DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and cacna1hb

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	XP_021331616.1	Gene:	cacna1hb / 100007317	ZFINID:	ZDB-GENE-090312-128	Length:	2102	Species:	Danio rerio

Alignment Length:	2208	Identity:	444/2208 - (20%)
Similarity:	745/2208 - (33%)	Gaps:	746/2208 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 ASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFS 457
            |.|..:...|..||:.||...||. |...||.|.|.:.|..:|....:...|....|     .||
Zfish    32 AFDDFIFAFFAVEMVVKMVALGVF-GPKCYLGDTWNRLDLFIVMAGMLEYSLDGHNV-----SFS 90

  Fly   458 YLSIMRAPRPLIMI------RFLRVFLKFSMPKSRINQIFKRSSQQIYNVTL--FFLFFMSLYGL 514
            .:..:|..|||..|      |.|...|..::|             .:.||.|  ||:||  ::|:
Zfish    91 AIRTVRVLRPLRAINRVPSMRILVTLLLDTLP-------------MLGNVLLLCFFVFF--IFGI 140

  Fly   515 LGVQFF-GELKNHCVMNNTEYDLYKRPILTINSLAIPDT-----FCSMDPDSG-YQCS------- 565
            :|||.: |.|:|.|..:|....||...........:.:|     .||.:.::| .:||
Zfish   141 VGVQLWAGLLRNRCFFDNNIRMLYNVSGSVSEYYRVDETDDIPFICSTNRENGMLRCSNVPKRRV 205

  Fly   566 PGMVC-MKMDFLSSYVI---------------------------GFNGFEDIATSIFTVYQAASQ 602
            .|..| :..|.::..|.                           |...|::|..:...::|..:.
Zfish   206 AGADCELTADNVTELVFKEAPHHGCVNWNLYYNTCNASEHNPHNGAINFDNIGYAWIAIFQVITL 270

  Fly   603 EGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQM--------- 658
            |||..|||..:|: .::....||..:|...::.:.|:.:.||...|:|.:.:..|:
Zfish   271 EGWADIMYYVMDA-HSFYNFIYFIFLIIVGSFFMINLCLVVIATQFSETKQRENQLMQEQRARFR 334

  Fly   659 ----------------------------------------------------------------W 659
                                                                            |
Zfish   335 SNESTLASLAEPGSCYEEMLKYLAHVCRKLWRHVVRIYGDLCPKRRKGVANPGTSLSVGGTNGYW 399

  Fly   660 GARG------------------------------------HIQKTAAS-----QILSGNDTGWRL 683
            ...|                                    ||.|...|     |.|.|...|...
Zfish   400 SDNGTKMGPTQYCMLHYHHPHQHYISNGIEMKTLQLDRDAHIAKKTPSLPLALQNLKGLRLGMNY 464

  Fly   684 VTIDDNK----------------HG--------------------GLAPETC------------- 699
            .||..:|                ||                    |:.|.||
Zfish   465 PTILPSKMYTNSHARGVKAPAFHHGIYGRKISVCGGYHDTYKLQHGVYPGTCSSVCVDSRVGLVS 529

  Fly   700 --------------------------------------------------------------HAI 702
                                                                          .|:
Zfish   530 SQSSSCPICAQEGDGVNCDSNGESDPEKQGPDVGSEQRKTNLDAEEKVSEKRNCVCMCVHYARAV 594

  Fly   703 LR----SPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYC 763
            |:    |.||...:|..||.|   |.:|..::..:| |...:......:|||.|..||.|.|:..
Zfish   595 LKRIVDSKYFNRGIMIAILIN---TLSMGVEYHEQP-DELTDVLEISNIVFTSLFVLEMLLKLSA 655

  Fly   764 LGWRGYYKHSIHKFELLLAAGTTLHIVPM----FYPSGLTYFQVLRVVRLIKASPMLEGFVYKIF 824
            .|...|..:..:.|:.::...:...||..    |  |.|..|::|||::|::..|.|...:..:.
Zfish   656 CGLFDYISNPYNIFDGIIVIISVCEIVGQADGGF--SVLRTFRLLRVLKLVRFLPALRRQLVVLM 718

