DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and scn5a

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_031760488.1 Gene:scn5a / 100485924 XenbaseID:XB-GENE-6037407 Length:1989 Species:Xenopus tropicalis


Alignment Length:2097 Identity:411/2097 - (19%)
Similarity:724/2097 - (34%) Gaps:732/2097 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   371 TSVSLNTPKTFERY---PSLQFIT-----------------FA----------------SDTAVT 399
            |.:.||..||..|:   |:|..|:                 |:                ||::..
 Frog    91 TFIVLNKGKTIFRFSATPALYIISPFHPIRRASIKILVHSLFSMFIMCTILTNCVFMAMSDSSAW 155

  Fly   400 L---------LFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPK 455
            |         ::|.|.:.|:..||.......:|:|.|...|.|::             |:....:
 Frog   156 LKYVEYTFTGIYTFESMIKILARGFCLKPFTFLRDPWNWLDFSVI-------------VMAYATE 207

  Fly   456 FSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-F 519
            |..|..:.|.|...::|.|:........|:.:..:. :|.:::.:|.:..:|.:|::.|.|:| |
 Frog   208 FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI-QSVRKLADVMILTVFCLSVFALTGLQLF 271

  Fly   520 FGELKNHCVMNNTEYDLYKRPILTINSLAIPDTF---------------------CSMDPDSGYQ 563
            .|.||..||.:...::..:..:|..::.::..::                     |....|:| :
 Frog   272 MGHLKQKCVRDLDYFNATRMGMLDWSNESMWSSYEAFISDPANIYHKDGAKDALLCGNSSDAG-K 335

  Fly   564 CSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----F 623
            |..|.:|||.....:|  |:..|:....:..::::..:|:.|..:..:.:      |||     .
 Frog   336 CPDGFICMKTGRNPNY--GYTSFDTFGWAFLSLFRLMTQDYWENLYQQTL------RAAGKTYMI 392

  Fly   624 YFSTMIFFLAWLVKNVFIAVITETFNEIRV-----------QFQQMW------------------ 659
            :|..:||..::.:.|:.:||:...:.|...           :|||..                  
 Frog   393 FFVFVIFLGSFYLVNLILAVVAMAYEEQNQATIAEAEAKEREFQQAMEQLKKEQEALASKGPDAA 457

  Fly   660 ----------------------------------------------------------------- 659
                                                                             
 Frog   458 SHSSCEMSPFSSKSAKERRNRRKKKKSSETEEYGEDMKPPRGEMDEESLRKMSILGIGFGPGSGK 522

  Fly   660 ----------------------------------GARGHI--------QKTAA--SQILSGNDTG 680
                                              |.||.:        |.|.:  |.:...|..|
 Frog   523 RRISQGSIFNFRFRNRDLCSETEFADDEVSNASDGHRGSLLVPRAGRRQSTQSQTSPLSFANTPG 587

  Fly   681 W-----RLVTIDDN----------------KHGGL-----------APETC-------------- 699
            :     |..::|.|                ..|||           |.|..              
 Frog   588 YTQNGKRNSSVDCNGVVSLVGGAGTYSNPTSPGGLLLPAVIVEKSGAEENASPTDLELSRMQLLM 652

  Fly   700 -HAI----LRSPYFRMLVMSVILANGIVTATMTFKHDGRPR-----DVFYERYY----------- 743
             ||:    :..|:.|...:|.:   .::|..:....:.|.:     :.|.:.|.           
 Frog   653 PHALSVEYVDQPFQRQRAVSTV---SVLTNALEELEESRQKCPPCWNHFAQSYLIWDCCSLWLDI 714

  Fly   744 -----------YIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGT-------TLHIV 790
                       :|:|..|..:.|.|||...     .:||.: .:||.:|:.|.       |..:|
 Frog   715 KDGVKFVVMDPFIDLTITICIVLNTLFMAL-----EHYKMT-PEFEYMLSVGNYVFTGIFTAEMV 773

