DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sens and gfi1b

DIOPT Version :9

Sequence 1:	NP_524818.1	Gene:	sens / 45328	FlyBaseID:	FBgn0002573	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001258770.1	Gene:	gfi1b / 100151531	ZFINID:	ZDB-GENE-091118-129	Length:	334	Species:	Danio rerio

Alignment Length:	332	Identity:	135/332 - (40%)
Similarity:	162/332 - (48%)	Gaps:	81/332 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 LKMEEQGDEEEHQVDPIVRK--------FKYERRTASISSLQSPISSLSAPASNAVQDLEFEVAQ 284
            |:.:|....|..||||:.|.        .|.||..      ..||.||  |.........|.:::
Zfish    42 LEPKECKSPERPQVDPVTRPSHRDPYDFIKCEREP------DCPIPSL--PELPTATRRPFYISE 98

  Fly   285 QQL------------YAHRSA---------FMAGLTGNNLELLTQHLKLKSE-QPQQQQQQHRIK 327
            .||            :.|..|         |...|..:...|...|||..:| ||......:
Zfish    99 PQLAEFPPYYKSSFGWDHGPASYQEFRHMGFSPSLLHHASSLYGAHLKQSAEPQPLDCSTHY--- 160

  Fly   328 DEQQQDNRSAAALMNLVAAAEFG---YMRNQHQQPQQQQ----QQQLHHQQQPQQHQ--HQQQHP 383
              ....|.......:.|.:...|   ::|..|...:..:    ::...|....:||.  |.|:
Zfish   161 --SPSSNTYHCITCDKVFSTSHGLEVHVRRSHSGTRPFECSICRKSFGHAVSLEQHMNVHSQE-- 221

  Fly   384 DSTATDVARRSSSSSSYQGENEEKRSGRNFQCKQCGKSFKRSSTLSTHLLIHSDTRPYPCQYCGK 448
                                       |:|:||.|||:|||||||||||||||||||||||||||
Zfish   222 ---------------------------RSFECKMCGKTFKRSSTLSTHLLIHSDTRPYPCQYCGK 259

  Fly   449 RFHQKSDMKKHTYIHTGEKPHKCTVCLKAFSQSSNLITHMRKHTGYKPFGCHLCDQSFQRKVDLR 513
            |||||||||||||||||||||||.||.||||||||||||.|||||:|||||.:|.:.||||||||
Zfish   260 RFHQKSDMKKHTYIHTGEKPHKCQVCCKAFSQSSNLITHSRKHTGFKPFGCEICSKGFQRKVDLR 324

  Fly   514 RHRESRH 520
            ||.||:|
Zfish   325 RHHESQH 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sens	NP_524818.1	zf-C2H2	413..435	CDD:278523	18/21 (86%)
		C2H2 Zn finger	415..435	CDD:275368	17/19 (89%)
		COG5048	423..>497	CDD:227381	69/73 (95%)
		zf-H2C2_2	428..452	CDD:290200	23/23 (100%)
		C2H2 Zn finger	443..463	CDD:275368	19/19 (100%)
		zf-H2C2_2	455..480	CDD:290200	22/24 (92%)
		C2H2 Zn finger	471..491	CDD:275368	16/19 (84%)
		C2H2 Zn finger	499..516	CDD:275368	11/16 (69%)
gfi1b	NP_001258770.1	TonB_N	18..93	CDD:292650	16/58 (28%)
		COG5048	<126..326	CDD:227381	109/233 (47%)
		C2H2 Zn finger	169..190	CDD:275368	3/20 (15%)
		C2H2 Zn finger	198..218	CDD:275368	3/19 (16%)
		zf-H2C2_2	210..235	CDD:290200	12/53 (23%)
		C2H2 Zn finger	226..246	CDD:275368	17/19 (89%)
		C2H2 Zn finger	254..274	CDD:275368	19/19 (100%)
		zf-H2C2_2	266..291	CDD:290200	22/24 (92%)
		C2H2 Zn finger	282..302	CDD:275368	16/19 (84%)
		C2H2 Zn finger	310..326	CDD:275368	10/15 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10685
eggNOG	1	0.900	-	-		E33208_3BCNN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2013
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810