Protein Alignment sens and ACE2

DIOPT Version :10

• Sequence 1: NP_524818.1
• Gene: sens / 45328
• FlyBaseID: FBgn0002573
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_013232.1
• Gene: ACE2 / 850822
• SGDID: S000004121
• Length: 770
• Species: Saccharomyces cerevisiae
• Alignment Length: 556
• Identity: 113/556 - (20%)
• Similarity: 204/556 - (36%)
• Gaps: 126/556 - (22%)

  Fly    47 AQKL-----NGRDLP----FLYNPLLYSSALLWPQFLLSSATALG----TPLTPMTPKSPASVVL 98
            ||||     |....|    .|..|.:.:..:.....::::.:|.|    .|.|.::|:...:.:.
Yeast   237 AQKLVSGATNSNSKPGSPVILKTPAMQNGRMKDNAIIVTTNSANGGYQFPPPTLISPRMSNTSIN 301

  Fly    99 GQRDRDF--ALTPEKEHE---LQMNNNNEN----------SKQDYQEQDEDMPLNLSTKERITSD 148
            |...|.:  ...|.|..|   |.:.::|..          |.|:|.       |||   :.:|.:
Yeast   302 GSPSRKYHRQRYPNKSPESNGLNLFSSNSGYLRDSELLSFSPQNYN-------LNL---DGLTYN 356

  Fly   149 DSNRDQYHSSSNNSSRSSSSSEVEQLHPMTS---LNVTPPPLSAVNLKSSSTPQQQRQRSQGNII 210
            |.|...  ..:||..::|:...:.:|...||   |:::|                   |..||.:
Yeast   357 DHNNTS--DKNNNDKKNSTGDNIFRLFEKTSPGGLSISP-------------------RINGNSL 400

  Fly   211 WSPASMCERSARREQYGLKMEEQGD-EEEHQVDPIVRKFKYERRTASISSLQSPISSLSAPASNA 274
            .||..:....:|.::|.     .|. ....|:.||      .::..|:.|..|.||.|    .:.
Yeast   401 RSPFLVGTDKSRDDRYA-----AGTFTPRTQLSPI------HKKRESVVSTVSTISQL----QDD 450

  Fly   275 VQDLEFEVAQQQLYAHRSAFMAGLTGNNLELLTQHLKLKSEQPQQQQQQHRIKDEQQQDNRSAAA 339
            .:.:.....|.....:.:|..:......:...:.:..:|:..||:...||.......::..:.|.
Yeast   451 TEPIHMRNTQNPTLRNANALASSSVLPPIPGSSNNTPIKNSLPQKHVFQHTPVKAPPKNGSNLAP 515

  Fly   340 LMNLVAAAEF------GYMRNQHQQPQQQQQ-----QQLHHQQQPQQHQ----HQQQHPDSTATD 389
            |:|.....:.      ....|.|.:.:...|     ..:|  :.|..|.    ..:..|.:|...
Yeast   516 LLNAPDLTDHQLEIKTPIRNNSHCEVESYPQVPPVTHDIH--KSPTLHSTSPLPDEIIPRTTPMK 578

  Fly   390 VARRSS-----SSSSYQGENEEKRSGRNFQC--KQCGKSFKRSSTLSTHLLIHSDTRPYPCQY-- 445
            :.::.:     :...|..|..:|.    |:|  ..|.|.|||...:.:|:..|...|||.|.:
Yeast   579 ITKKPTTLPPGTIDQYVKELPDKL----FECLYPNCNKVFKRRYNIRSHIQTHLQDRPYSCDFPG 639

  Fly   446 CGKRFHQKSDMKKHTYIHTGEKPHKCTVCLKAFSQSSNLITHMRKH--TGYKPFGCHLCDQSFQR 508
            |.|.|.:..|:.:|...|..:| :.|. |.|.|::...|:.|..:.  ||.|..     :.|..:
Yeast   640 CTKAFVRNHDLIRHKISHNAKK-YICP-CGKRFNREDALMVHRSRMICTGGKKL-----EHSINK 697

  Fly   509 KVDLRRHR--ESRHEEAPPVEDLKP-------LKME 535
            |:...:..  :|.|:.:|..|.:..       :|||
Yeast   698 KLTSPKKSLLDSPHDTSPVKETIARDKDGSVLMKME 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sens	NP_524818.1	zf-C2H2	413..435	CDD:395048	8/23 (35%)
		C2H2 Zn finger	415..435	CDD:275368	7/21 (33%)
		zf-C2H2	441..463	CDD:395048	7/23 (30%)
		C2H2 Zn finger	443..463	CDD:275368	6/21 (29%)
		zf-H2C2_2	455..480	CDD:463886	8/24 (33%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	483..506	CDD:463886	5/24 (21%)
		C2H2 Zn finger	499..516	CDD:275368	2/16 (13%)
ACE2	NP_013232.1	COG5048	176..683	CDD:227381	101/499 (20%)
		C2H2 Zn finger	605..627	CDD:275368	7/21 (33%)
		C2H2 Zn finger	635..657	CDD:275368	6/21 (29%)
		C2H2 Zn finger	664..680	CDD:275368	5/16 (31%)