DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sens and sens-2

DIOPT Version :9

Sequence 1:	NP_524818.1	Gene:	sens / 45328	FlyBaseID:	FBgn0002573	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001285692.1	Gene:	sens-2 / 33957	FlyBaseID:	FBgn0051632	Length:	746	Species:	Drosophila melanogaster

Alignment Length:	625	Identity:	197/625 - (31%)
Similarity:	257/625 - (41%)	Gaps:	172/625 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SPPPSPHSQQPS--PAGLGCHGAALDKQWMQRASAFNTVIASAAAQKLNGRDLPFLYNPLLYSSA 67
            :|.|:|:..||.  ||....|..|       ..|||..|:    .:|.|..|....::    .|.
  Fly   114 NPNPNPNHPQPQMPPASTSPHEYA-------PMSAFKAVL----PKKRNSDDASLAFS----ISR 163

  Fly    68 LLWPQFLLSSATALGTPLTPMTPKSPASVVLGQRDRDFALTPEKEHELQMNNNNENSKQDYQEQ- 131
            |:..:.|.:.|.|:|  |.|.||                 ..:..:.:.|.:.|:...|.:.:|
  Fly   164 LVKTEQLTAMAAAVG--LKPPTP-----------------LEDNNNSISMLSKNQQMHQQHHQQS 209

  Fly   132 ---DEDMPLNLSTKERITSDDSNRDQYHSSSNNSSRSSSSSEVE-----------QLHPMT---- 178
               ....|..:|..|::      |.|..|.|.:.|||..||:::           .||..:
  Fly   210 HLAQRPKPAFISASEKL------RRQSRSRSRSRSRSPCSSQIDMEDADSNHSHRSLHSRSRSRS 268

  Fly   179 -----SLNVTPPPLSAVNLKSSSTPQQQRQRSQGNIIWSPASMCE------------RSARREQY 226
                 |.:.:....|:|.|:..|.|...|..|...   :.||..|            .|.:.:.:
  Fly   269 RSRSHSRSRSHSSSSSVELEVDSPPGSPRISSPSG---ASASASELLITANGGGRSIGSKKSDLF 330

  Fly   227 GLKMEEQGDEEEHQVDPIVRKFKYERRT--------ASISSLQSPISSLSAPASNAVQDLEFEVA 283
            .:....:.||...|           |||        .:.|.|..|.:.|.|.......:.:..:.
  Fly   331 SVSALLRRDEPPPQ-----------RRTPRSPPLGHLTSSGLAMPFNPLEAMRQGYPPNYDAAMF 384

  Fly   284 QQQLYAHRSAFMAGLTGNNLELLTQHLKLKSEQPQQQQQQHRI-------KDEQQ---------- 331
            |:.|::....|.|.:..:           :.:|.||||||.:.       .|.|:
  Fly   385 QRPLFSPALPFFAAVAFH-----------QGQQQQQQQQQQQSGLAAGYHPDSQENLFRLRSLMV 438

  Fly   332 ------QDNRSAAALMNLVAAAEFGY---------MRNQH-QQPQQQQQQQLHHQ--QQPQQHQH 378
                  |:|.||||.....|||..|.         ....| ..|........||.  :.|..||.
  Fly   439 PLQSAGQNNSSAAAAAAAAAAAAVGVGVGVGVGVPPNGGHLGLPHSPHLHHFHHMAAKWPGLHQF 503

  Fly   379 QQQH-----------PDSTATDVARRSSSSSSYQGENEEKRSGRN---------------FQCKQ 417
            ...:           |........|.......|..|...|..|..               |:|||
  Fly   504 SDLYSCMKCEKMFSTPHGLEVHSRRTHHGKKPYACELCNKTFGHEVSLSQHRAVHNVEKVFECKQ 568

  Fly   418 CGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCLKAFSQSS 482
            |||.||||||||||||||||||||||.|||||||||||||||||||||||||||.||.|||||||
  Fly   569 CGKRFKRSSTLSTHLLIHSDTRPYPCNYCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSS 633

  Fly   483 NLITHMRKHTGYKPFGCHLCDQSFQRKVDLRRHRESRHEE 522
            |||||.|||||||||.|.||.::||||||||||:|::|.:
  Fly   634 NLITHSRKHTGYKPFSCKLCHKAFQRKVDLRRHKETQHTD 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sens	NP_524818.1	zf-C2H2	413..435	CDD:278523	19/21 (90%)
		C2H2 Zn finger	415..435	CDD:275368	18/19 (95%)
		COG5048	423..>497	CDD:227381	69/73 (95%)
		zf-H2C2_2	428..452	CDD:290200	22/23 (96%)
		C2H2 Zn finger	443..463	CDD:275368	18/19 (95%)
		zf-H2C2_2	455..480	CDD:290200	22/24 (92%)
		C2H2 Zn finger	471..491	CDD:275368	16/19 (84%)
		C2H2 Zn finger	499..516	CDD:275368	12/16 (75%)
sens-2	NP_001285692.1	COG5048	<504..672	CDD:227381	99/167 (59%)
		C2H2 Zn finger	509..530	CDD:275368	2/20 (10%)
		zf-H2C2_2	522..545	CDD:290200	4/22 (18%)
		C2H2 Zn finger	538..558	CDD:275368	3/19 (16%)
		zf-H2C2_2	550..575	CDD:290200	8/24 (33%)
		C2H2 Zn finger	566..586	CDD:275368	18/19 (95%)
		zf-H2C2_2	579..603	CDD:290200	22/23 (96%)
		C2H2 Zn finger	594..614	CDD:275368	18/19 (95%)
		zf-H2C2_2	606..631	CDD:290200	22/24 (92%)
		C2H2 Zn finger	622..642	CDD:275368	16/19 (84%)
		zf-H2C2_2	634..657	CDD:290200	17/22 (77%)
		C2H2 Zn finger	650..677	CDD:275368	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447761
Domainoid	1	1.000	50	1.000	Domainoid score	I7817
eggNOG	1	0.900	-	-		E33208_3BCNN
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2452
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2013
	6	5.690