DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and scn2a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_031749252.1 Gene:scn2a / 100486750 XenbaseID:XB-GENE-6447552 Length:1970 Species:Xenopus tropicalis


Alignment Length:2060 Identity:402/2060 - (19%)
Similarity:721/2060 - (35%) Gaps:648/2060 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   355 KLWVRRLMRLCALVSLTS----VSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGV 415
            |:.|..|..:..:.::.:    ::|:.|..:.:.....|         |.::|.|.:.|:..||.
 Frog   123 KILVHSLFNMLIMCTILTNCVFMTLSNPPEWTKNVEYTF---------TGIYTLESLIKILARGF 178

  Fly   416 LHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKF 480
            ...:..:|:|.|...|.|::             ||..|.:|..|..:.|.|...::|.|:.....
 Frog   179 CLEKFTFLRDPWNWLDFSVI-------------VLAYVTEFVNLGNVSALRTFRVLRALKTISVI 230

  Fly   481 SMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVM----NNTEYDLY--- 537
            ...|:.:..:. :|.:::.:|.:..:|.:|::.|:|:| |.|.|:|.|::    ::.:..||   
 Frog   231 PGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRNKCLLWPYNSSVDISLYEHF 294

  Fly   538 -----------KRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIAT 591
                       |.|::           |....|:| :|..|.||:|.....:|  |:..|:....
 Frog   295 NESLFYKLENQKDPLV-----------CGNSSDTG-KCPEGYVCVKAGRNPNY--GYTSFDTFNW 345

  Fly   592 SIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVITETFNE- 650
            :..::::..:|:.|..:....:      |||     .:|..:||..::.:.|:.:||:...:.| 
 Frog   346 AFLSLFRLMTQDCWENLYQLTL------RAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQ 404

  Fly   651 ----------IRVQFQQMWGARGHIQKTAA--------SQILSGNDTG----------------- 680
                      ...:||::...:...|..||        ||.|| .:.|                 
 Frog   405 NQATIEEAVQKEAEFQRLKKQQEEAQALAAAVADVFGESQELS-EEVGLEDASECSSTVSKLSSK 468

  Fly   681 -------WR-------------------------------------------------------- 682
                   ||                                                        
 Frog   469 SAKERRNWRKQRKQVAHCDGQEKGDKEKCYKSGSEDSIKRKGLNFTREGRRLEEYRKSSMPHQSL 533

  Fly   683 ----------------------------------------------------------------- 682
                                                                             
 Frog   534 LSIQGPVFSPRRNSKTSIFSFKDRAKDVGSENDFADDERSTFEEDSRRDPLFVPGRHRARRNSNI 598

  Fly   683 -----------LVTIDDNKHG------------------GLAPETCHA----------------I 702
                       |::::...|.                  ||.||....                :
 Frog   599 SQTSRSSRILPLLSMNGKMHSTVDCNGVVSLVGGSSAPIGLFPEGTTTETDRKRRPSSYKISMDL 663

  Fly   703 LRSPYFRMLVMSVILANGIVTATMTFKHDGRPR-------------------------------- 735
            :..|..|....|:.   .|:|.||....:.|.:                                
 Frog   664 MEDPSLRQRAQSIA---SILTNTMEELQESRRKCPSCWYKFANCFLIWDCCEAWLKVKRIVKLIV 725

  Fly   736 -DVFYE---------------------RYYYIEL------VFTCLLDLETLFKIYCLGWRGYYKH 772
             |.|.:                     ..|:|.:      |||.:...|.:.|:..|....|::.
 Frog   726 MDPFVDLAITISIVLNTIFMAVEHAHMTPYFISVLTTGNQVFTGIFTAEMVLKLIALDPYYYFQE 790

  Fly   773 SIHKFELLLAAGTTLHIVPMFYPSG-----LTYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLG 831
            ..:.|:.|:   .:|.::.:...|.     |..|::|||.:|.|:.|.|...: ||.|.. ..||
 Frog   791 GWNIFDGLI---VSLSLMELGLSSTGGFSVLRSFRLLRVFKLAKSWPTLNKLI-KIIGNSVGALG 851

  Fly   832 SLIIFTMCLLIISSSISMQLF--------CFL---CDFTKF--ESFPEAFMSMFQILTQEAWVEV 883
            :|.:....::.|.:.:.||||        |.:   |:..::  ..|..:|:.:|::|..| |:|.
 Frog   852 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAENCELPRWHMNDFFHSFLIVFRVLCGE-WIET 915

  Fly   884 MDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIK 948
            |.:.|....:::..||   |:|..:...|:||:||:|::|.:...|       .|...::.:|| 
 Frog   916 MWDCMEVAGQSMCLLV---FMLVMVIGNLVVLNLFLALLLSSFSSD-------NLSATDEDSEI- 969

  Fly   949 ETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKV--RESFMKHFVIELE--TEDSLVENCKRPMS 1009
                          ::.|:.: .||.......|:  ||.|.|.|:.:.:  .|...:|.......
 Frog   970 --------------NNIQIAV-GRIQRGVASGKIILREFFEKLFLQKQKDINETKQLEETPGKND 1019

  Fly  1010 ECWESNVVFRKQKPVRIMNKTAKVRAA-------GSSLRKLAITHIINDSNNQRLMLGDSAMLPV 1067
            .|...|.|      |.|:.:...||.:       |||:.|.|    .|:.....::...|..:.|
 Frog  1020 TCVLGNAV------VEILKEKNDVRDSDGMTSEIGSSVEKSA----ENEKEYMTVINKTSLTVAV 1074

  Fly  1068 VGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANS 1132
            ....|....::..|           ::|.|.|.....:.   |:|.                  |
 Frog  1075 PIAPGESDFENPNT-----------EEFSSESDPEETKE---KIKV------------------S 1107

