DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sens and GFI1B

DIOPT Version :9

Sequence 1:	NP_524818.1	Gene:	sens / 45328	FlyBaseID:	FBgn0002573	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001358837.1	Gene:	GFI1B / 8328	HGNCID:	4238	Length:	352	Species:	Homo sapiens

Alignment Length:	145	Identity:	100/145 - (68%)
Similarity:	112/145 - (77%)	Gaps:	7/145 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 HQHQQQHPDSTATDVARRSSSSSSYQGENEEKRSGRNFQCKQCGKSFKRSSTLSTHLLIHSDTRP 440
            |.|.|..|..::.:.|.........:.|       |:|:|:.|||:|||||||||||||||||||
Human   212 HVHSQGIPAGSSPEPAPDPPGPHFLRQE-------RSFECRMCGKAFKRSSTLSTHLLIHSDTRP 269

  Fly   441 YPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCLKAFSQSSNLITHMRKHTGYKPFGCHLCDQS 505
            ||||:||||||||||||||||||||||||||.||.||||||||||||.|||||:|||.|.||.:.
Human   270 YPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKG 334

  Fly   506 FQRKVDLRRHRESRH 520
            |||||||||||||:|
Human   335 FQRKVDLRRHRESQH 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sens	NP_524818.1	zf-C2H2	413..435	CDD:278523	17/21 (81%)
		C2H2 Zn finger	415..435	CDD:275368	16/19 (84%)
		COG5048	423..>497	CDD:227381	68/73 (93%)
		zf-H2C2_2	428..452	CDD:290200	22/23 (96%)
		C2H2 Zn finger	443..463	CDD:275368	18/19 (95%)
		zf-H2C2_2	455..480	CDD:290200	22/24 (92%)
		C2H2 Zn finger	471..491	CDD:275368	16/19 (84%)
		C2H2 Zn finger	499..516	CDD:275368	12/16 (75%)
GFI1B	NP_001358837.1	C2H2 Zn finger	165..186	CDD:275368
		C2H2 Zn finger	194..214	CDD:275368	1/1 (100%)
		C2H2 Zn finger	244..264	CDD:275368	16/19 (84%)
		COG5048	252..>329	CDD:227381	70/76 (92%)
		C2H2 Zn finger	272..292	CDD:275368	18/19 (95%)
		zf-H2C2_2	284..309	CDD:372612	22/24 (92%)
		C2H2 Zn finger	300..320	CDD:275368	16/19 (84%)
		C2H2 Zn finger	328..345	CDD:275368	12/16 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10890
eggNOG	1	0.900	-	-		E33208_3BCNN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2452
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2013
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760