  Fly   791 -------PMFY---------------------------PSGLTYFQVLRVVRLIKASPMLEGFVY 821
                   |.:|                           .|.|..|::|||.:|.|:.|.|...: 
 Frog   774 FKIIALDPYYYFQQGWNIFDSIIVCLSLMELCLASMGNLSVLRSFRLLRVFKLAKSWPTLNTLI- 837

  Fly   822 KIFGPG-KKLGSLIIFTMCLLIISSSISMQLF--------CFL---CDFTKF--ESFPEAFMSMF 872
            ||.|.. ..||:|.:....::.|.:.:.:|||        |.:   |...::  ..|..:|:.:|
 Frog   838 KIIGNSVGALGNLTLVLAIIVFIFAVVGVQLFGRNYFECVCKISAECKLPRWHMHDFFHSFLIVF 902

  Fly   873 QILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVIL-----DNLEL-DED 931
            ::|..| |:|.|.:.|....:   ||..:.|:|..:...|:||:||:|::|     |||.. |||
 Frog   903 RVLCGE-WIETMWDCMEVAGQ---PLCILVFMLVMVIGNLVVLNLFLALLLSSFSADNLSAPDED 963

  Fly   932 ---------IKKLKQ-LKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESF 986
                     |.:::: ::|.:     |..:.|...:|.: ||.|...                  
 Frog   964 GEMNNLQIAIARIQRGIRFVK-----KAIVDFFCNLFTR-PDKPAQA------------------ 1004

  Fly   987 MKHFVIELETEDSLVEN------------CKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSS 1039
               |...|.|::..:.|            ||....|...:|                      ..
 Frog  1005 ---FKSNLSTKNQNINNINLNNHINMSNTCKEDFREGNSTN----------------------GG 1044

  Fly  1040 LRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSV 1104
            :.|....:::::|::.......|..:|:       .|.......|.:.   :|..|....|.:..
 Frog  1045 ISKNGEKYVVSESDDYMTSPRLSVCVPI-------ALGESDVEYHEED---EQSIFTDVEISKEK 1099

  Fly  1105 RSGSI---------KLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQRE 1160
            :..||         |.::..|.|.|:.:..|.|                               |
 Frog  1100 QDDSISECSTVDLRKSRELIEQLPESSEEFADP-------------------------------E 1133

  Fly  1161 EDLRE--NHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTG------KERKVQYKSL-H 1216
            |...|  |.|.....|       |:...|:           .|..||      |.||..:|.: |
 Frog  1134 ECFTEDANRPDGTGCL-------RYCSCCR-----------IDITTGAGKIWWKLRKTCFKIVEH 1180

  Fly  1217 NFLGLVTYLDWVMIFATTLSCISMMFET--PNYRVMDHPTLQIAEYGFVIFMSLELALKILADGL 1279
            |      :.:..:||...||..::.||.  .:.:.:....|:.|:..|.....||:.||.:|.|.
 Frog  1181 N------WFETFIIFMILLSSGALAFEDIYIDQKKVVKTILEYADKVFTYVFVLEMLLKWVAYGF 1239

  Fly  1280 FFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVV 1344
                |.|..:....||.||..:|.:.|.....:.....:.:.|..||.:||||..:....||.||
 Frog  1240 ----KKYFTNAWCWLDFFIVDISVACLMVTTFSKGNVGSVKSLRTLRALRPLRALSRFEGMRVVV 1300

  Fly  1345 YELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDP---------TISRREDCVGVFMR 1400
            ..|......|:.|..:.::...||:..||.|:.|:..:|.:.         |:..:..|......
 Frog  1301 NALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGKCVNATTKEELSYLTVDNKSMCNDFINT 1365

  Fly  1401 RVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVG 1465
            ..:.||.|:                       ||||:|...|.|.:|.:||||:   |::..||.
 Frog  1366 EAYWTKTKV-----------------------NFDNVGAGYLALLQVATFKGWM---DIMYAAVD 1404