  Fly  1133 GRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDA 1197
            ..:....:||:....:|.:..:       |......|...|.|.....:.| ..||..:      
 Frog  1108 SSSEGSTIDIRAPGVERIEEFL-------DYEYEETFDPEPCFTDDCVASF-TCCQINI------ 1158

  Fly  1198 RLKDPLTGKE----RKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFE------TPNYRVMDH 1252
               :..||::    ||..|..:.:     ::.:..:||...||..::.||      ..|.:.:  
 Frog  1159 ---ENGTGRDWWNLRKTCYTIVEH-----SWFESFIIFMILLSSGALAFEDIYVEQRRNVKAI-- 1213

  Fly  1253 PTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNS 1317
              |:.|:..|.....:|:.||.:|.|..    .|..:....||..|..:|...|....|......
 Frog  1214 --LEYADKVFAYIFIMEMLLKWVAYGFI----KYFTNAWCWLDFIIVDISLVSLIANALGYSELG 1272

  Fly  1318 AAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLAR 1382
            |.:.|..||.:||||..:....||.||..|......|:.|..:.::...||:..||.|:.|:...
 Frog  1273 AIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYY 1337

  Fly  1383 CNDPT---------ISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIG 1438
            |.:.|         ::...||      |:::.    |.|...          |.|. :.||||:|
 Frog  1338 CVNTTSGVPFPATDVNNYSDC------RMYIN----TTGAAR----------WKNV-KVNFDNVG 1381

  Fly  1439 DAMLTLFEVLSFKGWL-------DVRDVLIKAVGPVHA------VYIHIYIFLGCMIGLTLFVGV 1490
            ...|.|.:|.:||||:       |.|::..:   |.:.      :|...:|..|....|.||:||
 Frog  1382 AGYLALLQVATFKGWMPIMYAAVDSREINEQ---PKYENNTTMYLYFVAFIIFGSFFTLNLFIGV 1443

  Fly  1491 VIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKR 1550
            :|.|:::.|     ....:|.:|:::.:..|:|...:|....||| ....:...:|......|..
 Frog  1444 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-ANCCQGLIFDFVTKQAFDI 1507

  Fly  1551 VIAVVVLINSMLLSI-TWIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDL 1614
            :|.:::.:|.:.:.| |..:.:.....|..::||...:|..|.::|.|:.. :.|:....|.:||
 Frog  1508 IIMILIFLNMVTMMIETDDQSQEMEMYLYRINAVFIILFTGEFLLKLISLR-QYYFTIGWNIFDL 1571

  Fly  1615 LVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGKHTTLKMLMLTVGVSVCKSF 1672
            :|.:..::.:.|..|:..   |||.   |.|:.|    |...:......::.|:..:.:|:...|
 Frog  1572 VVVILSIVGMFLADIIER---YFFSPTLFRVIRLARIGRILRLIKAAKGIRTLLFALMMSLPALF 1633

  Fly  1673 FIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMH----- 1732
            .|...:||::|.||:.|...|..||...||....||.:....:..||:|.|...|:.::.     
 Frog  1634 NIGLLLFLVMFIYAIFGMSNFAYVKKQSGIDDMFNFETFGNSMICLFQITTSAGWDLLLEPILNS 1698

  Fly  1733 ---DCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEED 1794
               ||   .|......:.::.||||.:..:.:|.::.:|...||:|:.:|:|:||||:  :.||.
 Frog  1699 GEPDC---DPNAEHPGSLFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAVILENFSV--ATEES 1758

  Fly  1795 A-LLSYADIRNFQNTWNIVDIHQRGVI--------------PVR-----RVKFI---LRLLKG-R 1835
            | .|...|...|...|...|......|              |:|     .::.|   |.::.| |
 Frog  1759 AEPLGEDDFEMFYEVWEKFDPSASQFIEYSKLSDFADALDPPLRVPKPNNIQLIAMDLPMVSGDR 1823

  Fly  1836 LEC-DPQKDRLLFKYMCY------ELDKLH----------NGEDVTFHDVINMLSYRSVDIRKAL 1883
            :.| |     :||.:...      |:|.|.          |...|.:..:...|.      ||  
 Frog  1824 IHCLD-----ILFAFTKRVLGEGGEMDSLRQPMEERFMTSNPSKVPYEPITTTLR------RK-- 1875

  Fly  1884 QLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQ 1948
                           :||.:.:.|    :.|.::.|.:  .:|.:....|.|....:.:.|...:
 Frog  1876 ---------------QEEQSAVVI----QRCYRRFRLK--KRQASQTYKGNRNKQIEEIERNVNK 1919

  Fly  1949 EDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKD 1993
            ..:.....:..::.||:|       ||:.|:...|  ..|..|||
 Frog  1920 SQQRYTTEISDTSTSTMS-------PPSYDSVEKT--QQEKYEKD 1955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 63/315 (20%)
Ion_trans 734..927 CDD:278921 57/271 (21%)
Ion_trans 1240..1497 CDD:278921 73/284 (26%)
Ion_trans 1571..1793 CDD:278921 61/236 (26%)
scn2aXP_031749252.1 Ion_trans 127..408 CDD:395416 64/323 (20%)
Na_trans_cytopl 488..678 CDD:403218 9/192 (5%)
Ion_trans 727..940 CDD:395416 50/220 (23%)
Na_trans_assoc 966..1175 CDD:399489 50/283 (18%)
Ion_trans 1179..1454 CDD:395416 78/311 (25%)
Na_channel_gate 1446..1498 CDD:240441 10/52 (19%)
Ion_trans 1503..1758 CDD:395416 67/263 (25%)
GPHH 1770..1817 CDD:407139 7/46 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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