAGRKFLAP 2070
            :.:||:| ....|..|:.   |..|..:||   |.|| |:.....:|..   .:.||..|....|
 Frog  1836 SSSGSNA-NINNANNTAL---VRLPCYRST---VSTVEGQSRPVTSRGSWKLGSKSSVSRDSRLP 1893

  Fly  2071 --TSSDPQQRSTLSDKERLHITSQ----------QRKKNSMTTLPHAGQLGQLAKQRGGGGEATK 2123
              ...:..|..|....|.:..:|:          .|.:.|....|..|::     :||......|
 Frog  1894 IICREEASQDETYDASEEVEYSSEPSLLCSEMFSDRDEESRQLTPSEGEV-----ERGLCPSPKK 1953

  Fly  2124 SSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGGHGGHGEHQMHHHHGGALGSP 2188
            .....|.|... ..||...:                                :.:.|.|..:.||
 Frog  1954 GFLRSASLGRR-ASFHLECL--------------------------------RRYRHQGAEMSSP 1985

  Fly  2189 SAMMSQM 2195
            .|::.|:
 Frog  1986 KAVLPQL 1992

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 63/276 (23%)
Ion_trans 734..927 CDD:278921 57/208 (27%)
Ion_trans 1240..1497 CDD:278921 79/276 (29%)
Ion_trans 1571..1793 CDD:278921 71/278 (26%)
cacna1cXP_012814814.1 Ion_trans 169..445 CDD:278921 63/278 (23%)
Ion_trans 570..793 CDD:278921 61/226 (27%)
Ion_trans 985..1230 CDD:278921 81/287 (28%)
Ion_trans 1290..1564 CDD:278921 72/288 (25%)
GPHH 1572..1635 CDD:293510 16/71 (23%)
Ca_chan_IQ 1637..1708 CDD:285917 11/72 (15%)
CAC1F_C 1731..2149 CDD:293490 61/307 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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