  Fly  1466 -------PVHAV------YIHIYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWC 1512
                   |::.:      |..|:|..|....|.||:||:|.|:::.|     ....:|.:|:::.
 Frog  1405 SREIEQQPIYEINKYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYY 1469

  Fly  1513 DLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERL 1577
            :..|:|...:|....||| ..|.:.|.:||.....|..:|.:::.:|.:.:.:.........|.|
 Frog  1470 NAMKKLGSKKPQKPIPRP-LNKFQGFVFDIVTKQAFDIIIMILICLNMVTMMVETDDQSKEIENL 1533

  Fly  1578 VI-VSAVLTFVFVVEVVMKNIAFTPRGY-----WQSRRNRYDLLVTVAGVIWIILQTILRNDLSY 1636
            :. ::.....:|..|.::|.:|.  |.|     |    |.:|.:|.:..::.|:|..|:.   .|
 Frog  1534 LYKINLAFVVLFSGECILKILAL--RYYFFTIGW----NIFDFVVVILSIVGIVLSDIIE---KY 1589

  Fly  1637 FFG---FMVVIL----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFG 1694
            |..   |.|:.|    |...:......::.|:..:.:|:...|.|...:||::|.||:.|...|.
 Frog  1590 FVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1654

  Fly  1695 TVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQ-PPYC----------TLGNNYW 1748
            .||...||....||.:....:..||:|.|...|:.:::..:.. ||.|          ||||   
 Frog  1655 YVKMESGIDDMFNFQTFGNSMICLFQITTSAGWDGLLNPILNSGPPDCDPDIANPGSPTLGN--- 1716

  Fly  1749 ETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFS----------------LFY------SN 1791
               |||.:..:.:|.::.:|...||:|:.:|||:||||                :||      ..
 Frog  1717 ---CGNPSVGICFFVSYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFEMFYEVWEKFDP 1778

  Fly  1792 EEDALLSYADIRNFQNTWNIVDIHQRGVIPVR-----RVKFI---LRLLKG-RLEC--------- 1838
            |....:||:.:.||.:|.:         .|:|     ::|.|   |.::.| |:.|         
 Frog  1779 EATQFISYSVLSNFADTLS---------EPLRIAKPNKIKLIAMDLPMVSGDRIHCLDILFAFTK 1834

  Fly  1839 ---------DPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVD-----IRKALQLEELL 1889
                     |..|.::..|:|.      .|...:::..:...|..:..:     |::|.: ..||
 Frog  1835 RVLGESGEMDALKVQMEEKFMA------ANPSKISYEPITTTLKRKQEEVSACVIQRAYR-RHLL 1892

  Fly  1890 ARE----EFEY--------LVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQP- 1941
            .|.    .|.|        ::|||..:.      ||.:..:..:|..:|.:. :..|.:|:..| 
 Frog  1893 CRSMKQASFLYRHRSCDDNIIEEEAPEK------EGLIAYMMTENYGRQLDK-VESLSSTSFPPS 1950

  Fly  1942 ---VMRPNIQEDKAPLG 1955
               |.|...:.....||
 Frog  1951 YDSVTRATSEHSPLKLG 1967

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 67/363 (18%)
Ion_trans 734..927 CDD:278921 63/279 (23%)
Ion_trans 1240..1497 CDD:278921 72/280 (26%)
Ion_trans 1571..1793 CDD:278921 67/267 (25%)
scn5aXP_031760488.1 Ion_trans 129..424 CDD:395416 59/317 (19%)
Na_trans_cytopl 485..675 CDD:403218 21/192 (11%)
Ion_trans 724..937 CDD:395416 52/223 (23%)
Na_trans_assoc 963..1176 CDD:399489 48/320 (15%)
Ion_trans 1180..1453 CDD:395416 79/308 (26%)
Na_channel_gate 1445..1497 CDD:240441 12/52 (23%)
Ion_trans 1502..1757 CDD:395416 68/269 (25%)
GPHH 1769..1816 CDD:407139 12/55 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

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