DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sens and ZNF683

DIOPT Version :9

Sequence 1:	NP_524818.1	Gene:	sens / 45328	FlyBaseID:	FBgn0002573	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_006710618.1	Gene:	ZNF683 / 257101	HGNCID:	28495	Length:	533	Species:	Homo sapiens

Alignment Length:	323	Identity:	92/323 - (28%)
Similarity:	138/323 - (42%)	Gaps:	66/323 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 SPISSLSAPASNAV-QDLEFEVAQQQLYAHRSAFMAGLTGNNLELLTQHLKLKSEQPQQQQQQHR 325
            ||::....|..|:: ::|.|.:         .||..|..   |.|...||......| ..|..|.
Human   177 SPLAFCPCPPVNSISKELPFLL---------HAFYPGYP---LLLPPPHLFTYGALP-SDQCPHL 228

  Fly   326 IKDEQQQDNRSAAALMNLVAAAEFGYMRNQHQQPQQQQQQQLHH----QQQPQQHQHQQQHPDST 386
            :...|.....:.|....|:...|.|:       |..:.:..|.:    |...|....|.::|.:.
Human   229 LMLPQDPSYPTMAMPSLLMMVNELGH-------PSARWETLLPYPGAFQASGQALPSQARNPGAG 286

  Fly   387 A--TD---VARRSSSS-------SSYQGENE-----EKRSGR-NFQCKQCGKSFKRSSTLSTHLL 433
            |  ||   :.|...:|       ||..|...     :|::|: .::|..|||||.:.|.|..||.
Human   287 AAPTDSPGLERGGMASPAKRVPLSSQTGTAALPYPLKKKNGKILYECNICGKSFGQLSNLKVHLR 351

  Fly   434 IHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCT--------------------VCLKAF 478
            :||..||:.|..|.|.|.|.:.::||..:||||:||||:                    ||.|.|
Human   352 VHSGERPFQCALCQKSFTQLAHLQKHHLVHTGERPHKCSIPWVPGRNHWKSFQAWREREVCHKRF 416

  Fly   479 SQSSNLITHMRKHTGYKPFGCHLCDQSFQRKVDLRRHRESRHEEAPPVEDLKPLKMEVSSSSC 541
            |.||||.||:|.|:|.:||.|.:|...|.:.:.|:.|...   .||....|...::.::|.:|
Human   417 SSSSNLKTHLRLHSGARPFQCSVCRSRFTQHIHLKLHHRL---HAPQPCGLVHTQLPLASLAC 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sens	NP_524818.1	zf-C2H2	413..435	CDD:278523	10/21 (48%)
		C2H2 Zn finger	415..435	CDD:275368	10/19 (53%)
		COG5048	423..>497	CDD:227381	37/93 (40%)
		zf-H2C2_2	428..452	CDD:290200	11/23 (48%)
		C2H2 Zn finger	443..463	CDD:275368	7/19 (37%)
		zf-H2C2_2	455..480	CDD:290200	14/44 (32%)
		C2H2 Zn finger	471..491	CDD:275368	13/39 (33%)
		C2H2 Zn finger	499..516	CDD:275368	4/16 (25%)
ZNF683	XP_006710618.1	COG5048	<326..>448	CDD:227381	49/121 (40%)
		zf-C2H2	331..353	CDD:278523	10/21 (48%)
		C2H2 Zn finger	333..353	CDD:275368	10/19 (53%)
		zf-H2C2_2	345..370	CDD:290200	11/24 (46%)
		C2H2 Zn finger	361..381	CDD:275368	7/19 (37%)
		C2H2 Zn finger	389..429	CDD:275368	13/39 (33%)
		zf-H2C2_2	421..446	CDD:290200	12/24 (50%)
		C2H2 Zn finger	437..457	CDD:275368	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100