  Fly   825 GPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDFT-------------KFESFPEAFMSMFQILT 876
            .....:.:..:..|..:.|.|.:.|.||.  |.||             .|:|...|.:::|||||
Zfish   719 KTMDNVATFCMLLMLFIFIFSILGMHLFG--CKFTLRLENGDTVSDRKNFDSLLWAIVTVFQILT 781

  Fly   877 QEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNL---------ELDEDI 932
            ||.|..|:...|..||    |..|:||:....|...::.:|.||::::..         :.|:|:
Zfish   782 QEDWNVVLYNGMASTS----PYAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDASRSDTDDDM 842

  Fly   933 K-------KLKQLKFREQSAEIKETLPFRLRIFE------------KFPDSPQMTILHRIPNDFM 978
            .       ||::|.......:::..:|......|            :|..:|:..:.|
Zfish   843 SSDYGDEDKLRELLNSGTEMKMQTLMPISNGHLEPRASMPPNNTHVQFNSTPRTEVSH------- 900

  Fly   979 LPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKL 1043
               :.....::.....|..|      :|.:|..|.|    |:.....:.:....:|.|.|..|:.
Zfish   901 ---IYSQSRRNSNTSTELHD------QRSLSSLWGS----RRSSWNSLGHAPNLLRRAQSGERES 952

  Fly  1044 AITHIINDSNNQRLMLGDSAMLPVVGTKGG---------------------GGLKSQGTITHSKP 1087
            .::....||.:..|...:.:.|..|...|.                     ||..|...|||.:|
Zfish   953 LLSGPGRDSIDDNLSEDEKSSLGGVSCLGSFDFPELLQVPRPYLECNGRLDGGYNSSPNITHPEP 1017

  Fly  1088 WR---VDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKR 1149
            ..   .:..:|        ..|..:.||:..|......            .|.|:
Zfish  1018 TSTQGAEDDEF--------EESWCLILKRLLEPYKPQW------------CRDHE---------- 1052

  Fly  1150 QQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIV-HARYDARLKDPLTGKERKVQYK 1213
                                 |..|:|...::.||..|||:: |..:|
Zfish  1053 ---------------------DWSLYLFAPQNNFRMRCQKVITHKMFD----------------- 1079

  Fly  1214 SLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYR--VMDHPTLQIAEYGFVIFMSLELALKILA 1276
              |           :::|....:||::..|.|:.:  ..:...|:::.|.|.:....|:.:|:::
Zfish  1080 --H-----------IVLFFIFFNCITIALERPDIQPDSTERIFLKVSNYIFTVIFVAEMTVKVVS 1131

  Fly  1277 DGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAA----------QLLMILRCVRPL 1331
            .||:..|.:|:|.....||.|:..||.       ::|..:.|:          ::|.:||.:|||
Zfish  1132 LGLYAGPGSYLKSSWNVLDGFLVFVSI-------VDILVSLASSGGNRILGILRVLRLLRTLRPL 1189

  Fly  1332 RIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARC---NDPTISRRED 1393
            |:.:..|.::.||..|....:.|..:..:......:|...||||:.|:...|   :...|:.:.:
Zfish  1190 RVISRAPGLKLVVETLITSLRPIGNIVLICCAFFIVFGILGVQLFKGKFYHCEGFDTRNITNKSE 1254

  Fly  1394 CVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRD 1458
            |:        ..|.|                 |.. |::||||:|.|:::||.:.|..||:::..
Zfish  1255 CL--------QAKYK-----------------WIR-RKYNFDNLGQALMSLFVLSSKDGWVNIMY 1293

  Fly  1459 VLIKAV----------GPVHAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCD 1513
            ..:.||          .|...:|...::.:.....|.:|||||:.|:.:.:........:||...
Zfish  1294 DGLDAVAVDQQPIRNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQDQEEEEARRREEK 1358

  Fly  1514 LKKRL--KIAQPLHLPPRPDGRKIRAFTYDI-TQHIIFKRVIAVVVLINSMLLSITWIKGEVH-T 1574
            .:||:  |..:.|..|...|....|.:.:.: |.|.: ...|.:::.||.:.:|:...:...: .
Zfish  1359 RQKRMEKKRRKALQRPYYADYSPTRLYIHTLCTSHYL-DLFITIIIAINVLTMSMEHYRQPKYLD 1422

