DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lsp2 and Lsp1gamma

DIOPT Version :9

Sequence 1:	NP_001287042.1	Gene:	Lsp2 / 45326	FlyBaseID:	FBgn0002565	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_523868.1	Gene:	Lsp1gamma / 38015	FlyBaseID:	FBgn0002564	Length:	772	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	253/783 - (32%)
Similarity:	396/783 - (50%)	Gaps:	128/783 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVIALAAVALLATLGQAKHLDSKVADKDFLMKQKFMYQILQHIYQDDVFTTPFGGSYVEYKPW-- 67
            |::.||.||.: |.........|:|||:||.||||:::|:..|.:..:|           :.|
  Fly     4 TLVILALVACV-TAFSVPTQKVKIADKNFLEKQKFLFEIVHRIDEPLMF-----------EEWIK 56

  Fly    68 ---EHVADYVHPEMLEHFFE-LWQHQP----FTDDMVWSVMYDKHEEYVVGLVRLFYFAKNWETF 124
               :.:.|....|..:.:.| ||:...    ......:..:...|.:...||...||:||:||||
  Fly    57 MGQKLITDKAQYETFDFYMEKLWESYKLGALLPKGEFFGALVKTHHKQAYGLFNFFYYAKDWETF 121

  Fly   125 QHVVYWARQHVNKQLFVYAVTIASLFRDDMQGVVLPAHYEIHPWSYFDSQALEWAEHYKMHGFHH 189
            ...|.|||.|||:.:||||:|:|.:.:.:.:|::||..|||.|..:|:|:.:..||.:....|..
  Fly   122 VRNVAWARIHVNEGMFVYALTLAVIHKPEFEGLILPQIYEIFPQYFFNSKFVYAAEKFDYEVFSK 186

  Fly   190 VKQMDNIYNVVIRTNYSNVHGS------------------------------------------- 211
            :...:..|..::..:||...|:
  Fly   187 LTMYEKEYKDILYKDYSEFTGNFYFYTKDWKTWQWYKMMGLDQEWYVEDKYFLRENLSQFVNDPK 251

  Fly   212 --------------LNYDHD---------LAYYLEDVGFNAFYYYFNLDYPFWTKGGEEHVLNKD 253
                          ::|..|         :.|:.||:|:||::||.|:||.|:. .|::..|:||
  Fly   252 YVDVVKGLKKFYMPVDYTRDIDFFNDETKMTYFTEDLGWNAYWYYLNMDYAFFL-NGKQFGLDKD 315

  Fly   254 RRGELYLYVHWQLLARWYLERLSHDLGEVPAFNMYVPTESGYASNLRTYYGVPQWHRENHHSFYH 318
            ||||.::|...|:|||:|.|||::..||:|.|..|...|.||...|..|.|:...:|:|::.||.
  Fly   316 RRGEYWIYNVQQILARYYQERLANGFGEIPEFFWYKQIEYGYDPQLIYYNGIGYSYRKNYYDFYT 380

  Fly   319 EHNYEHIEHVEMYTQRVMDWIH-------KNEKFDV---ETINVLGNIIQGNADSVDKKFYGSLD 373
            ...:|....::.:..||...:.       ..:.||:   |.|.::||.:|||||:.||.|:.
  Fly   381 YGKFEMYSQIQNFFSRVYKVLETGFYKTADGQVFDLHKPEAIKIVGNYLQGNADTFDKYFFN--- 442

  Fly   374 KLYRFIVNEGHHY----GHGD-ESFPGLFMHYDTSMRDPIFYEVYKTIVSHYWHLMETYPEYHKK 433
              |.:::  .|.|    .:.| |.||.:|::::|.:|||.||..||.....::........|.:|
  Fly   443 --YYYLL--AHMYFADVDYNDMEVFPNVFLNFETMLRDPFFYTFYKKFTDVFYTFKYYLKPYTQK 503

  Fly   434 DYAFEGVHIDAVHMPESLTTYFEHFDSDISNAVNVEPA-VEGSADPLYTFGRNSHYKGSSYVIKA 497
            |..:||:.|..|.: ..|.||::..|.|::|.:|.:.. |:|.    |.:.:         .:.|
  Fly   504 DLFYEGITIKDVSV-SKLVTYYDIVDFDVTNLLNDKMTFVDGQ----YIWDK---------ALLA 554

  Fly   498 RQQRLNHKPFEFTLDVTSDKAQDAVVKVFIGPKYDEHGHEIPLEHNYQNFFELEHFKVHLEAGVN 562
            ||.|||||||.|...:.|||.|..||:||:|||:||:|..|||::|.:||.:::.|.....||.|
  Fly   555 RQARLNHKPFNFEFTIDSDKVQKGVVRVFLGPKFDEYGRVIPLDYNRKNFVQIDSFVYPFIAGTN 619

  Fly   563 HIKRASGDFSFWVNDRTTYLELYQKLMDATNSDYKFKLDQSEAHCGVPNRMMLPRGKKGGQVFQF 627
            .|||:|.:||:...||.||.|||:.:|.|:...|.|.||.||.|...|:|::||:|.:.|...||
  Fly   620 TIKRSSKEFSWTAEDRITYTELYKYVMLASEGKYDFPLDISEPHNAFPDRLVLPKGWEQGMPMQF 684

  Fly   628 FYMVYPYHQPEVAQFTGYDPVVSCGVGHGSRYVDALPFGFPFNRPVKHDYYFDVHNFKFVDVKIF 692
            ::.|.|:.: ...||:.:|...|.|||.|:|:||..|||:||:|.:....:| |.|..|.|||::
  Fly   685 YFFVSPFAE-TYEQFSNFDYTYSSGVGSGTRFVDTKPFGYPFDRQIDESDFF-VPNGFFKDVKVY 747

  Fly   693 HRD 695
            :.|
  Fly   748 YVD 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lsp2	NP_001287042.1	Hemocyanin_N	33..156	CDD:281684	39/132 (30%)
		Hemocyanin_M	163..420	CDD:278784	92/337 (27%)
		Hemocyanin_C	430..693	CDD:281685	108/263 (41%)
Lsp1gamma	NP_523868.1	Hemocyanin_N	31..153	CDD:397678	39/132 (30%)
		Hemocyanin_M	159..490	CDD:395296	92/338 (27%)
		Hemocyanin_C	499..747	CDD:397679	108/263 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28IXN
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27073
OrthoDB	1	1.010	-	-		D130404at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11511
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3797
	7	6.860