  Fly  1575 ERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG 1639
            |.|...:...|.|||:|..:|.:||..|.:::.|.|:.||.:.:..::.|.|:.|   ||:....
Zfish  1423 EGLKYCNYFFTLVFVIEAALKLVAFGFRRFFKERWNQLDLAIVLLSIMGITLEEI---DLNASLP 1484

  Fly  1640 FMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFI--------IFGMFLLVFF-YALAGTILFGT 1695
            ....|:|...:......||:|.:..|:.......:        :..:|:|:|| ||..|..|||.
Zfish  1485 INPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK 1549

  Fly  1696 VKYG-----EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNF 1755
            :...     ||:.|.|.|.:.......|||:.||::||.||.|.:              .:|.|.
Zfish  1550 LDCTEENPCEGLSRHATFQNFGMAFLTLFRVSTGDNWNGIMKDTL--------------RECKND 1600

  Fly  1756 TA-------SLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSN-------EEDALL--------- 1797
            ..       |.:||.||.::..::::|::||::|::  |..||       |.||.|
Zfish  1601 KCLSYLPLLSPLYFVTFVLMAQFVLVNVVVAVLMKH--LEESNIDAREEAEMDAELKLELEAGRR 1663

  Fly  1798 ----SYADIRNFQNTWNIVDI--HQRGVIPVRRVKFILRLLKGRLECDPQKDRLLF----KYMCY 1852
                |.......:.|...::.  |.:|..|    .:...|..||    |...|:|.    .||.|
Zfish  1664 QSTASVGGAAGLEGTDAKIETLSHDQGKDP----NYGNFLTVGR----PSISRMLSLPNDSYMLY 1720

  Fly  1853 ELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKK 1917
            .:..|                |.|:.
Zfish  1721 PIKPL----------------YGSIH--------------------------------------- 1730

  Fly  1918 IRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPL---GAVDKSAISTISGAVAGACPP---- 1975
               :.:|||..:|.....:...||      .||.|.:   ||..:::::::.     |..|
Zfish  1731 ---ERSSKQDCTLPGSSLSLGTQP------SEDSAVMQVPGAASQTSLASVP-----APRPLNQR 1781

  Fly  1976 --TSDAF----------SPTFSSTENEEKDGSSSAVVQLP---------HSETSIAGTGSSATGA 2019
              ||:||          |.:..||..:.:|     .:|:|         |.:......|..:...
Zfish  1782 ARTSNAFRGLRRQQAIKSDSIDSTYADSRD-----ALQIPSKPCSSDNLHLKVPSVPIGGRSAPC 1841

  Fly  2020 ATATGTSSGLGVGPPTVQSTARHV---MTVGKRGYALNRSD------STGSSAGRKFLAP----T 2071
            :..|.....|.....:|| |.|||   .::..|..|:....      :|...|.|..|:|    .
Zfish  1842 SPQTSPPPPLRNRTASVQ-TNRHVYSQRSIPCRQTAIKPHPDAAVRLNTNRRASRHSLSPHHPSL 1905

  Fly  2072 SSDPQQRSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGE--------ATKSSS 2126
            |||.|.:.:|......|..:..||.|||.......| .|:.::....||        ::.|||
Zfish  1906 SSDTQSQDSLHVGAPRHQDTSLRKYNSMENNGFLSQ-PQIPRRHSTHGEELRLQQDPSSSSSS 1967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	76/310 (25%)
		Ion_trans	734..927	CDD:278921	57/218 (26%)
		Ion_trans	1240..1497	CDD:278921	66/281 (23%)
		Ion_trans	1571..1793	CDD:278921	65/250 (26%)
cacna1hb	XP_021331616.1	Ion_trans	1..323	CDD:306908	76/312 (24%)
		Ion_trans	601..828	CDD:306908	66/238 (28%)
		Ion_trans	1075..1347	CDD:306908	72/334 (22%)
		Ion_trans	1392..1597	CDD:306908	56/222 (25%)
		Herpes_TAF50	<1739..2026	CDD:308764	55/247 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920